Roxera bụ onye nnọchi anya otu ọgwụ na-emetụta metabolism lipid. Ihe dị mkpa sitere na Roxers bụ rosuvastatin, nke na - egbochi enzyme nke na - agbanwe cholesterol.
Isi ihe nke rosuvastatin bụ hepatocytes, ebe a na-agbakọta cholesterol na ụmụ irighiri mmiri nke lipoproteins na-akụda. Usoro nke ime ihe a bụ iwelie ọnụ ọgụgụ nke nnabata ngwụcha hepatocytes maka LDL, si otú a na-enye mmụba dị ukwuu na ndakpọ nke LDL, si otú a na-egbochi njikọ nke lipoproteins njikọta.
Ekele Roxer, cholesterol, ogige nke atherogenic, triglycerides (TAGs) na-ebelata, na ntinye uche nke ụmụ irighiri ihe mgbochi antiherogenic nke lipoproteins na-abawanye.
Mmetụta ọgwụgwọ a na-akpọ akpọ pụtara otu izu mgbe mmalite nke nchịkwa. N'ime izu anọ nke ọgwụgwọ, a na-enweta mmetụta ọgwụ kachasị, ma ọ bụrụhaala na a na-ewere ọgwụ ahụ n'ụzọ ezi uche dị na ya.
Ọgwụ a ga-edepụtara ọgwụ ọgwụ ahụ ka ọ na-eburu n'uche njirimara onye ọrịa ahụ.
Onwe-ogwu nke Roxeroy nwere ike bute otutu nsogbu ojoo adighi nma, tinyere rhabdomyolysis na odida akuko.
Pharmacokinetics na pharmacodynamics
Ogwu ahu nwere okpukpo iri abuo nke bioavailability. Mgbanwe na iji ọgwụ a na-arụ ọrụ site na mkpụrụ ndụ imeju.
Ihe dị ka 90% nke Roxers jikọtara na protein ndị dị na plasma, karịchaa na albumin. Pharmacokinetics adịghị agbanwe agbanwe mgbe a na-ewere ya mgbe niile.
Ihe dị ka 90% nke rosuvastatin bụ ndị a na-atụfu n'ụdị mbụ ya site na ngọngọ nri. Otu obere akụkụ ọgwụ a bụ metabolized n'ime akwara renal.
Ihe ngosi maka nhọpụta Roxers bụ:
- isi hypercholesterolemia;
- ahaghioke nke lipids;
- mkpụrụ ndụ ihe nketa hypercholesterolemia;
- hypertriglyceridemia;
- atherosclerosis;
- dị ka ọgwụ iji gbochie ọrịa na-akpata nnukwu ọrịa obi na ndị ọrịa na-enweghị ihe mgbaàmà ọria nke ọrịa obi na -akpata, mana n'ihe egwu dị elu.
Ọgwụ dị n'ụdị mbadamba ụrọ nwere ihe mkpuchi.
Otu mbadamba nwere ike ịnwe ọgwụ ndị a: milligram 5, milligram 10, milligrams 15, milligrams 20, milligrams 30, milligrams 40.
A na-ahọrọ dose ahụ dabere n'ụdị ọrịa ahụ yana ogo ahụ. Mmetụta ọgwụgwọ na-adabere na ọnụọgụ ọgwụ yana ugboro ole nke ọgwụ.
A na-ahụta njiri agbụrụ na mkpụrụ ndụ ihe nketa nke ọgwụ. N'ime ule ụlọ ọgwụ, agbụrụ Mongoloid, ma e jiri ya tụnyere Caucasoid, gosipụtara mmụba na ọkwa plasma nke rosuvastatin.
Mpempe akwụkwọ Roxer nwere carbohydrate lactose, n'ihi nke a, amachibidoro ọgwụ a maka ndị ọrịa nwere ụkọ lactase, yana yana ọrịa carbohydrate malabsorption.
N'ihi ọgbụgba enwere ike, isi ọwụwa na mmeghachi omume ndị ọzọ, a chọrọ nlebara anya na ịkpachara anya mgbe ị na-anya igwe ma na-ejikwa usoro ziri ezi.
Administrationchịkwa ọgwụ mgbe niile yana ọfụma na - egbochi mmepe mmeghachi omume ojoo. Ọ dị mkpa ị theụ ọgwụ ahụ na usoro kwesịrị ekwesị iji zere nrụgide na-emetụta imeju na akụrụ, ebe ọ bụ na akụkụ ahụ ndị a ka rosuvastatin metabolism na-apụta.
Dọkịta na-aga ahụ ga-ahọrọ ọ bụghị naanị ọnụọgụ ziri ezi, kamakwa nchikota ọgwụ ọgwụ n'etiti onwe ha. Nke a bụ n'ihi eziokwu ahụ bụ na ọtụtụ ndị ọrịa nwere atherosclerosis nwekwara nkụda mmụọ gbasara akwara.
Ntuziaka maka iji ọgwụ ahụ
A na-ewere Roxer dịka ndụmọdụ nke akwụkwọ mpempe akwụkwọ ahụ si dị maka ojiji.
O bu n'uche ogwu a ka eji eme ya. A machibidoro ya ịta ma ghee ọgwụ. A ga-ewere mbadamba ahụ n'ụdị mbụ ya, were nnukwu mmiri mmiri sachaa ya. Nnabata n'oge ọ bụla, n'agbanyeghị nri nri.
A na-ahụ nsonaazụ nke ọgwụ ahụ naanị ma ọ bụrụ na agbaso usoro nri pụrụ iche. Na nmalite nke ọgwụgwọ, a na-enye ọgwụ dị miligram 5 nke ihe ahụ kwa ụbọchị. Mgbe ị na-ahọrọ usoro onunu ogwu, a na-echebara ọkwa nke plasma cholesterol na ichebara ihe ọghọm nke ọrịa obi nwere ike ibute. Na mgbakwunye, toaa ntị n'ihe ọghọm dị na nsonaazụ ya.
Can nwere ike ịbawanye ọgwụ mgbe ọnwa gachara site na mmalite ọgwụgwọ. Ogwu nke 40 mg na aru oru otutu ihe ọghara isi ya ma e jiri ya tụnyere obere usoro nke ihe ahụ. A na-anabata mmụba dị otú ahụ maka otu ọnwa ma eme ya naanị na ndị ọrịa nwere ogo hypercholesterolemia yana nnukwu ihe egwu nke ọrịa ọrịa obi. A na-eme ọgwụgwọ n'okpuru nlekọta nke dibịa.
Mgbe ọnwa nke ọgwụgwọ gasịrị ma ọ bụrụ na mgbanwe nke ị ofụ ọgwụ ahụ, ọ dị mkpa iji duzie profaịlụ na-egosi mmerụ ahụ. Maka ndị ọrịa nwere ihe gbasara akụrụ na-ada ada (iwepu ihe na-erughị 30 mililirs kwa nkeji), anaghị anabata ọgwụ eji eme ihe.
Enweghị ike ịkọtara Rosuvastatin ndị ọrịa nwere ọrịa imeju n'oge oke. Ndị ọrịa kariri afọ iri isii na ise kwesịrị ikwesara iji usoro ọgwụgwọ nke obere obere ụbọchị ọ bụla.
Ihe ojoo na mgbochi Roxers
Mmeghachi omume ọjọọ na-adabere kpọmkwem n'ụdị ọgwụ ahụ yana n'ụdị onye ọrịa ahụ.
A na-ekewa nsonaazụ ya otu ugboro ihe omume na njiri mara nke ngosipụta.
Mmeghachi omume ndị a na-ahụkarị bụ mmeghachi omume hypersensitivity (edere Quincke, urticaria, ujo anaphylactic); isi ọwụwa Dizziness polyneuropathy; imebi ọrụ ncheta. Nmebi nke eriri afọ, n'ụdị afọ ntachi, nke afọ na-esochi afọ ọsịsa, ọgbụgbọ na ọgbụgbọ, ihe mgbu na ahụ erughị ala na-anọpụ iche; imeju dystrophy, ịba ọcha n'anya na ọrịa icteric siri ike; Stevens-Johnson syndrome; olu mgbu; myopathy na mbibi anụ ahụ; nkwonkwo mgbu ida protein na mmamịrị; mkpụrụ ndụ ọbara uhie na mmamịrị; ọnọdụ asthenic; akwara homonụ nke ogwurugwu.
N'ihi oke ọgwụ ọgwụ ọjọọ dị na ya, onye mepụtara na-egosi ọtụtụ mmachi na ojiji Roxers. Ihe ndị ọzọ ị ga-emeli:
- Activedị ọrụ ịba ọcha n'anya ma ọ bụ ọrịa ịba ọcha ọzọ.
- Nnukwu gbasara akụrụ.
- Myopathy
- N'ikuku na cytostatic cyclosporin.
- O were oge a na fibrates.
- Oge nke ime na lactation.
- Nlepụghị anya nke Lactose.
- Afọ ụmụaka.
- Ndi mmadu kwulite ogwu ahu.
Thenara ọgwụ n'oge afọ ime na lacting bụ contraindicated kpamkpam. A na-ejikọ contraraindication na ọrụ teratogenic dị elu nke ihe ahụ.
A na-egbochi Rosuvastatin n'ime ndị gbara afọ 18. N'iji nlezianya mee ọgwụ a, o kwesiri ka enye ndị agadi ọgwụ ahụ.
A na-ehibe nhọrọ nke onye na - arụ ọrụ n'ime ya maka ezighi ezi akwara, ebe ọ bụ na rosuvastatin nwere mmetụta nephrotoxic. Mgbe ị na-ewere ihe karịrị 30 mg kwa ụbọchị nke ihe ahụ, nyocha nke ọrụ akụrụ mgbe niile dị mkpa.
Ọgwụ bụ myotoxic. A chọpụtara Myalgia na nkwarụ akwara mgbe ha jikọtara ya na ọgwụ ndị ọzọ na-eweta mmerụ ahụ. Ọ bụrụ na onye ọrịa ahụ nwere mgbu mgbu, adịghị ike, na-achọgharị yana yana mmerụ ahụ a na-egbu egbu, a ga-amata onye dọkịta na-aga ya ozugbo. Ọ dịkwa mkpa iji ngwa ngwa kpebie mkpokọta nke phoineho photinhoase n'ime ọbara.
A kwụsịrị ọgwụgwọ ahụ na-abawanye ụba nke phosphokinase creatine ma ọ bụ nwee ọganihu nke akara nke mgbu akwara, mgbu na adịghị ike.
Mmekọrịta nke Roxers na ọgwụ ndị ọzọ
Emere Roxers ka enwere mmekọrịta n'etiti ọgwụ na ọgwụ ndị ọzọ.
Mgbe ị na-eji ọgwụ ahụ na ndị ọrụ ndị ọzọ, enwere ike ịtụle mmekọrịta dị n'etiti ha.
Site na ọgwụ ndị na-esonụ, ihe ahụ nwere ụfọdụ ọgwụ pharmacokinetic:
- Antimetabolite "Tsisklosporin". Site n'iji ọgwụ eji eme ihe jikọtara ọnụ, a na-achọpụta oke mmụba nke rosuvastatin dị na plasma.
- Warfarin. Oge nchịkwa ọgwụ na-akpatara onye ọrịa ọrịa ụfọdụ. Njikọtara ọnụ na anticoagulants na-apụtachaghị ìhè na-eme ka ndọtị rosuvastatin dịkwuo elu ma na-agbakọ ọnụego nhazi zuru ụwa ọnụ.
- Ezetimibe. N'otu oge, ị na-eji ọgwụ ndị a eme ihe, anaghị eme ka itinye uche gị n'ọbara. Mana ezetimibe nwere ike ịbawanye ohere nke mmeghachi omume myotoxic.
- Ọgwụ ndị ọzọ na-egbusi ike ọgwụgwụ. Site na nchịkwa nke oge a, ekwuputara ntinye uche nke Rosuvastatin na plasma. Nchikota ndi di otua n’enwe ike inweta akwara oria.
- Ọgwụ antiretroviral ọgwụ: nje virus immunodeficiency virus na-egbochi ndị na-egbochi ya. Nchikota di otua na - abawanye ọkwa plasma nke rosuvastatin.
- Antacids. Njikọ nke rosuvastatin na ọgwụ antacids, nke gụnyere aluminom na magnesium hydroxide, na-eduga n'ịbelata ọkwa nke rosuvastatin plasma site na ọkara. Iji belata mmetụta yiri ya, a na-enye ọgwụ mgbochi antacids awa abụọ mgbe ikpeazụ nke rosuvastatin.
- Antibiotic Erythromycin. Nchịkọta nke imekotaotu oge na-eduga n'ịbelata mkpo rosuvastatin. n'ihi ịba ụba nke eriri afọ.
- Ihe mgbochi ọgwụ a na-ejikọ ọnụ na ụdị ọgwụgwọ homonụ ndị ọzọ. Iji ihe ndị mejupụtara ya na rosuvastatin na-eme ka ịbawanye ụba nke ihe ndị na-eme ka homonụ dị na plasma ọbara. Iji wepu mmeghachi omume ndị dị otú a, a na-eme mgbanwe nke dose nke ikpeazụ.
- Cardiac glycosides.
Ndakọrịta na ọgwụ ndị dị n'elu dị ala. Ekwesịrị ka akwadoro oge ịme oge ahụ dabere na njirimara nke ndị ọrịa nwere.
Ọgwụ n’ahịa ụlọ
Enwere ike ịzụta ọgwụ a n'ụlọ ahịa ọgwụ ọ bụla na Russia na mba CIS.
Ọgwụ dị n’ahịa ụlọ na-enweghị ndenye ọgwụ.
Ọnụ ego ọ dabere na usoro ị theụ ọgwụ ahụ.
Taa ọnụahịa ahụ dịgasị:
- mbadamba ụrọ nwere ọgwụ nke 5 mg kwa 90 pcs. - 1056 rubles;
- mbadamba nkume ogwu nke 10 mg kwa 30 pcs. na 90 pcs. - 461 rub. na 999 rubles. dị ka ya si dị;
- mbadamba ụrọ nwere usoro ọgwụ nke 15 mg maka 30 na 90 PC. - 404 ite. na 1225 rubles. dị ka ya si dị;
- mbadamba nkume ogwu nke 20 mg kwa 30 pcs. ihe dị ka 690 rub.
Na ahịa ahịa ọgwụ Russia nke enwere ọtụtụ analogues nke Roxers. Analog bụ ọgwụ nwere otu ihe si arụ ọrụ. Ọgwụ ndị mepụtara mba ụwa Rosuvastatin bụ ikike dị n'ọtụtụ ọgwụ n'ahịa Russia. Aha ika nke ogwu ahu nwere ike di iche.
A na-emepụta ọgwụ ahụ site na nchegbu ndị Slovenian "Krka". Ma ọtụtụ ndị na-emepụta, gụnyere ndị nke ụlọ, na-etinye aka na ngụsị akwụkwọ nke rosuvastatin. Na mgbakwunye, enwere ndị nnọchi anya ndị ọzọ nke Statin otu.
Ntinye aka nke otu ihe di iche (Atorvastatin, Rosuvastatin Canon, Tevastor, wdg) bu ihe analogues na njiri mara nke ihe eji eme ihe. Nhọrọ nke otu ọgwụ dabere na njirimara onye ọrịa.
Roxer nwere ọtụtụ nyocha nke ndị ọrịa na-a thisụ ọgwụ a.
Ọtụtụ mgbe nyocha na-adị mma, belụsọ n'ụdị mmeghachi omume ọjọọ. Nyocha Roxera dị njọ n'ụdị ogologo oge nke ọgwụgwọ.
Ọtụtụ mgbe, mmetụta na-adịghị mma n'ahụ ahụ na-apụta n'ihi eziokwu ahụ bụ na onye ọrịa ahụ tookụrụ mmanya n'oge ọgwụgwọ, deere ọgwụ ahụ n'onwe ya ma ọ bụ gafere ogo a tụrụ aro maka ọnọdụ ya. Ntụleghachi ọgwụ dị otú ahụ abụghị ebumnuche ma ọ nweghị ike ịbụ ihe ndabere a pụrụ ịdabere na ya maka ịhapụ ị theụ ọgwụ.
Site na nchịkwa ezi uche, ọgwụ ahụ kwesịrị inyere onye ọrịa ahụ aka. Ọ bụ akụrụngwa na-eme ka mbelata nke ọgwụ nwere ike belata cholesterol na ihe ize ndụ nke atherosclerosis na nsogbu ya. Mmetụta ọzọ ị takingụ ọgwụ ahụ dị obere karịa mmetụta ọgwụgwọ a tụrụ anya ya.
Ọ dị mkpa ijikọta oriri niile na-ebelata ọgwụ nwere ike inye gị ezigbo nri na ndụ na-agagharị.
Integratedzọ ejikọtara ọnụ iji luso ọrịa obi ọgụ na ngosipụta ndị ọzọ nke atherosclerosis bụ ihe kachasị dị irè ma zie ezi.
A kọwara statins na vidiyo ahụ n'isiokwu a.
