N'ime ọgwụ maka ịgwọ ọbara mgbali elu (BP), Pyramil pụtara. Ọgwụ ahụ na-egbochi ọrụ enzymatic na ntụgharị nke angiotensin I. A na-ahụta mmetụta hypotensive na cardioprotective. Site na njikọta nke akụrụngwa abụọ a, ọ bịara kwe omume belata ihe ize ndụ nke ịrịa ọrịa infịction myocardial, ọrịa strok ma bulie ọnụego nhazigharị nke ndị ọrịa nwere ọnya ọgbụgba akwara.
International Nonproprietary Aha
Ramipril
N'ime ọgwụ maka ịgwọ ọbara mgbali elu (BP), Pyramil pụtara.
ATX
C09AA05
Ha weputara udi ya na ihe mebere ya
Ọgwụ ahụ dị n'ụdị mbadamba. Mbadamba biconvex dị ogologo nwere 5 ma ọ bụ 10 mg nke ramipril na-arụ ọrụ. Dị ka ihe inyeaka na mmepụta a na-eji:
- colloidal silicon dioxide;
- gbeceryl dibehenate;
- microcrystalline cellulose;
- glycine hydrochloride;
- pregelatinized stachi.
Mpempe 5 mg bụ pink dị ọcha n'ihi mgbakwunye nke ajị uhie na-adabere na iron. Ihe ize ndụ ahụ dị naanị n'akụkụ ihu.
Ejiri microcrystalline cellulose dị ka ihe inyeaka na mmepụta Pyramil.
Omume ọgwụ
Ọgwụ a bụ nke ndị ACE inhibitors (enzyme angiotensin-na-agbanwe ntụgharị). Mgbe ọ na-abanye na imeju, kemịkal na-arụ ọrụ na-arụ ọrụ hydrolyzes na-etolite ngwaahịa na-arụ ọrụ - ramiprilat, nke na-ebelata mmetụta ACE (enzyme angiotensin na-eme ka ntụgharị nke angiotensin I na angiotensin nke II na-eme ka ọ dịghachi mma).
Ramipril na-egbochi mkpụkọ plasma nke angiotensin II, na-ebelata ihe nzuzo nke aldosterone ma n'otu oge ahụ na-eme ka mmetụta nke renin dị ọzọ. N'okwu a, ihe mgbochi kinase II na-apụta, mmepụta prostaglandin na-abawanye ma bradycardin anaghị agbaji. N'ihi nsonaazụ nke ihe na-arụ ọrụ, ngụkọta akwara vaskụla na-ebelata (OPSS) na-ebelata, n'ihi nke ha na-agbasa.
Mlọ ọgwụ
Mgbe ejiri ọnụ kwuo ya, a na-etinye ọgwụ ahụ ngwa ngwa na obere eriri afọ, n'agbanyeghị nri. N'okpuru mmetụta nke esterase, hepatocytes na-enwe mgbanwe nke ramipril gaa ramiprilat. Ngwa ahịa ire ere na-egbochi enzyme angiotensin na-agbanwe ugboro 6 karịa ike ramipril. Ọgwụ na-erute ike kachasị plasma n'ime otu elekere mgbe nchịkwa, ebe a na-achọpụta ọnụego kachasị nke ramiprilat mgbe awa 2-4 gachara.
Mgbe ọ batara n’ọbara, akwara ahụ na - arụ ọrụ na - ejikọ protein protein site na 56-73% wee bido kesaa ya n’akpụkpọ ahụ niile. Ọkara ndụ nke ọgwụ ahụ na iji otu oge bụ 13-17 awa. A na-ekepụ Ramipril na metabolite na-arụ ọrụ n'ime akụkụ akụrụ site na 40-60%.
A na-ekepụ Ramipril na metabolite na-arụ ọrụ n'ime akụkụ akụrụ site na 40-60%.
Ihe ngosi maka ojiji
Edere ọgwụ ahụ maka ọgwụgwọ na mgbochi nke ọrịa ndị na-esonụ:
- nephropathy nke ọrịa mamịrị na-arịa ọrịa mamịrị na usoro ma ọ bụ usoro ọgwụgwọ n'ụlọ ọgwụ, tinyere ọbara mgbali akwara, proteinuria na mwepụta nke albumin na mmamịrị;
- ọrịa shuga mellitus gbagwojuru anya site n'ihe ndị ọzọ dị ize ndụ n'ụdị ọbara mgbali elu, ịbawanye ma ọ bụ ibelata cholesterol na obere lipoproteins dị ala, àgwà ọjọọ;
- ọbara mgbali elu na arịa ndị bụ isi;
- nnukwu obi nkụda mmụọ, nke tobara n’ime ụbọchị 2-9 ka nkụchi obi gasịrị.
Ọgwụ na - enyere aka belata ihe ize ndụ nke ịrịa ọrịa ọzọ na ndị merụrụla akwara mmiri ma ọ bụ aorta, nkụchi obi, angioplasty nke akwara ọbara. Ọgwụ bụ akụkụ nke ọgwụgwọ ọgwụgwọ maka ọrịa obi na - adịghị ala ala.
Ihe ngbanwe
N'ụfọdụ, akwadoghị ọgwụ ahụ ma ọ bụ amachibido maka iji:
- nnukwu akwara ma ọ bụ ụkọ akwara;
- kadiogenic ujo;
- ọbara mgbali elu ma ọ bụrụ na nrụgide systolic dị n'okpuru 90 mm Hg. st .;
- hyperaldosteronism;
- stenosis nke mitral valve, aorta, akwara akwara;
- ihe omumu ihe omimi;
- afọ ime na lactation;
- ụmụaka ndị gbara afọ 18;
- ịba ụba nke anụ ahụ na ihe nhazi ọgwụ.
A na-adọọ ịdọ aka na ntị mgbe ị na-ewere immunosuppressants, diuretics, saluretics.
Otu esi ewere Pyramil
Ezubere ọgwụ a maka nchịkwa ọnụ. A na-ekpebi usoro ịgwọ ọrịa kwa ụbọchị na oge nke ọgwụ na-adabere na njirimara onye ọrịa, akụkọ ahụike na ule ụlọ nyocha. Ọrụ dị mkpa iji kpebie usoro ọgwụgwọ ga-esite na ogo na ụdị ọrịa.
| Ọrịa | Usoro ọgwụgwọ |
| Ọbara mgbali elu | Na enweghị obi ike, usoro ubọchị a na-eru 2.5 mg. Ọgwụ ahụ na-ebili kwa izu 2-3 ọ bụla dabere na ndidi. Na enweghị ọgwụgwọ ọgwụgwọ kwa ụbọchị nke 10 mg nke ọgwụ ahụ, ọ dị mkpa ịkpọtụrụ dọkịta gị banyere nhọpụta nke ọgwụgwọ zuru oke. Ihe kacha anabata ike ị nweta bụ 10 mg kwa ụbọchị. |
| Ọrịa obi na-adịghị ala ala | 1.25 mg kwa ụbọchị. Usoro ọgwụgwọ a na-amụba kwa izu 1-2 ọ bụla dabere n'ọnọdụ onye ọrịa. A na-atụ aro ọnụego kwa ụbọchị site na mg mg 2 na nke dị elu ka ekesaa ya 1-2. |
| Belata ohere ọnya afọ, nkụchi obi | Otu usoro ubochi kwa ubochi bu 2.5 mg. N'ime izu atọ na-esote, a na-anabata mmụba nke usoro onunu ogwu (ụbọchị asaa asaa). |
| Obi dara mba mgbe nkụchi obi | Ọgwụgwọ bidoro ụbọchị 3-10 mgbe nkụchi obi gasịrị. Ọgwụ nke mbụ bụ 5mg kwa ụbọchị, kewara abụọ usoro (n'ụtụtụ na tupu ụra). Ka ubochi abuo gasiri, ubochi nile na adi elu rue 10 mg. Site na ntachi obi dị ala na usoro ịkwụ ụgwọ maka ụbọchị abụọ, a na-ebelata ọnụego kwa ụbọchị ka 1.25 mg kwa ụbọchị. |
| Ọrịa mamịrị na ọrịa anaghị arịa ọrịa mamịrị | 1.25 mg maka otu ihe, mgbakwunye na 5 mg. |
Na-arịa ọrịa shuga
Na mmalite ọgwụ eji agwọ ọgwụ, a na-atụ aro ka ọ were ọkara mbadamba ọgwụ nke 5 mg kwa ụbọchị otu ugboro. Dabere na ọnọdụ ahụike ọzọ, enwere ike ịgbatị ụkpụrụ kwa ụbọchị ka ọ bụrụ ọgwụ zuru oke nke 5 mg yana nkwụsị nke izu 2-3.
Mmetụta mmetụta Pyramil
A na-egosipụta mmetụta ọjọọ nke ị theụ ọgwụ na-adabere na mmeghachi omume nke anụ ahụ na kemịkalụ kemịkal nke ihe na-arụ ọrụ.
Na akụkụ ahụ nke ọhụụ
Anya nke ihe anya na-ebelata, defocusing na blurry apụta. N'ọnọdụ ndị na-adịghị ahụkebe, ọrịa conjunctivitis na-amalite.
Site na anụ ahụ na akwara
Usoro akwara ahụ na-emeghachi omume na ngosipụta ugboro ugboro nke akwara olu na mgbu mgbu.
Ọkpụkpụ afọ
Mmeghachi omume ọjọọ nke usoro nri nri n'oge ọgwụ ọjọọ gosipụtara onwe ha n'ụdị:
- mgbu na ahụ erughị ala na mpaghara epigastric;
- afọ ọsịsa, nsị, afọ ntachi;
- vomiting, ọgbụgbọ;
- dyspepsia;
- ọnụ kpọrọ nkụ
- agụụ riri nri na mmepe nke anorexia;
- ọrịa ogbu na nkwonkwo nke nwere obere ọnwụ.
Ikekwe mmụba na ọrụ nke aminotransferases na hepatocytes, nkwụnye ego hepatocellular. Enwere mmụba nke ihe ọ juiceụ ofụ mmiri pancreatic, mmụba n'ọbara plasma nke bilirubin n'ọbara, n'ihi nke ọrịa jaundice cholestatic.
Ahụhụ Hematopoietic
Na-emegide usoro ọgwụgwọ ọgwụ, enwere ohere ịbawanye agranulocytosis na neutropenia, enwere mbelata ọnụọgụ ọbara na ọkwa nke haemoglobin.
Sistemụ akwara Central
A na-egosipụta nsonaazụ n’akụkụ etiti na akwara
- ufu na isi ọwụwa;
- ọnwụnwa;
- parosmia;
- mmetụta anụ ọkụ;
- mfu itule;
- Aka na aka.
Na-emegide nguzozi nke uche, a na-ahụ nchekasị, ụjọ, nsogbu nke ihi ụra.
Site na usoro urinary
Enwere mmụba nke nsogbu ndọba n'ụwa, n'ihi protein a na-ahụ na mmamịrị, ọkwa nke creatinine na urea n'ọbara na-ebili.
Enwere mmụba nke nsogbu ndọba n'ụwa, n'ihi protein a na-ahụ na mmamịrị, ọkwa nke creatinine na urea n'ọbara na-ebili.
Site na sistem iku ume
A na-egosipụta mmetụta na-adịghị mma na sistem akụkụ okuku ume n'ụdị bronchitis, ụkwara akọrọ na-egbu oge, mkpụmkpụ ume, sinusitis.
Na anụahụ
Ndị ọrịa nwere ebumnuche igosipụta mmeghachi omume nfụkasị nwere ohere dị ukwuu nke ịmalite ọrịa akpịrị, urticaria na hyperhidrosis. Nlere anya na - adịghị ahụkebe - nlebara anya na ọkụ, alopecia, na - akawanye njọ nke ọrịa psoriasis, onycholysis.
Site na usoro mkpụrụ ndụ ihe nketa
N'ime ụmụ nwoke, n'oge usoro ọgwụgwọ ọgwụ, mbelata ikike ga-ekwe omume ruo na mmepe nke nrụrụ ọgbụgba (enweghi ike) na gynecomastia.
Site na usoro akwara obi
A na-egosipụta nsonaazụ nke ọgwụ na sistemụ mgbasa n'ụdị ọnọdụ ndị a:
- orthostatic hypotension;
- arrhythmia, tachycardia;
- vasculitis, ọrịa Raynaud;
- afufu;
- iwepu ihu.
Na-emegide ụbụrụ arịa arịa, mmepe nke nsogbu akwara ọbara.
Usoro endocrine
N'ikwu ya, ọdịdị nke mmepụta ọgwụ nchịkwa na-achịkwaghị achịkwa ga-ekwe omume.
N'akuku nke imeju na akụkụ biliary
Ewu nwere ịba ọcha n'anya na cholecystitis.
Site n'akụkụ nke metabolism
Ọdịnaya nke potassium n’ime ọbara na-abawanye.
Ahụhụ
Na ọnụnọ nke hyperensitivity na ramipril na ngwa enyemaka nke Pyramil, mmeghachi omume nfụkasị ndị a nwere ike ime:
- angioedema;
- Ọrịa Stevens-Johnson;
- ọnya, itching, erythema;
- alopecia;
- nsogbu anaphylactic.
Mmetụta ikike ịchịkwa usoro
N'ime oge ọgwụgwọ ọgwụ, a na-atụ aro ka ọ ghara ịnya ịnya ụgbọ ala, na-emekọrịta ihe site na usoro ndị siri ike, yana ihe omume ndị ọzọ chọrọ mgbanye na mmeghachi ngwa ngwa.
N’oge ọgwụ, a na-atụ aro ka ọ kwụsị ịkwọ ụgbọala.
Ntụziaka pụrụ iche
Tupu ịmalite ọgwụgwọ ọgwụ, ọ dị mkpa iji jupụta ụkọ sodium ma kpochapụ hypovolemia. Mgbe ha takingụsịrị ọgwụ nke mbụ, ndị ọrịa kwesịrị ịnọ n'okpuru nlekọta ahụike maka elekere 8, ebe enwere ihe ọghọm nke ịmalite hyperension orthostatic.
Na ọnụnọ nke cholestatic jaundice, akụkọ banyere edema, ọ dị mkpa ịkwụsị ị .ụ ọgwụ. N’oge mmegharị ahụ mgbe a wachara ya mma n’ọkpụkpụ mkpesa izugbe, ọ nwere ike iwetulata ọbara ọgbụgba, ya mere, ekwesịrị ịkagbu ọgwụ ahụ awa iri abụọ na anọ tupu a waa ya ahụ.
Jiri na agadi
A na-adụ ịdọ aka na ntị mgbe ndị rurula afọ 65 gbagoro n'ihi ohere ịbawanye gbasara akwara, ọrịa obi na ọrịa imeju.
Inye umuaka
Amachibidoro iji ihe ruru afọ 18.
Jiri n'oge ime na lactation
Ogwu ahu nwere uto nke teratogenic n’ime ẹmbrayo nke nwa ebu n’afọ, ya mere, iwere Pyramil n’oge amụrụ ma ọ bụ ime ka amachibidoro.
N'oge ọgwụgwọ ọgwụ, a na-atụ aro ịkwụsị lactation.
Ngwa maka ọrụ ezughi oke ọrụ
Ekwesighi iji ọgwụ na creatinine mee ihe na-erughị 20 ml / min. A na-adụ ịdọ aka na ntị na ndị ọrịa mgbe ntụgharị akụrụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Ekwesịrị ịkpachara anya mgbe imeju anaghị arụ ọrụ nke ọma. Na oke mmebi, a ga-akagbu nnabata nke Pyramil.
Pyfesa pyramil
Site n'iji ọgwụ ọjọọ eme ihe, a na-ahụ igosipụta ọdoụbiga ókè ókè:
- ọgba aghara na enweghị uche;
- onye nzuzu;
- ọdịda odida;
- ujo
- imebi nguzore nnu-mmiri n’ime ahu;
- wedata ọbara mgbali;
- bradycardia.
Ọ bụrụ na erughị 4 awa agafeela mgbe ị aụsịrị ọgwụ dị elu, mgbe ahụ ọ dị mkpa ka onye ahụ mebie ọfụma, hichaa afọ, nye adsorbent. Na oké mmanya, emebere ọgwụgwọ iji weghachi electrolytes na ọbara mgbali
Mmekọrịta na ọgwụ ndị ọzọ
Site na nhazi nke Pyramil nke oge a na ọgwụ ndị ọzọ, a na-ahụta mmeghachi omume ndị a:
- Ọgwụ nke nwere mmiri nnu ma ọ bụ na -eme ka mkpụrụ mmiri potassium na heparin na-akpata hyperkalemia.
- Enwere ike igbusi oke ike na ọgwụ ịrahụ ụra, ọgwụ na ọgwụ ọgwụ.
- Ihe ọghọm nke ibute leukopenia na ramipril na allopurinol, corticosteroids, procainamide na-abawanye.
- Ọgwụ antisteroidal na-egbochi mbuze na-ebelata mmetụta nke Pyramil ma na-abawanye ohere nke ọdịda akụrụ.
- Ramipril na-abawanye ike nke ure anapulactic n'oge ụta ahụhụ.
A na - ahụta ekweghị ekwe ọ jikọtara ya na ọgwụ nwere aliskiren, yana ndị antagonensin II antagonist, ndị na - eme ka mkpụrụ ndụ dị nro.
Mmanya ndakọrịta
Mgbe ị na-a ethụ mmanya ethyl, ọ ga-ekwe omume ịkwalite onyonyo nke vasodilation. Ramipril na - akwalite nsonaazụ ethanol na imeju, yabụ mgbe ị na-ewere Pyramil, ị ga-ezere ị alcoholụ mmanya.
Analogs
Ihe atụ nke Pyramil bụ:
- Amprilan;
- Pyramil Mmezi mbadamba;
- Tritace;
- Dilaprel.
Chinggbanwe ya na ogwu ozo ka emechara mgbe ya na dọkịta kpachara anya.
Ahịa ọgwụ na-ahapụ okwu
Ọ na-ere ọgwụ a site na ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ
N'ihi oke ihe egwu nke ibute mmeghachi omume na-adịghị mma nke anụ ahụ, amachibidoro ire Pyramil n'efu.
Ọnụ ahịa Pyramil
Onu ogugu ego nke ogwu ahu di na 193 ruo 300 rubles.
Ọnọdụ nchekwa maka ọgwụ
A na-atụ aro idobe ọgwụ ahụ n’ebe akọrọ, na-echebe ya site na ìhè anyanwụ, na okpomọkụ ruo + 25 Celsius.
Bọchị mmebi
Afọ 2
Emeputa
Sandoz, Slovenia.
Nyocha Pyramil
Tatyana Nikova, 37 afọ, Kazan
Dọkịta depụtara mbadamba Pyramil n'ihi na enwere m ọbara mgbali elu. Echezọwo nrụgide na mgbede ruo afọ 2. Mana ịkwesịrị ị takeụ ọgwụ ahụ mgbe niile. Azọpụtaghị mmetụta ahụ. Ezigbo uru dị mma maka ego. Site na nsonaazụ ndị ọzọ, enwere m ike igosipụta ụkwara.
Maria Sherchenko, 55 afọ, Ufa
Ana m a pụ ọgwụ iji belata nrụgide mgbe ọrịa strok gachara. Ọtụtụ enyereghị aka, mana zutere Pyramil. Na mbido, enweghi mmetụta ọ bụla n’ihi ntakịrị usoro onunu ogwu ahụ, mana ka izu abụọ gachara ịba ụba, nrụgide bidoro belata. Ahụ adị m mma, mana echekwa m ọgwụ ọtụtụ ọgwụ ike. Difficultchọta nchikota ziri ezi siri ike.
