Usoro ọgwụgwọ maka ọrịa shuga nke 2 gụnyere nlekọta nke ọgwụ hypoglycemic nke otu dị iche iche.
Ihe ndị a gụnyere usoro sulfonylurea.
Otu n'ime ndị nnọchite otu a bụ chlorpopamide.
Ihe omuma banyere ogwu
Chlorpropamide bụ ihe eji arụ ọrụ nke ihe arụ ọrụ nke usoro 1 nke ọtụtụ ụbọchị ana - akpọ sulfonylurea. Ndị otu ya na ọgwụ ọgwụ bụ hypoglycemic sịntetik elekọta mmadụ. Chlorpropamide adịghị mmiri mmiri, mana, n'ụzọ megidere, mmanya na-egbu mmiri.
N'adịghị ka ọgbọ ndị ọzọ sitere na usoro sulfonylurea, chlorpropamide na-eme obere oge. Iji nweta ọkwa kachasị mma nke glycemia, a na-eji ya na nnukwu doses.
A na-ekwupụta mmetụta nke ị theụ ọgwụ ahụ ka ukwuu ma e jiri ya tụnyere Glibenclamide na ndị nnọchi anya nke ọgbọ nke abụọ. Ọ na - arụpụta ma ọ bụrụ na ezughi oke homonụ (insulin) ezughi oke yana mbelata nke anụ ahụ na ya. Withgwọ chlorpropamide nwere mmetụta na ndị ọrịa nwere obere insipidus ọrịa shuga na / ma ọ bụ nwee ụdị shuga 2.
Chlorpropamide bu aha eji ama ogwu. Ọ na-etolite ntọala nke ọgwụ (bụ akụrụngwa nọ n'ọrụ). Dị na mbadamba nkume.
Omume ọgwụ
Ogwu nwere mmetụta hypoglycemic. Ihe ahụ na-ejikọ ya na ọwa potassium, na-akpali secretion nke insulin. N'ime anụ ahụ na ahụ gị na - enweta insulin, ọnụ ọgụgụ ndị na - anabata ndị homonụ na - abawanye.
Ọnụnọ insulin na-eweta insulin, ọkwa glucose na-ebelata. Ọ nwere ọrụ antidiuretic. N'ihi mmụba nke insulin, uru dị na-apụta.
Iwepụ glycemia abụghị ihe na-adabere na shuga ọbara. Chlorpropamide, dị ka sulfonylureas ndị ọzọ, nwere ihe ize ndụ nke hypoglycemia, mana ruo obere obere.
Mgbe ejikọtara ya na ndị nnọchianya hypoglycemic ndị ọzọ (biguanides, thiazolidinediones, lee mmekọrịta na ọgwụ ndị ọzọ), a na-ebelata usoro nke azụ ahụ ntakịrị.
Usoro nke usoro nke usoro sulfonylurea
Mlọ ọgwụ
Mgbe ọ batara na diges, tract chlorpropamide na-agbaso nke ọma. Mgbe otu elekere gachara, ihe ahụ dị n’ọbara, ya bụ itinye uche ya kacha ogologo - mgbe awa 2-4 gachara. Njikọ protin plasma> 90%.
Ọgwụ a na-eme ụbọchị dum iji bụrụ otu mkpụrụ. Iwepu ọkara ndụ bụ ihe dịka awa iri atọ na isii. A na - abụkarị ya na mmamịrị (ihe ruru 90%).
Ihe ngosi na contraindications
Ihe ngosi ndi eji eme ihe bu oria a na-adighi agha n’onodu insulin, yana oria shuga insipidus. Edere Chlorpropamide n'ọnọdụ ebe ọgwụgwọ nri, mmega ọgwụgwọ adịghị eweta nsonaazụ kwesịrị ekwesị na ntụzi nke ndị na-egosi.
N'etiti ihe mgbochi iji ọgwụ a gụnyere:
- hypersensitivity na chlorpropamide;
- Ọrịa shuga ;dị 1;
- hypersensitivity na sulfonylureas ndị ọzọ;
- metabolism na echiche megide kwupụta acidosis;
- ndu ọria;
- ketoacidosis;
- imeju na akụrụ;
- nnukwu ọrịa na-efe efe;
- afọ ime / lactation;
- nna nna na coma;
- afọ ụmụaka;
- ọdịda nke chlorpropamide ugboro ugboro;
- Ọnọdụ mgbe anụ ahụ gasịrị.
Usoro onunu ogwu na nhazi
Ọ bụ dọkịta dobere dose ahụ dabere na ọrịa shuga na enyemaka nke glycemia. Mgbe ị nweta ụgwọ nkwụsi ike na onye ọrịa, enwere ike belata ya. Dịka iwu, yana ọrịa shuga nke 2, ụkpụrụ kwa ụbọchị bụ 250-500 mg. Na arịa ọrịa shuga insipidus - 125 mg kwa ụbọchị. Mgbe ebugharị ya na ọgwụ ọgwụ ndị ọzọ, ọ ga-achọ ndozi usoro onunu ogwu.
Ntụziaka maka ojiji nke chlorpropamide na-egosi iji ọgwụ ahụ ọkara elekere tupu nri. Ọ dị mkpa iri ya otu mgbe. Ọ bụrụ na usoro onunu ogwu ahụ nyere ihe erughị mbadamba 2, mgbe ahụ, nnabata ga-ewere ọnọdụ n'ụtụtụ.
Vidio si n’aka ọkachamara banyere ọrịa shuga na otu esi agwọ ya:
Mmetụta akụkụ na ị andụbiga mmanya ókè
Nsonaazụ ndị na-esote nwere ike ime n'oge nlekọta chlorpropamide:
- ọgbụgbọ, ọgbụgbọ, ọnya afọ, oche na-ewe iwe;
- hypoglycemia;
- hyponatremia;
- ụtọ dị n’ọnụ ahụ, enweghị agụụ;
- enweghi ike ịhụ anya;
- rashes akpụkpọ nke ọdịdị dị iche;
- hemolytic anaemia;
- mmụba n'ihe ngosipụta imeju;
- thrombo-, leuko-, erythro-, granulocytopenia;
- isi ọwụwa na ọgbụgbọ;
- mbelata mgbali mgbali;
- adịghị ike, enweghị mmasị, iro ụra, nchegbu;
- jalestice cholestatic;
- njigide mmiri n’ime ahụ;
- nsogbu anaphylactic.
Site na ogo hypoglycemia dị nro / obere, onye ọrịa na-ewere gram 20-30 nke glucose. N’ọdị n’ihu, a na-emezi usoro onunu ogwu ya ka emegharia ihe oriri ya.
N'ọnọdụ ndị siri ike, nke na-esonye na coma na ahụchi, glucose na-aga n'ọbara. Ọzọkwa, enwere ike inye glucagon intravenly ma ọ bụ intramuscularly. Mgbe ịkwụsị hypoglycemia n'ime ụbọchị abụọ, a na-enyocha akara site na iji glucometer.
Njirimara ngwa
Tupu ịmalite ịtụrụ ime, ịhapụ ịhapụ chlorpropamide. A na-atụle njikwa ụdị shuga nke 2 na insulin na ọgwụ kachasị mma. N'oge a na-enye nwa ara, ha na-agbaso otu iwu.
A na-agagharị na ọgwụ ahụ site na ọkara mbadamba kwa ụbọchị, mgbe ahụ ka edepụtara ya maka mbadamba mbụ. Ndị ọrịa nwere nsogbu akụrụngwa ezigharị / yana ịwa ahụ ga-achọ nrụzigharị dose. Mgbe ị na-edepụta ọgwụ ole ọ drugụrụ ọgwụ ọhụụ, ndị okenye ka a ga-atụle.
Mgbe ị na-akwụ ụgwọ maka ọrịa ahụ, achọrọ mbelata usoro onunu ogwu. A na-arụzigharị mgbanwe na nha ahụ, ibu, na -aga mpaghara oge ọzọ.
N'ihi enweghi ihe omuma banyere nchekwa nke iji, adighi enye ogwu ogwu nye umuaka. N'ihe banyere mmerụ ahụ, tupu arụ ọrụ / mgbe ọ gasịrị, n'oge ọrịa na-efe efe, a na-ebuga onye ọrịa ahụ insulin nwa oge.
Ejila Bozetan mee ihe. Enwere ihe akaebe na o metụtara ndị ọrịa anata chlorpropamide. Ha kwuru na mmụba na ntụgharị hepatic (enzymes). Dabere na Njirimara nke ọgwụ abụọ ahụ, usoro nke excretion nke bile acid sitere na sel na-ebelata. Nke a gụnyere nchịkọta ha, nke na-eduga n'ịba nsị na-egbu egbu.
Mmekọrịta na ọgwụ ndị ọzọ
Biguanide Metformin
N'iji oge chlorpropamide na ọgwụ ndị ọzọ, nsonaazụ ya nwere ike ibelata ma ọ bụ mụbaa. Ndụmọdụ nke mmanye tupu ị medicinesụ ọgwụ ndị ọzọ.
Ịba ọgwụ edinam na-adị mgbe coadministered na insulin, ọzọ hypoglycemic ọgwụ ọjọọ, biguanides, coumarin nkwekọrịta, phenylbutazone, ọgwụ ọjọọ tetracycline, Mao inhibitors, fibrates, salicylates, miconazole, streroidami, nwoke homonụ, cytostatics, sulfonamides, quinolone nkwekọrịta, clofibrate, sulfinpyrazone.
Ọgwụ ndị na-esonụ na-ebelata mmetụta nke chlorpropamide: barbiturates, diuretics, adrenostimulants, estrogens, tableted contraves, nnukwu nicotinic acid, diazoxide, homonụ thyroid, phenytoin, glucocorticosteroids, sympathomimetics, phenothiazineerieri, Acetazolam.
Chlorpropamide bụ ihe nnọchianya hypoglycemic nke na-ezo aka na 1st ọgbọ sulfonylurea sitere. E jiri ya tụnyere ndị na-eso ụzọ ya, ọ na-enwe obere mbelata yana ewetara nsonaazụ ndị ọzọ akpọpụtara. Ugbu a, a naghị eji ọgwụ ahụ eme ihe.
