Ntụziaka ọgwụ ọgwụ Amaril maka iji mee ihe na-enye ntule dị ka ọgwụ nke ọgbọ ọhụrụ nke ọgwụ iji lụsịa ọrịa shuga nke 2. Otu n'ime nkwa kachasị taa bụ Glibenclamide-HB-419 sitere na otu ụdị sulfonylurea. Ihe karịrị ọkara ndị ọrịa shuga na ụdị nke abụọ ahụtawo ya.
Njirimara ọgwụ ọgwụ
Amaryl bụ ọgwụ hypoglycemic nke na-enyere aka ịchịkwa shuga plasma. Ngwakọta dị nro nke ọgwụ ahụ bụ glimepiride. Dị ka onye buuru ya ụzọ, Glibenclamide, Amaril sitere na otu sulfonylurea, nke na-eme ka njikọ nke insulin si na sel nke pant ndị dị na Langerhans.
Iji mezuo nsonaazụ ahụ ebumnuche, ha na-eji ikike nghọta dị omimi na-egbochi oghere potassium nke ATP. Mgbe sulfonylurea na-ejikọ ndị na-anabata ihe dị na membran-b, mkpụrụ ndụ na-agbanwe usoro K-AT. Block igbochi ọwa kalselị na mmụba na ATP / ADP na cytoplasm na-akpalite membrane depolarization. Nke a na - eme ka ntọhapụ nke ụzọ calcium ma mee ka ntinye nke calcium cytosolic dịkwuo elu.
Nsonaazụ nke nnweta ụdị exocytosis nke nsogbu dị na nzuzo, nke bụ usoro itinye aka na ngwakọta n'ime sel, yana ọ ga-abụ nnwepụta insulin n'ime ọbara.
Glimepiride bụ onye nnọchi anya ọgbọ nke atọ nke sulfonylureas. Ọ na-akpali ntọhapụ nke homonụ nke palọ na ngwa ngwa, ma na - akwalite insulin nke protein na mkpụrụ ndụ nwere ume.
Ọkpụkpụ akwara na-eme ka glucose na-eji ike nke ukwuu site na ibufere protein site na membranes. Site n'ụdị ọrịa shuga na-enweghị insulin, a na-eji nwayọ nwayọ were were nwayọọ nwayọọ were n’arụ shuga n’arụ. Glimepiride na-akwalite mmụba nke protein protein na-ebugharị ma na-eme ka ọrụ ha dịkwuo elu. Pancdị mmetụta puru iche a na-enye aka belata insulin iguzogide (insensitivity) na homonụ.
Amaryl na-egbochi mkpokọ glucogen site na imeju n'ihi mmụba nke fructose-2,6-bisphosphate na antiaggregant (mgbochi nke usoro thrombus), antiatherogenic (ibelata akara nke cholesterol "ọjọọ") yana antioxidant (regenerative, mgbochi ịka nká). A na-eji nwayọ nwayọ nwayọ n'ihi mmụba nke ọdịnaya b-tocopherol na ọrụ nke enzymes antioxidant.
Pharmacokinetics nke ọgwụ
N'ime ihe mejupụtara Amaril, ihe kacha arụ ọrụ bụ glimepiride sitere na otu ụdị sulfonylurea. A na-eji Povidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose na dyes E172, E132 dị ka ihe nzacha.
Amaryl na - ebido enzymes imeju 100%, yabụ, iji ọgwụ a agbagote oge anaghị eyi egwu ị nweta oke ya na akụkụ ahụ. N'ihi nhazi, etolite ihe abụọ nke glipemiride: hydroxymetabolite na carboxymethabolite. E nyere metabolite izizi ya na akụrụngwa ọgwụ na-enye nsonaazụ hypoglycemic kwụsiri ike.
N'ime ọbara, a na-ahụkarị ọdịnaya kachasị arụ ọrụ mgbe elekere abụọ na ọkara gachara. N'inwe ọgwụ nje zuru oke, ọgwụ ahụ anaghị amachi ndị ọrịa mamịrị ịhọrọ nri nri nke ọ “ji” ọgwụ ahụ. Mkpuchi ikike ahụ ga-abụ 100%.
A na-ahụta mmelite dị mkpa na ntụgharị glycemic ọbụna na nsogbu nsogbu nke imeju, ọkachasị, na okenye (karịa afọ 65) yana ọrịa imeju, mkpocha akụkụ nke arụ ọrụ bụ ihe nkịtị.
Etu esi eji Amaryl
A na-emepụta ọgwụ n'ụdị mbadamba osisi oval nke nwere oghere nkewa, nke ga-enye gị ohere kewaa dose ahụ na ọkara. Agba nke mbadamba nkume ahụ na-adabere na usoro onodu ogwu: 1 mg nke glimepiride - shei pink, 2 mg - greenish, 3 mg - odo.
A họrọghị ihe osise a site na ohere: ọ bụrụ na enwere ike iji akara mara mbadamba mbadamba ụrọ, nke a na-ebelata ihe ize ndụ nke ịdoụbiga ihe ọghọm mberede, ọkachasị ndị ọrịa agadi
Mbadamba ụrọ na-etinye na blisters nke 15 PC. Igbe ọ bụla nwere ike ịnwe ụdị 2 ruo 6 dị ka epekele ndị a.
Njirimara nke iji Amaril:
- Erere mbadamba nkume (ma ọ bụ akụkụ ya) kpamkpam, jiri mmiri sachaa ya ọbụlagodi 150 ml. Ozugbo ị medicationụsịrị ọgwụ, ịkwesịrị iri nri.
- Endocrinologist na-ahọrọ usoro ọgwụgwọ dabere na nsonaazụ nyocha nke mmiri ọmụmụ.
- Jiri usoro obere Amaril malite. Ọ bụrụ na oke nke 1 mg mgbe oge ụfọdụ egosighi nsonaazụ ahụ ezubere, ọnụego a na-abawanye.
- A na-agbanwe ọgwụ ahụ nwayọ nwayọ, n'ime izu 1-2, nke mere na ahụ nwere oge iji kwado ọnọdụ ọhụụ. Kwa ụbọchị, ị nwere ike iwelie ọnụego ihe na-erughị 1 mg. Ogo ọgwụ kachasị bụ 6 mg / ụbọchị. Ọ bụ dọkịta na-ekpebi oke onwe ya.
- Ọ dị mkpa iji dozie ịdị mkpa nke mgbanwe ọrịa shuga ma ọ bụ olu nke ibu, yana ihe ize ndụ nke hypoglycemia (na agụụ, erighị nri, ị alcoholụbiga mmanya ókè, nsogbu akụrụ na nsogbu imeju).
- Oge eji ya na oge onodu ogwu ya ga-agbadata na ndu nke ndu na njiri mara nke metabolism. Ọtụtụ mgbe, a na-edebere otu Amaril ozi otu ụbọchị yana ihe mmado na nri. Ọ bụrụ na nri ụtụtụ zuru oke, ị nwere ike drinkụọ ọgwụ ọgwụ n'ụtụtụ, ma ọ bụrụ n'ụzọ ihe atụ - ọ ka mma ijikọ oriri na nri ehihie.
- Do overụbiga ihe ókè na-eyi ọbara hypoglycemia ume, mgbe glucose dị na lymph na-agbadata na 3.5 mol / L ma ọ bụ belata. Ọnọdụ ahụ nwere ike ịdị ogologo oge: site na awa 12 ruo ụbọchị 3.
Mmanụ mbadamba amaryl (na ngwugwu 30 iberibe) dị maka orire na ọnụahịa:
- 260 nkp - 1 mg nke ọ bụla;
- 500 ite - 2 mg nke ọ bụla;
- 770 nkp. - 3 mg nke ọ bụla;
- 1020 rub. - 4 mg nke ọ bụla.
Inwere ike ichota mbadamba 60, 90,120.
Ọgwụ ndị ọzọ
Ndị ọrịa mamịrị, ọkachasị “nwere ahụmịhe”, dịka iwu, nwere ọtụtụ ọghọm ndị metụtara nkụda mmụọ: ọbara mgbali, obi na nsogbu akwara, ọgba aghara metabolic, akụrụ na ọrịa imeju. Jiri ngwa a, ị ga-ewere ọ bụghị naanị ọgwụ belata shuga.
Maka mgbochi nke abn na-arịa ọbara na obi, a na-enye ọgwụ ọgwụ aspirin. Amaryl na - ewepu ya site na protein protein, mana ọkwa ya na ọbara ka na - agbanweghi. Mmetụta zuru ezu nke iji ihe mgbagwoju anya nwere ike ịka mma.
Enwekwukwa ọrụ AMARE ya adianade insulin, Allopurinu, coumarin nkwekọrịta, anabolic Steroid, guanethidine, chloramphenicol, fluoxetine, fenfluramine, pentoxifylline, Feniramidolu, fibric acid nkwekọrịta, phenylbutazone, miconazole, azapropazone, probenecid, quinolones, oxyphenbutazone, salicylates, tetracycline, sulfinpyrazone, Tritocqualin na sulfonamides.
Amaril na-ebelata ikike ịgbakwunye Epinephrine, glucocorticosteroids Diazoxide, laxatives, Glucagon, barbiturates, Acetazolamide, saluretics, thiazide diuretics, nicotinic acid, Phenytoin, Phenothiazine, Rifampicin, Chlorpromazine, na protsinin, na nnu.
Amaryl gbakwunyere na-egbochi ihe mgbochi H2 receptor, reserpine na clonidine na-enye nsonaazụ a na-atụghị anya ya na nsị nke glucometer n'ụzọ ọ bụla. Otu nsonaazụ yiri nke ahụ na-enye mmanya na Amaril.
Ọgwụ a anaghị emetụta ọrụ nke ndị na - egbochi ACE (Ramipril) na ndị na - anticoagulant (Warfarin) n'ụzọ ọ bụla.
Hypoglycemic Ndakọrịta
Ọ bụrụ na a ga-eji ọgwụ ọgwụ hypoglycemic ọ bụla dochie ya na Amaril, usoro ọgwụ dị ntakịrị (1 mg) ka edepụtara, ọbụlagodi ọnọdụ onye ọrịa ahụ natara ọgwụ gara aga na oke kachasị. Nke mbu, a na-enyocha mmeghachi omume nke anụ ahụ na-arịa ọrịa shuga izu abụọ, emesia dozie usoro ahụ.
Ọ bụrụ na ejiri onye na-ahụ maka ọgwụ mgbochi nwere ogologo ọkara tupu Amaril zere mmepe nke hypoglycemia, ekwesịrị ịkwụsịtụ ruo ọtụtụ ụbọchị mgbe akagbuo.
Ọ bụrụ na ọrịa mamịrị jisiri ike nwee ike nke pancreas imepụta homonụ nke ya, mgbe ahụ injections insulin nwere ike dochie 100% Amaryl. Usoro ahụ amalitekwara na 1 mg / ụbọchị.
Mgbe usoro ịkwụ ụgwọ shuga Metformin ọdịnala anaghị anabata nchịkwa shuga zuru ezu, enwere ike ịgbakwunye 1 mg nke Amaril. Ọ bụrụ na nsonaazụ anaghị enye afọ ojuju, a na-eji nwayọ nwayọ gbanwee 6 mg / ụbọchị.
Ọ bụrụ na atụmatụ Amaril + Metformin emezughi ihe a tụrụ anya ya, insulin na-edochi ya, ma na-edobe usoro iwu Amaril. In insulin inje na-amalite site na obere usoro onunu ogwu. Ọ bụrụ na ndị na - egosi glucometer anaghị agba ume, mụbaa insulin. Ibe ọgwụ ọzọ ka dị mma, ebe ọ na - enye gị ohere iji 40% belata oriri homonụ ma e jiri ya gwọọ ọrịa homonụ dị ọcha.
Na mgbakwunye na Amaril, endocrinologist nwekwara nhọrọ maka analogues: Amaperid, Glemaz, Diapyrid, Diameprid, Glimepiride, Diagliside, Reclide, Amix, Glibamide, Gllepid, Glayri, Panmicron, Glibenclamide, Gligenclad, Glliblik Dimari, Dimari, Dimari, Dimari, Dimari Glimaril, Glyclazide, Manil, Maninil, Glimed, Glioral, Olior, Glynez, Glyrid, Gluktam, Glypomar, Glyrenorm, Diabeton, Diabresid.
Maka onye ebum n’obi ya, onye ka akwadoro ogwu ya
Emepụtara ọgwụ ahụ maka ịgwọ ụdị ọrịa shuga 2. A na-eji ya na monotherapy yana yana usoro ọgwụgwọ siri ike na Metformin ma ọ bụ Insulin.
Akụkụ dị ike nke Amaril na-emerụ ihe mgbochi nke Plasenta, ọgwụ a na-abanyekwa na mmiri ara. Maka nke a, odobeghi maka nne di ime na ndi na-enye nwa ara. Ọ bụrụ na nwanyị chọrọ ịbụ nne, tupu ime ịtụrụ ime nwatakịrị, a ga-agbarịrị ya na ọgwụ ịgba ọgwụ insulin n'enweghị Amaril. Maka oge nri, a na-echekwa ọkwa ndị ahụ, ọ bụrụ n ’ịchọrọ ọfụma na Amaril, a na-akwụsị ịfeụ ara.
Anaghị anabata iji ọgwụ ahụ eme ihe na akpịrị ọrịa shuga na ọnọdụ ebute coma ahụ. Na nsogbu siri ike nke ọrịa shuga (dịka ketoacidosis), agbakwunyeghị Amaryl. Ọgwụ a adịghịkwa mma maka ndị ọrịa mamịrị nwere ụdị ọrịa mbụ.
Site na nsogbu nke akụrụ na umeji arụ ọrụ, Amaril abaghị uru, a kọwapụtaghị Amaril maka ọrịa hemodialysis na ndị ọrịa mamịrị, yana maka nnabata onye ọ bụla na glipemiride ma ọ bụ ọgwụ ndị ọzọ nke klaasị sulfonamide na sulfonylurea.
Site na paresis eriri afọ ma ọ bụ mgbochi afọ, mmịnye ọgwụ na-akpaghasị ya, yabụ Amaril edepụtaghị nsogbu ndị ahụ n'oge nsogbu. Ha na-achọ ịgbanwe insulin na ọtụtụ mmerụ ahụ, ịwa ahụ, ọrịa ọkụ, oke ọkụ.
Amaril nwere ike ibute mmeghachi omume hypoglycemic. Mgbe ụfọdụ ndị ọrịa na-eme mkpesa na anya mmiri, ụfọdụ na-akawanye mma maka ụra, enwere ahụ ịma jijiji, ọsụsọ gabigara ókè, na ọgba aghara okwu. Na ọrịa shuga, a na-enwekarị oge agụụ na-achịkwaghị achịkwa, ọgba aghara dyspeptik, ahụ erughị ala na mpaghara imeju. Enwere ike ịrụ ọrụ nke ụda obi, ihe ọkụ n’ahụ. Ọbara ọbara na-aka njọ mgbe ụfọdụ.
Nsonaazụ ịdoụbiga mmanya ókè
Longụ ọgwụ ogologo oge, yana ịdoụbiga ọgwụ ike ókè, nwere ike ịkpasu hypoglycemia, ihe mgbaàmà nke akọwapụtara na ngalaba gara aga.
Onye na-arịa ọrịa shuga kwesịrị inwe ndumodu ntụziaka ya na nkọwa dị mkpirikpi banyere ọrịa ya na ihe sitere na ngwa ngwa carbohydrates (swiiti, kuki). Ihe ọ juiceụ orụ ma ọ bụ tii dị ụtọ dịkwa mma, ọ bụ naanị na-enweghị ụtọ ọ bụla. N'ọnọdụ siri ike, a ga-emerịrị onye ọrịa ahụ ngwa ngwa n'ụlọ ọgwụ maka lavage gastric na nchịkwa nke ihe ndị na-anabata ihe (carbon na-arụ ọrụ, wdg).
Nsonaazụ
N'ọnọdụ ndị a na-adịghị ahụkebe, ojiji nke Amaril na-esokwa nsonaazụ n'akụkụ n'ụdị ọnwụ nke ọhụụ, nsogbu na sistemụ mgbasa, nsogbu nke metabolic, nsogbu nke eriri afọ.
Otu n'ime ihe ndị kasị ewu ewu:
- Ọrịa glycemic syndrome, nke mfu nke ike, ịda mba na mkpụkọ, ọdịda ọhụhụ, arrhythmia, agụụ na-achịkwaghị achịkwa, ịsụsọ oke.
- Ọdịiche dị iche iche na egosipụta shuga, na-eme ka ahụhụ anya.
- Ọrịa dyspeptik, imebi nke ure nke discation, na-apụ n'anya mgbe ewepụrụ ọgwụ ahụ.
- Alịlarị nrụrụ aka dị iche iche (ọnya ọnya, itching, hives, vasculitis nfụkasị, ujo anafilactic, ọbara mgbali ala na mkpụmkpụ ume).
Amarnwere Amaril n'ụzọ dị njọ na-emetụta ọsọ nke psychomotor mmeghachi omume - ịnya ụgbọ ala, yana ọrụ chọrọ nlebara anya, ọkachasị na usoro ọgwụgwọ mbụ, enweghị nkwekọ na usoro ọgwụgwọ Amaril.
Echiche ndị dọkịta na ndị ọrịa mamịrị gbasara Amaril
Nyocha nke endocrinologists ndị na-ezute kwa ụbọchị ngosipụta niile nke ọrịa jọgburu onwe ya bụ ebumnuche kachasị, n'ihi na ha nwere ohere ịmụ banyere mmeghachi omume nke ndị ọrịa na ọgwụ iji nweta nkwubi okwu banyere ịdị irè ya.
Dabere na ndị dọkịta, na usoro usoro ọgwụgwọ ahaziri nke ọma, Amaril na-enyere aka mezie atụmatụ glycemic ngwa ngwa. Ndị ọrịa mamịrị na-a theụ ọgwụ ahụ nwere mkpesa nke hypoglycemia mgbe ahọpụtaghị usoro ịsụ ya. Ma, banyere ọgwụ Amaril, nyocha ndị ọrịa nwere nchekwube.
Ihe oriri dị obere, nri anụ ahụ dosed, njikwa ibu nwere nnukwu mmetụta na ọgwụgwọ Amaril. Onye ọrịa mamịrị kwesịrị ịgwa endocrinologist n'oge oge banyere nsonaazụ ndị ọzọ, mgbaàmà nke hypo- na hyperglycemia nke na-amalite na Amaril.
Ọgwụgwọ gụnyekwara inyocha onwe onye mgbe niile n’ihe na-egosi shuga na ileba anya n’ọrụ nke imeju, nnwale ụlọ nyocha, ọkachasị nnwale maka ọbara ọgbụgba, nke a na-ahụta ugbua dịka ebumnuche kachasị maka ịtụle ọnọdụ onye ọrịa nwere ọrịa shuga. Nke a ga - enyere aka ịchọpụta ogo nguzogide Amaril maka idozi usoro ọgwụgwọ.
Nwere ike ịmụ maka atụmatụ ndị ọzọ nke Amaril site na vidiyo ahụ.
