Indapamide - ọgwụ a nwapụtara maka ọbara mgbali elu

Indapamide bụ nke abụọ, nke kachasị ugbua, ọgbọ nke thiazide-dịka diuretics. Isi mmetụta nke ọgwụ ahụ bụ mgbatị ọsọ ọbara, ngwa ngwa na ogologo oge nke mgbali ọbara. Ọ na-amalite ịrụ ọrụ mgbe ọkara elekere gachara, mgbe awa 2 gachara nsonaazụ ahụ ga-akachasị ma nọgide n'ogo dịkarịa ala awa 24. Uru dị mkpa nke ọgwụ a bụ enweghị mmetụta na metabolism, ikike iji melite ọnọdụ nke akụrụ na obi. Dika ihe nlere anya nile, enwere ike ijiko Indapamide na usoro nke otutu ma ama ama nke nchebe: ndi sartan na ndi oru ACE.

Onye ka edebara ahapamide ka edere

Ndị ọrịa niile nwere ọbara mgbali chọrọ ọgwụgwọ oge niile, nke mejupụtara ị dailyụ ọgwụ kwa ụbọchị. Ajubeghị nkwupụta a na ngalaba ahụike ọkachamara. Achọpụtara na nchịkwa nrụgide ọgwụ ọjọọ ọ dịkarịa ala ugboro abụọ na-ebelata ohere nke ọrịa obi, gụnyere ndị na-egbu egbu. Enweghị arụmụka gbasara nrụgide nke ịmalite ọgwụ. N'ụwa niile, a na-ewere ọkwa dị oke mkpa maka ọtụtụ ndị ọrịa 140/90, ọbụlagodi na nrụgide ahụ na-ebili asymptomatally ma ghara ịkpata nsogbu ọ bụla. Zere na-ewere ọgwụ naanị jiri ọbara mgbali elu. Iji mee nke a, ị ga-efufu ibu, ịhapụ ụtaba na mmanya, gbanwee nri.

Nanị ihe ngosipụta maka iji Indapamide egosipụtara na ntuziaka bụ ọbara mgbali elu. A na-ejikọkarị ọbara mgbali elu na ọrịa obi, akụrụ, arịa ọbara, ya mere, ọgwụ ndị enyere iji belata ya, a ga-enyocha maka nchekwa na ịdị irè na ìgwè ndị ọrịa a.

Gịnị na-enyere Indapamide:

1. Ndalata nke nrụgide mgbe ị na-ewere Indapamide bụ: nke mgbago - 25, nke ala - 13 mm Hg
2. Nnyocha egosila na ọrụ antihypertensive nke 1.5 g nke ebepamide bụ 20 mg nke enalapril.
3. Ogologo oge ịba ụba ogologo oge na-eduga n'ịbawanye ventricle nke ekpe. Mgbanwe ndị dị otú a bụ ọrịa ọgba aghara, ọrịa strok, nkụda obi. Mbadamba ụrọ indapamide na-enye aka mbelata nke ọkara myocardial aka ekpe, karịa enalapril.
4. Maka ọrịa akụrụ, Indapamide adịchaghị arụ ọrụ. A ga-ekpebi ịdị irè ya site na ọdịda nke 46% na ọkwa nke albumin na mmamịrị, nke a na-atụle otu n'ime ihe ịrịba ama mbụ nke ọdịda akụrụ.
5. Ọgwụ enweghị mmetụta na-adịghị mma na shuga, potassium na cholesterol, ya mere, enwere ike iji ya mee ihe n'ọbara. Maka ọgwụgwọ ọbara ọgbụgba na ndị ọrịa mamịrị, a na-edenye diuretics obere obere, jikọtara ya na ndị na - egbochi ACE ma ọ bụ Losartan.
6. Ngwongwo ahu puru iche nke Indapamide n’etiti diuretics bu mmụba nke ọkwa cholesterol HDL nke “dị mma” site na nkezi 5.5%.

Kedu ka ọgwụ si arụ ọrụ?

Isi ihe diure diuretism bụ mmụba na ikuku iku ume. N'otu oge ahụ, ọnụọgụ mmiri n'ime akwara na arịa ọbara na-ada, mgbali ahụ na-ebelata. N'ime ọnwa ọgwụgwọ, ọnụọgụ nke mmiri mmiri na - agbadata site na 10-15%, ibu n'ihi oke mmiri na-ebelata ihe dịka 1.5 n'arọ.

Indapamide n'ime ndị otu ya nwere ebe pụrụ iche, ndị dọkịta na-akpọ ya onye ọrịa diuretic na-enweghị mmetụta diuretic. Nkwupụta a bara uru naanị maka obere usoro. Ọgwụ a anaghị emetụta oke mmamịrị, mana ọ nwere oke ntụsara ahụ na arịa ọbara naanị mgbe ejiri ya ≤ 2.5 mg. Ọ bụrụ na ị were 5 mg, mmamịrị mmụba ga-abawanye site na 20%.

N'ihi ihe nrụgide na-ada:

1. A machibidoro oghere ndị a na-eme ka calcium n’ọrụ, na-eduga ná mbelata nke mkpokọta kalsel dị na mgbidi nke akwara ndị ahụ, ma ruzie n’ịbawanye arịa ọbara.
2. A na-eme ka ọda kalsam dị iche iche rụọ ọrụ, ya mere, itinye mkpụrụ nke calcium n’ime sel na-ebelata, njikọ nitric oxide na mgbidi akwara na-abawanye, arịa ndị ahụ na-ezukwa ike.
3. A na - akpali akpali ihiwu nke prostacyclin, n'ihi nke ike nke platelet iji kee mkpụkọ ọbara ma kegide n'ahụ mgbidi arịa ọbara na - ebelata, ụda olu nke akwara nke akwara vaskụla na-ebelata.

Mwepụta wepụtara na usoro onunu ogwu

A na-emepụta ọgwụ mbụ nwere ebepamide site na ụlọ ọrụ ọgwụ Servier n'okpuru aha akara Arifon. Na mgbakwunye na Arifon mbụ, ọtụtụ aha na ebepamide ka edebara aha na Russia, gụnyere n'okpuru otu aha Indapamide. A na-eme analọg Arifon n'ụdị capsules ma ọ bụ mbadamba ihe mkpuchi. N’oge na-adịbeghị anya, ọgwụ ọgwụ ndị na-eji ihe ndozi nke mkpụrụedemede emegharịrị ewu ewu ewuwo.

Ọbara mgbali elu na nrụgide ga - abụ ihe gara aga - n'efu

Ọria obi na ọrịa strok bụ ihe kpatara ihe dị ka 70% ọnwụ niile dị n'ụwa. Asaa n’ime mmadụ iri n’ime mmadụ asaa na-anwụ n’ihi akpachiri akwara mkpụrụ obi ma ọ bụ ụbụrụ. N'ihe fọrọ nke nta ka ọ bụrụ n'ọnọdụ niile, ihe kpatara njedebe dị otú ahụ jọgburu onwe ya bụ otu - mgbali nrụgide n'ihi ọbara mgbali elu.

O kwere omume ma dị mkpa iji belata nrụgide, ma ọ bụghị ihe ọ bụla. Mana nke a anaghị agwọ ọrịa ahụ n'onwe ya, kama ọ na - enyere aka ịlụ ọgụ nyocha, ọ bụghị ihe kpatara ọrịa ahụ.

• Normalization nke nrụgide - 97%
• Mwepu nke akwara mbufụt - 80%
• Mwepu nke obi ike - 99%
• Bibie isi ọwụwa - 92%
• Mmụba na ume n'ụbọchị, na-eme ka ụra na-ehi ụra n'abalị - 97%

Kedụ ụdị emepụtara Indapamide na ego ole:

Dabere na ndị ọkachamara n'ihe gbasara obi, ọ ka mma ịzụta Indapamide nkịtị na capsules. A na-echekwa ọgwụ ahụ na capsules ogologo oge, nwere bioavailability dị elu, na-abanye ngwa ngwa, nwere ihe ndị ọzọ na-enyere aka, nke pụtara na ọ na-akpata allergies obere oge.

Indadị kachasị nke ebepamide bụ mbadamba ọrụ ogologo oge. A na-ewepụta ihe dị n’ọrụ n’ime ha nwayọ nwayọ n’ihi teknụzụ pụrụ iche: a na-ekesa obere ebepamide n’ime sel ahụ. N'otu oge, ngba ahụ, cellulose na-eji nwayọọ nwayọọ ghọọ gel. Ọ ga-ewe ihe dị ka awa iri na isii iji gbasaa mbadamba.

N'iji ya na mbadamba oge ochie, ebepamide na-arụ ọrụ ogologo oge na-eme ka mmetụta kwụsie ike ma sie ike karị, mgbanwe nrụgide kwa ụbọchị mgbe ị na-ewere ya dị ala. Dabere na ike nke ime ihe, 2.5 mg nke Indapamide nkịtị bụ 1.5 mg ogologo. Imirikiti mmetụta ndị na-emetụta ya bụ dabere na dose, ya bụ, ugboro ole ha na ogo ha na-abawanye site na ịba ụba. Iwere mbadamba Indapamide dị ogologo oge na-ebelata ihe ọghọm dị na nsonaazụ, n'ụzọ bụ isi mbelata ogo potassium.

Pdị ebepamide a na-ahụkarị nwere ike ịbụ na usoro nke 1.5 mg. N'elu ngwugwu ahụ kwesịrị ịbụ ihe ngosipụta maka "agbatị ogologo oge", "ntọhapụ gbanwere", "ntọhapụ a na-achịkwa", aha nwere ike ịnwe "retard", "MV", "ogologo", "SR", "CP".

Etu ị ga-esi

Ojiji ebepamide iji belata nrụgide anaghị achọ ịrị elu nke nta nke nta. Mbadamba nkume ahụ na-amalite ị drinkụ mmiri ozugbo. Ọgwụ ahụ na-agbakọta n'ime ọbara nke nta nke nta, yabụ enwere ike ikpebi ịdị irè ya naanị mgbe izu 1 gachara.

Iwu nnabata site na ntuziaka maka ojiji:

Biko rịba ama: tupu ịmalite ọgwụgwọ iji ọrịa ọ bụla, ọ bụ ihe amamihe dị na ya inyocha ụfọdụ usoro ọbara: potassium, sugar, creatinine, urea. Ọ bụrụ na nsonaazụ nnwale ahụ dị iche n'ụkpụrụ gị, gakwuru dọkịta gị, ebe ọ bụ na ị diụ ọgwụ nwere ike ịdị ize ndụ.

Ogologo oge ole ka m nwere ike iji ebepamide na-enweghị nkwụsịtụ

A na-ahapụ ọgwụ mgbochi indapamide ị toụ ihe ọ forụ forụ na-akparaghị ókè, ma ọ bụrụhaala na ha nyere ọkwa nke mgbagha a na-anabata nke ọma, ya bụ, ha anaghị akpata nsonaazụ ndị na-emebi ahụike. Akwụsịla ị theụ ọgwụ ahụ, ọbụlagodi na nrụgide ahụ alọghachila nkịtị.

N'ihe na-erughị 0.01% nke ndị ọrịa hypertensive na ọgwụgwọ ogologo oge na mbadamba Indapamide na analogues, mgbanwe nke ọnya ọbara na-apụta: ụkọ nke leukocytes, platelet, hemolytic ma ọ bụ aplastic anaemia. Maka ịchọpụta mmebi ndị a n'oge a, ntụziaka ahụ na-atụ aro ka e lee nnwale ọbara kwa ọnwa isii.

Indapamide, na obere obere karịa ọgwụ ndị ọzọ na - eme ka a na - ekpochapụ potassium n'ahụ ahụ. Ka o sina dị, ndị ọrịa na-arịa ọbara mgbali elu nwere ihe ize ndụ maka mbadamba ogologo oge nwere ike ịmalite hypokalemia. Ihe ndị dị n'ihe ize ndụ gụnyere ịka nká, cirrhosis, edema, ọrịa obi. Ihe ịrịba ama nke hypokalemia bụ ike ọgwụgwụ, olu mgbu. Na nyocha nke ndị ọrịa na-arịa oke ume bụ ndị nwetagoro ọnọdụ a, ha na-ekwukwa banyere adịghị ike dị egwu - "ejidela aka n'ụkwụ ha", afọ ntachi. Mgbochi hypokalemia bụ oriri nke oriri dị elu na potassium: mkpo, akwụkwọ nri, azụ, mkpụrụ osisi a mịrị amị.

Eleghị anya mmetụta

Omume achọghị ihe nke Indapamide na ugboro ole omume ha:

Ntụziaka maka iji ya gosipụta na ọ ga-ekwe omume mmeghachi omume dị njọ na nnukwu mbadamba ihe Indapamide, belata na iji ụdị ogologo.

Ihe ngbanwe

Ndepụta contraindications maka Indapamide dị mkpụmkpụ. Enweghị ike ị drugụ ọgwụ ahụ:

• ọ bụrụ n’ịdị n’otu n’ime ihe ndị mejupụtara ya na-akpasu mmeghachi omume nfụkasị ahụ;
• yana ihe nfụkasị sitere na ụdị sulfonamide - nimesulide (Nise, Nimesil, wdg), celecoxib (Celebrex);
• ya na nnukwu akụrụ ma ọ bụ ụkọ akwara;
• bụrụ na ebidoro hypokalemia;
• ya na hypolactasia - mbadamba nwere lactose.

Oge ịtụrụ ime, nwata, na inye ara ara adịghị ele anya mgbochi ike. N'ụdị ndị a, ị Inụ Indapamide bụ ihe a na-achọghị, mana ọ ga-ekwe omume site na nhọpụta ma n'okpuru nlekọta dọkịta.

Ntụziaka maka iji Indapamide egosighi ihe ịnwere ike ị takingụ ya na mmanya. Agbanyeghị, na nyocha ndị dọkịta, a na-enyocha ndakọrịta mmanya na ọgwụ ahụ dị ka ihe dị ize ndụ ahụike. Otu iji ethanol nwere ike ime ka nrụgide dị ukwuu. Abuseme ihe mgbe niile na-eme ka ịbawanye ụba nke hypokalemia dị, na-ewepụ mmetụta hypoensive nke Indapamide.

Analogs na nnọchi

A na-eme ọgwụ ahụ kpam kpam na nhazi ya na usoro onunu ogwu ya, ya bụ, ọgwụ ndị a edebanyere aha na Russian Federation bụ analogues nke Indapamide:

Enwere ike dochie ha na Indapamide na-enweghị nyocha ọzọ nke dibịa na-aga. Dabere na nyocha nke ndị ọrịa na-a theụ ọgwụ ahụ, ogo kachasị elu nke ndepụta a bụ mbadamba Arifon na Indap.

Tụnyere ọgwụ ndị yiri ya

N'etiti thiazide na thiazide yiri diuretics, ebepamide nwere ike ịsọ mpi na hydrochlorothiazide (ọgwụ Hydrochlorothiazide, Hypothiazide, Enap bangaren, Lorista na ọtụtụ ọgwụ ndị ọzọ antihypertensive) na chlortalidone (mbadamba Oxodoline, otu n'ime Tenorik na Tenoretik).

Atụmatụ ọgwụ ndị a bụ:

• ike nke ihe 2,5 mg nke ebepamide bụ 25 mg nke hydrochlorothiazide na chlortalidone;
• hydrochlorothiazide na chlortalidone enweghị ike dochie anya ebepamide na ọrịa akụrụ. Ha na-abụpụta ya site na akụrụ na-agbanweghi, yabụ, na akwara ọdịda, oke nnyefere yikarịrị. Indapamide bụ imeju mejupụtara ya, ọ nweghị ihe karịrị 5% dị n'ụdị a na-arụ ọrụ, yabụ, ọ nwere ike ị drunkụbiga mmanya ókè ruo na oke akụrụ;
• E jiri ya tụnyere hydrochlorothiazide, ebepamide nwere mmetụta nchebe siri ike na akụrụ. N'ime afọ abụọ nke oriri ya, GFR na-abawanye site na nkezi 28%. Mgbe ị na-ewere hydrochlorothiazide - belata 17%;
• chlortalidone na-arụ ọrụ ruo ụbọchị 3, yabụ enwere ike iji ya na ndị ọrịa na-enweghị ike ị theụ ọgwụ ahụ n'onwe ha;
• Mbadamba ọgwụ ndị dị na Indapamide adịghị emetụta metabolism nke carbohydrate, yabụ, enwere ike iji ha maka ọrịa shuga. Hydrochlorothiazide na-eme ka iguzogide insulin guzogide.

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