Denye insulin Aspart iji kwụọ ọrịa shuga

Iji dozie ọkwa shuga dị n'ọbara, a na-enye ndị ọrịa mamịrị nhazi insulin. Otu n'ime ụdị ihe dị iche iche na-arụ ọrụ hypoglycemic bụ insulin aspart.

Ọgwụ bụ analog nke bio insine nke insulin na-arụ, ya na obere ọrụ. A na-eji ya dị ka akụkụ nke isi ọgwụgwọ maka ọrịa shuga mellitus ma na-amụgharị mkpa nke insulin, na-emegide mmepụta homonụ ahụ.

Nkọwapụta ọgwụ ọjọọ

Ogwu a di n ’uzo nke osisa ogwu nye ya. Ibe insulin bu nke ogwu nke emeputara site na iji teknụzụ bioengineering. A na - enweta ya site na ị degharịa DNA nke ụdị Saccharomyces cerevisiae, yana edochi otu n'ime amino asịd.

Ihe ogwu a na-aru aru nke ihe n’ile anya bu n’obi n’inweta glucose, iji belata shuga obara n’aria ndi nwere oria mellitus.

Ulinmịnye insulin na-arụpụta ụlọ nnabata insulin na-enye usoro ndị a:

• Transportgbọ njem na glucose;
• Mkpakọ Enzyme;
• Glycogenogenesis;
• Ọgwụ metabolism n’arụ ọrụ glucose;
• Ichebe glycogen na hepatocytes.

E nwere ụzọ abụọ esi mepụta aspart:

1. Otu oge. Ngwọta doro anya, nwere obere ọrụ (awa 3-5), mgbe nchịkwa subcutaneous gasịrị. Nyere ya ka o ghazie glycemia mgbe ị na-eri nri carbohydrate.
2. Biphasic. Ejikọtara nkwadebe ya n'ụdị nkwusioru naanị maka ọgwụgwọ maka ọrịa shuga 2. ọ dabere na ngwakọta insulin dị mkpụmkpụ yana ọgwụ na-eme ihe na-ajụ. Mmetụta na-ewelata shuga na-ewe awa 6.

Ebe ọ bụ na ụdị otu nwere oge dị mkpụmkpụ na metabolism, a na-eji ya dị ka akụkụ nke usoro ọgwụgwọ siri ike na insulin na-arụ ọrụ ogologo oge. A na-eji ọgwụ Biphasic eme ihe dị ka ihe ọzọ maka ọgwụ ndị na-ebelata shuga, ma ọ bụ na ha.

Azụmaahịa aha na mpempe akwụkwọ ntọhapụ

A na-eweputa aspart ma n ’ụdị ọcha ma dịka akụkụ nke nkwadebe siri ike. E nwere ọtụtụ usoro onodu ogwu eji eme ka insulin na-arụ ọrụ dịka ihe kachasị arụ ọrụ. Azumahia a gha eme ya dabere na mejuputara ya.

Thelọ ọrụ Danish bụ Novo Nordisk.

Ntụziaka maka ojiji

Ofzọ eji eme ihe na ị andụ ọgwụ ahụ dabere n'ụdị usoro onunu ogwu, ụdị ọrịa, ọnụnọ nke ọnya ọnya na afọ onye ọrịa.

Nkwupụta izugbe, maka ụdị ụdị abụọ dị iche iche, bụ ndị a:

• A na-edobe ọnya ijiji (na abụba abụba), ebe ọ bụ na insulin obere na-efunyụọ ihe ọ na-ewepụta ngwa ngwa site n'ahụ ahụ, yana ntụtụ intramuscular;
• A ga-agbanwerịrị saịtị ịgba agba mgbe niile, ebe ọ bụ na abụba nwere ike etolite na akwa abụba.
• Mpaghara lipodystrophic;
• A naghị atụ aro iji agịga iji gbochie ọrịa.

Etu esi eji insulin aspart? Ntụziaka maka ojiji nwere ntuziaka dị iche iche maka ọgwụ otu-na ọgwụ abụọ.

Ojiji nke dị otu ụdị

Onye nnọchite nke ụdị ọgwụ hypoglycemic bụ NovoRapid. Ọ bụ ọgwụ na-eme ngwa ngwa na obere oge eji eme ya. Mmetụta ahụ glycemic na-apụta mgbe nkeji 10-20 gachara, mgbe ọgwụ ntụtụ ma ọ bụ infusion. A na-ahụ mmetụta kachasị mgbe ejiri nkeji iri anọ wee jiri nwayọọ nwayọọ belata, na-eru opekempe mgbe elekere 5 gachara.

Iji nọgide na-enwe glycemia nkịtị, na-enweghị usoro mmụba ma ọ bụ ibelata shuga (na mpụga usoro kwesịrị ekwesị), ọ dị mkpa iji nlezianya nyochaa ọkwa glucose ọbara.

A na-eme ya site na iji usoro ndị a:

• Mita ọbara glucose;
• Usoro CGMS maka ọgwụgwọ mmiri (usoro nlele glucose elektrọn).

Ekwesịrị ịnwe nha tupu iri nri. Maka ngụkọta ziri ezi nke otu ọgwụ, ọgwụ shuga tupu nri emee atụmatụ, a na-ejikwa ụkpụrụ postprandial iji dozie akara.

A na-eji NovoRapid arụ ọrụ subcutaneously site na iji sirinji insulin 100 U, pensụl pen ma ọ bụ mgbapụta insulin. Ọ bụ naanị ndị ọrụ ahụike ruru eru ka a na-anabata nchịkwa intrais, n'ọnọdụ ọnọdụ nlekọta mberede. Onu ogugu maka otu ihe ogwu ahu bu ndi dibia bekee biara.

A na-agbakọ chọrọ kwa ụbọchị n'otu n'otu, dabere n'echiche nke onye ọrịa na oke ahụ. Ihe a choro kwa ubochi kwesiri ya bu udiri aru nke 0-1-1 U / n'arọ. Nweghị ike ịbanye na ọgwụ kwa ụbọchị maka aspart ozugbo, ebe nke a ga - eduga hypoglycemia na coma. A na-agbakọ otu dose maka iche maka nri carbohydrate ọ bụla.

Mkpa onye insulin na-eme ihe dị mkpirikpi dabere na homonụ na mmega ahụ, yana oge ụbọchị. Na oge ututu, enwere ike ịba ụba, ma mgbe mgbatị ahụ siri ike ma ọ bụ na mgbede - nwere ike ibelata.

Ojiji nke biphasic aspart

A na-eji NovoMix (onye nnọchite nke biphasic aspart) maka ndị ọrịa nwere ụdị ụdị 2. Usoro a tụrụ aro, na mmalite ọgwụgwọ, bụ nkeji iri na abụọ, nke a na-ahazi na mgbede, tupu nri. Iji rụpụta nsonaazụ a na-achịkwa karịa, a na-atụ aro kee nkewa otu n'ime ụzọ abụọ. Site na ntinye a, ha tinyere 6 nke NovoMix tupu nri ụtụtụ na na mgbede, tupu nri.

Naanị nchịkwa nchịkwa nke biphasic aspart ka akwadoro. Iji chịkwaa ọ̀kwa shuga na imeghari ọ̀gù, ọ dị mkpa ị tụta ọkwa ọbara. A na-eme nhazi dose mgbe ịdepụtara usoro profaịlụ, na-eburu n'uche ibu shuga (n'ụtụtụ, na afọ efu), ruo ụbọchị 3.

Ngwurugwu mgbochi na nsonaazụ ya

E nwere ọtụtụ ihe na-atụ aro iji insulin wezuga na ịkpachara anya. Nkwekọrita na mgbochi dị iche iche na-emetụta ma otu oge na ụdị ọgwụ a jikọtara ọnụ. Nkwekọrịta bụ isi bụ ekweghị mmadụ nwee ihe ọzọ na ihe ndị ọzọ mejupụtara ọgwụ.

A maara ọtụtụ ihe mgbochi maka ijikọ aspart, yana ọgwụ ndị ọzọ:

1. Sulfites na ọgwụ ọjọọ nke otu thiol na-ebipụ iche;
2. Mbadamba Hypoglycemic, thioctic acid, beta-blockers, yana ụfọdụ ọgwụ nje na-eme ka mmetụta hypoglycemic dị elu;
3. Otu thiazolidinedione na-abawanye ohere nke nkụda obi.

N'ọnọdụ ndị a na-adịghị ahụkebe, a na-emepụta ọgwụ mgbochi ọbara n'ime ọbara nke na-ebelata ihe ọ bụla glycemic mmetụta nke aspart. Ọgwụ zuru oke ma ọ bụ oke nchịkwa nke ọgwụ ahụ, yana nghazi na-ezighi ezi nke otu ọgwụ, nwere ike ibute hyperglycemia ma ọ bụ hypoglycemia.

EGO Dodoụbiga ọgwụ ike ókè na-eduga n'inwe ọnwụ na ọnwụ.

Mmetụta ndị dị n'akụkụ bụ mpaghara n'okike, na-egosipụta na saịtị ịgba ahụ. Mgbe ogwu ogbugba, obere ọbara ọbara ma ọ bụ ọzịza, itching, obere hematomas nwere ike ịhụ. Site na iwepu onye ọrịa site na ọnọdụ hypoglycemic dịtela aka, neuropathy mgbu na obere oge nwere ike ịmalite.

Akwụ ụgwọ na analogues

Costgwọ ọgwụ ọjọọ ahụ na-adabere n’ụdị emepụtara insulin aspart. Ọnụ ego ọgwụ na analogues na egosiri na tebụl.

Analogs nke aspart nwere mmetụta yiri ya, mana emere ya na ihe ndị ọzọ na-arụ ọrụ. Emere ọgwụ ndị a maka iji ọgwụ eme ọgwụ.

Insulin aspart bụ ihe bara uru hypoglycemic. O nweghi onu ogugu nke contraindications ma ejiri ya dika akuku nke usoro ogwu di omimi banyere oria mamellitus, ma aru ndia. Ogwu ahu dabara adaba ma umuaka ma ndi okenye.