LDL kọlesterol: ọkwa ọbara dị ala

LDL dị ala cholesterol lapoprotein dị ntakịrị. Ọ bụ ụdị njem cholesterol buru ibu na ahụ. A na-akpọkarị ihe a dịka p-lipoproteins, bụ nke etolite na obere eriri afọ na imeju.

N'ime ọbara mmadụ, LDL cholesterol na - ebu abụba (gụnyere kọlestrọl) site na sel gaa na sel. Enwere echiche na ntanye LDL nwere njikọ karịa na o nwere ike imepe atherosclerosis karịa ọkwa cholesterol dum. Ọgwụ na-akọwa nke a site n'eziokwu bụ na ọ bụ nke pere mpe na-ahụ maka nnabata nke cholesterol n'ahụ akụkụ na arịa niile.

Nyere ọnọdụ pathologies nke vaskụla endothelium, nke bilitere n’ihi ihe dị iche iche (hycysteine ​​dị elu, ọbara mgbali elu, ụmụ irighiri ụtaba, nke batara n’ahụ mgbe ị na-a smokingụ sịga), a na-ahụ ihe ọdịdọ.

Mkpụrụ ndụ LDL nke mgbidi nke arịa ọbara. Ọzọkwa, a na-emegharị ha n'okpuru mmetụta nke ọnọdụ mpaghara nke usoro mkpali yana ịmalite ikpo ọkụ nke atherosclerotic na-emechi oghere lumen n'ime arịa na-ebute thrombosis, nke dị ize ndụ karịsịa maka ọrịa shuga mellitus.

Ihe nwere ike ibute nsogbu dị na mmalite nke atherosclerosis gụnyere:

• afọ ụmụ nwoke ndị gbara afọ iri anọ na ise, na ụmụ nwanyị si afọ 55;
• ketara eketa (n'okwu banyere nkụchi obi ma ọ bụ ọnwụ mberede nke ụmụ nwoke na-erubeghị afọ 55 na ụmụ nwanyị nọ n'okpuru 65);
• ọrịa shuga mellitus;
• ise anwụrụ;
• ọbara mgbali elu

Ọ bụrụ na opekata mpe otu n’ime ihe ndị a dị ize ndụ na-apụta, mgbe ahụ ihe ndị achọrọ nke LDL cholesterol dị n’ọbara ga-abụ ndị nọ n'okpuru 3.37 37mol / L

A ga-atụle ụkpụrụ niile dị na oke sitere na 3.37 ruo 4.12 μmol / L dị ka ihe nwere ike ịdị egwu maka mmepe nke atherosclerosis dị ala. A ga-ahụta data niile nke ga-akarị 4.14 mmol / l dị ka ihe dị oke mma n'ihe egwu nke ọrịa obi na akwara, yana atherosclerosis.

Kedu ihe dị mkpa maka nyocha LDL?

Dịka anyị kwuworo, cholesterol dị ala dị obere nwere njikọ chiri anya na o nwere ike imepe atherosclerosis. Maka nke a, ọ dị nnukwu mkpa ibu ụzọ kpebie ma ọ so na otu klaasị.

N'iburu nke a, ọ dị mkpa ịdị na-ekewapụta LDL cholesterol, nke bụ nke atherogenic kachasị elu maka ihe ụfọdụ.

LDL kọlesterol na-eburu 2/3 nke ngụkọta nke plasma ma bụrụkwa sọst kacha nwee cholesterol. Ihe ndị dị n’ime ya nwere ike iru pasent iri anọ na ise ma ọ bụ karịa.

Site na-ekpebi beta-cholesterol, ndị dọkịta na-ekpebikwa ya na LDL cholesterol. Ogo ya ga-adị ihe dịka 21-25 nm, nke ga - enye ohere cholesterol dị ala (HDL) ịbanye na mgbidi nke arịa ọbara yana oke njupụta. Ọ bụrụ na HDL nwere ike iwepu mgbidi ahụ ngwa ngwa site na ihe mgbochi endothelial, na-enyere aka iwepụ abụba, mgbe ahụ, LDL na-egbu oge n'ime ha ogologo oge. Nke a bụ n'ihi na ịhọrọ ịdị mma maka sel akwara dị mma na glucose-aminoglycans.

LDL cholesterol bu uzo mbu cholesterol, nke di nkpa maka mgbidi akwara. Mgbe ọnọdụ pathologies, ọ na - abụ isi iyi nke nchịkọta cholesterol na mgbidi nke arịa ọbara.

N'ihi nke a, n'ụdị hyperlipoproteinemia nke abụọ, nke ọkwa beta-cholesterol na-egosipụta, n'oge na-agafe agafe, ana - akpọkwa atherosclerosis, yana ọrịa obi obi.

Nchọpụta cholesterol LDL na-aghọ ihe ọmụma. Ọ bụrụ na ekwuru na ndagwurugwu pụtara ìhè, mgbe ahụ anyị nwere ike ikwu maka nsogbu ahụike siri ike.

Olee ọrịa cholesterol LDL na-eme?

Enwere otutu ihe ngosi maka nyocha nke cholesterol LDL, dịka ọmụmaatụ:

1. atherosclerosis na ụfọdụ ọrịa metụtara ya (infarction myocardial infarction, obi obi ọgụ);
2. ọrịa imeju
3. Ọmụmụ nyocha nyocha na-eme dị ka akụkụ nke ụzọ ndị ọzọ maka ịchọpụta profaịlụ dị mma nke mmadụ.

Nnyocha nke cholesterol nke LDL dị mkpa iji lelee ma ọ bụ jiri mmụba rụọ ọrụ nke imeju yana akụkụ ahụ nke akwara. Nchịkọta a anaghị enye nkwado maka nkwadebe pụrụ iche.

Naanị ịchọrọ imepụta ya na afọ efu, ekwesịrị ime nri ikpeazụ tupu elekere 12-14 tupu ule achọrọ.

N'ime ụlọ ọgwụ, a ga-ewere ọbara ọbara, nyocha ahụ ga-ewe awa iri abụọ na anọ.

Otu esi egbutu nsonaazụ n'onwe gị?

Iji mara nsonaazụ nyocha ahụ tupu nleta dọkịta gị, ịkwesịrị itinye okpokoro dị n'okpuru. K; Na mgbakwunye, enwere otu ngwaọrụ ịlele cholesterol, nke mere na n’ime ụlọ ị ga - enweta azịza nke ọdịnaya ya.

Determinationzọ mkpebi siri ike, nke ewerere dịka ihe ndabere, bụ mgbako dịka usoro Friedwald si kwuo. Usedkpụrụ ndị e ji mee ihe bụ:

• cholesterol zuru ezu;
• triglycerides;
• Cholesterol HDL.

A ga-atụle ụkpụrụ LDL nwere triglyceridemia dị ukwuu (karịa 5.0 - 5.5 mmol / L) ka a ga-atụle nbelata ụgha.

Kpụrụ Ntuziaka:

Oburu na, dika ihe omumu a, enwetara data nke di elu enyere iwu, yabụ n’okwu a anyi nwere ike ikwu maka oria:

• jaundice mgbochi;
• oke ibu;
• ihe nketa mbụ hypercholesterolemia (ụdị hyperlipoproteinemia IA, yana ụdị nke IIB), ọnya mmalite nke arịa arịa, akwara xanthoma;
• ọrịa shuga mellitus;
• hypothyroidism;
• nephrotic syndrome, yana ọdịda akụrụngwa na usoro ọmụmụ;
• anorexia nervosa;
• Itsenko-Cushing's syndrome.

Ihe ndị egosiputara ga-abụ n’oge afọ ime, iji ọgwụ (diuretics, mgbochi mbadamba ụrọ, androgens, glucocorticosteroids, progestins), yana nri nke juputara na lipids na cholesterol.

Ihe ngosipụta dị ka iwu ga - esi mara ụdị ọrịa ndị a:

1. hyperthyroidism;
2. Ọrịa Reine;
3. ọrịa anaemia na-adịghị ala ala;
4. mmezi nke ike metabolism (hypobetaproteinemia, abetaproteinemia, alfa-lipoprotein deficiency, LAT deficiency (lecithin cholesterol acyl synetatase), ụdị 1 hyperlipoproteinemia, enweghi nke lipoprotein lipase cofactor);
5. nsogbu nke ike ịmị mkpụrụ;
6. nnukwu nsogbu;
7. ọrịa ogbu na nkwonkwo;
8. myeloma
9. nsogbu akụrụ na-adịghị ala ala.

A ga - enweta nsonaazụ ọzọ dị otú ahụ site n'iji ọgwụ ụfọdụ (lovastatin, interferon, cholestyramine, thyroxine, neomycin, estrogen), yana nri nwere polygasturated abụba abụba, mana adịghị ike na lipids na cholesterol.