Llọ ọgwụ Glimepiride (INN) nke ụlọ ọrụ na-ahụ maka ọgwụ na-ere ọgwụ Pharmstandard na-ebelata ọkwa glycemia nke ọma na ndị ọrịa nwere nchọpụta ụdị shuga mellitus 2.
Karịsịa, onye na-ahụ maka ọgwụ antidiedi na-enyere aka na enweghi ike usoro ọgwụgwọ nri, mmega ahụ na oke ibu. Dịka ọgwụ ọ bụla, glimepiride nwere ụfọdụ njikwa ọgwụ nke ma dọkịta na onye ọrịa ahụ kwesịrị ịma gbasara ya.
Aha Latin nke ngwaọrụ a bụ Glimepiride. Akụkụ bụ isi nke ọgwụ ahụ bụ otu ụdị sulfonylureas. Onye mepụtara tinyekwara obere ego nke ihe ndị ọzọ na ngwaahịa ahụ: shuga mmiri ara ehi (lactose), microcrystalline cellulose, sodium lauryl sulfate, stgelatinized starch, magnesium stearate na ụfọdụ ntutu.
Onye na-ahụ maka ọgwụ na-emepụta ọgwụ antidiabet n'ụdị mbadamba (1 mbadamba ihe nwere 1, 2, 3 ma ọ bụ 4 mg nke glimepiride).
A na-a oụ ọgwụ ahụ ọnụ, were obere mmiri washedacha ya. Mgbe ịbanyesịrị n'ahụ mmadụ, a na-eru ihe kachasị elu nke ihe arụ ọrụ n'ime ihe ruru awa 2.5. Iri nri adịghị emetụta nnabata nke glimepiride.
A na-egosipụta ihe ndị bụ isi nke akụrụngwa nọ n'ọrụ dị ka ndị a:
- Na-akwalite mmepụta nke hormone na-ebelata shuga sitere na mkpụrụ ndụ beta nke agwaetiti Langerhans.
- Nzaghachi dị mma nke sel mkpụrụ ndụ na - akpali akpali nke glucose. Okwesiri iburu n'uche na ego insulin mepụtara abaghi uru karia n’okpuru ikike nke ogwu ogwu - okike ndi ozo.
- Inhibido glucose na-egbochi site na umeji na -ebelata mmịkọta nke homonụ na-ebelata mmiri site na imeju.
- Mmụba dị elu nke mkpụrụ ndụ ndị chọrọ ịlụ ọgụ na uru akwara nke insulin.
- Glimeperid na-abawanye ọdịnaya nke alfa-tocopherol, ọrụ nke glutathione peroxidase, catalase, na superoxide dismutase. Nke a na - eduga n'ịbelata mmepe nke nrụgide oxidative, nke na - arịa ọrịa shuga 2 dị mgbe niile.
- Ihe mgbochi nke cyclooxygenase, yana mbelata nke ntụgharị nke thromboxane A2 site na arachidonic acid. Usoro a nwere mmetụta antithrombotic.
- Normalization nke lipid na mbelata nke ịba malondialdehyde na plasma ọbara. Usoro abụọ a na-eduga na ọgwụ mgbochi atherogenic nke ọgwụ.
Otu ụzọ n'ụzọ atọ nke metabolites nke glimepiride bụ eriri afọ na-ewepụta ụzọ abụọ n'ụzọ atọ - site na akụrụ ya.
N'ime ndị ọrịa na-arịa ọrịa akụrụ, nhichapụ nke glimepiride na-abawanye ma ntinye uche nke ụkpụrụ ya na ọbara ọbara na-ebelata.
Ntuziaka maka mbadamba mbadamba
Ndenye ọgwụ n’aka ọkachamara na-agwọ ọrịa bụ isi ọnọdụ ị nwere ike ịzụta ọgwụ Glimepiride. Mgbe ị na-azụ ọgwụ, ọ bụ omenala ị attentiona ntị na nkọwapụta akọwapụtara na ntuziaka ejikọtara.
Ọ bụ ọgwụ endocrinologist kpebie usoro ị drugụ ọgwụ ahụ na oge ọgwụgwọ ya, dabere na ogo ịba ọcha n'anya nke onye ọrịa yana ọnọdụ ahụike ya dum. Mgbe ị na-a Gụ Glimepiride, ntuziaka maka iji ya nwere ozi na ọ dị mkpa ị toụ 1 mg otu ugboro n'ụbọchị. Site na imezu ọgwụ kachasị mma, a nwere ike iwere usoro a iji kwado ọkwa shuga nkịtị.
Ọ bụrụ na usoro ọgwụgwọ dị ala (1 mg) adịghị arụ ọrụ, ndị dọkịta jiri nwayọọ nwayọọ depụta 2 mg, 3 mg ma ọ bụ 4 mg nke ọgwụ kwa ụbọchị. N'ọnọdụ ndị a na-adịghị ahụkebe, ị canụ ọgwụ nwere ike ịba ụba 3 mg ugboro abụọ n'ụbọchị n'okpuru nlekọta dọkịta siri ike.
Mbadamba ga-a zuru kpamkpam, ọ bụghị ata ma jiri mmiri mmiri sachaa ya. Ọ bụrụ n’ikpefere ịpụ ọgwụ ahụ, ịnweghị ike okpukpu abụọ nke usoro onunu ogwu.
Btinye glimepiride na insulin, ọ̀gaghị ọgwụ a na-ekwu okwu adịghị mkpa ịgbanwe. Ejiri ọgwụ insulin na-eji obere elekere, jiri nwayọ na-abawanye ya. Combined jikọtara ọnụ ọgwụ abụọ chọrọ nlebara anya pụrụ iche n’aka dọkịta.
Mgbe ị na-agbanwe usoro ọgwụgwọ ọgwụgwọ, dịka ọmụmaatụ, n'ihi mgbanwe site na onye ọzọ na-ahụ maka ọgwụ antidiabet na glimepiride, ha na-amalite site na nke kacha nta (1 mg).
Ọnọdụ nke mgbanwe site na ọgwụ insulin gaa Glimepiride ga-ekwe omume, mgbe onye ọrịa ahụ na-ejigide ọrụ nzuzo nke mkpụrụ ndụ beta pancreatic na ụdị ọrịa shuga 2. N'okpuru nlekọta nke dọkịta, ndị ọrịa na-ewere 1 mg ọgwụ ahụ otu ugboro n'ụbọchị.
Mgbe ị na-azụta ọgwụ na-egbu egbu, ị kwesịrị ị paya ntị na ụbọchị mmebi ya. Maka glimepiride, ọ bụ afọ 2.
Contraindications na mmeghachi omume ọjọọ
Dịka ọgwụ ọ bụla ọzọ, ọgwụ Glimepiride contraindications na mmetụta ọjọọ nwere ike ịbụ ihe kpatara amachibido iji ya maka ụfọdụ ndị ọrịa.
Ebe ọ bụ na ngwakọta nke mbadamba ahụ nwere ihe ndị na-akpata mmeghachi omume nfụkasị, otu n'ime ihe ndị bụ isi contraindications nke ọgwụ hypoglycemic a bụ hypersensitivity nke mmiri ndị dị otú ahụ.
Na mgbakwunye, nnabata nke ego amachibidoro mgbe:
- ọrịa mamịrị ketoacidosis;
- ọrịa shuga na-akpata insulin;
- akpịrị na-arịa ọrịa shuga, precoma;
- akụrụ ma ọ bụ nsị imeju;
- buru nwata;
- inye ara.
Ndị mmepe nke ọgwụ a emeela ọtụtụ ọmụmụ ọgwụ na ụlọ ahịa na-azụ ahịa. N’ihi nke a, ha jisiri ike depụta nsonaazụ nke nsonaazụ, nke gụnyere:
- Mmeghachi omume nke anụ ahụ (itching, ihe ọkụ ọkụ, urticaria).
- Ọrịa mgbu afọ (afọ ọsịsa, vomiting, ọgbụgbọ, mgbu afọ).
- Ọrụ imeju na-arụ ọrụ (ịba ọcha n'anya, ịba ụba enzymes imeju, jaundice, ọdịda imeju na cholestasis).
- Ndalata ogo shuga (hypoglycemia).
- Mmeghachi omume hypersensitivity (ọbara mgbali ala, mkpụmkpụ ume, ujo).
- Mbelata mkpokọta sodium n'ime ọbara.
- Nta anya acho achoghi oria (na - aputa ihe na izu izizi nke oria).
- Ọgba aghara nke usoro hematopoietic (mmepe nke agranulocytosis, leukopenia, hemolytic anaemia na ọrịa shuga mellitus, thrombocytopenia, pancytopenia).
N'ihe banyere ịdoụbiga mmanya ókè, hypoglycemia na-adị, na-adịgide site na awa 12 ruo 72. N'ihi ị aụ ọgwụ dị ukwuu, onye ọrịa ahụ nwere mgbaàmà ndị a:
- mgbu n'akụkụ aka nri;
- ọgbụgbọ na ọgbụgbọ;
- mkpali;
- nkwonkwo akwara nke imebi aru;
- ịmụba ụra;
- ihe ntachi obi na enweghị nhazi;
- mmepe coma.
Ihe mgbaàmà ndị dị n'elu n'ọtụtụ ọnọdụ na-akpata site na nnabata nke ọgwụ na usoro nri. Dịka ọgwụgwọ, ọ dị mkpa ịsa ahụ ma ọ bụ vomiting. Iji mee nke a, were carbon na-arụ ọrụ ma ọ bụ adsorbents ndị ọzọ, yana ọgwụ. Enwere ike ịnwe ikpe ụlọ ọgwụ nke onye ọrịa na glucose ọbara.
Mmekọrịta na ọgwụ ndị ọzọ
Maka ọtụtụ ndị na-arịa ọrịa shuga, ajụjụ na-ebilite ma a ga-ewere Glimepiride na ọgwụ ndị ọzọ ma e wezụga inje insulin. Ọ dịghị mfe inye azịza. Enwere otutu ogwu ogwu nwere ike inwe mmetuta di iche iche na adighi nma glimepiride. Yabụ, ụfọdụ mụbara mmetụta hypoglycemic ya, ebe ndị ọzọ, n'ụzọ megidere, belata ya.
N'akụkụ a, ndị dọkịta na-akwadosi ike na ndị ọrịa ha na-akọ banyere mgbanwe niile na ọnọdụ ahụike ha, yana ọrịa ọ bụla metụtara ọnya.
Tebụl na-egosi ọgwụ ndị bụ isi na ihe ndị na-emetụta glimepiride. Ojiji ha n'otu oge bụ ihe a na-achọghị, mana n'ọnọdụ ụfọdụ, enwere ike ịkọ ya n'okpuru nlekọta siri ike nke ọkachamara na-agwọ ọrịa.
Ọgwụ ndị pụrụ ịkwalite mmetụta hypoglycemic bụ:
- inje insulin;
- Fenfluramine;
- Fibrates;
- ụdị coumarin;
- Disopyramids;
- Allopurinol;
- Chloramphenicol;
- Cyclophosphamide;
- Feniramidol;
- Fluoxetine;
- Guanethidine;
- MA inhibitors, PASK;
- Phenylbutazone;
- Sulfonamides;
- Ndị na - egbochi ACE;
- anabolics;
- Probenicide;
- Isophosphamides;
- Miconazole;
- Pentoxifylline;
- Azapropazone;
- Tetracycline;
- quinolones.
Ọgwụ na -ebelata mmetụta belata shuga mgbe ejikọtara ya na glimepiride:
- Acetazolamide.
- Corticosteroids.
- Diazoxide.
- Diuretics.
- Sympathomimetics.
- Nri
- Progestogens.
- Phenytoin.
- Homonụ thyroid.
- Estrogens.
- Phenothiazine.
- Glucagon.
- Rifampicin.
- Barbiturates
- Nicotinic acid
- Adrenaline.
- Ngwurugwu Coumarin.
Ọ dịkwa mkpa ịkpachara anya na ihe ndị dị ka mmanya na-egbu egbu na histamine H2 na-egbochi ihe (Clonidine na Reserpine).
Ngwakọta Coumarin nwere ike ịbawanye ma wedata ọrịa glycemia na ndị ọrịa.
Akwụ ụgwọ, nyocha na analogues nke ọgwụ
Nwere ike ịzụta ọgwụ a na ụlọ ahịa mgbe niile na ebe nrụọrụ weebụ gọọmentị rụpụtara ya, mgbe ị hụsịrị foto nke ngwugwu pụrụ iche tupu oge eruo.
Enwere ike ịnata glimepiride na usoro prefereniere.
Maka Glimepiride, ọnụahịa ahụ dịgasị iche dabere n'ụdị usoro onunu ogwu yana ọnụ ọgụgụ mbadamba na ngwugwu ahụ.
N'okpuru bụ ozi na ọnụ ahịa ọgwụ (Pharmstandard, Russia):
- Glimepiride 1 mg - site na 100 ruo 145 rubles;
- Glimepiride 2 mg - site na 115 ruo 240 rubles;
- Glimepiride 3 mg - site na 160 ruo 275 rubles;
- Glimepepiride 4 mg - site na 210 ruo 330 rubles.
Dịka ị siri hụ, ọnụ ahịa a na-anabata onye ọrịa ọ bụla, na agbanyeghị ego ha na-enweta. Na ntanetị ị nwere ike ịhụ nyocha dị iche iche gbasara ọgwụ. Dị ka a na-achị, ndị ọrịa mamịrị nwere afọ ojuju maka ihe ọgwụ a, na mgbakwunye, ịkwesịrị ị drinkụ ya naanị otu ugboro n'ụbọchị.
N'ihi nsonaazụ ma ọ bụ contraindications, dọkịta nwere ike ịkọwa ọtụtụ nnọchi. N'ime ha, ọgwụ ndị a na-emekọrịta (ndị nwere otu ihe na-arụ ọrụ) na ọgwụ analog (nke nwere ihe dị iche iche, mana na-enwe otu ụdị ọgwụgwọ).
Ngwaahịa ndị kachasị ewu ewu nwere otu ihe eji eme ihe bụ:
- Ọgwụ Glimepiride Teva - ọgwụ dị irè nke na-ebelata glucose ọbara. Ndị nrụpụta kachasị bụ Israel na Hungary. Na Glimepiride Teva, ntụziaka ahụ nwere ihe fọrọ obere ka ọ bụrụ otu ntụziaka metụtara ya. Agbanyeghị, ọgwụ onunu ogwu ahụ dị iche na ọgwụ ụlọ. Ọnụ ego nke 1 pack of Glimepiride Teva 3 mg Nke 30 bụ 250 rubles.
- Glimepiride Canon bụ ọgwụ ọzọ a pụrụ ịdabere na ya na-alụ ọgụ megide mgbaze elu na ọrịa shuga. Emeputa Glimepiride Canon na-ewere ọnọdụ na Russia site n'aka ụlọ ọrụ ọgwụ Canonfarm Production. Glimepiride Canon enweghị ọdịiche pụrụ iche, ntuziaka ahụ na-egosi otu ụdị contraindications na mmerụ ahụ. Nkezi ego Glimepiride Canon (4 mg Nke 30) bu 260 rubles. Ọgwụ Glimepirid Canon nwere ọtụtụ analogues ma nwee ike ịba uru mgbe ọgwụ adịghị mma maka onye ọrịa.
- Altar bu ogwu ama ama n’etiti ndi oria. Glimepiride, nke bụ akụkụ nke ọgwụ Altar, na-akpali ịhapụ insulin site na mkpụrụ ndụ beta. Alta nwere otu ngwa a. Onye rụpụtara ngwaahịa Altar bụ Berlin-Chemie. Ọnụ ego maka 1 mkpọ nke Altar bụ nkezi 250 rudders.
Enwere otutu ọgwụ nwere ụdị ọgwụgwọ ahụ, dịka ọmụmaatụ:
- Metformin bụ ihe nnọchianya hypoglycemic na-ewu ewu. Akụkụ bụ isi nke otu aha (metformin), na-eji nwayọ wedata glucose, ọ fọrọ nke nta ka ọ bụrụ na ọ na-eduga hypoglycemia. Ma, Metformin nwere ndepụta dị ogologo nke contraindications na mmetụta ndị ọ na-enwe. Nkezi ego ọgwụ Metformin (500 mg Nke 60) bụ 130 rubles. Ebe ọ bụ na akụrụngwa a bụ akụkụ nke nnukwu ọgwụ, ị nwere ike ịchọta ụdị dị iche iche - Metformin Richter, Canon, Teva, BMS.
- Ọgwụ hypoglycemic ndị ọzọ - Siofor 1000, Vertex, Diabeton MV, Amaril, wdg.
Yabụ, ọ bụrụ na n'ihi ihe ụfọdụ glimepiride adabaghị, analogues nwere ike dochie ya. Agbanyeghị, akụrụngwa a dị irè na mmepe nke hyperglycemia.
Enyere ozi banyere ọgwụ ịbelata shuga kachasị dị na vidiyo dị n'isiokwu a.
