Galvus Met - ntuziaka zuru oke maka ojiji, nyocha nke ndị ọrịa mamịrị na ndị dọkịta

Galvus Mmanụ a isụ bụ ọgwụ jikọtara ọnụ na ike ọgwụ hypoglycemic. Emeputara ya ka oria oria ojoo na ndi oria egbu n’aria oria nkeoma. Ọgwụ na-achịkwa metabolism nke insulin na glucagon.

Medicallọ Ọgwụ Ahụike Europe kwenyere na Galvus Mmanụ dị irè karịa onye buuru ya ụzọ, Galvus, bụ ihe amamihe dị na ya iji naanị maka ntachi obi na metformin.

Nkọwa nke ụdị usoro onunu ogwu

Na netwọ ọgwụ ụlọ ọgwụ, a na-enye ọgwụ ahụ n'ụdị mbadamba mkpuchi, nke ọ bụla nwere ihe abụọ na-arụ ọrụ: 50 mg nke vildagliptin na 500, 850 ma ọ bụ 1000 mg nke metformin. A na-eji magnesium stearate, hyprolose, hypromellose, talc, titanium dioxide, macrogol 4000 na iron oxide na-eji akwa.

E nwere mbadamba ụrọ iri. Efere ndị ahụ na igbe nke iberibe atọ, ngwugwu nke ọ bụla Galvus Met nwere ntuziaka.

• 50/500 mg - oval mbadamba nwere ihu dị mma na shei nke hue na-acha odo odo. Etubiri LLO n'otu akụkụ yana NVR na azụ.
• 50/850 mg - ụdị tebụl yiri nke ahụ, naanị shei ahụ bụ odo-agba ntụ yana akara ahụ kwesịrị ekwesị: SEH n'aka nke ọzọ na NVR n'aka nke ọzọ.
• 50/1000 mg - mbadamba ihe dị iche na ụdị nke gara aga na ndo ndo nke edo edo ọzọ na mgbakwunye nke isi awọ na ndebiri: NVR - n'akụkụ ihu yana FLO - na azụ.

Ohere nke ọgwụ ọgwụ

A nwere ike iji ọgwụ hypoglycemic nke ụdị ọgwụ abụọ mejupụtara, nke ọ bụla nwere usoro nke ya. Ike ha dị mgbagwoju anya na-enye gị ohere ijikwa glycemia n'ehihie.

1. Vildagliptin - onye na-egbochi nke dipeptidyl peptidase-4 (DPP-4) - na-eme ka ikike nke sel dị na insulin, na-abawanye nrụpụta ya. A na-enye nsonaazụ a site na ụdị glyptin nke mmepụta nke protein dị mkpa maka pancreas - ụdị glucagon yiri peptide 1 (GLP-1) na glucose na-adabere glucose polypeptide (HIP).
2. Metformin, kọlụm nke ìgwè hydrochloride biguanide, na-ahụkarị ihe ngosi glycemic site na mbenata ọnụego nnabata nke carbohydrates na obere eriri afọ, na-ebelata mmepụta nke glycogen na imeju na ịkwalite ojiji na akwara anụ ahụ. Na onyinye nwere ike ịkpalite hypoglycemia.

Site na iji ọgwụ a na-ekwu okwu, vildagliptin na metformin na-abanye n'ọbara ọbara site na mgbidi nke eriri afọ, na-eru usoro ọgwụgwọ na 25-25 nkeji ma jiri ya kesaa akụkụ ahụ na anụ ahụ. Usoro nke metabolic nke Galvus Met na-eme na imeju. Ngwa ahịa ire ure na-apụta na mmamịrị. Oge a ga-eji gosipụta ọkara n'ime ihe ndị a na-ejikarị eme ihe dị ka awa atọ.

N'oge usoro ọgwụgwọ siri ike na ọgwụ abụọ na ọnụego kwa ụbọchị nke metformin 1500-3000 mg na vildagliptin 50 mg, kesara ihe karịrị ngwa abụọ, a na-edekọ nnukwu Mbelata ọbara n'otu afọ. N'otu oge ahụ, glycosylated hemoglobin indices belatara site na 0.7%, ma e jiri ya tụnyere otu njikwa, nke natara naanị metformin.

N'ime ndị ọrịa mamịrị nọ na usoro ọgwụgwọ dị mgbagwoju anya nke Galvus Metom, edekọghị nrụzi dị mkpa. N'ime ihe karịrị izu 24 nke iji ọgwụ ọjọọ eme ihe, ekpughere mbelata dị ukwuu n'ọbara ndị ọrịa na-arịa ụdị ọrịa shuga 2. Hypoglycemic ikpe dere obere opekempe.

Mgbe etinyere Galvus Meta n'oge insulin na-agwọ ya (na nha nke 41 nkeji) na ndị ọrụ afọ ofufo na-arịa ọrịa shuga na-ekere òkè n'ọmụmụ ihe ahụ, ọkwa nke gemocosylated hemoglobin dara 0.72%. Hypoglycemia na mpaghara nyocha na na otu placebo adịghị iche n'ọtụtụ oge.

Site n'iji glimepiride mee ihe (site na 4 mg / ụbọchị) na Galvus Met, e dekọtara mbelata dị ukwuu na hemoglobin glycosylated - site 0.76%.

Njirimara nke pharmacokinetics

Vildagliptin

Ọ bụrụ na i were mbadamba ihe iri tupu nri, ihe ndị dị ike na-etinye obi gị dum ngwa ngwa, na-eru ogo ya mgbe elekere 105 gasịrị. Mgbe ị na-eji ọgwụ ahụ nri, nri a na-agbakwụnye ga-agbada ntakịrị.

Nnukwu ogwu nke ọgwụ ahụ dị elu - 85%. Nkesa nke metabolite n'etiti plasma na erythrocytes bụ otu, ọ na - esite ike na protein protein - naanị 9.3%.

Mainzọ kachasị dị na mkpocha ọgwụ bụ biotransformation, 69% nke dose n'ime ahụ na-agbanwe ka metabolitelogically adịghị metabolite LAY151. Ntughari nke vildagliptin na-aputa site na akụrụ (85%) na eriri afọ (23%).

Ndị nnọchi anya agbụrụ dị iche iche, nwoke ma ọ bụ nwanyị, nke ibu dị iche iche na-egosi ihe dịka otu ọgwụ ọgwụ ahụ.

Site na enweghi ike ịba ọcha n'anya n'ụdị dị nro ma ọ bụ agafeghị oke, bioav adị nke vildagliptin na-agbadata na 20%, n'ụdị siri ike ọ na-abawanye site na 22%.

Site na usoro gbasara akụrụ, ụdị dị nro, nke na-adịghị mma nke AUC, vildagliptin na-eto 1.4 ruo ugboro abụọ.

A mụbeghị nsonaazụ nke vildagliptin na ọgwụ ọgwụ nke ụmụaka.

Metformin

Na usoro onunu ogwu nke 500 mg, bioavailability nke metformin bụ 50-60% ma ọ bụrụ na ewere ya tupu nri. Site na iji usoro onodu ogwu na abawanye, ihe ngosi a na abawanye. Ọ bụrụ na ị theụrụ ọgwụ ya na nri, bioavailability na-ebelata.

N’ime otu ọgwụ, metabolite fọrọ nke nta ka ọ ghara ejikọ ya na protein ndị dị na plasma (maka ntụle, nkwadebe sulfonylurea na-ejikọ 90%). N'iji ogologo oge, ọgwụ ahụ jiri nwayọ banye n'ime sel ọbara.

Single intravenous intravenous injection of ọgwụ si ndị ọrụ afọ ofufo nwere ahụ ike gosipụtara ntụpọ nkịtị nke otu ihe mejupụtara. Ahụghị metabolites n'ime imeju. N'ime ndị ọrịa mamịrị, ihe ruru 90% ọgwụ a takenụrụ na-akpụrụ akụrụ n’ime awa iri abụọ na anọ.

Ndi iche na nmekorita nwoke na nwanyi anaghi emetuta ọgwụ nke ogwu. Ndị ọrịa shuga nke agbụrụ dị iche iche dekọrọ otu arụmọrụ nke metformin.

A mụbeghị atụmatụ nke nnabata, nkesa na mkpocha ọgwụ ahụ na ndị ọrịa nwere ọrịa imeju. Site na usoro gbasara akụrụ, ọkara ndụ na-abawanye. N'ihi mbelata ikike akụrụ n’ime ndị ọrịa tozuru oke, a na-achọpụta nsonaazụ yiri ya. Enweghị data na nsonaazụ ọgwụ ahụ na nsonaazụ ọgwụgwọ na ụmụaka.

Onye ka egosiputara ogwu ahu

Emebere ngwakọta a iji gwọọ ndị ọrịa mamịrị nwere ọrịa shuga 2. Dabere na Galvus Meta, e nwere usoro ọgwụgwọ dị iche iche.

1. Monotherapy - iji hazie shuga, iji ọgwụ mee ihe - Galvus Met.
2. Iji ihe dị iche iche eme ihe nke Metformin na Vildagliptin dị ka ọgwụ nnwere onwe.
3. Usoro nkwonkwo jikọrọ ya na usoro sulfanylurea.
4. Ulo akwukwo ato na mgbakwunye nke insulin na Galvus Meta.
5. Dị ka ọgwụ mbụ e jiri mee ihe na mmalite ọgwụgwọ ọgwụ, mgbe nri obere ala na-ebu ibu ma na-ebugharị ebumnuche adịghị arụpụta nsonaazụ achọrọ.

Ọgwụgwọ Galvus dị mma maka ndị dị ime na ndị na-enye nwa ara

Nnyocha ndị e mere na anụmanụ dị ime, nke a na-ahụ maka ọgwụ nke vildagliptin ugboro 200 karịa nke kwesịrị, gosiri na ọgwụ adịghị emerụ mmepe nke ẹmbrayos na enweghị mmetụta teratogenic. Ojiji Galvus Meta na usoro onunu ogwu nke 1/10 gosiputara ihe yiri ya.

Emebeghị ka mmetụta nke ọgwụ na nwa ebu n’afọ gụọ akwụkwọ nke ọma, yabụ enyeghị ụmụ nwanyị dị ime iwu. Metformin na-abanye na mmiri ara ara, enweghi data na ntinye nke vildagliptin.

Na mkpokọta, Galvus Met anaghị eji mmiri ara ara eme ihe.

Na onye hypoglycemic n'ụlọnga na-contraindicated

A na - enyeghi usoro ihe ọmụmụ banyere ọgwụ metabolite:

• Onwe onye, ​​ogba aghara n’ihe obula nke ogwu ahu;
• Ọrịa shuga 1dị 1 - na-arịa ọrịa insulin na-emetụta ụdị a, achọrọ insulin;
• Bọchị ole na ole tupu arụ ọrụ ahụ, nyocha X-ray na radioisotropic nyocha, nchọpụta ọrịa;
• Acetonemia bụ nsogbu ọrịa sitere na ọdịdị nke ihe ketone na mmiri ọmụmụ, ọkachasị na nke a na-arịa hyperglycemia;
• Ọrịa ọgbụgba (n'ọrịa ma ọ bụ nke na-adịghị ala ala), usoro ndị na-akpasu akpịrị nkụ - mmiri akpịrị nke anụ ahụ n'ihi afọ ọsịsa ma ọ bụ vomiting, ahụ ọkụ, ọrịa (sepsis, usoro iku ume);
• Ọkpụkpụ nke imeju na-ejikọta ya na ọnọdụ ndị na-ebelata arụmọrụ ya (cirrhosis, ịba ọcha n'anya);
• Ọrịa obi, nkụchi obi, mkpụmkpụ ume;
• Mmanya na-egbu egbu dị ka ọrịa ma ọ bụ mmanya ị ;ụbiga mmanya;
• Hypocaloric oriri na-edozi, mgbe ihe ruru 1000 kcal / ụbọchị na-abanye ahụ .;
• Oge ọ bụla nke ime na lactation;
• Childrenmụaka - nchekwa na mmetụta ọgwụ a akwụbeghị.

Etu esi etinye ọgwụ ahụ

A ga-elo mbadamba ihe a niile, na-enweghị ịta ata ma ọ bụ na-agbanye ya, jiri mmiri zuru oke washedachaa ya. Ọ bụrụ na i jiri ọgwụ a were ọgwụ, ị ga-ebelata ihe ọ ga-emebi.

Ngwọta nke Galvus Meta na-adabere na nkwụghachi ụgwọ shuga, nsonaazụ nke ọgwụgwọ gara aga na analogues, yana oge ọrịa ahụ. N'ọnọdụ ọ bụla, usoro ọgwụgwọ bụ dọkịta.

Ọ bụrụ na edepụtara ọgwụ ahụ maka oge mbụ, dị ka mgbakwunye na nri adịghị arụ ọrụ nke ọma na mmega ahụ, ụkpụrụ ya ga-abụ 50/500 mg (ihe ngosi mbụ bụ vildagliptin, nke abụọ bụ metformin). N'ọdịnihu, na-ezughi oke ọgwụgwọ, nke na-ekpebisi ike site na usoro nyocha, usoro ọgwụgwọ ahụ nwere ike idozi ya.

Mgbe onye ọrịa maara ọgwụ ndị ahụ (ọ were ha iche ma ọ bụ na ngwakọta ndị ọzọ), ha na-atụ aro otu nhọrọ - 50/850 mg ma ọ bụ 50/1000 mg.

N'ime afọ tozuru oke ma ọ bụ na-etolite ọrịa akụrụ, a na-atụkarị aro ka a theụọ ya.

Iji tụọ nsonaazụ nke ọgwụgwọ Galvus Metom, ọ dị mkpa ịlele ọkwa nke sugars (ma n'ụlọ, yana glucometer, na n'ụlọ nyocha) mgbe niile.

Nsonaazụ

A naghị edekọ mmetụta ndị na-achọghị ka oge a, mana ọ dị mkpa ịmụ ndepụta ahụ tupu itinye shuga.

1. Ọkpụkpụ ọnya afọ - ọrịa dyspeptik, obi mgbawa, pancreatitis, uto metal na ọnụ, mmịpụta nke vitamin B12 adịghị mma.
2. CNS - mwepu nke nhazi, isi ọwụwa, aka na-ama jijiji.
3. Duits na bile ducts - ịba ọcha n'anya na nsị akwara.
4. Usoro akwara - nkwonkwo na olu mgbu.
5. Akpụkpọ - blisters, ọzịza, akpụkpọ akpọnwụ.
6. Metabolism - lactic acidosis (mmụba na mkpokọta uric acid, mmeghachi omume acidic nke gburugburu).
7. Allergy - rashes skin, itching, urticaria; na mmeghachi omume siri ike - akụkụ ụbụrụ anginedema Quincke (ọrịre nke ihu na akụkụ ahụ) yana ujo anacticlactic (mbelata ọbara mgbali elu, nke ọtụtụ akụkụ ahụ mebere).

   
   

Mgbe ụfọdụ hypoglycemia na-amalite site na ọsụsọ nke ọsụsọ oyi, aka na-ama jijiji. Na mgbaàmà mbụ, ịkwesịrị ị drinkụ ọkara iko tii ma ọ bụ ihe ọ juiceụ juiceụ dị ụtọ, rie swiiti.

Ntụziaka pụrụ iche

Mgbe ọ na-ede akwụkwọ ọgwụ, o kwesịrị ịmụ ntuziaka n’onwe ya. Ntụziaka pụrụ iche ga - enyere aka ịzere nsonaazụ ndị ọzọ.

• Galvus Met abụghị analogue nke insulin, ọ dị mkpa, nke mbụ, maka ndị ọrịa mamịrị nwere ọrịa shuga na-akpata insulin.
• Na usoro ị withụ ọgwụ ahụ, achọrọ ilebara shuga ọbara anya (ma nyocha ya na nke ọ bụla, na-eji glucometer).
• Kwa ọnwa, ụzọ nyocha ụlọ na-atụle ọnọdụ akụrụ, imeju na ịta lactic acid.
• N'oge ọgwụgwọ, Galvus Metom anabataghị ị drinkụ mmanya - nke a nwere ike itinye aka na mmepe nke lactic acidosis.
• Ntinye vitamin B12 na-ezighi ezi, n'ihi ị ofụ ọgwụ, nwere ike ịkpalite anaemia na neuropathy.
• Childrenmụaka, ndị dị ime na ndị na-enye nwa ara Galvus Met anaghị anabata.
• Ngwaọrụ nọ n'ọrụ nke metabolite na-akpakọrịta na ọtụtụ ọgwụ, mgbe ị na-edepụta usoro ọgwụgwọ, ekwesịrị ịgwa dọkịta banyere ọgwụ niile ewere.
• Mmuta nke Galvus Meta na mmeghachi omume psychomotor na ogo nke itinye uche n'ihe. Mgbe ị na-arụ ọrụ na igwe na usoro n’oge a na-eji ọgwụ ahụ, mmadụ ga-akpachara anya.

Dodoụbiga ya ókè

Ọ bụrụ na ọgwụ a tụrụ aro gafere ọtụtụ oge, myalgia, hypoglycemia, ọrịa dyspeptik, edema nke nsọtụ, lactic acidosis (site na oke nke metformin) na-etolite. Ihe ịrịba ama nke ịdoụbiga mmanya ókè na-apụ n'anya mgbe ịkwụsị usoro ọgwụgwọ.

Site na mgbaàmà ndị dị otú ahụ, a na-akagbu ọgwụ ahụ, jiri ya eriri afọ na-agwọ ọrịa ma na-eme ọgwụgwọ Symptomatic. N'iji hemodialysis, naanị metformin nwere ike ịpụ apụ kpamkpam, vildagliptin nwere akụkụ ụfọdụ.

Metal Galvus - analogues

Ọ bụrụ na anyị na-atụnyere ihe mejupụtara na nsonaazụ ọgwụgwọ, mgbe ahụ dabere na akụrụngwa ndị nọ n'ọrụ na nrụpụta ọgwụgwọ, analogues nwere ike ịbụ:

• Nova metara;
• Sofamet;
• Trazenta;
• Methadiene;
• Pliva ike.

Nkwado nchekwa na ọnụ ahịa ọgwụ

Dabere na ntuziaka, Galvus Met dabara adaba iji rụọ ọrụ n’ime ọnwa iri na asatọ site na ụbọchị a tọhapụ, na-echekwa nchekwa kwesịrị ekwesị. A ga-ekpochapụ ọgwụ gwụsịrị. Ebe gbara ọchịchịrị na ebe a na-agaghị enweta ohere nlebara anya ụmụaka dabara adabara maka nchekwa, yana ọnọdụ okpomọkụ ruo 30 Celsius.

A na-ahapụ ọgwụ ọgwụ. Maka Galvus Met, a ga-ekpebi usoro ọgwụgwọ ahụ site na usoro onunu ogwu:

1. 50/500 mg - nkezi nke 1457 rubles;
2. 50/850 mg - nkezi nke 1469 rubles;
3. 50/1000 mg - nkezi nke 1465 rubles.

Ọbụlagodi na iji otu ụbọchị kwa ụbọchị, ọ bụghị ndị ọrịa shuga niile nwere afọ ojuju maka ego a, ọtụtụ mkpesa ndị sitere n’aka ndị na-akwụ ezumike nka nwere obere ego. Agbanyeghị, ngwaahịa nke ụlọ ọrụ Switzerland bụ Novartis Pharma bụ nke na-egosipụta ọdịiche ha mgbe niile, na ha esoghị na ngalaba mmefu ego nke ndị ọrụ hypoglycemic.

Galvus Met - nyocha nke ndị ọrịa mamịrị na ndị dọkịta

Na nzukọ akụkọ ha, endocrinologists na-aza nsonaazụ nsonaazụ nke ọgwụgwọ Galvus Metom. A naghị atụ aro ya ka etinyere ya maka nsogbu oncological, ebe ọ bụ na DPP-4, enzyme na-egbochi mmepe nke neoplasms, Galvus Metom na-egbochi ya. Na ọrịa cancer ara, a na-enyekarị insulin ọgwụ. Nyochaa ndị ọrịa gbasara Galvus Mete, agwakọta isiokwu bụ isi.

Ozi banyere ọgwụ Galvus Met jikọtara mmetụta hypoglycemic na insulin na glycogen n'ime ahụ na-esite na ntuziaka gọọmentị, mana enyere ya maka ebumnuche ọhụụ na enweghị ike ịbụ nduzi maka nchọpụta ma ọ bụ ọgwụ onwe.