Amitriptyline Nycomed bụ onye otu nke otu egwuregwu tricyclic antidepressant. Ọgwụ bụ ụdị ụgwọ dị ala, nke dị mkpa, n'ihi na oge ọgwụgwọ dị ọtụtụ izu ma ọ bụ ọbụna ọnwa.
International Nonproprietary Aha
Amitriptyline.
Amitriptyline Nycomed bụ onye otu nke otu egwuregwu tricyclic antidepressant.
ATX
N06AA09.
Ha weputara udi ya na ihe mebere ya
Ngwaahịa ahụ dị n’ụdị mbadamba nkume. Nke a bụ nkwadebe otu ihe, nwere 1 ihe na - arụ ọrụ - amitriptyline. Mbadamba nkume ndị ahụ nwere shei, n'ihi nke ọkwa ọgwụ ike na mucous membranes nke digestive tract belata. Ntinye uche nke ihe na-arụ ọrụ: 10 ma ọ bụ 25 mg (na mbadamba 1). Ngwunye ọgwụ nwere ọtụtụ ihe adịghị arụ ọrụ nke a na-eji nweta ọgwụ chọrọ:
- steeti magnesium;
- microcrystalline cellulose;
- silica;
- talc;
- lactose monohydrate.
- stachi.
A na-emepụta Amitriptyline n'ụdị mbadamba mkpuchi, n'ihi nke a na-ebelata ogo nke oke ọgwụ ọjọọ na azụ mucous nke eriri afọ.
Ihe mkpuchi nke ngwaahịa a dịkwa ọtụtụ:
- macrogol;
- dimethicone;
- prolylene glycol;
- titanium dioxide;
- hypromellose;
- ntụ ntụ talcum.
Mbadamba ụrọ ndị a dị n’ime karama eji 50 pcs.
Omume ọgwụ
Ofkpụrụ nke usoro nke tricyclic antidepressants sitere na mgbochi nke ijide monoamines, nke norepinephrine, dopamine na serotonin nọchiri anya. Ihe ndị a dị ha mkpa maka mmetụta nke ọ joyụ.
Ọgwụ, dịka ụzọ ndị ọzọ nke otu tricyclic antidepressant otu, nwere ndọghachi azụ dị ukwuu - ọnụ ọgụgụ dị ukwuu nke nsonaazụ na-adị n'oge ọgwụgwọ. Nke a bụ n'ihi ụkpụrụ anaghị eme nhọrọ. N'ihi nke a, ọgwụ ọ bụghị nanị na-emetụta ijide monoamines, kamakwa na-egbochi mmeghachi omume ndị ọzọ nke mmiri ọgwụ.
Amitriptyline na-arụ ọtụtụ oge n'otu oge. Ihe bụ isi ya bụ antidepressant. Ọzọkwa, ọgwụ ahụ na-enye nsonaazụ, anxiolytic, hypnotic. Nke a pụtara na n’oge ọgwụgwọ ọ bụghị naanị na ọnọdụ uche onye ọrịa ka akpatabeghị, kamakwa a na-eweghachi ụra, nchekasị na-apụ n'anya.
Amitriptyline na-enye nsonaazụ hypnotic, n'ihi nke onye ọrịa ahụ na-eweghachi ụra.
N'ihi ikike igbochi reuptake nke monoamines, a na-achọpụta mmụba na mkpokọta synaptik nke sistemụ akwara. Na mgbakwunye, akụrụngwa arụmọrụ nke Amitriptyline Nycomed na-egbochi M1- na M2-muscarinic cholinergic ndị na-anabata ya, ndị na-anabata ya, na n'otu oge alp1-adrenergic ndị na-anabata ya. A na-ahụ mmetụta dị mma nke ọgwụgwọ na ọgwụ antidepressant a n'ihi njikọ dị n'etiti ndị neurotransmitters ndị dị na synapses nke ụbụrụ na ọnọdụ mmetụta uche.
Akụkụ ọzọ nke ọgwụ ahụ bụ mmetụta dịtụ nwayọ. A naghị enweta ezigbo mmetụta ozugbo, mana mgbe ntinye uche nke ihe na-arụ ọrụ n'ime plasma ọbara ruru ogo ha. Na mgbakwunye, na ị rute n’otu ọkwa (ọ dịgasị dabere na ntụtụ), a na-egosipụta mmetụta na-enye ume ọgụgụ isi. Agbanyeghị, nsonaazụ ọ bụla na-agbadogide nzụlite nke mmụba na mkpokọta nke nnukwu metabolite nke amitriptyline - northriptyline.
Site na mmụba na mbelata na usoro onunu ogwu, Njirimara nke ogwu a gbanwere. Yabụ, mgbe ị ruru ọkwa ụfọdụ, ọrụ nke nortriptyline na-ebelata, arụmọrụ nke amitriptyline na-abawanye. Agbanyeghị, ana-ahụkarị mbelata ihe ndị na - egbochi ọgwụ ịideụ mmiri. Maka nke a, ịnweghị ike iji ọgwụ ahụ n'onwe gị, n'ihi na ọ dị mkpa ịhọrọ usoro ọgwụgwọ kwesịrị ekwesị na-eburu n'uche njirimara nke ahụ. Ekwesiri iburu n'uche na iwere obere ogwu agaghị enye nsonaazụ achọrọ.
Site na amitriptyline, ị nwere ike ijikwa ọnụego obi gị. Nke a bụ n'ihi mmetụta antiarrhythmic nke ọgwụ.
Ọgwụ na-arụ ọrụ dịkwa mma na-emebi ọrụ CCC. Dịka ọmụmaatụ, enwere ike iji ya jikwaa ọnụọgụ obi. Nke a bụ n'ihi mmetụta antiarrhythmic nke ọgwụ. Mgbe ị na-ede ọgwụ ahụ na usoro ọgwụgwọ, a ga-achọpụta mbelata nke ike usoro ventricular.
Mlọ ọgwụ
Amitriptyline bụ ihe ejiri mara ngwa ngwa. Mgbe awa 2-6 gachara, arụ ọrụ kacha elu nke ihe a ruru. A na - ahuta ya site na ogo bioavailability (50%). Mana ikere na protein protein dị elu - 95%. Nyere na ogwu ahu na enyeputa ihe ichoro mgbe omachara ihe nlebara anya nke ihe aru oru n’aru, ekwesighi inwe uto oma n’abia tupu izu 1 emesia. Nke a bụ n'ihi eziokwu ahụ bụ na a chọrọ oge dị otú ahụ iji mezuo isi ọnọdụ nke akara nke pathology na-amalite na-apụ n'anya.
A na-agbanye ọgwụ na-arụ ọrụ n'ime imeju. Nke mbu, eweputara ihe na - eme ihe ndi ozo. Mgbe ahụ, ma amitriptyline na metabolite ya na-arụ ọrụ bụ hydroxylated, ndị na-esote ntọhapụ nke ihe ndị nwere ike. Ọkara ndụ nke ọgwụ ahụ sitere na awa 9 ruo 46, nke ọnọdụ nke anụ ahụ metụtara, ọnụnọ nke ọrịa ndị ọzọ.
Ihe enyere n'iwu
Ọ dị mma ị useụ ọgwụ maka ọtụtụ nsogbu uche, ọkachasị:
- ụdị ịda mba dị iche iche, yana nsogbu ịrahụ ụra, ụjọ, ebe ọgwụ a na-enyocha enyocha dị ka usoro ọgwụgwọ kachasị;
- dị ka akụkụ nke usoro ọgwụgwọ siri ike, a na-enye ọgwụ mgbochi n'ọtụtụ ọnọdụ: omume, phobic, nsogbu mmetụta uche, ọnya bladder (na-egosipụta ya na ngosipụta n'abalị), anorexia, bulimia.
Ihe ngbanwe
Enwere ọtụtụ mgbochi na ojiji nke ọgwụ a:
- mmeghachi omume na-adịghị mma nke otu ọ bụla na mejupụtara (arụ ọrụ na arụ ọrụ);
- infarction myocardial, tinyere akụkọ banyere;
- nsị ethanol na-egbu egbu;
- ọnya ọnya ọnya na-esonye ya na mmụọ adịghị ya mma;
- nsị na ọgwụ (antidepressants, psychotropic ma ọ bụ hypnotics);
- arrhythmia;
- glaucoma akụkụ;
- mmebi nke intraventricular, n'okirikiri ụzọ ndụ;
- ọrịa mkpụrụ ndụ ihe nketa na-ejikọ aka na ụkọ lactase, enweghị ndidi nke lactose, ọrịa glucose-galactose malabsorption;
- ụbụrụ dị ukwuu na akwara nke prostate gland, nke na-eduga na mbelata nke lumen urera;
- ahụ mkpọnwụ mgbochi ime;
- ọkwa potassium na-ebelata;
- bradycardia.
Jiri nlezianya
Ikwu contraindications:
- ọbara mgbali elu;
- ọnọdụ ọnụnọ nke ọrịa na-esote mgbanwe na ihe mejupụtara na akụrụngwa nke ọbara;
- ụba intraocular mgbali na ọrịa ndị ọzọ nke akụkụ nke ọhụụ;
- usoro ogwu ọ bụla tinyere njide urinary;
- ogwe
- schizophrenia
- Akwụkwụ na-adọ
- Ọrịa ụbụrụ;
- mmebi nke gland thyroid (hypothyroidism).
Etu ị ga-ewere Amitriptyline Nycomed
A na-ahọrọ usoro ọgwụgwọ dịka ụdị ọrịa ahụ si dị. Buru n'uche afọ, ogo nke mmepe nke pathology, ọnụnọ nke ihe mgbochi na iji Amitriptyline Nycomed. Mbadamba ekwesighi ịta ata. Denye ọgwụ ike mgbe ị risịrị nri.
Usoro inyocha maka ndị okenye
Ọgwụgwọ kwesịrị ibido n ’ọgwụ nke 50-75 mg. Mgbe ahụ ọ na-abawanye, ma ọ bụrụ na ọ dị mkpa, site na 25-50 mg. A na-ewere ego a otu ugboro tupu alakpu ụra ma ọ bụ ekewa abụọ. Agbanyeghị, ịnweghị ike ịgabiga kwa ụbọchị nke 200 mg. Oge nkuzi - ọnwa 6.
Amitriptyline Nycomed usoro usoro ọgwụgwọ maka ụmụaka
Nyefee ya na enuresis: 25 mg otu oge ka ndị ọrịa sitere na 7 ruo afọ 12, karịa afọ 12 - 50 mg. Ọ bụ ihe amamihe dị na ya ịnwe ego tupu ị lakpuo ụra.
Na-a drugụ ọgwụ maka ọrịa shuga
Ọgwụ a na-a affectsụ na-emetụta mmetụta insulin gosipụtara, ọ nwekwara ike kpalite mgbanwe mgbanwe ịba ụba. Maka nke a, n'ọtụtụ oge, achọrọ ịmegharị dose. Egoro ọgwụ ahụ n’otu n’otu.
Ego ole ka ọ dị irè
Ngwá ọrụ ahụ na-eweta mmetụta n'ime izu ole na ole. Ọ na-amalite ịrụ ọrụ n'oge awa mbụ mgbe ịmalite ọgwụgwọ. Nsonaazụ rụpụtara na-anọ ụbọchị 1-2.
Otu esi akagbu Amitriptyline Nycomed n'ụzọ ziri ezi
Iji zere ọrịa ndọrọpụ, a na-atụ aro ka ọ jiri nwayọ belata dose ahụ.
Nsonaazụ
Ekwesịrị iburu n'uche na ọgwụ a na-ekwu okwu na-enye aka n'ọdịdị nke ọtụtụ mmeghachi omume na-adịghị mma.
Ọkpụkpụ afọ
Na ọgbụgbọ, akọrọ mucous akpụkpọ ahụ, mgbanwe na stool Ọdịdị (afọ ntachi). Site na nri diges, ihe mgbaàmà ndị a na-ebutekarị: erughị ala n’ọnụ, ọnya afọ, caries. Ọrịa na-apụtakarị, afọ ọsịsa, ọgbụgbọ, mbufe nke ire, ịba ọcha n'anya, jaundice, mgbochi afọ.
Ahụhụ Hematopoietic
Ọkpụkpụ ọkpụkpụ arụpụtarala arụ ọrụ, ọtụtụ ọnụọgụ ọrịa nke enwere mgbanwe n'ọdịdị na akụrụngwa nke ọbara.
Sistemụ akwara Central
Adịghị ike n'ozuzu, ura, ụjọ nke akaji, isi ọwụwa na ọgbụgba, ntị na-adịghị mma, okwu, ụtọ.
Site n'akụkụ nke metabolism
Gbanwee na agụụ: ịba ụba, ibelata. N’ihi nke a, oke ahụ na-abawanye ma ọ bụ belata.
Ahụhụ
Vasculitis, urticaria, nke ekpughere site na itching, ihe ngbu.
Mmetụta ikike ịchịkwa usoro
N'oge ọgwụgwọ, ị kwesịrị ịhapụ ịnya ụgbọ ala, n'ihi na ọgwụ ahụ na-enye aka na nsị nke sistem ahụ, na-emetụta akụkụ nke ọhụụ na ịnụ ihe, ma na-akpasu nsogbu uche.
Ntụziaka pụrụ iche
Usoro ọgwụgwọ amalite site na ịchịkwa ọbara mgbali.
Mgbe ị na-agbanwe ọnọdụ ahụ ya, o kwesịrị ilezi anya;
Ndị ọrịa karịrị afọ iri ise nwere ohere nke mmerụ ọkpụkpụ.
Oge ụfọdụ ọ nwere ike ịdị mkpa ijikwa ọnụọgụ ọbara.
Ihe igbu onwe ya na-adịgide ruo oge ahụ ihe mepere emepe na-enyere aka belata ihe mgbaàmà nke nsogbu uche.
N'ime ndị na-eto eto (ruo afọ 24), ihe ize ndụ nke igbu onwe ya na ọgwụgwọ ya na Amitriptyline Nycomed na-abawanye.
Tupu ịmalite ọrụ dị ukwuu, usoro eze, ịkwesịrị ịkwụsị ị .ụ ọgwụ ahụ.
Jiri n'oge ime na lactation
Edeghị ya.
Jiri na agadi
Ọ bụ ihe na-anabata iji ọgwụ na-emegide ọrịa, mana ekwesịrị ịkpachara anya. Ikwesiri ịmalite usoro ọgwụgwọ na 25-30 mg (otu ugboro n'ụbọchị). Dịkwuo ego nke ọgwụ 1 oge ọ bụla ụbọchị abụọ. Oke kachasị kwa ụbọchị bụ 100 mg.
Ngwa maka ọrụ ezughi oke ọrụ
N'ime ndị ọrịa nwere ọrịa nke akụkụ a, excretion nke metabolites na-arụ ọrụ nke Amitriptyline Nycomed si anụ ahụ na-adalata. Enweghị iwu mgbochi siri ike na ị takingụ ọgwụ ahụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Ahapụrụ ya iji nlezianya. Site na ọrụ umeji ezughi oke, a na-ebelata dose ahụ.
Dodoụbiga ya ókè
Iri ngafe nke amitriptyline nwere ike ibute mgbochi intraventricular. A na-emewanye mmetụta ndị ọzọ na-emetụta. Ọgwụ: a na-asa afọ iji belata ọgwụ ọjọọ ọgwụ, a na-enye ọgwụ sorbents, ma ọ bụrụ na ọ dị mkpa, a na-achịkwa cholinesterase inhibitors, a chọrọ nrụgide normalization, a na-ejikwa mmiri-electrolyte.
Mmekọrịta na ọgwụ ndị ọzọ
A na - akwalite mgbochi nke usoro ụjọ ahụ na nchikota ọgwụ a na - a narụ na ọgwụ mgbochi, ọgwụ mgbochi mkparịta ụka, hypnotics, anesthetics, narcotic analgesics.
Yana Amitriptyline, ejighi MAO inhibitors. Okwesighi ijiko ya na Adrenaline, Ephedrine, Dopamine, Noradrenaline, Phenylephedrine.
Mmanya ndakọrịta
Achịkọta mmanya na-egbu egbu na ọgwụ mgbochi ọrịa.
Analogs
A na-eji ọgwụ ọgwụ dị irè eme ihe kama nke Amitriptyline Nycomed:
- Anafranil;
- Melipramine;
- Ladisan;
- Doxepin na ndị ọzọ
Kedu ihe dị iche n’etiti Amitriptyline na Amitriptyline Nycomed
Ọgwụ a na akpọpụtara Nycomed n'aha adịghị eme n'ụdị osisa. Enwere ike ịzụta ya naanị na mbadamba. Amitriptyline dị n'ụdị dị iche iche: siri ike, mmiri (ntụtụ). Nkwadebe nke otu ndị a dị na otu ụdị ọnụahịa. Enwere ike iche na oke ihe eji eme ihe.
Ọnọdụ ezumike Amitriptyline Nycomed si n'ụlọ ahịa ọgwụ
Ogwu bu ogwu.
Enwere m ike ịzụta na ndenye ọgwụ
Ee e.
Ọnụahịa maka Amitriptyline Nycomed
Nkezi ọnụ bụ 60 rubles.
Ọnọdụ nchekwa maka ọgwụ
Needmụaka kwesịrị imechi ohere ngwaahịa a. Ọnọdụ nchekwa a tụrụ aro: + 15 ... + 25 ° С.
Bọchị mmebi
Ọgwụ ahụ na-ejigide akụrụngwa ya maka afọ 5 site na ụbọchị ewepụtara.
Emepụtara Amitriptyline Nycomed
Takeda Pharma A / S, Denmark.
Nyocha banyere Amitriptyline Nycomed
Ndị isi mgbaka
Chukhrov V.V., psyche, onye gbara afọ 49, Chelyabinsk
Ọgwụ ochie, analorọ ọhụụ apụtalarị na nke enwere mmetụta na-adịghị mma maka ọgwụgwọ.
Kochev V.O., Psychiatrist, 34 afọ, Stavropol
Ngwọta ọgwụ dị irè, na-ewepụkwa isi ọwụwa na psychosomatics. Nwere ike kpasuo oge igbu oge.
Ndị ọrịa
Larisa, 34 dị afọ, Barnaul
Ejiri m mbadamba 10 mg. Mmetụta ọgwụgwọ ahụ mechara izu atọ, nke dị ogologo. Mana, n’ikpeazụ, a kwụsịrị ịda mba.
Marina, dị afọ 41, Moscow
Were ọgwụ a. Naanị ogologo oge enweghị m ike ijigide. Na mbu, dọkịta ahụ dọrọ aka ná ntị na nsonaazụ dị mma na-apụta n'ime ọnwa mbụ mgbe mmalite nke usoro ahụ. Nke abuo, ogwugwo nsogbu nke ogwu a ekwenyeghi ọgwụgwọ ozo.
