Bagomet - ọgwụ na-ebelata shuga ọbara. Ntụziaka maka ojiji

Bagomet bu ogwu nke nwere ike hypoglycemic, nke eji eme ihe iji kwusi oria aria insulin na - adighi agha insulin (DM), oburu na ọgwụgwọ ogwu adighi adi ezigbo ike.

Atụmatụ ọgwụ nke Bagomet

Bagomet bụ ọgwụ hypoglycemic na-ebelata ma shuga na-ebu ọnụ ma na-arụ ọrụ mgbe ọ risịrị. Ọgwụ anaghị emetụta njikọ nke insulin. Otu n'ime nsogbu ndị metụtara ọrịa hypoglycemia abụghị nke ekwesighi. O nwere ike ịgwọ ọrịa pụtara mgbe mgbochi nke glycogenolysis na gluconeogenesis, na - akpalite mgbochi nke glycogen na imeju.

Bagomet na - akwalite arụmọrụ nke enzyme nke na - eme ka njikọ glycogen na - eme ka ọ dịkwuo elu, na - eme ka ikike nke nnyefe glucose dị na - ebuwanye ibu. Ọgwụ ahụ na - eme ka metabolism dị ọcha - nke nwere ụdị ọrịa shuga 2 enwere ohere ida.

Bagomet jiri ya na ndị otu ya na-atụnyere nke ọma n'ihe banyere oke ngwa ngwa.

Mgbe etinyere nri, a na-enweta ọgwụ ahụ ngwa ngwa site na nri diges, a na-abanyekarị uche kachasị n'ime awa abụọ na ọkara. Na-akụda ohere nke ọgwụ yiri nri. Ihe ngosi bioavailability nke Bagomet bu ihe ruru 60% nke ngụkọta nke ọgwụ a enyere ndị akụkụ.

Dabere na nsonaazụ nke ọmụmụ ọgwụ, anyị nwere ike ikwubi na ọgwụ na-agafe ngwa ngwa site na anụ ahụ, na-achọpụta ya na plasma. Ihe ndị mejupụtara ọgwụ ahụ ejikọghị na protein, ọ nwere ike ịbanye na sel ọbara ọbara, mana n'ọbara, ha dị obere ma e jiri ya tụnyere plasma.

Nnyocha ndị ahụ gosipụtara na ọgwụ ahụ dị na ahụ adịghị metabolized - akụrụ na-egosipụta ya na steeti mbụ ya. N'okwu a, ọkara ndụ ahụ bụ awa isii na ọkara. Bagometular filtration na renal tubule excretion na-akpasu iwe ọpụpụ, yabụ, ndị ọrịa niile nwere ọrịa gbasara akụrụ nọ n'ihe ize ndụ.

Ọkara ndụ na-abawanye, nke pụtara na enwere ihe ọghọm nke ịnakọta ọgwụ.

Ihe ngosiputa na uzo eji eji ya

A na-eme Bagomet maka ịgwọ ndị ọrịa mamịrị na-arịa ụdị ọrịa na-enweghị insulin na-adị (na enweghị ketoacidosis na nzaghachi na-ezughị ezu na ọgwụgwọ na sulfonylureas).

Ezubere ọgwụ ahụ maka ojiji nke ime. Jiri mmiri kwoo mbadamba ihe niile. Nke a na - abụkarị nri ma ọ bụ ozugbo ọ gachara. Usoro ọgwụgwọ oge mbụ bụ 500-100 mg / ụbọchị, dabere na ọkwa nke glycemia. Nwere ike ịhazigharị usoro ọnụọgụ ọgwụ naanị ka izu abụọ nke nnabata ya na ileba anya nke ndị na-egosi glycemic.

Ọ bụrụ na dọkịta emebeghị mkpebi onwe onye banyere onye ọrịa, mgbe ahụ, a na-enye usoro ọgwụgwọ ọgwụgwọ toro eto site na 1500 ruo 2000 mg. Ọ gaghị ekwe omume ịgafe ụkpụrụ kachasị. Ọ bụrụ na ọgwụ na-akpalite ọgba aghara nke stool, ị nwere ike imebi usoro kwa ụbọchị site na ugboro 2-3.

Site na usoro ogwu di mgbagwoju anya "Bagomet gbakwunyere insulin kwadebere", usoro onunu ogwu bu 1500 mg / ubochi. Maka mbadamba nkume nwere ikike ogologo oge, oke kachasị mma kwa ụbọchị bụ 850 mg -1000 mg. Site na iji nnabata nkịtị, ha na-akwụsị na mmezi nke 1700 mg / ụbọchị, yana njedebe - 2550 mg / ụbọchị. Na usoro ọgwụgwọ siri ike na ọgwụ ndị ọzọ na-ebutelata shuga, a na-enye otu mbadamba (850 mg ma ọ bụ 100 mg).

N'oge ịbụ okenye, Bagomet anaghị ewe ihe karịrị 1000 mg / ụbọchị. Nwere ike ịkọ ọgwụ maka ụmụaka gafere afọ 10. Childrenmụaka, yana ndị okenye, kwesiri ịmalite usoro ọgwụgwọ site na 500-850 mg / ụbọchị. N'oge nwata, ọgwụ kachasị ukwuu kwa ụbọchị bụ 2000 mg.

Nsonaazụ

N'ozuzu, ọtụtụ ndị ọrịa na-anabata ọgwụ ahụ nke ọma, mana, dị ka ọgwụ ọ bụla, enwere ike inwe mmetụta ndị ọzọ.

Nchoputa preclinical gosiri na Bagomet anaghị akpasu mutagenicity, carcinogenicity na teratogenicity. A gosipụtara mmetụta na-anọpụ iche na ọrụ omumu.

Ihe ngbanwe

A naghị atụ aro ka ịrịa Bagomet na ọrịa ndị a:

• Ọrịa mamịrị ketoacidosis, ọrịa shuga na ọnọdụ nna nna;
• Nsogbu iku ume;
• Ọrịa Cardiac, ọkachasị na nkụchi obi;
• Ọgba aghara ọbara;
• Lactic acidosis;
• Mmanya na-egbu egbu, akpịrị ịkpọ nkụ;
• Unana ukfu;
• Nnukwu ikike dị na usoro nke usoro Bagomet;
• Operụ ọrụ chọrọ ka ewechie mbadamba ụrọ nke insulin insulin;
• Ọkpụkpụ imeju;
• Ime na inye nwa ara;
• X-ray na-eji ayodiin dị ka ihe dị iche (mgbochi - maka ụbọchị 2 tupu yana nyocha ahụ);
• Nri Hypogalogy;
• Ndị tozuru oke (mgbe afọ 60) dị afọ, ọkachasị na ibu dị egwu na-akpasu iro acidosis ike;
• Children'smụaka (rue afọ 10) afọ.

Ndụmọdụ ndị dị ime

Nnyocha nyocha ahụ akwadobeghị akụrụngwa nke mutagenic na teratogenic nke Bagomet, mana edeghị ya maka ụmụ nwanyị dị ime. Ọgwụ nwere ike ịbanye na mmiri ara ara, ma ọ bụrụ na enweghị usoro ọzọ dị na Bagomet, a ghafere nwata ahụ ka inye ya nri.

Nsonaazụ Njikọ Ọgwụ

Ike nke hypoglycemic nke Bagomet na-eme ka sulfonamides, insulin, acarbose, ọgwụ mgbochi anti-steroidal, ACE na MAO inhibitors, oxytetracycline, β-blockers na-eme ka ikike ha dịkwuo elu.

Glucocorticosteroids, GOK, epinephrine, glucagon, ọgwụ hormonal thyroid, sympathomimetics, thiazide na "loop" diuretics, phenothiazine na ọgwụ nicotinic acid gbochiri ọrụ ya.

A na - egbochi cimetidine na - ewepu Bagomet n’arụ ahụ. Ihe ikike anumanu nke anakpo Coumarin na egbochi mgbochi Bagomet.

Of useụ mmanya na-egbu oge na-akpalite lactic acidosis. Ngosiputa ya bu oke nkpomoku, myalgia, erughi ala n’onu aru, nsogbu nke dyspeptik, mkpirisi iku ume, oria, anaghi ahu nri. Na mbụ enyo mmadụ enwetara, a na-elebara ya anya n’ụlọ ọgwụ, a na-emekwa ka nchọpụta ahụ pụta ìhè site n’inyocha oke nke lactate n’arụ na anụ ahụ.

Doụbiga nrịba ama

Ọ bụrụ na onunu ogwu nke Bagomet karịrị akachasị anabata iwu, lactic acidosis nwere nsonaazụ kacha njọ n'ụdị coma na ọbụna ọnwụ ga-ekwe omume. Ọ bụ mmetụta ahụ ka ọ na-akpata site na ịba ụba nke ọgwụ n'ime ahụ yana nsogbu na mpụta ya site na akụrụ. Nsogbu na-ebilite n'ime awa ole na ole ma jikọta mgbaàmà njirimara:

• Ọrịa Dyspeptik;
• Hypothermia;
• Imebi ụda nke mkpọchi afọ;
• Mgbu n’afọ;
• Myalgia;
• Ọnwụ;
• Ainta nkụ na ọrịa shuga.

Y’oburu n’adiri ufodu ihe edeputara egosiputa, aghaghi igbubigoro Bagomet ngwa ngwa, onye gha enye ya ulo ogwu.

Mwepụta wepụtara, ihe mejupụtara, ọnọdụ nchekwa

Mbadamba ụrọ nwere ike inwe ụdị dị iche iche na agba dị iche iche, dabere na usoro onyonyo: ọcha, gburugburu na convex - 500 mg nke ọ bụla, n'ụdị capsules - 850 mg bluish na agba na 1000 mg na ọcha. Nke ikpeazụ nwere ogologo ọrụ. Otu njiri mara ụdị mwepụta ahụ bụ akara nkewa yana akara ndị nrụpụta, nke dị n’elu mbadamba nkume niile.

Otu mbadamba ihe sitere na 500 ruo 100 mg nke metformin hydrochloride nke na-arụ ọrụ na mgbakwunye ndị nwere ụdị n'ụdị sodium, povidone, stearic acid, ọka ọka, lactose monohydrate.

Ekwesịrị itinye ihe enyemaka na enyemaka ọgwụ n'ụlọ ebe ụmụaka anaghị enweta ya, mgbe ọ dị ihe dị ka 25 Celsius. Debe Bagomet ihe kariri afọ abụọ.

Mmechi na analogues nke ogwu

Ihe anakpo Bagomet gunyere ogwu nke ma ndi otu a (ogwu antidiabetic) na ihe ndi ahu na aru aru (metformin).

1. Methamine;
2. NovoFormin;
3. Mpempe;
4. Mpempe.

Ihe atụ nke Bagomet bu ogwu nke opekata mpe otu oria ma obu onodu na - agbako na akaebe, na udiri oria abuo.

1. Avandia
2. Apidra
3. Baeta;
4. Glemaz;
5. Glidiab;
6. Glucobay;
7. Glurenorm;
8. Lymphomyozot;
9. Levemir Penfill;
10. Levemir Flekspen;
11. Multisorb;
12. Methamine;
13. NovoFormin;
14. Piroglar;
15. Mpempe;
16. Mpempe.

Site na ọgwụgwọ dị mgbagwoju anya na ọgwụ ndị ọzọ nwere otu mmetụta, ọ dị mkpa ịtụle ohere nke hypoglycemia. Ọgwụ ahụ nwere ike ịkpaghasị nhazi ma mee ka mmeghachi omume psychomotor kwụsịlata, yabụ mgbe ị na - eji usoro ziri ezi ma ọ bụ mgbe ị na - akwọ ụgbọala, ọ ka mma ịkwụsị ị theụ ọgwụ. Ojiji nke Bagomet choro ịkwanye mmanu na obere carb nke na-egbochi oriri nke carbohydrates n'ime ọbara.

Nyocha banyere Bagomet

Banyere ọgwụ Bagomet, nyocha nke ndị dọkịta na-akacha mma. Dị ka ndị ọkachamara si kwuo, ị suchụ ụdị ọgwụ a ma ama na-eme ka nchịkwa glycemic nke glucose ọbara dị ka awa 12. Ohere dị otú a na-ekwe ya nkwa ụfọdụ: ị nwere ike belata ugboro ole ị na-a theụ ọgwụ, melite ileba anya nke usoro metabolic. N'otu oge ahụ, a na - eme ka nnabata nke ihe na - arụ ọrụ site na nri digesive ma belata ihe ize ndụ nke ịmalite inwe mmetụta ọjọọ.

Nkọwa nke ọgwụ ahụ enweghị ike ịbụ nduzi maka ojiji. Tupu ịzụta, ịkwesịrị ịgakwuru ọgwụ endocrinologist, tupu ị theụ ọgwụ Bagomet, gụọ ntuziaka maka ojiji sitere na onye nrụpụta. Enyere ozi banyere Bagomet maka mmekorita nke mmadu niile na ike ya abughi ntuziaka maka ọgwụgwọ onwe. Ezi usoro ọgwụgwọ, na-eburu n'uche ogo nke ọrịa shuga, ọrịa na-efe efe na ọnọdụ ahụike nke ndị ọrịa mamịrị, nwere ike imepe ya.