Gluconorm bụ ọnụ ala, dị irè, nke a na-amụ nke ọma, mana ọ bụghị ọgwụ na-enweghị nchebe mgbe niile. Edere ya maka ndị ọrịa mamịrị 2 ịbelata glucose ọbara. Ihe abuo na - enye uto okpomoku - glibenclamide na metformin. Dabere na ọmụmụ, ijikọ ọgwụ ndị a nwere ike iwetulatara hemoglobin glycly site na 1% ma e were ya otu n'ime ha. Maka ọtụtụ ndị ọrịa shuga, nke a bụ ezigbo nsonaazụ, nke na-eme ka o kwe omume ịkwụ ụgwọ maka ọrịa shuga mellitus, ya mere, iji zere nsogbu ya na-akpata.
Ihe butere nsogbu Gluconorm bụ ihe egwu nke hypoglycemia, yabụ ha na-anwa ịghara inye ndị ọrịa ọgwụ ha nwere ike ịda ngwa ngwa shuga.
Ihe na-egosi maka nhọpụta nke gluconorm
N'ọtụtụ ndị ọrịa nwere ọrịa mellitus, otu ọgwụ enweghị ike ijigide glucose n'ụzọ nkịtị, yabụ ndị dọkịta na-ejikarị ọgwụgwọ ejikọtara ọnụ. Ihe ngosi maka nhọpụta ya bụ gemoclobin glycated dị elu karịa 6.5-7%. Ihe kachasị dị nkọ banyere njikọta nke metformin yana agịga sulfonylurea (PSM), gliptins na incretin mimetics. Njikọ ndị a niile na-emetụta ma nkwụghachi insulin na olu nke imepụta insulin, yabụ na-enye nsonaazụ kachasị mma.
Nchikota nke metformin + sulfonylurea bu ihe kariri. Ihe n’enweghi ike imekorita ibe ha, emela ka odi ndu. Glibenclamide bụ ihe kachasị ike ma mụọ gbasara PSM niile. O nwere ọnụahịa dị ala ma na-ere ya na ahịa ọgwụ niile, yabụ, na njikọta metformin, glibenclamide ka edepụtara ọtụtụ oge karịa ọgwụ ndị ọzọ. Maka ịdị mfe nke iji ya, etinyere mbadamba ihe abụọ nwere ihe abụọ a na - arụ ọrụ arụ ọrụ - Gluconorm na analogues ya.
Dịka ntuziaka ahụ si dị, a na-eji Gluconorm naanị maka ụdị shuga 2, ọ bụrụ na nrụzi nri, egwuregwu, na metformin enyeghị ọdịda glucose iji mepụta ụkpụrụ. Ogwu metformin ekwesịghị ịbụ nke kachasị mma (2000 mg) ma ọ bụ onye ọrịa mamịrị na-anabata. Ọzọkwa, enwere ike ibute gluconorm site na ndị ọrịa na-a previouslyụbu glibenclamide na mbụ na metformin iche.
Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie
- Normalization shuga -95%
- Mwepu nke akwara mbufụt - 70%
- Mwepu nke obi ike -90%
- Bibie ọbara mgbali elu - 92%
- Mmụba na ume n'ụbọchị, na-eme ka ụra na-ehi ụra n'abalị -97%
Nchoputa emere: obere mbadamba ihe ndị ọrịa na-ewere kwa ụbọchị, ka ọ na-enwekwu mmasị ịgbaso usoro ọgwụ niile dọkịta, nke pụtara na ịdị elu ọgwụgwọ dị elu. Nke ahụ bụ, were Gluconorm kama mbadamba mbadamba abụọ bụ obere nzọụkwụ maka ụgwọ kachasị mma maka ọrịa shuga.
Na mgbakwunye, mmụba okpukpu abụọ nke usoro mbadamba shuga dị ala adịghị enye mbelata otu shuga. Nke ahụ bụ, ọgwụ abụọ n'ime obere obere ga-arụ ọrụ karịa nke ọma ma nye nsonaazụ dị ala karịa otu ọgwụ na oke usoro.
Ngwakọta na mmetụta nke ọgwụ ahụ
A na-emepụta Gluconorm site na ụlọ ọrụ Russia Pharmstandard na mmekorita ya na Indian Biopharm. Ọgwụ dị na nsụgharị 2:
- A na-eme mbadamba gluconorm na India, nke ejiri ya na Russia. Ogwu ahu nwere usoro ogwu akpukpo aru nke 2.5-400, ya bu, okpokoro nke metformin obula nwere 400 mg, glibenclamide 2.5 mg.
- A na-emepụta mbadamba Gluconorm Plus na Russia site na ọgwụ ọgwụ zụrụ na India na China. Ha nwere onunu ogwu 2: 2.5-500 maka ndi oria di n’inwe nnuku insulin na 5-500 diri ndi oria n’enweghi oke ibu, kama na enwepu insulin nke oma.
Ekele dị iche iche maka usoro ị ga-esi mee ya, ị nwere ike ịhọrọ oke ziri ezi maka onye ọrịa ọ bụla nwere ụdị shuga 2.
Ka anyị tulee n ’ụzọ zuru ezu otu akụkụ nke ọgwụ Gluconorm si arụ ọrụ. Metformin na-ebelata ma postprandial na ngwa ngwa glycemia bụ nke kachasị n'ihi mbelata nguzogide insulin. Ihe na-eme ka glucose na-eme ka arịa karịa ngwa ngwa ka mmetụta anụ ahụ nye insulin na-abawanye. Metformin na --ebekwa usoro glucose dị n’ahụ n’ime ihe ndị na - eme mkpụkọ ahụ, na - eme ka ọ banye n’ime ọbara site na ngụgụ nri.
Maka ndị na-arịa ọrịa shuga, akụrụngwa ndị ọzọ nke metformin na-ejikọghị yana mbelata nke glycemia dịkwa ezigbo mkpa. Ọgwụ na-egbochi mmepe nke angiopathy site na ịkọwapụta ọbara ọcha, na-eme ka anụ ahụ dị mma. Dabere na akụkọ ụfọdụ, metformin nwere ike igbochi ọdịdị neoplasms. Dị ka ndị ọrịa si kwuo, ọ na -ebelata agụụ, na-enyere aka ịnọgide na-enwe oke ibu, na-akpali ibu ibu, ma na-abawanye uru nke nri.
Glibenclamide bụ ọgbọ PSM 2. Ọ na - eme ihe na sel beta pancreatic: ọ na - ebelata etu ụzọ ha si elebara ọkwa glucose ọbara, si otú a na - abawanye mmepụta insulin. Glibenclamide na - akwalitekwa glycogenogenesis, usoro ịchekwa glucose na akwara na umeji. N'adịghị ka metformin, ọgwụ a nwere ike ibute hypoglycemia, dị njọ karịa ndị nnọchiteanya ndị ọzọ nke otu PSM - glimepiride na glyclazide. A na-ewere Glibenclamide dị ka onye kachasị ike, kamakwa ọ kachasị dị ize ndụ nke PSM. A naghị akwado ya maka ndị ọrịa mamịrị nwere nnukwu ọrịa hypoglycemia.
Etu ị ga-esi nweta ọgwụ Gluconorm
Ihe kachasị emetụta metformin bụ mgbaze, glibenclamide - hypoglycemia. Nwere ike belata ihe egwu nke nsonaazụ na-adịghị mma nke ọgwụgwọ na gluconorm, were ọgwụ n’otu oge nri ma jiri nwayọ na-abawanye ọgwụ, na-amalite site na nke kacha nta.
Usoro onunu ogwu nke Gluconorm dika ntuziaka ndi a si di:
Njirimara nke nnabata | Gluconorm | Gluconorm Plus | |
2,5-500 | 5-500 | ||
Na-amalite dose, taabụ. | 1-2 | 1 | 1 |
Ikike mmachi, taabụ. | 5 | 6 | 4 |
Iwu nke ịba ụba usoro onunu ogwu | Anyị na-abawanye ọgwụ site na 1 mbadamba ụbọchị 3 ọ bụla ma ọ bụrụ na onye ọrịa ebutela metformin nke ọma. Ọ bụrụ na edeghị ọgwụ metformin maka ndị ọrịa mamịrị, ma ọ bụ na ọ nabataghị ya nke ọma, gbakwunye mbadamba nkume nke abụọ tupu izu abụọ agafee. | ||
Mmachi maka ndị ọrịa mamịrị na ọrịa akụrụ na ọrịa imeju | Maka iwepu gluconorm n'ahụ, ezigbo imeju na akụrụ ọrụ dị mkpa. Ọ bụrụ na ezughi oke nke akụkụ ahụ ndị a na-adịchaghị ala, ntụziaka ahụ na-atụ aro ka a na -elegide usoro kachasị nta. Amalite na oke ọdịda dara ada, amachibidoro ọgwụ a. | ||
Ọnọdụ ngwa | Na-a 1ụ otu mbadamba 1 na nri ụtụtụ, 2 ma ọ bụ 4 na nri ụtụtụ na nri abalị. 3, 5, 6 taabụ. kewara 3 doses. |
Site na nguzogide insulin siri ike, nke bu ihe e ji mara ndi buru oke ibu, enwere ike inye ha ọgwụ ndi ozo. Ọtụtụ mgbe na nke a, ha na-a itụ ya tupu ị lakpuo ụra. A na-ewere oke kachasị mma kwa ụbọchị nke metformin dịka 2000 mg, nke kachasị - 3000 mg. Mmụba na-abawanye na usoro usoro ọgwụgwọ dị ize ndụ na lactic acidosis.
Ebe enweghi carbohydrates na nri, Gluconorm na-ebute hypoglycemia. Iji gbochie ya, achịcha ndị dị mbadamba mmanya na-egbu egbu. Ngwaahịa ga-enwerịrị carbohydrates, ọkachasị nwayọ. Gaghị ekwe ka ogologo oge dị n'etiti nri, yabụ a na-atụ aro ndị ọrịa karịa nri pụrụ iche. Nyocha nke ndị ọrịa mamịrị na-egosi na n’ịgba mbọ anụ ahụ, shuga nwere ike daa n’ime nkeji. N'oge a, ị ga - elebara ahụike gị anya.
Mmetụta akụkụ na ị andụbiga mmanya ókè
Kedu ihe nsonaazụ ndị ọrịa mamịrị nwere ike izute mgbe eji Gluconorm ma ọ bụ ihe atụ ya:
- hypoglycemia n'ihi nke PSM;
- mmeghachi omume site na ngwara nri, ihe kpatara ya bụ metformin. Dabere na nyocha, ọtụtụ ndị ọrịa mamịrị na-ebute oria na ọrịa ụtụtụ. Ntụziaka maka ojiji dọrọ aka ná ntị na mgbu afọ na ọgbụgbọ na-ekwe omume. Ọ bụrụ na nsogbu ndị dị otú ahụ bilitere, ahapụla Gluconorm ozugbo, ọ na-abụkarị n'otu izu ka anụ ahụ na-emegharị ma kwụsị ị respondingụ ọgwụ dịka;
- imebi usoro nguzobe ọbara. Ole ngwakọta cellular n’ime ọbara nwere ike ịda. Mgbe a kwụsịrị ọgwụgwọ Gluconorm, a na-eweghachi ihe ndị metụtara ọbara;
- lactic acidosis bụ ọrịa shuga na-adịghị ahụkebe, njiri mara ụdị 2. Na-enweghị enyemaka ahụike, ọ na-eduga ná nsogbu;
- anabataghị mmanya na ụdị mmanya;
- sistemụ akwara na-enwe ike imeghachi omume maka gluconorm na isi ọwụwa na adịghị ike;
- Mmeghachi omume nfụkasị ahụ ga-ekwe omume, ruo anaphylactic.
Nsonaazụ ndị dị ka hypoglycemia na lactic acidosis bụ nsonaazụ nke ịba ụba nke Gluconorm. O nwere ike:
- Direct: onye na-arịa ọrịa shuga rankụrụ ihe ọ theụ thanụ karịa nke enyere n'iwu.
- Iretọ. Hypoglycemia nwere ike ime mgbe enweghi nri carbohydrates na nri ma ọ bụ na - emeju glucose ngwa ngwa n'oge arụ ọrụ anụ ahụ na nnukwu nrụgide, ma nke uche na nke anụ ahụ. Formationmepụta lactate na-abawanye na ọnọdụ nke ịxụbiga mmanya ókè, ọdịda anụ ahụ na-eduga hypoxia, nwere nnukwu mmerụ na ọrịa na-efe efe.
Omume maka ịdoụbiga mmanya ókè dịka ntuziaka ndị a si dị: hypoglycemia dị nwayọ na-akwụsị site na glucose ma ọ bụ ngwaahịa nwere nnukwu ọdịnaya. Lactic acidosis na hypoglycemia, ya na mmachi na-enweghị isi, chọrọ ụlọ ọgwụ ngwa ngwa.
Ihe ngbanwe
Mgbe Gluconorm maka ọrịa shuga enweghị ike iji:
- ya na mmata ya na ihe ndi ozo n’eme ka aru di gi nma. Nje a gụnyere mmeghachi omume nfụkasị ahụ, yana kwupụtara ihe ndị a na-achọghị nke chọrọ ịkwụsị ọgwụ ahụ;
- ọ bụrụ na a chọpụta ụdị shuga 1;
- n'oge ọgwụgwọ nnukwu ọrịa shuga, ọrịa dị ukwuu na mmerụ ahụ. Ọ bụ dibia bekee na-ekpebi mkpebi a na-agafe na oge nwa oge ịgwọ ọrịa insulin;
- enwere nnukwu nsogbu ezigharị ma ọ bụ nnukwu nsogbu nke ụdị nkwarụ ahụ;
- n'oge ime na HB. Mgbochi nke iji Gluconorm siri ike, ebe ọ bụ na PSM na nhazi nke mbadamba ihe nwere ike ịkpaghasị mmepe nwa ebu n'afọ, iduga hypoglycemia n'ime nwatakịrị ahụ;
- mgbe ị na-a agentsụ ndị na-egbu egbu. Nchikota nke Gluconorm na miconazole ma obu fluconazole bu otutu hypoglycemia. Edepụtara ndepụta ọgwụ na-emetụta ihe nke Gluconorm na ntuziaka maka ojiji;
- ọ bụrụ na ndị ọrịa mamịrị enwelarị lactic acidosis ma ọ bụ nwee nnukwu nsogbu nke ịmalite ya.
Analogs na nnọchi
Ndị na-agbanwe okwu | Emeputa | Oma ahia |
Analogues zuru ezu gluconorm | Canonpharma | Metglib |
Berlin-Chemie, ụlọ nyocha Guidotti | Glibomet | |
Analogs Gluconorm Plus | Maslọ ọgwụ | Glibenfage |
Canopharma | Metglib Force | |
Merck Sante | Ndị Glucovans | |
Valeant | Bagomet Plus | |
Nkwadebe Metformin | Vertex, Gideon Richter, Medisorb, IzvarinoFarma, wdg. | Metformin |
Maslọ ọgwụ | Merifatin | |
Mek | Ọkpụkpụ | |
Nkwadebe nke Glibenclamide | Maslọ ọgwụ | Statiglin |
Onye na-ere ọgwụ, Atoll, Moskhimpharmpreparaty, wdg. | Glibenclamide | |
Berlin Chemie | Maninil | |
Ọgwụ abụọ nwere akụrụngwa: metformin + PSM | Sanofi | Amaryl, dịka akụkụ nke PSM glimepiride |
Akrikhin | Glimecomb, nwere PSM Gliclazide |
Analogues zuru oke, yana metformin na glibenclamide dị iche iche, nwere ike ị drunkụbiga mmanya ókè na usoro onunu ogwu dika Gluconorm. Ọ bụrụ na ị na-achọ ịtụgharị na usoro ọgwụgwọ ọzọ dị na sulfonylurea, Ọ ga-ahọrọ nhọrọ ọzọ. Ndị dọkịta na-atụ aro ka ịgbanwee site na Gluconorm gaa Amaryl ma ọ bụ Glimecomb ka ndị ọrịa mamịrị nwere ọrịa carbohydrate ụdị 2, nke na-enwekarị hypoglycemia.
Dabere na nyocha, arụmọrụ nke Gluconorm na analogues dị nso, mana ndị na-arịa ọrịa shuga ka na-ahọrọ Glybomet nke German, na-atụle ya ọgwụ kachasị mma.
Iwu nchekwa na ọnụahịa
Gluconorm dị irè ruo afọ 3 site na ụbọchị emepụtara. A na-ahapụ Gluconorm Plus ịchekwa ihe karịrị afọ 2. Ntụziaka ahụ enweghị ihe ndị pụrụ iche maka ọnọdụ nchekwa, o zuru ezu iji lelee usoro ikuku nke anaghị elu karịa ogo 25.
Ndị na-arịa ọrịa shuga Russia nwere ike ịnweta ọgwụ abụọ dị ka ọgwụ onye dọkịta ọ bụla ma ọ bụ endocrinologist si debere n’efu. Purchasezụta nkeonwe ga-efu ọnụ ala: ọnụahịa nke otu mbadamba 40 nke Gluconorm bụ ihe dị ka 230 rubles, ọnụ ahịa Gluconorm Plus sitere na 155 ruo 215 rubles. maka mbadamba 30. Maka ntụle, ọnụahịa nke Glibomet mbụ bụ ihe dịka 320 rubles.