Diapiride bụ ọgwụ nwere mmetụta hypoglycemic dị ogologo. Ọgwụ a bụ nke ọtụtụ usoro sulfonylurea.
International Nonproprietary Aha
Ego INN - Glimepiride.
Diapiride bụ ọgwụ nwere mmetụta hypoglycemic dị ogologo.
ATX
Koodu ATX: A10VB12.
Ha weputara udi ya na ihe mebere ya
A na-eme ọgwụ ahụ n'ụdị mbadamba dị iche iche na usoro nke ihe arụ ọrụ. N’ime kaadiboodu bu mbadamba 30 n’ime blisters. Otu mbadamba 1 nwere 2, 3 ma ọ bụ 4 mg nke glimepiride (ihe na-arụ ọrụ). Mbadamba ọgwụ ndị nwere onunu ogwu nke 2 mg bụ akwụkwọ ndụ akwụkwọ ndụ, 3 mg dị edo edo, 4 mg bụ acha anụnụ anụnụ.
Ngwakọta nke mbadamba ihe ndị a nwere ụdị ndị a:
- lactose monohydrate;
- microcrystalline cellulose;
- sodium stachi glycolate;
- povidone;
- ọla edo iron;
- steeti magnesium;
- indigo carmine.
Glimepiride nwere mmetụta hypoglycemic site na mkpali ịhapụ insulin.
Omume ọgwụ
Glimepiride nwere mmetụta hypoglycemic site na mkpali ịhapụ insulin. Ihe a na - arụ na membranes nke β-sel nke pancreas, na - emechi ụzọ ndị potassium. N'ihi ya, mkpụrụ ndụ ndị a na-enwe mmetụta nke ọma karịa ogo shuga dị n’ahụ, a na-ahapụkwa insulin ngwa ngwa na ngwa ngwa.
Enwekwara mmụba na sel nke insulin, yana imeju ya na-ebelata. N'otu oge ahụ, a na-egbochi gluconeogenesis. Ahụsi ike na akwara na-ejide ụmụ irighiri glucose ngwa ngwa n'ihi mmụba nke ụba protein ebu.
Ihe na-arụ ọrụ na-eme ka nrụgide oxidative sie ike site na-akpali mmepụta α-tocopherol na ịkwalite ọrụ nke enzymes antioxidant.
Mlọ ọgwụ
Mgbe nchịkwa ọnụ gasịrị, glimepiride na-abanye ngwa ngwa na ngwangwa ahụ wee banye n'ọbara. Iri nri anaghị ibelata nnabata ọgwụ a. Ihe a na-abanye n'ọbara kachasị na plasma ọbara n'ime awa 2-2.5.
Mgbe nchịkwa ọnụ gasịrị, glimepiride na-abanye ngwa ngwa na ngwangwa ahụ wee banye n'ọbara.
Ejiri Glimepiride bụ ezigbo njikọ na protein protein (99%). A na-eme metabolism nke ọgwụ ahụ na imeju. Ọ bụ akụrụ na eriri afọ na-ewepụta metabolites ndị na-esite. A na-esi ọgwụ ahụ wepụta ọgwụ ahụ n'ime awa 10-16. Mgbe ị na-ewere Diapiride, a naghị ahụ nchịkọta ihe ndị dị na ahụ (ọbụlagodi iji ogologo oge).
Ihe ngosi maka ojiji
A na-eji ọgwụ ahụ agwọ ndị ọrịa nwere ụdị ọrịa mellitus nke II. Edere mbadamba mbadamba mgbe ọ na-agaghị ekwe omume ịhazi shuga ọbara site na iji nri kwesịrị ekwesị na mmega ahụ.
Ihe ngbanwe
Amachibidoro ị medicineụ ọgwụ ma ọ bụrụ na enwere ọgwụ ndị a:
- Anabataghị Onye ọ bụla na sulfonamides.
- Ntinye obi na mmiri.
- Coma
- Ketoacidosis.
- Veredị ọrịa imeju ma ọ bụ akụrụ dị njọ.
- Ọrịa shuga 1dị 1.
- Oge nke ime na lactation.
- Afọ ụmụaka.
Jiri nlezianya
N'okpuru nlezianya nke dọkịta, a na-eji ọgwụ ahụ eme ihe maka ọrụ ngwa ngwa, ịhoụbiga mmanya ókè, ahụ ọkụ, nsị thyroid, enweghị ume adrenal na ọrịa siri ike.
Mgbe usoro ọgwụgwọ ahụ siri ike, mmerụ ahụ, ọkụ, a na-adụ ndị ọrịa ume ka ha gbanwee gaa na ọgwụ insulin.
Etu esi ewere diapiride?
A na-eji ọgwụ a oụ ọgwụ na mmiri. Ọ bụ ihe amamihe dị na ikpokọta mbadamba mbadamba nri iji gbochie afọ iri na ise.
Na-arịa ọrịa shuga
Maka ọgwụgwọ nke ụdị ọrịa shuga mellitus nke II na-abụghị insulin, a na-a drugụ ọgwụ a 1-2 ugboro n'ụbọchị. Na mmalite nke dose, dose bụ 1 mg na usoro nke glimepiride. Ọ bụrụ na ezuru ịmeju glucose n'ime ọbara, mgbe ahụ ọnụọgụ ahụ anaghị aba ụba.
Site na mmetụta na-ezughị ezu, a na-eji nwayọọ nwayọọ mụbaa ọgwụ ahụ ruo 2, 3 ma ọ bụ 4 mg. Oge dị n'etiti mgbanwe usoro ọgwụgwọ kwesịrị ịbụ opekata mpe 7. Mgbe ụfọdụ, a na-edenye ndị ọrịa 6 mg nke glimepiride kwa ụbọchị (nke kachasị na-anabata kwa ụbọchị).
Ndị dọkịta nwere ike inye ọgwụ nhazi ọgwụ na metformin ma ọ bụ insulin iji rụpụta oke. Drugsụ ọgwụ ndị a nwere ike ibute mmụba nke insulin. N'okwu a, a na-ebelata dose ahụ ma ọ bụ kagbuo kpamkpam.
Mmetụta ndị metụtara Diapyrid
Na akụkụ ahụ nke ọhụụ
N'oge ọgwụgwọ, nsogbu ọgbaghara na-adịghị ala ala (nbibi nwa oge) nwere ike ime. Ihe na - akpata nsonaazụ ya bụ mgbanwe shuga dị n’ọbara.
Maka ọgwụgwọ nke ụdị ọrịa shuga mellitus nke II na-abụghị insulin, a na-a drugụ ọgwụ a 1-2 ugboro n'ụbọchị.
Ọkpụkpụ afọ
Mmetụta na igwu nri nri:
- ọgbụgbọ na ọgbụgbọ
- afọ ọsịsa
- mgbu afọ;
- ọrịa imeju (ịba ọcha n'anya, ọrịa imeju, wdg).
Ahụhụ Hematopoietic
Mmetụta akụkụ sitere na sistemu hematopoietic:
- thrombocytopenia;
- leukopenia;
- anaemia
- granulocytopenia;
- erythrocytopenia;
- agranulocytosis;
- pancytopenia.
Sistemụ akwara Central
Si n'akụkụ nke Central ụjọ usoro a hụrụ:
- isi ọwụwa
- Dizziness
- ọgba aghara nke nsụhọ;
- ehighi ura
- ike ọgwụgwụ;
- ọnọdụ ịda mba;
- ibelata mmeghachi omume psychomotor;
- nkwarụ okwu;
- oke aka nke ukwu;
- ogwe.
Site n'akụkụ nke metabolism
A na - egosipụta hypoglycemia nke na - adịghị mma na metabolism.
Ahụhụ
N'oge nchịkwa, enwere mmeghachi omume nfụkasị:
- akpụkpọ anụ
- urticaria;
- ihe odide
- nfụkasị vasculitis.
Maka oge ị ofụ ọgwụ ahụ site na sistem akwara, isi ọwụwa nwere ike ịpụta.
Maka oge ị withụ ọgwụ ahụ site na sistemụ akwara, enwere ike ịpụta.
Maka oge ị withụ ọgwụ ahụ site n'akụkụ akụkụ akwara ozi, enwere ike ịpụta ọgba aghara.
Ruo oge ị withụ ọgwụ ọjọọ site na sistemụ akwara, ụra ehighị ụra nwere ike ịpụta.
Maka oge ị ofụ ọgwụ ahụ site na sistemụ akwara, ike ọgwụgwụ mụbara nwere ike ịpụta.
N'ime oge ọgwụgwọ ahụ site na ọgwụ ahụ site na sistemụ akwara nke etiti, ọnọdụ ịda mba nwere ike ịpụta.
Ruo oge usoro ị withụ ọgwụ ya site na sistem akụkụ akwara, enwere ike ịmị ihe.
Mmetụta ikike ịchịkwa usoro
Ọgwụ nwere ike belata ọsọ nke mmeghachi omume psychomotor ma mee ka ọgbụgba. Na nmalite ọgwụgwọ, yana mgbe ị na-agbazi doses, a naghị atụ aro ịkwọ ụgbọala na ịrụ ọrụ ndị ọzọ chọrọ mgbanye uche ka ukwuu.
Ntụziaka pụrụ iche
Ọ bụrụ n’ọkwa glucose dị n’ọbara na-agbadata n’usoro dị ala kwa ụbọchị (1 mg nke glimepiride), a na-atụ aro ka iji nwayọ kwụsị ị theụ ọgwụ. Enwere ike nweta mmetụta hypoglycemic na nke a site na iji usoro ọgwụgwọ (enweghị ọgwụ).
N'oge usoro ọgwụgwọ, ịkwesịrị inyocha ọbara glucose, haemoglobin glycosylated, yana umeji, sel ọbara na platelet dị n'ọbara.
Jiri na agadi
Ewere ka eji ya rụọ ọrụ maka ndị ọrịa nke afọ dị iche iche, ewezuga ụmụaka. Ma ndị agadi na-eji ọgwụ ogologo oge nwere ike ịmalite hypoglycemia. Iji zere usoro ogwu a, ndị dọkịta na-enye ndị ọrịa agadi nri nri pụrụ iche na obere ọgwụ ọgwụ (ọ bụrụ na ọ ga-ekwe omume).
Inye umuaka
Ewere ọgwụ a ka ọ jiri afọ 18 gachara.
Jiri n'oge ime na lactation
N'oge ime na lactation, ị thisụ ọgwụ a na contraindicated.
Ọ bụrụ n’ọkwa glucose dị n’ọbara na-agbadata n’usoro dị ala kwa ụbọchị (1 mg nke glimepiride), a na-atụ aro ka iji nwayọ kwụsị ị theụ ọgwụ.
Ngwa maka ọrụ ezughi oke ọrụ
Ọrịa akụrụ siri ike, ọ nweghị ọgwụ ọ bụla ka ọ depụtara. A na-ebuga ndị ọrịa dị otú ahụ na ọgwụ insulin. N'ime usoro mmalite nke ọdịda akụrụ, iji mbadamba ọgwụ ga-ekwe omume n'okpuru nlekọta dọkịta.
Jiri maka ọrụ imeju na-arụ ọrụ
Ọrịa imeju siri ike bụ ọgwụ mgbochi iji ọgwụ. Na ọrịa dị nro ma ọ bụ na-agafeghị oke, nchịkwa ya na obere doses ga-ekwe omume. Ekwesịrị ịnwe usoro ọgwụgwọ ahụ na ijikwa imeju.
Dodoụbiga mmanya ókè nke Diapiride
Do overụbiga ọgwụ ike ókè na-eduga n'inwe mmeghachi omume hypoglycemic (mmụba shuga dị n'ọbara). N'okwu a, onye ọrịa na-enwe ike ọgwụgwụ, ụra, ure. Ohere nwere ike wepu. Iji wepu ihe mgbaàmà nke oke ịdoụbiga mmanya ókè, ha na-amalite ọgwụgwọ Symptomatic.
Do overụbiga ọgwụ ike ókè na-eduga n'inwe mmeghachi omume hypoglycemic (mmụba shuga dị n'ọbara).
Mmekọrịta na ọgwụ ndị ọzọ
Ekwesịrị ị takenụ ọgwụ ahụ na ịkpachara anya yana ọgwụ ndị dị ka:
- Fluconazole
- Phenylbutazone
- Azapropazone.
- Sulfinpyrazone.
- Oxyphenbutazone.
- Pentoxifylline.
- Tritokvalin.
- Mmebi iwu.
- Fenfluramine.
- Probenecid.
- Anticoagulants sitere na otu coumarin.
- Salicylates.
- Antfọdụ antidepressants (MAO inhibitors).
- Fibrates.
- Fluoxetine.
- Cyclophosphamide.
- Feniramidol.
- Ifosfamide.
- Miconazole
- Ọgwụ Tetracycline na ọgwụ mgbochi quinolone.
- Ọgwụ hypoglycemic ndị ọzọ.
- Anabolic steroid.
- Ihe mgbochi ACE.
- PASK (para-aminosalicylic acid).
A na-ahụ mbelata mmetụta nke ọgwụ ahụ mgbe ejikọtara ya na Phenothiazine na usoro ya.
Site na iji ego ndị a na-eme n'otu oge, a na-eme ka mmetụta hypoglycemic nke Diapiride dịkwuo mma. A na-ahụ mbelata mmetụta nke ọgwụ ahụ mgbe ejikọtara ya na Phenothiazine yana usoro ya, estrogens na progestogens, glucagon, nicotinic acid, corticosteroids, barbiturates, Phenytoin, Acetazolamide, diuretics na ọgwụ maka ọgwụgwọ nke thyroid gland.
Mmanya ndakọrịta
Ọgwụ nwere nnabata nkwekọ na ethanol. Ihe ọcoụcoụ na-egbu egbu nwere ike ịbawanye ma wedata mmetụta ọgwụgwọ Diapiride.
Analogs
Enwere ụdị analogues nke ọgwụ:
- Gliclazide.
- Maninil.
- Ọrịa mamịrị.
- Glidiab.
- Glurenorm.
Ahịa ọgwụ na-ahapụ okwu
Enwere m ike ịzụta na ndenye ọgwụ?
Ọgwụ na-enye ọgwụ ọgwụ.
Ọnụahịa
Ọnụ ọnụ nke Diapiride na ụlọ ahịa ọgwụ dị site na 110 ruo 270 rubles, dabere na usoro nke ihe arụ ọrụ.
Ọnọdụ nchekwa maka ọgwụ
Debe mbadamba ihe n’ebe a kpọrọ nkụ na ebe gbara ọchịchịrị maka ụmụaka, na-enwe okpomọkụ ruo + 25 Celsius.
Bọchị mmebi
Ndụ shelf bụ afọ 2.
Emeputa
Onye na-emepụta PJSC "Farmak" (Ukraine).
Nyocha
Lyudmila, onye gbara afọ 44, Izhevsk.
Amalitere m iji ọgwụ a dị ka dọkịta si debelata shuga ọbara. Ọgwụ a na-akwụ ụgwọ ma baa ezigbo uru. Ọ na - enyere aka ịchekwa ọkwa shuga.
Alexey, 56 afọ, Moscow.
Anọwo m na-arịa ụdị ọrịa shuga 2 ruo ihe karịrị afọ 5. Ana m a pụ ọgwụ ndị a na obere usoro. N'iji ya eme ihe mgbe niile, ọ̀tụ̀tụ̀ glucose ọbara na-adị ike. Nsonaazụ anaghị adị. Ma m na-anwa ijikọ ọgwụ na nri iji zere nnukwu shuga.
Anna, 39 afọ, Voronezh.
Ọgwụ endocrinologist tụụrụ ọgwụ antidiabet a. Anaghị m anabata ọgwụ a n'ụzọ dị mfe, anaghị m enwe mmetụta nfụkasị ọ bụla. Ọnụ ahịa ya dabara m kpamkpam. Ọbara ọbara dị n'ọbara. Ana m akwado ya!
