Diabetology bụ mpaghara na-etolite etolite na ogwu. N'afọ ndị na-adịbeghị anya, e mepụtala ọtụtụ ọgwụ ọgwụ dị iche iche na-eme ka nchịkwa nke ụdị shuga 2 dị mfe. A na-akpọ mmebi sayensị nke afọ iri gara aga, incretin mimetics, nke belata gemoclobin glycated site na 1%. N'okwu a, ahụ ahụ onye ọrịa shuga na-eji nwayọ belata; ọgwụ ndị na-abawanye adịghị ebute ihe ndị dị egwu dị ka hypoglycemia.
Omume ndị a niile (nnọpụiche n'ihe banyere oke ahụ, enweghị oke mmetụta na-adịghị mma, nrụpụta dị elu gbakwunyere ọnụ ahịa dị oke ọnụ) metụtakwara ọgwụ ọdịnala Metformin, nke nọ na-ebute ụzọ n'ọgwụgwọ ụdị ọrịa shuga 2 maka ọkara ọkara.
Ejikọtara ọgwụ America na Combogliz Prolong na-agakọ uru nke metformin na incretinomimetics, na ụdị a na-adị ogologo oge na-enye ohere nke iji yana nchekwa ọzọ.
Njirimara ọgwụ ọgwụ
Combogliz Prolong bụ ngwongwo ziri ezi nke saxagliptin na metformin, na-enye ndị dibịa na ndị ọrịa shuga ohere ọhụrụ iji chịkwaa profaịlụ glycemic ha.
Saxagliptin
Saxagliptin bụ onye nnọchi anya ọgwụ ọgwụ dị na ya. Ọ bụ eriri afọ na-emepụta eriri afọ mgbe carbohydrates banye na ya. E nwere ụdị homonụ 2 dị mma: GLP-1 (peptide glucagon-dịka glucose) na HIP (polypeptide glucose na-adabere glucose).
N’ịbanye n'ime n'ọkwa ọbara, ha 70% na-akpali mmepụta nke insulin na-emebi emebi site na mkpụrụ ndụ β na-ahụ maka usoro a.
Na myirịta, incretins na-egbochi egbochi glucagon njikọ gbochie mwepu nke ihe di n’ime ya, mekwaa ka odiri n’odi ndu ozo.
Emebere ya na ndi oria di oria n’aria oria nke abuo, imeputa ihe ndi mmadu n’enweghi ume ala n'ihi na enzyme DPP-4 (dipeptidyl peptidase) na-emebi ngwa-ngwa. Ndị na-abawanye uru na-egbochi ọrụ nke DPP-4, ebe ha na-ejigide arụmọrụ nke ndị nwere nnọkọ endogenous. Ihe anaakrọ nke GLP-1 enweghị uche na enzyme a na-eme ihe ike.
Saxagliptin bụghị naanị ịgbatị ndụ nke incretins, kama ọ na-enye aka na uto nke ọnụ ọgụgụ ha n'ime usoro physiological (karịa oge 2). Inweta incretinomimetiks na-ebelata ihe ngosipụta nke ma ebu ọnụ ma postprandial glycemia. Akụkụ ndị a nke ọgwụ nwere ike iwepụ ọnọdụ hypoglycemic.
Metformin
Mpempe ọgwụ antihyperglycemic, nke naanị onye nnọchite otu biguanide, anaghị emetụta mkpụrụ ndụ b, yabụ, ọ naghị akpali insulin na-ebu oke akwara.
Ọ na - achịkwa usoro mbuze nke glycemia site na igbochi mwepụta nke glycogen na imeju na 30%. Metformin na - egbochi nnabata glucose molekụla na eriri afọ, na - eme ka mmetụta nke ndị na - anabata mkpụrụ ndụ nwee ike ịmụrụ insulin nke ha. Site n’ime ka ebulata glucose na akwara dịkwuo elu, ọ na-eme ka ume ume maka mkpa anụ ahụ wee belata ogo mgbanwe nke shuga na-akọwaghị n’ime abụba.
Metformin na ntọhapụ agbanwere nwere uru ndị ọzọ - opekempe nsonaazụ sitere na eriri afọ, ime ka ịdị arọ ya dị. Ihe mejupụtara mmiri ọricụricụ na-egbu egbu, akpụkpọ ahụ na-agbaze ngwa ngwa, ihe a na-eme ka ọsuụ na-apụta wee bụrụ gel. Site na matriks gel a, a na-ahapụ ọgwụ ahụ otu otu ụbọchị, na-enye ọnọdụ maka ịnwe kachasị.
Ngwakọta nke incretinomimetic na metformin bụ ndị ndị dọkịta matara dị ka nke kachasị mma na ọkwa ọ bụla nke ịchịkwa ụdị shuga 2. Na mgbakwunye na ịdị mma nke ịnata na iguzosi ike n'ihe nye ụdị usoro ọgwụgwọ a, isi nkatọ bụ arụmọrụ dị elu na nchekwa echepụtara. Maka ndị na - arịa ọrịa shuga buru ibu, nke a bụ nhọrọ kachasị mma, ebe ọ bụ na ọgwụ anaghị enye aka na oke ibu, mmepe nke ọdịda akwara, pancreatitis, na oncology.
Mwepụta wepụtara na ihe mebere Kombiglyze ogologo
Companylọ ọrụ America na-emepụta ọgwụ Bristol-Myers Squibb na-ewepụta ọgwụ ọgwụ ọgwụ n'ụdị mbadamba ndị nwere agba nwere ikike agwakọrịtara.
Capsule ọ bụla nwere 500 ma ọ bụ 1,000 mg nke ihe mejupụtara nke Metformin na 2.5 ma ọ bụ 5 mg nke Saxagliptin. Na mgbakwunye na ihe ndị bụ isi, a na-emeju ihe ndị mejupụtara ya na ndị na-ese ihe: magnesium stearate, sodium carmellose, hypromellose. Agba nke shei ahụ nwere ike ịdị odo, pink ma ọ bụ beige, dabere na usoro ị ga-esi. A na-akwakọ akwa Capsules na sel nke akwụkwọ ndụ. Igbe kaadiboodu nwere ike inwe 4-8 dị etu a.
Hapugharia ọgwụ eji ede ihe. Na Combogliz Ruo oge ọnụahịa ahụ dabere na usoro onunu ogwu: 1000 mg + 5 mg (mbadamba 28) - ihe ruru 3250 rubles .; 1000 mg + 2.5 mg (mbadamba 56 kwa iko) - ruo 3130 rubles.
Ndụ nchekwa nke ọgwụ a karịrị afọ 3. A ga-ekpochapụ ọgwụ gwụsịrị. Ọgwụ anaghị achọ ọnọdụ pụrụ iche maka nchekwa.
Combogliz Prolong: ntuziaka maka ojiji
Dọkịta ahụ na-ahọpụta usoro nhazi ihe na usoro onyonyo n'otu n'otu, na-eburu n'uche ihe ngosipụta nke glucometer, ahụike izugbe, afọ nke ọrịa mamịrị, mmeghachi omume nke mbadamba ihe. Na mkpokọta, Ntụziaka ahụ na-enye ụdị ndụmọdụ a.
A na-ewerekarị ọgwụ ogologo oge ka ụbọchị 1 / ụbọchị. n'otu oge.
Na-a aụ otu mbadamba n'ụtụtụ ma ọ bụ na mgbede, na-enweghị mkpị. Maka usoro eji ahapụ ngwa agha, nguzosi ike nke shei na-arụ ọrụ pụrụ iche.
Usoro onunu ogwu bu mmadu, dika mmalite monotherapy o nwere ike ibu 1 mbadamba (500 mg nke metformin + 2.5 mg nke saxagliptin), oburu n’enweghi ike inweta glycemic zuru oke, a na-abawanye ogwu a rue mbadamba abuo (1000 mg nke metformin + 5 mg nke saxagliptin).
Site n’otu oge eji ọgwụ eme ihe maka ịgwọ ọrịa na-efe efe, ekwesịrị ibute nsonaazụ ha na ibe ha. Karịsịa, ya na nhazi nke inhibitors nke CYP3A4 / 5 isoenzymes (Indinavir, Ketoconazole, Nefazodon, Itraconazole, Atazanavir), a na-enye obere akara nke saxagliptin - 2.5 mg.
Ọgwụ nke dabere na metformin nwere ogologo oge nke mmetụta adịghị mma n'ụdị nkwarụ dyspeptik dị obere karịa analogues na mwepụta ngwa ngwa. Nke mere na ahu na - emeghari onodu ohuru, o nweghi ihe nro maka ntu ogugu, a ga-ebu ụzọ tinye otu ụzọ kwesiri iji mezuo ihe ọ bụla.
Ekwesiri iburu ngbanwe ndu o bula n’eme ihe banyere ogwu a, ya mere odi nkpa igwa ndi dọkịta banyere ha n’oge.
Analogs Kombiglyce Prolong
Maka Combogliz Prolong, ntụnyere nwere otu ihe eji arụ ọrụ nwere ike ịbụ Comboglis XR, nke emepụtara na intali na UK. Ọnụahịa nke analog sitere na 1650 rubles. (28 mbadamba 1000 mg nke metformin na 2.5 mg nke saxagliptin).
Ngwakọta ọgwụgwọ nke Avandamet, Yanumet, Glimecomb, GalvusMet na Bagomet gbakwunyere na-enwe mmetụta ọgwụgwọ ahụ yiri ya.
Denye ọgwụ ike dabere na otu akụrụngwa na-arụ ọrụ dịka Glyformin Prolong, Glucofage, Metadiene, Sofamet, Diaformin Od, Ongliza, Matospanin, Metfogamma, Siofora.
Onye egosiri ogwu
Edere Combogliz ogologo maka ụdị shuga 2 iji mee ka njikwa glycemic dị ka mgbakwunye nri nri dị ala na mmega ahụ zuru oke, ma ọ bụrụ na mgbanwe ndụ adịghị enye nsonaazụ achọrọ yana nchikota saxagliptin na metformin kwesịrị ekwesị maka onye ọrịa.
Ekeresimesi na adịghị nso
Ọbụlagodi ọgwụ nke nwere nchekwa nchekwa dị elu, nke bụ Combogliz Prolong, ka enyeghị ya iwu maka ntachi obi na ike nke onye ahụ.
- Egosighi ogwu ogwu a nye ndi nne di ime na ndi na-ete nwa ara (a na-ewega ha na insulin) nwa oge, nihi enweghi ezigbo ihe akaebe zuru oke maka aru oru ya, enyeghi ya umuaka.
- Ọgwụ a adabaghị maka ndị ọrịa mamịrị nwere ọrịa 1.
- Na dysfunctions renal, yana ọnọdụ ndị na-akpasu ha iwe, egosighi ọgwụ a.
- Ejila ọgwụ ịgwọ ndị ọrịa nwere ọrịa na-akpata ụnwụ oxygen nke anụ ahụ.
- Site na ketoacidosis (ụdị ọrịa mamịrị) na ma ọ bụ na-enweghị coma, a naghị ewere ọgwụ ahụ nwa oge.
- A na-akagbu ọgwụ mgbe a na-arụ ọrụ, ya na nnukwu mmerụ ahụ, na-agba nnukwu ọkụ. Nnyocha X-ray nwere akara ayodiin n’ime ọrịa mamịrị nwere ike imebi akụrụ, ya mere agbanwere ya ka bụrụ insulin. Na ngụkọta, a na-egosi ọgwụ insulin maka awa 48 tupu yana awa 48 ka usoro ndị ahụ gasịrị, ọkachasị, ọ dabere na ọnọdụ akụrụ na ọdịmma ndị ọrịa niile.
- Ọrịa imeju, lactic acidosis na ị alcoholụbiga mmanya ókè sokwa na listi contraindications. Can nweghị ike ịkọwa ọgwụ ahụ nye ndị ọrịa nwere ọrịa agbụrụ galactose enweghị.
E kwesịrị ị attentiona ntị na ndị ọrịa shuga tozuru oke, ọkachasị na nri na-edozi ahụ, ọrịa akwara na enweghi mmega ahụ zuru oke nke nwere ike ịkpalite hypoglycemia.
Effects nwere ike ịchọpụta mmetụta na-achọghị na ị overụbiga mmanya ókè
Saksagliptin nke nwere ike dị iche iche nwere ike ibute ọnọdụ:
- Ọrịa Sinusitis
- Migraines
- Mgbu afọ;
- Vomiting;
- Ọrịa ọnya afọ;
- Ọrịa ọgbụgba nke mkpọda afọ;
- Thrombocytopenia;
- Nasopharyngitis;
- Hypoglycemia;
- Ọnya afọ;
- Uwe n’iru;
- Ọrịa mgbu
- Urticaria.
Ihe omumu ihe omumu gosiputara mbelata vitamin B12 site na iji ogwu ogologo oge, yana mbelata onu ogugu nke lymphocytes. Ọnọdụ nke ịdoụbiga mmanya ókè bụ alụghị di ma ọ bụ nwunye, na-abakarị na iji ogologo oge nke iji saxagliptin. Ọgwụ anaghị akpata egbu egbu, yana oke ọgwụ ahụ, hemodialysis dị irè. N’ime ya, a na-eme ọgwụgwọ symptomatic.
Formdoụ ọgwụ metformin karịrị akarị, ihe kachasị njọ bụ lactic acidosis.. Nwere ike ịmata ọnọdụ ahụ site na akara ndị a:
- Nkwụsị;
- Nchileke eswi;
- Mgbu afọ;
- Ọbara mgbali elu;
- Hypothermia;
- Akwara akpụ;
- Obi ọgba aghara.
N’ọnọdụ siri ike, nsogbu adịghịzi, ike ọgwụgwụ, precoma na coma na-etolite. Onye merụrụ ahụ chọrọ ụlọ ọgwụ ngwa ngwa, na-enweghị nlekọta ahụike zuru ezu, ọ nwere ike ịnwụ. Wepu metformin bupụrụ site na hemodialysis, ọ dị mkpa ịtụle na mwepu creatinine ruru 170 ml / min.
Ka ịrịa ọrịa shuga na-emezu ihe ndị dọkịta na-atụ maka ya, belata obere ihe ọghọm. N'ihe banyere Combogliz ruo ogologo oge, ọ bụghị ihe siri ike ịgbaso usoro nke ị theụ ọgwụ.
Nhọrọ maka imekọrịta ọgwụ ndị ọzọ
Mgbe ị na-etolite usoro ọgwụgwọ maka Combogliz Prolong, ọ dị mkpa ịdọ ndị endocrinologist aka na ntị gbasara ọgwụ niile onye ọrịa shuga na-ewere iji gwọọ ọrịa na-efe efe. Offọdụ n'ime ha nwere ike welie ike ịbelata ike nke Comboglize, ndị ọzọ na-egbochi ọrụ ya.
Maka echiche n'ozuzu, ị nwere ike ịnyagharịa tebụl.
Saxagliptin | Metformin |
Mmetụta hyperglycemic | |
| Rifampicin, Pioglitazone, Magnesium na Aluminom Hydroxides / Simethicone | GCS, diuretics, nicotinic acid homonụ thyroid, estoniazid, sympathomimetics, phenothiazines, estrogens, phenytoin, ndị nwere ihe na-egbochi calcium. |
Na-akpalite ọnọdụ hypoglycemic | |
| Amprenavir, Diltiazem, Erythromycin, Fluconazole, Aprepitant, Verapamil, mkpụrụ osisi grape, Ketoconazole, ọgwụ sulfonylurea, Glibenclamide, Ketoconazole, isoenzymes CYP3A 4/5, Famotidine | Ndị ọrụ Cationic, Furosemide, ethanol na ọgwụ, Nifedipine |
Amprenavir, Diltiazem, Erythromycin, Fluconazole, Aprepitant, Verapamil, mmanya mkpụrụ osisi, Ketoconazole, sulfonylurea ọgwụ, Glibenclamide, Ketoconazole, CYP3A 4/5 isoenzymes, Famotidine
Ndị ọrụ Cationic, Furosemide, ethanol na ọgwụ, Nifedipine
O doro anya na nnwale na nyocha nke onwe ya na ọgwụ onwe ya na Combogliz Prolong nwere ike ibute nsonaazụ ahụike.
Combogliz Prolong: nyocha nke ndị ọrịa mamịrị
Ndị dọkịta na-ahụ maka ịdị irè nke ọgwụgwọ ọgwụ Combogliz Prolong na-arịba ama na iche adịghị iche, ndị ọrịa mamịrị enweghị obi abụọ na ike ya.
Ijikwa ọrịa shuga zuru oke chọrọ usoro agbakwunyere: nri obere obere carb, nri na-agụ akwụkwọ glucometer kwa ụbọchị, mmega ahụ zuru oke yana nkwado ahụike. Naanị na nchikota a ị nwere ike ịtụkwasị obi na 100% mmetụta Combogliz Prolong.
Na vidiyo ahụ, prọfesọ-endocrinologist A.S. Ametov na-ekwu banyere ụkpụrụ ọhụụ nke njikwa ụdị shuga 2.
