Rosuvastatin Canon bụ ọgwụ nwere akụrụngwa na-eme ka mbelata. Ọgwụ a bụ nke otu statins.
Ọgwụ bụ nhọrọ na-egbochi oke nke HMG-CoA reductase, nke bụ maka ngbanwe nke 3-hydroxy-3-methylglutaryl coenzyme A na mevalonate, nke bụ ihe na-ebute cholesterol.
Ebumnuche ebumnuche nke ọgwụ ahụ bụ imeju, anụ ahụ nke na-eme usoro cholesterol njikọ na catabolism nke lipoproteins dị ala.
Ọgwụ ahụ na-egbochi ọrụ HMG-CoA reductase. Mgbe ị na-a theụ ọgwụ ahụ, ihe dị ka 90% nke rosuvastatin na-ekesa na plasma ọbara.
Ojiji nke ogwu a na - enyere aka ịbawanye ọnụ ọgụgụ nke ndị na - anabata LDL na akpụkpọ ahụ nke hepatocytes, nke na - abawanye njide na catabolism nke lipoproteins dị ala. Mmetụta dị otú ahụ na ahụ na-eduga n'ịbelata ọkwa LDL na plasma.
A na-ahụta ọgwụgwọ ọgwụgwọ nke iji ọgwụ ahụ emeelarị otu izu mgbe ịmalite ọgwụgwọ. Mgbe izu abụọ gasị, ọgwụgwọ ọgwụgwọ rute oke. Mgbe oge a gasịrị, a na-ahụta mbelata nke ọma na ọkwa nke cholesterol dị n'ahụ ma na-aga n'ihu na usoro nlekọta ọgwụ a ka ana-elekwa ya anya n'ọtụtụ ebe.
Ojiji nke ọgwụ a nwere ike itinye aka na mbelata oke n'ihi iwepụ oke lipids na ya.
Leasedị wepụtara ya na ihe mejupụtara kemịkal
Onye rụpụtara yapụtara ọgwụ ahụ n'ụdị mbadamba nkume. A na-eji ihe nkiri na-acha ọbara ọbara kpuchie elu mbadamba nkume ndị ahụ.
Isdị ahụ dị okirikiri, biconvex. N'elu ebe obibi, a na-ebute ihe egwu. N'akụkụ obe, ọgwụ nwere ihe fọrọ nke nta ka ọ bụrụ agba ọcha.
Ihe kachasị dị n'ime ọgwụ ahụ bụ calcium rauvastatin. Ihe mejuputara ihe a mejuputara ya na onu ogugu ya ruru puku iri na iri.
Na mgbakwunye na kọmpụta ndị na-arụ ọrụ, a na-etinye kemịkalụ kemịkal ndị a na usoro mbadamba:
- calcium hydrogen phosphate mmiri riri;
- pregelatinized ọka stachi;
- steeti magnesium;
- povidone;
- microcrystalline cellulose.
Ngwakọta nke ihe eji eme ihe nkiri na tebụl gụnyere ihe ndị a:
- Selecoat AQ-01032 acha ọbara ọbara.
- Hydroxypropyl methyl cellulose.
- Macrogol-400.
- Macrogol-6000.
- Titanium dioxide
- Aluminom varnish dabere na mmiri Ponso 4R.
Onye mepụtara mbadamba ihe emepụtara na-etinye ha na nchekwa ekwentị cellular nke PVC. N'elu ngwugwu a ejiri kpuchie alumini kpuchie. A na-emechi ngwugwu ndị a na igbe kaadiboodu, ebe etinye ntuziaka maka ị ofụ ọgwụ ahụ.
Ọgwụ a dị na mbadamba ụrọ nwere usoro dị iche iche nke ihe eji arụ ọrụ. N'ime ụlọ ahịa ọgwụ, dabere na mkpa, ị nwere ike ịzụta ọgwụ nwere ọgwụ nke rauvastatin 10, 20 na 40 mg na otu mbadamba. Ọnụahịa ọgwụ ahụ dabere na mpaghara ire ere na Russian Federation, ịta nke ihe ndị bụ isi na-arụ ọrụ na mejupụtara ọgwụ ahụ na ọnụ ọgụgụ mbadamba otu ngwugwu. Ọnụ ego nke otu ngwugwu, dabere na usoro akọwapụtara, nwere ike ịdị iche site na 350 ruo 850 rubles.
Onye ọrịa nwere ike ịzụta ọgwụ ma ọ bụrụ na o nwere ọgwụ n'aka dọkịta na-abịa.
Ekwesịrị ịchekwa ọgwụ a na okpomọkụ agaghị agafe ogo 25 Celsius n'ebe akọrọ adịghị ụmụaka na anụmanụ. A ga-echekwa ebe nchekwa ahụ site na ìhè anyanwụ. Ndụ nchekwa nke ọgwụ ahụ bụ afọ abụọ.
Ka oge a gasịrị, amachibidoro iji ọgwụ a, ị ga-ewepụ ya.
Ihe ngosi na contraindications maka ojiji
Tupu ị usingụ ọgwụ Rosuvastatin Canon, ị ga-akpachara anya nyochaa ntuziaka maka ojiji, nyocha nke ọgwụ site n'aka ndị dọkịta na ndị ọrịa, wee mara ọnụ ahịa ọgwụ ahụ site na iji usoro dị iche nke ọgwụ na-arụ ọrụ siri ike.
Nduzi banyere ị theụ ọgwụ ahụ na-atụ aro ị takingụ ọgwụ ahụ naanị mgbe ị nyochachara dọkịta gị.
Dọkịta na-ekpebi ezigbo usoro onunu ogwu, na-eburu n'uche ozi niile dịnụ gbasara ahụike na njirimara nke ahụ onye ọrịa.
Isi ihe eji egosi ogwu eji ya na ntuziaka maka ojiji bu onodu ndi a:
- ọnụnọ nke Fredrickon hypercholesterolemia (ụdị IIa, gụnyere ezinụlọ heterozygous hypercholesterolemia) ma ọ bụ hypercholesterolemia agwakọta (ụdị IIb) dị ka mgbakwunye na nri, n'ọnọdụ ndị ahụ, iji usoro ọgwụgwọ na-abụghị ọgwụ ọgwụ (mmega ahụ, ibu dị arọ) ezughị;
- ọnụnọ nke famzyal homozygous hypercholesterolemia, na mgbakwunye na nri nri na ọgwụ ndị ọzọ na-agbatị egbugbere ọnụ (dịka ọmụmaatụ, LDL-apheresis), ma ọ bụ n'ọnọdụ ebe iji ụdị ọgwụgwọ ahụ adịghị arụ ọrụ nke ọma;
- ọnụnọ nke hypertriglyceridemia (ụdị nke IV dị ka Fredrickson) dị ka mgbakwunye na nri eji eme.
Ihe mgbochi iji ọgwụ a nwere ọdịiche dabere na ntinye uche na mbadamba ihe nke ihe bụ isi na - arụ ọrụ.
Yabụ maka mbadamba nkume nwere 10 na 20 mg nke rosuvastatin, onye ọrịa ahụ nwere contraindications ndị a:
- Ọrịa imeju na-arụ ọrụ na-aga n'ihu, gụnyere ịba ụba n'ime ọrụ transaminase.
- Ọdọ akụrụ na-arụ ọrụ nke ukwuu.
- Ọnụnọ nke myopathy na onye ọrịa.
- Ojiji nke iji ọgwụ agwọ ọrịa cyclosporine.
- Oge ịgba aka na oge ịra nwa.
- Asọmpi na mmalite nke nsogbu myotoxic.
- Afọ erughị afọ 18.
- Ọgwụ na ọgwụ ndị mejupụtara ọgwụ ahụ.
Mgbe ị na-eji mbadamba ụrọ nwere rosuvastatin 40 mg, contraindications maka ojiji bụ:
- akwara na akwara imeju;
- na-ebu nwata na inye ara;
- iji ihe eji eme ya;
- ọnụnọ ọrịa imeju na oke mmepe;
- ọnụnọ n'ime ahụ nke akpọ akpọ ịnagide akụkụ nke ọgwụ.
Doụfe ọgwụ ókè n'ọrịa onye ọrịa na-apụta mgbe ị na-a severalụ ọtụtụ ọgwụ kwa ụbọchị.
N'ihe banyere ịdoụbiga mmanya ókè, a na-enye ọgwụ ọgwụgwọ Symptomatic yana ọrụ imeju, yana ọrụ CPK.
Onweghi ọgwụ mgbochi akọwapụtara nke ọma mgbe oke ị occursụbiga mmanya ókè mere. Usoro ọgwụgwọ metụtara akwara ụkwụ adịghị arụ ọrụ.
Ntuziaka maka iji ọgwụ ahụ
A na-ahụ maka ọgwụ a site n'ọnụ, n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri.
A ga-elo mbadamba ihe niile n’emebighị ya, ebe iwere ihe a, yana ị ofụ mmiri dị ukwuu.
N'ihe banyere nhọpụta nke ọgwụ ị aụ ọgwụ 5 mg, mbadamba nkume nwere ọtụtụ akụrụngwa na-arụ ọrụ nke 10 mg nwere ike kewaa na ọkara.
Tupu ịmalite Rosuvastatin na usoro ọgwụgwọ, onye ọrịa chọrọ ka onye ọrịa ahụ rubere nri hypocholesterol siri ike ruo oge ụfọdụ. A na-achọ nnabata maka ụdị nri a mgbe ịmalite ọgwụ.
A na-ahọpụta usoro onodu ogwu maka cholesterol n’etiti dibia n’ebido n’echebara nsonaazụ nyocha na omumu nke aru onye oria ka etinyechara udiri nri na udiri ya.
Na mgbakwunye, usoro ogwu eji eme ihe nwere ike imetụta ebumnuche usoro ọgwụgwọ yana ọdịdị mmeghachi omume nke anụ ahụ maka iji Canon na ọgwụgwọ Rosuvastatin.
Dabere na ntuziaka maka ojiji, usoro ọgwụgwọ a tụrụ aro ka ị initialụ ọgwụ mbido bụ 5 ma ọ bụ 10 mg otu ugboro n'ụbọchị.
Site na iji rosuvastatin na-eme n'otu oge yana fibrates ma ọ bụ nicotinic acid na usoro nke na-erughị 1 gram kwa ụbọchị, usoro ọgwụgwọ mbụ bụ 5 mg otu ugboro n'ụbọchị.
Mgbe ị na-ahọrọ ọgwụ, dọkịta ga-eduzi nsonaazụ nke nha nke cholesterol n'ahụ ahụ onye ọrịa ma na-eburu n'uche ihe ize ndụ nke ịmalite ọrịa ọrịa obi. Na mgbakwunye, ọkachamara ahụ ga-eburu n'uche ihe egwu dị na nsonaazụ ndị ọzọ site n'iji ọgwụ na usoro ọgwụgwọ.
Ọ bụrụ na ọ dị mkpa, a na-edozi usoro ị usedụ ọgwụ ị usedụ n'izu anọ ọ bụla.
Ojiji nke 40 mg ka a na-eme ya naanị n’etiti ndị ọrịa nwere nnukwu ọria mmepe nke hypercholesterolemia na ọnụnọ nke nnukwu ihe ọghọm nke nsogbu na ọrụ nke akụrụngwa obi, yana ịchọpụta ọbara mgbali elu na onye ọrịa. N'ihe banyere iji ọgwụ kacha ekwe ọfụma n'oge ọgwụgwọ, dọkịta kwesịrị ịga lebara onye ọrịa ahụ anya.
A na - enye ndị ọgwụ nwere oke akụrụngwa yana nsogbu akwara dị ala.
Maka ụdị ndị ọrịa a, ọgwụ a tụrụ aro bụ 5 mg kwa ụbọchị na otu usoro.
Nsonaazụ na analogues nke Rosuvastatin Canon
N'oge ị theụ ọgwụ ahụ, mmetụta ndị ọzọ nwere ike ịmalite n'ahụ ahụ onye ọrịa.
Ugboro nsonaazụ ya na-adabere na usoro eji eme ihe yana njirimara physiological nke onye ọrịa.
Site n'akụkụ akụkụ akwara ozi, isi ọwụwa, ọgbụgbọ na, n'ọnọdụ ụfọdụ, ncheta nwere ike ime.
N’akụkụ akụkụ nke digestive, a na-egosipụta mmetụta n’akụkụ ahụ nke afọ ntachi, ọgbụgbọ, mgbu afọ, n’ọnọdụ ndị a na-adịghị ahụkebe, mmepe nke pancreatitis na jaundice.
Usoro iku ume nwere ike ịza ọgwụ ọgwụ nwere ihe ngosi ndị dị ka ụkwara na mkpirisi iku ume.
Site na usoro akwara, ọdịdị nke myalgia ga-ekwe omume. Myopathies na, n'ọnọdụ ndị anaghị adịkarị, ọrịa ogbu na nkwonkwo.
Na akụkụ nke urinary, mmeghachi omume n'akụkụ nwere ike igosipụta onwe ya n'ụdị proteinuria, ịba ụba na, n'ọnọdụ obere, hematuria.
N'ihi ị theụ ọgwụ ahụ, onye ọrịa ahụ nwere ike ịnweta mgbaàmà nke ụdị shuga 2.
Ọ bụrụ na ahụike akụkụ ahụ ya na ị takingụ ọgwụ ahụ achọpụtala, enwere ike dochie ya na nkwado nke dibia bekee nwere ọgwụ analogues dị.
Ruo taa, ndị na-emepụta ọgwụ na-enye ihe karịrị ọgwụ iri 10 nke bụ analogues nke Rosuvastatin Canon.
Ngwá ọrụ ndị a:
- Akorta,
- Mertenil.
- Rosart.
- Rosistark.
- Rosuvastatin Sotex.
- Rosuvastatin SZ.
- Rosulip.
- Rosucard.
- Roxer.
- Rustor.
- Tevastor
Ọgwụ ndị a niile nwere otu mmetụta na ahụ, mana ha nwere nnukwu ọdịiche dị na ọnụ ahịa, nke na-enye onye ọrịa ohere ịhọrọ ọgwụgwọ kachasị mma, na ọnụ ahịa yana mmetụta ọgwụgwọ na-arụ ahụ.
Banyere ogwu Rosuvastatin ka a kọwara na vidiyo n’isiokwu a.
