Ọgwụ Clopidogrel-Teva: ntuziaka maka ojiji

Clopidogrel-Teva bụ ọgwụ nke na - egbochi nchịkọta platelet ma belata arịa ụgbọ mmiri. A na-eji ngwá ọrụ ahụ maka ọgwụgwọ na mgbochi nke ọrịa obi.

International Nonproprietary Aha

INN - Clopidogrel.

Clopidogrel-Teva bụ ọgwụ nke na - egbochi nchịkọta platelet ma belata arịa ụgbọ mmiri.

ATX

Koodu ATX: B01AC04.

Ha weputara udi ya na ihe mebere ya

Ọgwụ dị n'ụdị mbadamba elongated nke agba pink na-acha odo odo. Ihe nọ n'ọrụ bụ clopidogrel hydrosulfate (na ego nke 75 mg).

Ndị e mere:

• lactose monohydrate;
• microcrystalline cellulose;
• hyprolosis;
• crospovidone;
• hydrogenated oil oil nke ụdị M;
• sodium lauryl sulfate.

Ihe nkiri ahụ mejupụtara ihe ndị a:

• lactose monohydrate;
• hypromellose 15 cP;
• titanium dioxide;
• macrogol;
• oxides na-acha ọbara ọbara na nke edo edo (ihe nchara);
• indigo carmine.

Ọgwụ dị n'ụdị mbadamba nkume.

Omume ọgwụ

Ihe dị ike nke ọgwụ ahụ na-ebelata nchịkọta platelet. ADP nucleotides (adenosine diphosphates) na-agbadata ndị na-egbochi glycoprotein ma na-ekekọta platelet. N'okpuru mmetụta nke clopidogrel, a na-akụghasị usoro ndị a ma si otú ahụ belata nchịkọta platelet (mkpakọrịta). Ọrụ (PDE) nke phosphodiesterase anaghị agbanwe ihe ahụ.

Mmetụta ọgwụ mgbochi ọgwụ ahụ na-adị ndụ niile nke platelet (ihe dịka ụbọchị 7).

Mlọ ọgwụ

Mgbe a na-ewere ya ọnụ, mbadamba nkume ndị ahụ na-abanye n'ime ngwa ngwa. Clopidogrel nwere bioavailability dị elu, mana agbanweghị agbanwe agbanwe (nke a bụ prodrug). Ọ dị n'ọbara nwa oge ma bụrụ nke na-eme ngwa ngwa n'imeju na imeju na-eme ka metabolites nọ n'ọrụ na arụ ọrụ. Mgbe ahụ clopidogrel na metabolite na-arụ ọrụ na-ejikọ protein protein niile.

Otu awa mgbe ị theụsịrị ọgwụ ahụ na ọbara, a na-ahụta mkpụmkpụ nke metabolites na-adịghị arụ ọrụ na clopidogrel na plasma, a na-enweta ọgwụ carbonxylic.

Ọgwụ ahụ na-apụta na mmamịrị ma na-ata ahụ n'ime ụbọchị ise. A na-ewepụta metabolite nọ n'ọrụ n'ime awa iri na isii.

Edere Clopidogrel-Teva maka infarction myocardial.

Ọrịa Ischemic bụ ihe ngosipụta maka iji ọgwụ.

A na-eji Clopidogrel-Teva na ọgwụgwọ nke firamillation atrial.

Ihe ngosi maka iji ogwu ahu bu thrombosis.

Ihe ngosi maka ojiji

Edere ọgwụ ahụ maka igbochi nsogbu ọrịa obi na okwu ndị a:

1. Myocardial infarction.
2. Ọkpụkpụ ọrịa Ischemic.
3. Ọrịa coronary syndrome na-enweghị mmụba na mpaghara ST.
4. Thrombosis (ejikọtara ya na acetylsalicylic acid).
5. Thromboembolism.
6. Atrial fibrillation.
7. Na ọnụnọ nke contraindications maka ojiji nke anticoagulants nke emeghị ihe ọ bụla.

Ihe ngbanwe

Mkpokoro ka e were were nye ndị ọrịa nwere ọrịa imeju (oke ọrịa), ịpersụ ọgwụ na ọbara ma ọ bụ oke ọbara ọgbụgba.

Contraindications bụkwa ịtụrụ ime, ịrara ụmụaka na ụmụaka na-erubeghị afọ 18.

Jiri nlezianya

N'iji nlezianya, a na-enye ọgwụ ahụ maka ọrụ akwara nwere nsogbu (ezughi oke na nhichapụ creatinine nke 5-15 ml / min), mmụba ọbara (hematuria, menorrhagia), yana mgbe ọ rụsịrị ọrụ ịwa ahụ, mmerụ ahụ na ọdịda na sistemụ ahụike.

N'ime ọgwụgwọ ndị ọrịa nwere ọrịa imeju, a na-eme coagulogram oge niile na-enyocha ọrụ nke imeju.

N'iji nlezianya, a na-enye ọgwụ ahụ maka ọrụ akwara nwere nsogbu.

Etu esi ewere clopidogrel-teva?

Ndị ọrịa nwere infarction myocardial ka etinyere 75 mg nke ọgwụ (mbadamba 1) kwa ụbọchị maka ụbọchị 7-35. Ọ bụrụ na ọrịa strok gachara, a na-a theụ ọgwụ ahụ n’otu usoro ahụ, mana usoro ọgwụgwọ ahụ nwere ike ịdịru ọnwa isii.

A na-atụ aro ka ndị ọrịa na-arịa ọrịa na-arịa nnukwu ọrịa na-enweghị mmụba na mpaghara ST ka ha were 300 mg kwa ụbọchị dị ka ọgwụ mbụ. Mgbe ahụ, a na-ebelata ọgwụ ahụ ka 75 mg kwa ụbọchị, mana agwakọta antiplatelet na acetylsalicylic acid. A na-eme ọgwụgwọ ahụ ruo otu afọ.

Na-arịa ọrịa shuga

N'ime ndị ọrịa nwere ọrịa mellitus, a na-ahụkarị nchịkọta platelet mụbara. Maka mgbochi nke ọrịa obi na ọrịa coronary, etinyere 75 mg nke clopidogrel-Teva kwa ụbọchị.

Dọkịta ga-ekpebi oge nlekọta ọrụ yana ị ofụ insulin na-adabere na ọnọdụ onye ọrịa.

Nsonaazụ nke clopidogrel-Teva

Na akụkụ ahụ akụkụ nke ọhụụ

N'azụ ị theụ ọgwụ, ọbara ọgbụgba (azụ na njikọta) nwere ike ime.

Site na anụ ahụ na akwara

Mmetụta na-adịghị mma na musculoskeletal sistem. Ọrịa ogbu ogbu na nkwonkwo, ogbu na nkwonkwo na myalgia ga-ekwe omume.

Ọgwụ nwere ike iduga mmepe nke colitis.

Ọkpụkpụ afọ

A na-egosipụta nsonaazụ na eriri afọ dị ka ndị a:

• mgbu afọ;
• ọbara ọgbụgba na eriri afọ;
• ọgbụgbọ na ọgbụgbọ
• afọ ọsịsa
• ọnya ọnya;
• eriri afọ;
• ọnụ;
• ịba ọcha n'anya;
• ọria aru
• stomatitis
• imeju imeju.

Ahụhụ Hematopoietic

Site n'akụkụ nke usoro a na-ahụ:

• thrombocytopenia;
• leukocytopenia;
• eosinophilia.

Sistemụ akwara Central

Ọgwụ ọgwụ anaghị emetụta sistemụ ụjọ. N'ọnọdụ ndị a na-adịghị ahụkebe, isi ọwụwa, nkụda mmụọ, na ọgba aghara na-apụta.

Site na usoro urinary

Nsonaazụ sitere na akụkụ urinary:

• hematuria;
• glomerulonephritis;
• mụbara creatinine n’ime ọbara.

N'akụkụ ndabere nke ị theụ ọgwụ ahụ, ọnya ọbara nwere ike ime.

Clopidogrel-Teva nwere ike ibute ọrịa ogbu na nkwonkwo.

N'ọnọdụ ụfọdụ, ọgwụ nwere ike ibute gastritis.

N'ọnọdụ ndị na-adịghị ahụkebe, clopidogrel-Teva na-akpata isi ọwụwa na ọgbụgbọ.

Theụ ọgwụ ahụ nwere ike ibute afọ ọsịsa.

Ọ bụ ọgbụgbọ na ọgbụgbọ bụ ọgbụgba ọgwụ.

Clopidogrel-Teva nwere ike ibute imi.

Site na sistem iku ume

Mmetụta na sistem iku ume:

• imi;
• ọbara ọgbụgba;
• ọla;
• ọrịa pneumonitis na-arịa ọrịa interstitial.

Site na usoro mkpụrụ ndụ ihe nketa

Ntọala mmetụta adịghị ike.

Site na usoro akwara obi

Site na obi usoro na-hụrụ:

• ọbara ọgbụgba
• hypotension akwara;
• vasculitis.

Ahụhụ

Mmeghachi omume nfụkasị ahụ na-esonụ nwere ike ime:

• Ire Quincke;
• ọrịa ọbara;
• urticaria;
• itching

Na-emegide nzụlite ọgwụ ahụ, mmeghachi omume nfụkasị ahụ nwere ike ime.

Mmetụta ikike ịchịkwa usoro

Patientsfọdụ ndị ọrịa na-enwe isi ọwụwa na ọgbụgbọ mgbe ha na-a Cụ Clopidogrel-Teva. Ekwesịrị ịkpachara anya mgbe ị na-achịkwa igwe ma ọ bụ na-arụ ọrụ chọrọ nlebara anya dị ukwuu.

Ntụziaka pụrụ iche

Tupu ịwa ahụ, a ga-akwụsị ọgwụ ahụ (ụbọchị 5-7 tupu ịwa ahụ) n'ihi oke ọnya ọbara ọgbụgba.

Jiri na agadi

A na-eji ọgwụ ahụ agwọ ndị ọrịa agadi. Ma na nke a, a na-eme ọgwụgwọ ahụ na-enweghị oke ibu (otu ngaji nke 300 mg) na mmalite ọgwụgwọ.

Cribdebere Clopidogrel-Teva maka ụmụaka

Amachibidoro ọgwụ a maka ụmụaka na-erubeghị afọ 18.

Jiri n'oge ime na lactation

Ime afọ na inye ara bụ ihe mgbochi maka iji ọgwụ a.

I nweghi ike iji ogwu n’oge di ime.

Jiri maka ọrụ imeju na-arụ ọrụ

Edebere ndị ọrịa nwere ọrịa imeju (cirrhosis, ọdịda imeju) ọgwụ ahụ ka akpachara anya. Iji zere ọbara ọgbụgba, ọgwụgwọ kwesịrị ijikọta ya na ilele ọrụ umeji na-arụ ọrụ.

Clopidogrel-Teva overdose

Site na otu nchịkwa ọnụ nke ọgwụ buru ibu (ihe ruru 1050 mg), enweghị nnukwu nsonaazụ maka ahụ.

Iji ogologo oge na nnukwu doses nwere ike ibute ọbara ọgbụgba.

Mmekọrịta na ọgwụ ndị ọzọ

N'ihi ihe dị n'ọbara, ọ machibidoro ị takeụ ọgwụ a yana ọgwụ ndị dị ka:

1. Anticoagulants.
2. Ndị na-egbochi Glycoprotein IIa / IIIb.
3. Ndị NSAID.

Ekwesịrị ijikọ ya na heparin.

Ekwesịrị ijikọ ya na thrombolytics na heparin. N'iji imekota oge ya na omeprazole, esomeprazole na ndị ọzọ na-egbochi proton mgbapụta, mbelata nke mmetụta antiplatelet na-apụta.

Mmanya ndakọrịta

A naghị atụ aro ka a gwakọta ọgwụ a na iji ihe ọholicụholicụ na-egbu egbu. Ahụ nwere ike egbu egbu nke ahụ ahụ, nke gosipụtara site na ọgbụgbọ, afọ ọsịsa, ụdara, ahụ ọkụ, ọdịda iku ume na palpitations.

Analogs

Ọgwụ ndị a ma ama nwere ụdị mmetụta ahụ bụ:

1. Lopirel.
2. Plavix.
3. Sylt.
4. Plagril.
5. Ọgbakọ.
6. Egithromb.

Ihe na-arụ ọrụ nke analogues ndị a bụ clopidogrel.

Ahịa ọgwụ na-ahapụ okwu

Enwere m ike ịzụta na ndenye ọgwụ?

Dabere na ntuziaka a, ọgwụ dị n'okpuru ọgwụ.

Ọnụ ego Clopidogrel-Teva

Ọnụ ego nke ngwugwu nke mbadamba iri na anọ sitere na 290 ruo 340 rubles, mbadamba 28 - 600-700 rubles.

Ọnọdụ nchekwa maka ọgwụ

Ekwesịrị idobe nchekwa na ebe gbara ọchịchịrị na okpomọkụ agaghị agafe + 25 Celsius.

Bọchị mmebi

Ọgwụ dị mma maka afọ 2.

Emeputa

Emeputa - Teva (Israel).

Ọgwụ na-enye ọgwụ ọgwụ.

Nyocha nke clopidogrel-Teva

Irina, 42 afọ, Moscow.

Mgbe m nyochara ọbara, achọtara mụbara platelet. Dọkịta tiri Clopidogrel. Ejiri m ọgwụ ahụ izu atọ, ọnụọgụ platelet n'ime ọbara eweghachiri na nkịtị.

Alexander, onye dị afọ 56, Izhevsk.

Amalitere m ị thisụ ọgwụ a na nkwado nke dọkịta mgbe ọrịa strok gachara. Anọọla m ya ọnwa 2 ma anaghị m eme mkpesa maka ọdịmma m. Enweghị mmetụta ọ bụla emetụla. Ọgwụ bara uru ego ahụ.

Leonid, afọ 63, Volgograd.

Ejiri m ọgwụ ndị a iji gbochie nsogbu ahụ gbasara ịwa ahụ n’afọ. N'ime oge ọmụmụ ahụ, ọgwụ ahụ nyere aka gbochie ọbara ọgbụgba. Anabatara m nnabata ya nke ọma; ahụghị m ihe ọjọọ ọ bụla.