Etu ị ga-esi jiri ọgwụ Minirin mee ihe?

Minirin bụ ọgwụ nwere nsogbu nke diuretics (diuretics). A na-eji ọgwụ a n'ọtụtụ ebe n'ọgwụgwọ ndị mmadụ ọrịa insipidus na polyuria. Ọgwụ bụ analog nke vasopressin (hormone nke hypothalamus).

International Nonproprietary Aha

Aha ọgwụ mba ụwa a bụ Desmopressin.

Minirin bụ ọgwụ nwere nsogbu nke diuretics (diuretics).

ATX

Koodu Minin maka ATX (nhazi aru na ihe mmezi) bu H01BA02.

Weputara udi ya na ihe mebere ya

A na-eji ọgwụ Desmopressin eme ihe n'ụdị mbadamba maka nchịkwa ọnụ na ịgba maka ọgwụ (intranasal). Oge ndebanye maka ịgba ahụ emebiela. Mbadamba miniri nwere ihe ndị a:

• convex;
• ọdịdị oval ma ọ bụ nke okirikiri (dabere na dose);
• n'ihe e dere ede na ihe egwu;
• agba ọcha;
• nwere 100 μg nke desmopressin, nke kwekọrọ na 0.1 na 0.2 mg nke ọgwụ.

Ihe mejupụtara mbadamba nkume ndị ahụ nwekwara ọtụtụ ihe inyeaka dị ka stachi.

Ngwakọta nke mbadamba ahụ nwekwara ọtụtụ ihe inyeaka (magnesium stearate, stachi, shuga mmiri ara ehi na povidone). Mbadamba ụrọ juru n'ime karama plastik nke 30 PC. na igbe kaadiboodu.

Ihe nchoputa nke Desmopressin nwere ihe ndi ahu na aru oru, mmiri, sodium chloride na ihe ndi ozo. 1 ml nke ịgba nwere 0.1 μg nke ọgwụ.

Omume ọgwụ

Ọgwụ nwere mmetụta ndị a:

1. Ọ na - akwalite mmiri (reabsorption) (mmiri na - eweghachi mmiri) n'akụkụ akụkụ dị warara nke akụrụ, nke na - eme ka njigide mmiri dị.
2. Na-abawanye ike nke obere arịa ke akwara akụrụ.
3. Na -ebelata diuresis (mmepụta mmamịrị).
4. Mmụba osmolarity (ịta ihe niile etisasịwo) nke mmamịrị.
5. Na-ebelata osmolarity ọbara.
6. Na-akwalite mmeputa nke ihe dịka Willebrand factor (glycoprotein dị mkpa iji nọgide na-enwe ọkwa mmiri ọbara na gbochie ọfu ya).
7. Nke nta na-emetụta akwara dị mma nke akụkụ ahụ na akwara ọbara.
8. Na-enyere aka belata polyuria na nocturia.
9. Na-egbochi mmepụta homonụ nke adrenal gland ACTH n'ime ndị nwere ọrịa Cushing.

Ngwongwo dị mkpa nke ọgwụ bụ na ọ naghị eme ka ọbara mgbali elu.

Ngwongwo dị mkpa nke ọgwụ bụ na ọ naghị eme ka ọbara mgbali elu. Nke a dị mkpa maka nkụda obi. Mgbe ị na-ewere mbadamba, a na-ahụ nsonaazụ kachasị mma mgbe awa 4-7 gachara. Mmetụta ọgwụgwọ ahụ na-adịgide awa 4-8, dabere na usoro nke ọgwụ ahụ.

Mlọ ọgwụ

Ejiri ogwu mara obere bioavailability mgbe ewere ya n'ụdị mbadamba ụrọ dị n'okpuru ala. Iri nri na-eme ka nnweta nke desmopressin na-aka njọ. A na-ahụta ọgwụ kachasị na ọbara n'ọbara elekere 2 mgbe ịrechara mbadamba ahụ. Ọgwụ a abanyeghị na usoro akwara ozi (ụbụrụ) ma jiri nwayọ nwayọ karịa tụnyere vasopressin. Ọgwụ bụ ọkachasị ndị akụrụ nwere mmamịrị. Iwepu ọkara ndụ na-eme awa 2-3.

Ihe ngosi maka ojiji

Edere ọgwụ maka ọgwụ ndị a:

1. Ọrịa shuga nke Central na-arịa ọrịa shuga. Ejiri ọrịa a site na mbelata nke njikọta homonụ antidiuretic megide nzụlite mmebi nke sistem hypothalamic-pituitary.
2. Enuresis (urinary incontinence) na ụmụaka mgbe afọ ise gachara.
3. Nocturia n'ime ndị okenye.
4. Polydipsia (na-a amountsụ nnukwu mmiri n'agbanyeghị akpịrị ịkpọ nkụ) mgbe a wasịrị ya ahụ.

E gosipụtara minirin maka nocturia na ndị okenye.

Edere ọgwụ a maka insipidus ọrịa shuga nke ụdị etiti ahụ.

Ngwá ọrụ na - enyere aka na enuresis (urinary incontinence) na ụmụaka mgbe afọ ise gachara.

Mbadamba ụta ga-eripịa mgbe nri gachara, wee jiri mmiri dị ọcha sachaa ya.

N'ihi mmetụta antidiuretic ya, enwere ike iji desmopressin ọ bụghị naanị maka ebumnuche ọgwụ, kamakwa maka ebumnuche nchọpụta iji chọpụta ọrụ akụrụ ma chọpụta ọrịa insipidus.

Ihe ngbanwe

Ihe mgbochi megide iji desmopressin acetate bu:

• hypernaiti;
• akpịrị ịkpọ nkụ maka psychogenic si;
• polydipsia congenital (isi);
• ọrịa mmebi nke mmepụta nke homonụ antidiuretic;
• akwara obi;
• mbelata osmolarity nke plasma ọbara;
• ọdịda odida;
• mkpokọta mmiri n’ime akwara;
• ụdị akwụghị ọtọ nke angina pectoris;
• ọrịa ọrịa ọrịa ọrịa Wilbrand;
• ọnọdụ chọrọ iji ọgwụ ọgwụ diuretic.

Na ọdịda akụrụngwa, a ga-eji ọgwụ kpachara anya.

Jiri nlezianya

A na-eji nwayọ na-agwọ ọrịa minirin na:

• ọdịda odida;
• nnọchi anụ ahụ arụ ọrụ nke eriri afo yana n ’ịchacha;
• electrolyte ahaghioke;
• nnukwu nsogbu nke ọbara mgbali intracranial;
• na-ebu nwa ebu n'afọ.

Akpachara anya maka ọgwụgwọ n’etiti ụmụaka na-erubeghị afọ 1 na ndị okenye. N'ime ọgwụgwọ ndị agadi, ọ dị mkpa ịchịkwa ọdịnaya sodium n'ime ọbara.

Akpachara anya maka ọgwụgwọ n’etiti ụmụaka na-erubeghị afọ 1 na ndị okenye.

Uzo esi ewere Minirin

A na-ahọrọ usoro onyonye ahụ n'otu n'otu na-eburu afọ, ihe ngosi na ọnụọgụ concomitant pathology. Maka mgbatị urinary (enuresis ehihie ma ọ bụ abalị), ọgwụ ga-ebu ụzọ 200ụọ mmiri 200 mcg n'oge ụra. N'ọnọdụ ndị siri ike ma ka ị na-eme mkpesa, usoro ọgwụgwọ ahụ na-erute 400 mcg.

N'ime oge ọgwụgwọ, ịkwesịrị ka amachi mmiri ị na-abanye n'ehihie.

Ọgwụgwọ nwere ike ịnọ ọnwa atọ. Ekwesịrị iburu mbadamba Desmopressin mgbe nri gasịrị. Mgbe ụfọdụ, a na-enye ọgwụ ka ọ were n ’ụzọ 60 na 120 mcg.

Ọgwụ nke polyctia nocturnal

Na nocturnal polyuria, uso kwa ụbọchị na mmalite ọgwụgwọ bụ 100 mcg. Ọ bụrụ na ọrịa ahụ adịchaghị mma mgbe otu izu gachara site na mmalite ọgwụgwọ, usoro ịba ụba ga-abawanye 200 mcg.

Ọ bụrụ na enweghị mmetụta ọ bụla ruo otu ọnwa, a na-akwụsị ọgwụgwọ na Minirin.

Ọrịa mamịrị

N'ime ọrịa shuga mellitus, usoro onunu ogwu bụ 100-200 mcg / day. Na Central insipidus, a na-ewere ọgwụ ahụ ugboro atọ n'ụbọchị, 100 mcg. Ọ bụrụ na ọ dị mkpa, dozigha usoro ọgwụgwọ ahụ. Thebọchị kwa ụbọchị bụ 0.2-1.2 mg. Iji nọgide na-etinye ọgwụ ịchọrọ na ọbara, ịkwesịrị iji 200 microgram nke Minirin.

Mmetụta ndị metụtara Minirin

A na - ejikọkarị mmetụta ndị na - adịghị mma na ị drinkingụ mmanya na - adịghị mma n'oge ọgwụgwọ, mbelata nke sodium n'ọbara (hyponatremia), njigide mmiri n'ime ahụ, yana enweghị nrube isi na usoro usoro oriri.

Isi ọwụwa nwere ike ime mgbe ụfọdụ mgbe ị na-ewere Minirin.

Sistemụ akwara Central

Mgbe ị na-ewere Minirin, nsogbu ndị ọrịa na-esochi ya ga-ekwe omume:

• Dizziness
• ogwe
• isi ọwụwa.

Ọkpụkpụ afọ

N’akụkụ nke usoro nri, mmetụta ndị na-adịghị mma nke ọgwụ ga-ekwe omume, dị ka ọnụ akọrọ, ọgbụgbọ, mgbu afọ na ọgbụgbọ.

Ahụhụ

Achọpụtaghị mmeghachi omume nfụkasị maka ọgwụ a. A na-anabata ọgwụ a nke ọma.

Mmetụta ikike ịchịkwa usoro

Ọgwụ a anaghị emetụta ikike ịchịkwa teknụzụ.

Ọgwụ a anaghị emetụta ikike ịchịkwa teknụzụ.

Ntụziaka pụrụ iche

Mgbe ị na-ewere Minirin, ị ga-esoro ntuziaka ndị a:

• a doụ ọtụtụ mmiri mmiri 1 awa tupu yana awa 8 mgbe ị therọrọ mbadamba;
• mee nyocha ọbara iji chọpụta ihe mejupụtara ionic;
• gwọọ ọrịa niile na ọnọdụ ọrịa tupu usoro ọgwụgwọ, ya na akpịrị ịkpọ nkụ, nsogbu ọnyụnyụ na nnukwu mmamịrị ọgbụgba;
• sanitize foci nke nnukwu urinary tract na-efe efe;
• kagbuo ọgwụ ahụ ma a bụrụ nke mmeghachi omume sistem n'ụdị fever na gastroenteritis (mbufụt nke afọ na obere eriri afọ).

Nhọpụta nke Minirin ka ụmụaka

Maynwere ike inye ụmụaka mbadamba Sublingual (ackingụ).

Jiri n'oge ime na lactation

Edinyere ọgwụ ahụ n’uche nye ndị nọọsụ na ụmụ nwanyị dị ime. N'ime ihe omumu, enweghi mmetụta ojoo nke desmopressin na nwa ebu n’afọ.

Edinyere ọgwụ ahụ n’uche nye ndị nọọsụ na ụmụ nwanyị dị ime.

Jiri na agadi

Ntụziaka maka ojiji nke Minirin na-egosi na ndị ọrịa karịa afọ 65 na-enwekarị hyponatremia. Ha agbadala sodium plasma.

Ngwa maka ọrụ ezughi oke ọrụ

Site na mwepụ nke creatinine erughị 50 ml / min, amachibidoro ọgwụ.

Jiri maka ọrụ imeju na-arụ ọrụ

Ikekwe ojiji nke Minirin maka ọrịa imeju.

Dodoụbiga Minirin ókè

A na - egosipụta oke ịdoụ ọgwụ ahụ site na akara nke igbu oge na mmiri anụ ahụ (nkwarụ, ọrịa edematous, nsụsị mmụọ) yana oke mmetụta. Enyemaka gụnyere ịkwụsị ọgwụgwọ. Ọ bụrụ na ọ dị mkpa, a na-ewebata azịza electrolyte. Site na edema, a na-enye ọgwụ ntụpọ (Furosemide).

A na - egosipụta n ’ịdoụ ọgwụ gabigara ókè site na akara nke igbu oge n’arụ ahụ (nkwarụ, ọrịa edematous, nsụsị mmụọ).

Mmekọrịta na ọgwụ ndị ọzọ

A na-atụ aro iji otu oge maka Minirin na ọgwụ ndị a:

• Loperamide;
• NSAIDs (Indomethacin);
• ọgwụ nke na-agbatị umeji eriri afọ;
• dimethicone;
• ọgwụ mgbochi tricyclic;
• chlorpromazine;
• carbamazepine;
• serotonin reuptake inhibitors.

Mmetụta Minirin na-akụda ike mgbe ejikọtara ọgwụ ahụ na tetracyclines, nkwadebe lithium, norepinephrine na glibutide. Desmopressin na - akwalite mmetụta ọbara mgbali nke ọgwụ ụfọdụ.

Mmanya ndakọrịta

Of useụ mmanya mgbe a na-agwọ Minirin adịghị mma.

Of useụ mmanya mgbe a na-agwọ Minirin adịghị mma.

Analogs

Ọgwụ ndị a metụtara ọgwụ analorọ nke Minirin:

1. Desmopressin.
2. Nativa.
3. Ọgwụ ngwa ngwa.
4. Agbagọ.
5. Presinex (dị n'ụdị ịgba mmiri imi).
6. Vasomirin.

Ọgwụ Minirina gbazee adịghị ere.

Ahịa ọgwụ na-ahapụ okwu

Ogwu bu ogwu.

Ọnụ ego maka Minirin

Ọgwụ dị na ụlọ ahịa ọgwụ na-efu site na 1300 rubles.

Ọnọdụ nchekwa maka ọgwụ

A na-echekwa ha na ọnọdụ okpomọkụ dị n'okpuru 25 Celsius C n'ebe akọrọ ụmụaka na-apụghị iru.

Ekwesighi iji Minirin nwere Loperamide n'otu oge.

Bọchị mmebi

Mbadamba ahụ dị mma maka afọ 2 site na ụbọchị a rụpụtara ha.

Emeputa

A na-emepụta ọgwụ ahụ na analogues ya na Russia (Nativa), Germany, Switzerland, Italy (Presinex), Iceland, Norway, Georgia na Canada.

Nyocha banyere Minirin

Galina, onye dị afọ 35, Moscow: “Nwa m nwoke dị afọ itoolu nwere nkụda mmụọ. Dọkịta ahụ depụtara ọgwụ dabere na desmopressin. Mgbe ọ takingụsịrị ọgwụ mbụ, nwa ahụ kwụsịrị ịrara n'ihe ndina.

Zlata, onye dị afọ 38, Kirov: "Nwa anyị nwoke na nwa nwanyị nke nwanyị m nwanyị nwere otu ọrịa - ịkwa akwa. A na-enyocha ha ma lekọta ha anya. Dọkịta dụrụ m ọdụ ka m jiri Minirin. Etinyekwala onwe gị n’elu ihe ndina ma bie ndụ dị mma. "