“N'ihi ụba ọrịa shuga na-arịwanye elu n'ụwa n'afọ ndị na-adịbeghị anya, a na-elekarị pancreas anya dị ka ngwa nri, kama ọ bụ isi iyi nke na-emepụta insulin - hormone nke na-achịkwa shuga ọbara.
Mana onye matala onwe ya ihe isi ike niile nke ọrịa pancreatitis, ọ marala na lipase bụ enzyme nke na - emebi abụba na - esite na nri eri, na etu o si ewute ya mgbe ebuliri lipase a n’ọbara.
Gịnị bụ lipase?
Asụsụ ala akọrọ nke sayensị nwere ike ịmị mkpụrụ ọgwụ pacastic dị ka enzyme site na subclass nke esterases (na klaasị nke hydrolases) wee dee myirịta nke ngwa ya na hepatic ọbara lipase.
Mgbe a na-akọwapụta ihe dị n’elu, ekwesịrị ime ka ọ pụta ìhè na hydrolases gụnyere kemịkal kemịkal-biocatalysts (enzymes) nke hydrolyze (gbarie) abụba nri (triglycerides) n’ime glycerol na ihe ndị ọzọ sitere na klas acid na-elu.
N’aka ozo, n’enweghi ike nke enzyme a, nke so n’ime ihe ọ pancụ pancụ nke palọ, ọ gaghị ekwe omume ma iweghara abụba n’arụ, ma ọ bụ abụba abụba dị na ya, nke pụtara ndụ dịka. Maka abụba, ma mkpanaka ma n'ụdị nchekwa, ahụ kwesịrị ịchọ ọtụtụ ebumnuche - site na ịmepụta kọmpụta mkpụkọ, nke na-adịgide adịgide, na-echekwa anụ ahụ pụọ na mmebi ahụ na ọnya mgbe ọ na-ala azụ (chee ihu - na azụ na ịkwakọrọ).
Ọrụ nke ihe dị na ahụ
N'ime ụmụ amụrụ ọhụrụ, nke lipases niile dị n'ime ahụ, ọgwụ lingual libase na-abanye na egwuregwu ahụ - enzyme nke ga - enyere aka emulsify (nyefee n'ụdị adaba maka mmiri ara) abụba mmiri ara (triacylglycerols) n'ọnụ n'ọnụ, n'ihi na ọ bụ ihe glands na-arụ ọrụ nke a na-ekwu okwu.
Ahụ ụmụaka nwere njiri mara ya:
- uto na ngwa ngwa nke ahụ na akụkụ anaghị egosi na okike nke ụlọ ahịa glycogen dị mkpa;
- usoro glucose ezumike ezughị ezu.
N'iburu nke a, triacylglycerols (ha bụkwa triglycerides, triglycerols, abụba na-anọpụ iche, abụba ọkụ), na-adị iche na ọdịnaya dị ukwuu nke ọdụdụ abụba juru afọ, ihe fọrọ nke nta ka ọ bụrụ isi iyi ọ bụghị naanị ume, kamakwa ọkụ maka ahụ nwatakịrị ahụ.
Ebe ọ bụ na ntu nwere okenye anaghị enwe enzymes nke na-egbochi ọgbụgba egbugbere ọnụ n’ọnụ, yana ọgwụ triacylglycerols na-edobe n’ime afọ site na lipase nke ihe ọ juiceụ isụ ya dị ntakịrị, ihe omimi bụ isi nke ndụ ebighebi ebugharị na lumen nke akụkụ eriri afọ nke a na-akpọ obere eriri afọ - ọkachasị, n’akwara nke eriri afọ. , akpọrọ duodenum (nke bụ ngalaba mbụ ha).
Ọ bụrụ na ọrụ nke enzyme lingual bụ nanị emulsification nke ara ara, na maka gastric lipase ọ bụ ndakpọ nke tributirins nke mmanụ dị iche iche, mgbe ahụ (n'adịghị ka hepatic lipase, nke na-etinye aka na mbibi nke sọsọ VLDLPs nke nnukwu njupụta na chylomicrons), pancreatic gland lipase jikọtara ya niile - abụba abụba sitere na nri ma ọ nweela nhazi akụkụ site na enzymes gastric.
Mana nnukwu nkume a na-egwu nri anaghịkwa arụ ọrụ naanị - maka ọrụ ọ na-aga nke ọma, ọtụtụ ihe ndị ọzọ dị mkpa:
- calcium ion (n'ihi na ọgwụ pensụl bụ ihe na-eme ka a nwee ike ịmị mkpụrụ).
- mmalite nke emulsion nke oriri nwere ike ịbụ site na bile na-egbochi ime eriri afọ.
Nke bụ eziokwu bụ na iji 'chaa' proenzyme (nke bụbu ihe na-adịghị arụ ọrụ) nke prolipase ka enzyme pancreatic zuru, ọ dị mkpa ibido ya na duodenum site na mmụba bile acid, yana colipase, otu enzymes nke dị na ihe ọ pancụ pancụ pancreatic.
Ghọta ihe kpatara ọtụtụ "mgbali kemịkalụ" na-eme, ọ na - enyere aka ịghọta na lipase dị mkpa maka:
- mgbasa, nhazi na ikewa abụba n'ime ụmụ irighiri ihe dị iche iche;
- mwepu nke vitamin fatịlaịza (A, K, E, D), yana abụba abụba nke polyunsaturated bakan;
- na-ejigide ọkwa mgbanwe ike niile nke plasma lipids na-eme.
Ọnọdụ nke ọtụtụ anụ ahụ na-adabere na ọkwa nke pancreatic lipase.
Yabụ, n'ihi erughi ya, ihe omume nke:
- dyslipoproteinemia (karịchaa, ụdị IA hyperlipoproteinemia);
- ngafe triglycerides ke ọbara lipoproteins;
- ụlọ ọgwụ nke ọrịa obi ischemic (ọrịa obi na-efe efe);
- xanthomas (na ebumnuche agbasa);
- ihe egwu nke malabsorption (nsogbu nri) nke agwara nwere abali ogologo.
Ọ na-anọgide ịgbakwunye na ọrụ kachasị nke enzyme pancreatic gland na-eme na ntụpọ alkaline nke 8-9 (ebe onye na-egosi 4-5 budata belata arụmọrụ nke emulsified triacyl glycerols).
N'ihi eziokwu ahụ bụ na n'ọtụtụ ọrịa, ọrụ nke enzyme a na-abawanye nke ukwuu (ya na ya banye n'ime ọbara), ọdịnaya ya na mmiri nke ndu a na-enyere anyị aka ikpe ọnụnọ nke ọrịa nke anụ ahụ na ọnọdụ pathologies nke pancreatic gland. Ya mere, ọdịnaya nke enzyme ahụ dị na ọbara (ma ala ma ala) na-arụ ọrụ dịka nyocha nyocha maka ụdị nsogbu somatic ụfọdụ.
Na-enye nkuzi vidiyo na enzymes:
Ihe kpatara Enzyme Mmụba
Nyere na lipase norm n’ime ọbara (dịka nyocha nke usoro turbidimetric) dị ihe dị ka nkeji 190 / ml maka ụmụ nwoke na ụmụ nwanyị toro eto, maka ụmụaka na-erubeghị afọ iri na asatọ - n’ime otu narị nkeji 130 / ml (nkeji ọrụ enzymatic na 1 ml ọbara), mmụba na ngosipụta a. nwere ike igosipụta nsogbu mgbanwe nri zuru oke na usoro ọmụmụ.
Yabụ, imebiga ihe ókè n'ọbara (ya na ụta ya na otu mgbe ọ na - eme nri).
- ọria aru
- akpụ nke ọnya na-egbu mgbu;
- ọrịa na - egbu egbu nke ọnya afọ;
- Ọnọdụ nnukwu (ụdị nke biliary colic, infarction myocardial).
Otu esemokwu si na:
- ihe mgbochi eriri afọ;
- peritonitis;
- ọkpọ ma ọ bụ mmerụ ahụ dị nro.
Ejiri ọnọdụ dị n'ụkpụrụ:
- oke ibu;
- gout
- ọrịa shuga mellitus;
- ọdịda odida;
- ara ara.
Ebumnuche Dị ala
Ihe kpatara iwetulata ọkwa ọbara ọbara ọbara nwere ike ịbụ:
- trigba abụba triglyceride n'ime nri riri (nri adịghị edozi, nri a na-edozi edozi);
- pathology (oncological) pathology (ewepu, agbanyeghị, kansa nke pancreas n'onwe ya);
- ihe ozo, odi obere na adighi eme (ma obu nke achoputaghi).
Lipase ọbara dị ala nwekwara ike iso:
- ndu ojọgu;
- na mgbanwe nke nnukwu pancreatitis na ụdị ala ala.
N'ikpeazụ, ọnọdụ a nwere ike ibute:
- fibrosis cystic;
- fibrosis cystic;
- enweghi nsogbu akwara (n'ihi iwepu ya).
