Atomax na-ezo aka na ọgwụ ọgwụ-emume nke ọgbọ III, nke nwere mmetụta na-ebelata ikelata. Ọ bụ ngọngọ nke nhọrọ HMG-CoA reductase, enzyme nke na - egbochi njedebe cholesterol njikọ.
Ojiji nke ọgwụ ahụ dabara adaba na ọgwụgwọ hypercholisterinemia na thyroglobulin dị elu (TG). Site na Atomax, enwere ike ibunye metabolism nke mmanu mmanu ana - apusi iguzo nsonaazụ nke cholesterol di elu.
N'ime ihe a ị nwere ike ịchọta ozi zuru ezu banyere ọgwụ ọgwụ Atomax, ntuziaka maka ojiji, ọnụahịa, nyocha ndị ọrịa na ọgwụ ndị yiri ya.
Mwepụta wepụtara ya na ihe mejupụtara
Atomax bụ ọgwụ achọrọ iji gbochie HMG-CoA reductase, nke a na - ebute nsụkọta cholesterol na mkpụrụ ndụ akwara. N'adịghị ka statins nke ọgbọ mbụ, Atomax bụ ọgwụ nke sitere na sịntetik.
Na ahịa ọgwụ ị nwere ike ịchọta ọgwụ ọgwụ ụlọ ọrụ India HeteroDrags Limited na osisi ụlọ nke Nizhpharm OJSC, Skopinsky Pharmaceutical Plant LLC.
Atomax dị n'ụdị mbadamba ọcha nke gbara agba gburugburu akụkụ ya. Site n’elu ka ekpuchiri ha ahihia fim. Otu ngwugwu nwere mbadamba iri atọ.
Mbadamba ụrọ ahụ gụnyere 10 ma ọ bụ 20 mg nke ihe na - arụ ọrụ - atorvastatin calcium trihydrate.
Na mgbakwunye na akụrụngwa bụ isi, mbadamba ihe ọ bụla na shei ya nwere ụfọdụ ego:
- sodium croscarmellose;
- mee ntụ ntụ nke ọcha;
- lactose n'efu;
- steeti magnesium;
- ọka ọka;
- kaboneti carbonate;
- povidone;
- silloon dioxide anakpo colloidal;
- crospovidone;
- triacetin;
Na mgbakwunye, a na-etinye sọks titanium dioxide na nkwadebe ahụ.
Usoro nke ihe eji arụ ọrụ
Dịka anyị kwuru na mbụ, a na-enweta mmetụta mmachi nke Atomax site na igbochi HMG-CoA reductase. Ebumnuche nke enzyme a bụ ịtụgharị methylglutarylcoenzyme A na mevalonic acid, nke bụ usoro nke cholesterol.
Atorvastatin na-arụ ọrụ na mkpụrụ ndụ imeju, na-ebelata ego nke LDL na mmepụta cholesterol. Ejiri ya maka ndị ọrịa na-arịa ọrịa hypercholesterolemia, nke enweghị ike ịgwọ ya na ọgwụ ndị ọzọ belata cholesterol. Mgbanwe nke mbelata cholesterol na-adabere na oke nke ihe bụ isi.
Atomax adighi akwado ka ewere ya n’oge nri, dika iri nri na - ebelata oke nke mmiri. Akụkụ ahụ nọ n'ọrụ na-etinye obi gị dum na ngọngọ diges. A na-ahụ ọdịnaya kachasị nke atorvastatin ruo awa 2 mgbe etinyere ọrụ.
N'okpuru nduzi nke enzymes pụrụ iche CY na CYP3A4, metabolism na-eme na imeju, n'ihi nke a na-etolite metabolites parahydroxylated. Mgbe ahụ, ewepụrụ metabolites n'ahụ ya na bile.
Ihe ngosi na contraindications maka iji ogwu
Ejiri Atomax belata cholesterol. Dọkịta na-edepụta ọgwụ ọgwụ na nri nri maka ọrịa ndị dị ka isi, heterozygous ezinụlọ na hypercholesterolemia na-abụghị nke ezinụlọ.
Iji mbadamba ụrọ dịkwa mkpa maka ụba mkpụrụ nke thyroglobulin (TG), mgbe ọgwụgwọ nri anaghị eweta nsonaazụ achọrọ.
Atorvastatin na -ebelata cholesterol nke ọma na ndị ọrịa nwere hypercholesterolemia homozygous familialia, mgbe ọgwụgwọ na nri anaghị agwọ onwe ya.
A machibidoro Atomax iwu maka ụfọdụ ndị ọrịa. Ntụziaka ahụ nwere ndepụta nke contraindications maka iji ọgwụ a:
- Childrenmụaka na ndị nọ n’agbata afọ iri na asatọ.
- Oge ị ga-amụ nwa na inye ya ara.
- Hepatic dysfunction nke amaghi.
- Ntinye aka na mmiri nke ngwaahịa a.
Ejiri ọgwụ ahụ jiri nlezianya mee ihe banyere hypotension akwara, nleghara anya nke electrolytes, malfunctions nke usoro endocrine, ọrịa imeju, a chronicụrụma na-adịghị ala ala na Akwụkwụ na-adọ, enweghị ike ịchịkwa.
Ntuziaka maka iji ọgwụ ahụ
Isi ihe dị mkpa na ọgwụgwọ Atomax bụ idebe nri pụrụ iche. Ihe oriri na-edozi ahụ iji belata oriri nke nwere cholesterol dị elu. Ya mere, nri anaghị ewepụ iri viscera (akụrụ, ụbụrụ), yolks akwa, bọta, anụ ezi, wdg.
Usoro onorvastatin dịgasị iche site na 10 ruo 80 mg. Dịka iwu, dibịa bekee depụtara ọgwụ izizi nke 10 mg kwa ụbọchị. Ọtụtụ ihe na-emetụta usoro ị aụ ọgwụ, dị ka ọkwa nke LDL na kọlestrọl ọnụ, ebumnuche ọgwụgwọ na arụmọrụ ya.
Ibawanye usoro ogwu nwere ike rụrụ mgbe ụbọchị 14-21 gachara. N'okwu a, ntinye nke lipids na plasma ọbara bụ ihe amanyere.
Mgbe ọgwụgwọ 14 gachara, a na-achọpụta mbelata nke ọkwa cholesterol, mgbe ụbọchị iri abụọ na abụọ gachara, a na-enweta ike ọgwụgwọ kachasị. Site na usoro ọgwụgwọ ogologo oge, metabolism metabolism na-alaghachi na nkịtị.
Must ga-echekwa ọgwụ a ebe a na-echekwa ya site na obere ụmụaka. Usoro nchekwa okpomọkụ nke nchekwa dị na 5 ruo 20 Celsius.
Ndụ shelf bụ afọ abụọ, mgbe oge a gasịrị, amachibidoro ị medicineụ ọgwụ.
Ihe m Pụrụ Ime na do Overụbiga mmanya ókè
A machibidoro ịnwe nchịkwa nke ọgwụ maka ọgwụgwọ ọgwụ ọgwụ.
Mgbe ufodu, ogwu nwere ike ibute mmeghachi omume ojoo n’onye oria.
Tupu iji Atomax, ịkwesịrị ịgakwuru dọkịta gị.
Akwụkwọ ntụziaka a na - ekwupụta omume enwere ike ịme ụdị mmetụta ndị a:
- Ọgba aghara nke usoro akwara dị n’etiti ahụ: ọrịa asthenic, ụra na-adịghị mma ma ọ bụ ụra, ụra abalị, amnesia, dizziness, isi ọwụwa, nkụda mmụọ, tinnitus, nsogbu obibi, paresthesia, neuropathy akụkụ, uto ọgba aghara, ọnụ akọrọ.
- Mmeghachi omume metụtara akụkụ anụ ahụ na -akụ ahụ: mmepe nke ntị chiri, nkụkpọ nkụ.
- Nsogbu nke akwara na akwara obara: obi ajuju, oria ajuju, oria anakpo (hyperension), oromhostatocytopenia, onodu ubara, obi na akpo.
- Dysfunction of the digestive tract and biliary system: afọ ntachi, afọ ọsịsa, ọgbụgbọ na ọgbụgbọ, mgbu nke afọ, hepatic colic, belching, obi mgbawa, ịba ụba gas na -eme, nnukwu pancreatitis.
- Mmeghachi omume nke anụ ahụ: itching, ihe ọkụ ọkụ, eczema, mgbu nke ihu, eserese.
- Nsogbu nke uru ahụ: akwara olu nke ala akụkụ ahụ, azụ mgbu nke nkwonkwo na azụ, myositis, rhabdomyolysis, ogbu na nkwonkwo, iwe nke gout.
- Urination na-enweghị nsogbu: urination na-egbu oge, cystitis.
- Ọkpụkpụ nke palọmeta: hematuria (ọbara na mmamịrị), albuminuria (protein na mmamịrị).
- Mmeghachi omume ndị ọzọ: ọbara mgbali elu, agụụ mmekọahụ na-ebelata, dysfunction dysfunction, alopecia, sweating overrese, seborrhea, stomatitis, goms ọbara ọgbụgba, eriri akụkụ, ikpu na imi.
Atụ atorvastatin dị elu na-eme ka ohere nke akụrụ ghara ibute ọrịa, yana myopathy (ọrịa neuromuscular) na rhabdomyolysis (oke ogo myopathy).
Ruo ugbu a, enweghi ọgwụ pụrụ iche maka ọgwụ a.
Ọ bụrụ n ’ihe ịrịba ama nke ịdoụbiga mmanya ókè, a ga-ewepụ ha. N'okwu a, ọrịa ịba ọcha n'anya anaghị arụ ọrụ.
Mmekọrịta na ọgwụ ndị ọzọ
Ihe aru oru nke ogwu nwere ike imeghari n'etiti onwe ha n'uzo di iche iche, n'ihi nke ọgwụgwọ oria Atomax nwere ike idi elu ma obu wedata ya.
Ohere inwe mmekọrịta n'etiti ihe dị iche iche nke ọgwụ dị iche iche chọrọ na onye ọrịa ahụ ga-agwa dibịa na-aga ahụ maka ị medicationsụ ọgwụ na-emetụta ọrụ Atomax.
Ntuziaka maka iji ọgwụ hypoliplera, enwere ozi zuru oke banyere njikọta nke ọgwụ ndị ọzọ.
Ntụziaka na-agwa:
- Ejikọtara ọnụ na cyclosporine, erythromycin, fibrates na antifungal (otu ìgwè nke ihe mgbu) na-abawanye ihe ize ndụ nke ọrịa akwara ozi - myopathy.
- N'oge nyocha, nchịkwa oge nke Antipyrine anaghị eme mgbanwe dị ukwuu na ọgwụ ọgwụ. Ya mere, a na-anabata nkwonkwo ọgwụ abụọ.
- Yiri ojiji nke ihe na - egbochi ihe nwere magnesium hydroxide ma ọ bụ aluminom hydroxide, na - eduga n'ịbelata ọdịnaya nke atorvastatin na plasma.
- Njikọ nke Atomax yana ọgwụ mgbochi afọ ime nke nwere tinylestradiol na norethindrone na-abawanye AUC nke ihe ndị a.
- Ojiji nke colestipol n’otu oge belata ogo atorvastatin. N'aka nke a na-eme ka mmerụ ahụ dị ala belata.
- Atomax nwere ike iwelie ọdịnaya digoxin n'ime n'ọbara. Ọ bụrụ na ọ dị mkpa, ịgwọ ọgwụ a kwesịrị ka ọ bụrụ nlekọta ahụike siri ike.
- Nlekọta nke Azithromycin adịghị emetụta ọdịnaya nke ngwa ọrụ Atomax nọ n'ọrụ na plasma ọbara.
- Ojiji nke erythromycin na clarithromycin na-akpata mmụba nke ọkwa nke atorvastatin n'ọbara.
- N'oge nyocha nke ụlọ ọgwụ, achọpụtaghị mmeghachi omume kemịkal n'etiti Atomax na Cimetidine, Warfarin.
- A na-achọpụta mmụba na ọkwa nke ihe na-arụ ọrụ mgbe ejikọtara ọgwụ ahụ na mgbochi mgbochi.
- Ọ bụrụ na ọ dị mkpa, dọkịta ahụ na-enye gị ohere ikpokọta Atomax na ọgwụ, nke gụnyere Amplodipine.
- Emebeghị nnyocha banyere otú ọgwụ si emekọrịta ọgwụ ọgwụ mgbochi.
Site na njikọta nke Atomax na estrogens, enweghị ihe ọjọọ ọ bụla hụrụ.
Ọnụahịa, nyocha na analogues
O nweghi ihe omuma banyere odi nma nke iji Atomax na intaneti. Eziokwu ahụ bụ na ka ọ dị ugbu a, a na-eji ihe owuwu oria IV eme ihe na ahụike. Ọgwụ ndị a nwere usoro onunu ogwu ha, ha anaghị akpata ọtụtụ nsonaazụ.
Atomax siri ezigbo ike ịzụta na ụlọ ahịa ọgwụ nke mba ahụ n'ihi eziokwu ahụ bụ na ọ dịchabeghị eji ya. Na nkezi, ọnụahịa nke ngwugwu (mbadamba 30 nke 10 mg) sitere na 385 ruo 420 rubles. Ọ bụrụ na ọ dị mkpa, enwere ike inye ọgwụ ahụ ntanetị na weebụsaịtị nrụọrụ weebụ nke ndị nrụpụta.
Onu ogugu n’ilele banyere ihe nlere na egbusi ike n’ogugu ha. Maka oge kachasị, ha na-ekwu maka omume nke mmeghachi omume ọjọọ mgbe ha na-a theụ ọgwụ ahụ. Agbanyeghị, enwere echiche dị iche.
N'ihi contraindications dị iche iche na mmeghachi omume na-adịghị mma, mgbe ụfọdụ, dọkịta na-edepụta otu okwu (ọgwụ nwere otu ihe ahụ na-arụ ọrụ) ma ọ bụ analog (nke mejupụtara ihe dị iche iche, mana na-ewepụta ụdị ọgwụgwọ ahụ).
Enwere ike ịzụta okwu Atomax ndị a na ahịa ọgwụ Russia.
- Atovastatin (Nke 30 na 10 mg - 125 rubles);
- Atorvastatin-Teva (Mba. 30 maka 10 mg - 105 rubles);
- Atoris (Nke 30 maka 10 mg - 330 rubles);
- Liprimar (Nke 10 na 10 mg - 198 rubles);
- Novostat (Mba. 30 maka 10 mg - 310 rubles);
- Tulip (Nke 30 maka 10 mg - 235 rubles);
- Torvacard (Nke 30 na 10 mg - 270 rubles).
N'etiti ihe atụ nke dị mma nke Atomax, ọ dị mkpa ịmata ọdịiche dị iche iche ọgwụ ọjọọ:
- Akorta (Nke 30 maka 10 mg - 510 rubles);
- Krestor (Nke 7 maka 10 mg - 670 rubles);
- Mertenil (Nke 30 maka 10 mg - 540 rubles);
- Rosuvastatin (Nke 28 na 10 mg - 405 rubles);
- Simvastatin (Mba. 30 na 10 mg - 155 rubles).
N'ịga ọmụmụ ọgwụ Atomax nke ọma, ntuziaka maka ojiji, ọnụahịa, analogues na echiche nke ndị na - ere ahịa, onye ọrịa ahụ, ya na ndị ọkachamara na - aga ya, ga - enwe ike iji echiche ichebara mkpa ị takingụ ọgwụ ahụ.
Enyere ozi banyere akpụ na vidiyo na edemede a.
