Ọgwụ bụ otu ọgwụ ọgwụ hypoglycemic. Edere ya ọnụ. Ọrụ bụ isi bụ ịgbanye usoro ịkpụpụta insulin. Agbanyeghị, nke a apụtaghị na enwere ike iji ya maka ọnọdụ ọrịa na - akpata insulin. Oke ọgwụ a na-agbasawanye n'ihi nsonaazụ na pancreas. O nwere otutu contraindications, mgbochi mgbochi na ojiji. Iji wepu mmeghachi omume na-adịghị mma ma nwekwuo arụmọrụ, ekwesịrị ị theụ ọgwụ a n’oge enyere.
International Nonproprietary Aha
Glimepiride.
Ọrụ bụ isi nke glimepiride bụ nsonaazụ na mmepụta insulin.
ATX
A10BB12.
Ha weputara udi ya na ihe mebere ya
A na-enye ọgwụ ahụ na nsụgharị dị iche iche, na-adị iche na usoro nke ihe ahụ na-arụ ọrụ: 2, 3 na 4 mg. You nwere ike ịzụta ya na ụdị siri ike. Mbadamba nwere oke arụmọrụ nke otu aha. Ngwakọta ahụ nwekwara ihe ndị ọzọ:
- lactose;
- microcrystalline cellulose;
- pregelatinized stachi;
- sodium lauryl sulfate;
- stereta magnesium.
Ọzọkwa, ọgwụ nwere ike ịnwe nchara. Agbanyeghị, ha abụghị akụkụ nke ụdị glimepiride niile, kama ha dị na mbadamba nkume nke iji usoro ihe bụ 3 mg. A na-enye ọgwụ ahụ na ngwugwu 30 PC.
Omume ọgwụ
Ọgwụ na-anọchite anya ndị ọrịa hypoglycemic nke sulfonamides otu. Ọ bụ ọgwụ ọjọọ si n’ọgbọ nke atọ. Ofkpụrụ nke ọrụ na-arụ ọrụ na ntinye nke usoro mwepụta insulin. A na - enweta mmetụta a site na - akpali ụfọdụ mkpụrụ ndụ nke akụkụ endocrine nke pancreas. Ha na-arụ ọtụtụ ọrụ: na-eme ka ntọhapụ nke insulin, n'otu oge ahụ na-enyere aka belata glucose ọbara.
Ọgwụ nwere mmetụta dabere na ya. Yabụ, na mbelata nke ịgba glimepiride, ike ịhapụ insulin na-ebelata. Agbanyeghị, na data mbụ a, ọgwụ ahụ na-ejikwa otu glucose plasma dị ka ụfọdụ nke analogues na usoro onyonyo ka ukwuu. A na - enweta nsonaazụ a n'ihi mmụba nke insulin.
Ọgwụ na-sịntetik. N'ihi ike ịme ka ọnọdụ onye ọrịa dị ka ọ dị mgbe mmetụta insulin ezughị, a na-eji ya maka ọrịa mellitus na-abụghị insulin na-arịa ọrịa shuga na ụdị II mellitus. Usoro nke mmanu nke insulin na-eweta. Ọ sitere na nnyefe nke glucose na mkpụrụ ndụ beta nke pancreas, nke na-eduga n'ịba ụba na ọrụ nke mmepụta AFT. Zymịiko Enzyme na-egbochi ụzọ calcium nke ATP.
A na-eji Glimepiride mee ihe maka ọrịa mellitus na-arịa insulin na-abụghị insulin.
Nke a na - eduga na - emeghasị usoro nke iwepụta potassium na sel. Mgbe ahụ depolarization nke sel akpụkpọ ahụ na-amalite. N'oge a, ụzọ ndị nwere ike ịdabere na calcium na-emeghe, nke na-eduga n'ịbawanye ụba nke calcium na cytoplasm nke mkpụrụ ndụ beta. Na ngwụcha ngwụcha, ngagharị nke insulin na-eme ka mkpụrụ ndụ meziwanye ngwa ngwa, n'ihi nke a, granul ndị nwere insulin na-ejikọ ọnụ na sel ahụ.
Uru nke ọgwụ a nwere ntakịrị ntakịrị ihe na-eme ka mwepụta insulin daa, si otú ahụ belata ihe ize ndụ nke hypoglycemia. Ngwongwo ndi ozo: mbelata nke onu mmanu insulin site na imeju, mbelata na imeputa glucose na aru nke aru a. Na mgbakwunye, amachibido ọtụtụ usoro mmiri ọgwụ nje ndị na-eduga n'ịmepụta mkpụkọ nke ọbara. Nke a na - eweta mmetụta antithrombotic.
Ngwongwo ozo bu ikike nke Glimepiride iji gosiputa ihe mgbochi antiherogenic. Nke a pụtara na ekele maka ya ka egbochi mgbochi ọrịa nke akụrụngwa obi. A na-enweta nsonaazụ a site na ịme ihe dị mma. Na mgbakwunye, mbelata ọkwa nke obere aldehyde.
N'ihi nke a, ịba ụba nke lipid oxidation na-ebelata. Ọgwụ a na-enyocha na-etinyekwa aka na usoro biochemical ndị ọzọ, karịchaa, ọ na-ewepụ ngosipụta nke nrụgide oxidative na-eso ndị ọrịa nwere ọrịa mellitus.
Mlọ ọgwụ
Ọgwụ na-eme ihe ngwa ngwa. Mgbe nkeji 120 gachara, arụ ọrụ kacha elu glimepiride ruru. A na-ahụzi nsonaazụ ya na-adị 1 ụbọchị. Mgbe nke a gasịrị, ịta nke ihe arụ ọrụ na-amalite ibelata. Mgbaze nke usoro ndu sitere na mmiri na - emetụta ihe mejupụtara ya na - emetụta izu abụọ.
Uru nke ngwa a bụ ngwa ngwa zuru oke. Ọgwụ a na-enyocha bụ 100a nwere bioa. Mgbe ọ batara na imeju, usoro nhazi nke oxidation nke ihe ahụ na-amalite. N'okwu a, a na-ahapụ metabolite nọ n'ọrụ, nke na-esighi ike karịa glimepiride n'ihe banyere ike ikpughere anụ ahụ. Usoro metabolic na-aga n'ihu. N'ihi ya, a na-ahapụ kọpị na-anaghị arụ ọrụ.
Iwepu ọkara ndụ na-eme awa 5-8. Ogologo oge ya dabere na steeti ahụ na ọnụnọ nke ọrịa ndị ọzọ. A na-egosipụta akụkụ nọ n'ọrụ n'ụdị gbanwetụrụ. Ọzọkwa, a na-ewepu ihe ka ukwuu n'ime ahụ ahụ mgbe a na-etinye uru, mmiri fọdụrụnụ n'oge mmerụ ahụ.
Ọkara ọkara nke ndụ glimepiride si n'ahụ bụ 5-8 awa.
Ihe ngosi maka ojiji
Ọgwụ nwere mpaghara dị warara eji. Yabụ, edepụtara ya maka ụdị shuga II. Ọ bụrụ na ọgwụgwọ ahụ esighi ike, ha na-agbanwe site na monotherapy gaa ọgwụgwọ dị mgbagwoju anya. N'okwu a, enwere ike ịkwado mgbakwunye insulin ma ọ bụ Metformin (250 mg).
Ihe ngbanwe
Amachibidoro iji ngwaọrụ a na-ajụ ajụjụ n'ọnọdụ ndị a:
- metabolic acidosis, ya na metabolism metabolism na-emetụta ya;
- akpịrị na-arịa ọrịa shuga, precoma;
- ụdị 1 ọrịa shuga mellitus;
- pathologies nke nri akwụsịsịrị ịnabata ma ọ bụ usoro a nwere ọtụtụ nsogbu;
- mmeghachi omume mmadụ na-adịghị mma maka ihe ndị mejupụtara ọgwụ a na ndị ọrụ ndị ọzọ sitere na otu nke sulfonamides na usoro sulfonylurea;
- ihe egwu di elu nke hypoglycemia;
- mmeghachi omume na-adịghị mma maka lactose, ụkọ lactase, ọrịa glucose-galactose malabsorption syndrome.
Jiri nlezianya
Ekwesịrị inyocha ọnọdụ onye ọrịa n'oge ọgwụgwọ ya na ọgwụ ahụ mgbe enwere mkpa nchịkwa insulin:
- na-ere ọkụ nke mebiri emebi nke ihe dị na mpụga;
- nnukwu ịwa ahụ;
- otutu mmerụ ahụ;
- ọrịa nke nsogbu ịba ọrịa nri na-abawanye, dịka ọmụmaatụ, mgbochi afọ na ime ọ bụ paresis nke afọ.
Etu esi ewere glimepiride
Mbadamba nkume ndị ahụ bu n'uche maka nchịkwa ọnụ. Enweghị ike ịta ata, mana a na-atụ aro ka ejiri mmiri .ụ mmiri. A na-ewere ọgwụ ahụ na afọ efu, tupu nri.
Na-arịa ọrịa shuga
N'okwu ụfọdụ, na mbido mbụ, a na-enye 1 mg nke ihe ahụ ọgwụ 1 oge kwa ụbọchị. Mgbe ahụ, n'iji izu 1-2, ego a buru ibu ruo 2 mg, emesịa 3 mg. Na usoro ikpeazụ, a na-enye 4 mg ọgwụ. Oke ọgwụ kwa ụbọchị bụ 6 mg.
Enweghi ike ị beụ mbadamba nkume ndị ahụ, mana a na-atụ aro ka ejiri mmiri lodaa ya.
Dabere na otu ụkpụrụ ahụ, ọ dị mkpa ịme ihe ma ọ bụrụ na ezubere ị takeụ ọgwụ a na-atụgharị ọnụ na oge Metformin. Nwere ike ibugharị onye ọrịa na Metformin na insulin. N'okwu a, gaa n'ihu usoro ọgwụgwọ na nha iji gbochie ọgwụgwọ ya. Ekwesịrị idozi ego a. Ọgwụ insulin na-agbadikwa nwayọọ nwayọọ. Jiri ego kacha nta malite mgbe ị na - eji agwọ ọrịa.
Mgbe ọ dị mkpa ịnyefe onye ọrịa site na otu ọgwụ hypoglycemic na ọgwụ a na-atụle, a na-atụkwa usoro nke glimepiride opekempe nke mbụ. Ọnụ a tụrụ aro nke ihe na-arụ ọrụ bụ 1 mg. Mgbe ahụ ọ na-abawanye na ọkwa achọrọ.
Nsonaazụ nke gliperimide
Ọgwụ nwere ike itinye aka na mmepe nke ọtụtụ usoro nje, nke ekwesịrị ịtụle mgbe ị na-ahọpụta.
Na akụkụ ahụ nke ọhụụ
Ahụhụ anya (usoro atụgharị).
Ọkpụkpụ afọ
Nausea, vomiting megide ndabere nke ọrịa a, stools rụrụ arụ, ihe mgbu nke epigastric, ọrụ imeju na - arụ ọrụ, nke gosipụtara site na ọrịa jaundice, ịba ọcha n'anya, mgbanwe na isi ihe ngosipụta nke ọrụ imeju n'oge ọmụmụ ụlọ nyocha.
Ahụhụ Hematopoietic
Ọtụtụ ọrịa na-etolite n'ihi mgbanwe nke mejupụtara ọbara ahụ, dịka leukopenia, wdg.
Site n'akụkụ nke metabolism
Hypoglycemic mmeghachi omume. Ọtụtụ mgbe, ha na-etolite mgbe njedebe nke usoro ọgwụgwọ n'ihi mgbanwe nri. Mgbe ụfọdụ ihe kpatara ya bụ imebi onunu ogwu a n’oge ọgwụgwọ.
Ahụhụ
Ọtụtụ mgbe, urticaria na-etolite, mana ihe iriba ama akara nwere ike ime: ike gwụrụ anụ ahụ, dyspnea, ụjọ anaphylactic.
Mmetụta ikike ịchịkwa usoro
Achọghị itinye aka na ọrụ nke achọrọ nlekọta dị elu. Nke a bụ n'ihi eziokwu ahụ bụ na n'oge usoro ọgwụgwọ mbụ ma ọ bụ mgbe ịgbanwere site na otu ọgwụ hypoglycemic gaa na nke ọzọ, ihe mgbaàmà ndị a nwere ike ịpụta: enweghị nlebara anya, ibelata ọnụego nke mmeghachi omume psychomotor.
Mgbe ị Afterụsịrị ọgwụ ahụ, ujo anaphylactic nwere ike ịmalite.
Ntụziaka pụrụ iche
A na-atụ aro ị takeụ ọgwụ ahụ n'oge oge a. N'ihi nke a, a na-enweta nkwụsi ike nke ọnọdụ onye ọrịa ngwa ngwa. Ọ bụrụ n ’ọhụhụ na otu oge atọrọ gị, amachibidoro ya n’ibe gị iji mee ka ọ̀gwụ ahụ dịkwuo elu. Gakwuru dibia.
Ọ bụrụ na ọrịa nke hypoglycemia pụtara mgbe ị na-eji mbadamba ihe nwere 1 mg nke glimepiride, mgbe ahụ enwere ike ịme ọkwa glucose naanị site na nri pụrụ iche.
Ka ị na-anata ọgwụ na ajụjụ, mkpa maka ya belata. Nke a bụ n'ihi mmụba nwayọọ nwayọọ na uche insulin.
Ekwesịrị iburu n'uche na n'ime ndị ọrịa nwere ọrịa ọrịa nke usoro endocrine, ihe ize ndụ nke ịmalite ọrịa ezighi ezi na-abawanye.
Nyere na a na-echekwa mmetụta dị mma nke glimepiride ọtụtụ izu, enwere ike ịchọ nkwụsịtụ mgbe ị na-agbanwe site na otu ọgwụ hypoglycemic gaa na nke ọzọ.
Mgbe ị na-a Gụ Glimepiride, ọ dị mkpa ka a na-eduzi ule oge niile iji nyochaa oke glucose na ọbara, yana haemoglobin glycated.
Mgbe ị na-a theụ ọgwụ ahụ, ọ dị mkpa iji duzie ule oge niile. N'okwu a, nchịkọta nke glucose n'ọbara, yana hemoglobin nke glycated.
Jiri na agadi
Ngwongwo ogwu nke ogwu a agbanweghi na ndi oria ndi otu a. Yabụ, idozigharị ọgwụ adịghị mkpa.
Inye umuaka
Edeghị ya.
Jiri n'oge ime na lactation
Amachibidoro ọgwụ a maka iji ya. N’ime usoro ịtụrụ ime ma ọ bụ n’oge a na-a breastụ ara, a na-agafere nwaanyị insulin.
Ngwa maka ọrụ ezughi oke ọrụ
Edeghị ya.
Jiri maka ọrụ imeju na-arụ ọrụ
A naghị akwado ya ka ị useụ ọgwụ ahụ n'ihi ike a na-ekere òkè nke ahụ a na usoro iji wepụ ọgwụ.
Glimepiride nnyefere
Ọ bụrụ na ọnụ ọgụgụ ọgwụ ahụ na-abawanye, hypoglycemia ga-amalite n'oge na-adịghị anya. A na-edozi ọnọdụ a na - efe efe maka awa 12-72. Mgbaàmà: obi ọgbụgba, obi erughị ala, ọbara mgbali elu, mgbu obi, palpitations, adịghị ike nke izugbe, ọgbụgbọ, ịgbakwunye ọgbụgbọ, afọ iri nri na isi ọwụwa. Mgbasa ozi adsorbents, laxatives na - enyere aka iwepu ihe ịrịba ama.
Ọ bụrụ na e were ọgwụ hiri nne buru ibu, a na-atụ aro mkpokọ gastric nke dextrose. A na-eme ụdị aghụghọ a n'ụlọ ọgwụ. Ọzọkwa, ọ dị mkpa ịchịkwa ọkwa nke glucose dị n'ọbara.
Mmekọrịta na ọgwụ ndị ọzọ
Ịba siri nke glimepiride hụrụ mgbe n'itinye insulinosoderzhaschih mmadụ, hypoglycemic ọgwụ ọjọọ, Ace inhibitors, anabolic Steroid, coumarin nkwekọrịta, allopurinol, chloramphenicol, cyclophosphamide, disopyramide, Feniramidola, fenfluramine, fluoxetine, Dizopiramidona, ọgwụ ọjọọ nke ifosfamide, guanethidine, Miconazole, Pentoxifylline, phenylbutazone, pụtara otu salicylates, quinolones, tetracyclines, sulfonamides.
A na-achọpụta mmụba nke glimepiride site n'otu oge iji ihe ndị nwere insulin, ọgwụ hypoglycemic, ọgwụ coumarin.
Ọgwụ ndị ọzọ, n'ụzọ megidere, belata ịdị irè nke glimepiride. Ndị a gụnyere: Acetazolamide, barbiturates, corticosteroids, diuretics, Epinephrine, Diazoxide, nicotinic acid, sympathomimetics, laxatives, Glucagon, estrogen- na progesterone nwere ọgwụ, Rifampicin, Phenytoin, homonụ nke edepụtara maka ọrịa thyroid.
Mmanya ndakọrịta
A naghị atụ aro ka ị drinksụ mmanya nwere ihe ọ alcoholụ alcoholụ na-egbu egbu na glimepiride, n'ihi na o siri ike ịkọ ihe ga-esi na ya pụta. Mmanya na-egbu egbu nwere ike iwelie ma mee ka ọ gharazie ịdị ike nke ihe ndị nnọchianya nọ na ajụjụ.
Analogs
Kama glimepiride enyere:
- Glibenclamide;
- Glianov;
- Amaryl;
- Diabeton, wdg.
Ahịa ọgwụ na-ahapụ okwu
Ogwu bu ogwu.
Enwere m ike ịzụta na ndenye ọgwụ
Enweghị ohere dị otú ahụ.
Ọnụahịa
Ọnụ ego ahụ dịgasị iche dabere na usoro nke glimepiride ma ọ bụ 190-350 rubles.
Ọnọdụ nchekwa maka ọgwụ
Shouldmụaka ekwesịghị inwe ohere ị accessụ ọgwụ. A na-anabata ikuku ikuku n'ime ụlọ - ruo + 25 Celsius С.
Bọchị mmebi
Enwere ike iji ọgwụ ahụ mee ihe n'ime afọ 2 site na ụbọchị ahapụ.
Emeputa
"Onye na - ere ọgwụ - Leksredstva", Russia
Nyocha
Alice, onye gbara afọ 42, Kirov
Erere maka ndị ọrịa mamịrị ka mma karịa ịgba ntụtụ, maka na ọ ka dabara adaba, ọ dịghị mkpa ka ị nwee nkà ịgba ntụtụ. Ọ bụghịkwa mmadụ niile nwere ike ịnabata ụdị ọbara a. N'ihi ya, ajụrụ m dọkịta ka o bulie ọgwụ ahụ n'ụdị siri ike. Gere iwepụ ihe mgbaàmà. Nsonaazụ emeghị.
Elena, 46 afọ, St Petersburg
Ọ bụrụ na arụ ọrụ imeju na-arịa ya, enweghị ọgwụ ọ bụla edepụtara. Maka nke a, agbanweela m ya. Mgbe ọ dị afọ 45, a chọpụtara ọrịa ịba ọcha n'anya. Mana enwere m mmasị na ihe Glimepiride, ọ na-enye ọsịsa ọgwụgwọ ngwa ngwa, nsonaazụ enwetara na-akwado ogologo oge.
