Ọgwụ cholesterol na-ebelata ọgwụ: nyocha na nyocha

Y’oburu na inye nri mmanu adighi adighi nma nke oma, enwere ike inye ogwu ogwu nke ga ewepu imebi ihe ndi n’abuba. Ọ bụrụ n’ọkwa cholesterol dị n’ọbara dị elu karịa 6.5 mmol / l, mgbe ahụ, dọkịta ahụ nwere ike ịkwado ọgwụgwọ pụrụ iche iji belata ya tupu oge a.

Isi nhazi ọkwa ọgwụ

Nke mbu, ekwesiri iburu n'uche ogwu ndi na-agbada egbugbere ọnụ. Ndị a gụnyere:

1. fibrates;
2. akpụ
3. ọgwụ anion gbanwere ọgwụ ọgwụ na resins na-ebelata ihe oriri nke cholesterol na eriri afọ;
4. nicotinic acid;
5. probucol.

Site na usoro eji arụ ọrụ, enwere ike ike ọgwụ ndị a na ọtụtụ mpaghara:

• ọgwụ ndị na-egbochi mmepụta cholesterol dị ala (ọ na-akpọkarị ya ihe ọjọọ): statins, fibrates, nicotinic acid, probucol, benzaflavin;
• ndị na-ahụ maka ihe nwere ike ịkwụsịlata iwere cholesterol: guar, ndị na - eso acid bile;
• Ndị na-edozi abụba metabolism na-abawanye cholesterol dị elu: lipostabil, ihe dị mkpa.

Ndị na - eme usoro nke bile acids

A na-akpọkarị ọgwụ ọgwụ bile acid na-eme ka ọnụnọ mgbanwe anion. Ozugbo ọgwụ ndị a batara na eriri afọ, a na-ejide acid ma mesịa kpochapụ ahụ.

Nke ikpeazu na-emeghachi omume na usoro a site na ịme ka njikọta nke bile acids ọhụrụ si n'ụlọ ahịa cholesterol dị adị. A na-ewere cholesterol site n'ọbara ọbara, nke na-enyere aka belata ya.

Industrylọ ọrụ na-emepụta ọgwụ na-enye ọgwụ ogwu cholestyramine, yana colestipol, iji belata cholesterol ọbara. Enwere ike iji ha mee ihe na mkpanaka 2-4, yana mmachi nke mbido mmiri na mmiri.

Enweghi ike itinye mmiri resị Anion n'ime ọbara ma 'rụọ ọrụ' naanị na eriri afọ. N'ihi nkọwa a, ọgwụ anaghị enwe ike ọfụma n'ahụ n'ahụ.

Nsonaazụ ndị nwere ike ịgụnye:

• bloating;
• ọgbụgbọ
• afọ ntachi.

Ọ bụrụ na -eri ọtụtụ usoro acid bile na nnukwu doses ogologo oge, mgbe ahụ na nke a, enwere ike imebi nnabata nke ụfọdụ vitamin, yana acid.

Ọgwụ na otu a belatara mkpokọta nke akpọrọ cholesterol ọjọọ, ọnụnọ nke triglycerides n'ime ọbara na-adịgidekwa otu ọkwa.

Ibelata cholesterol

N'ihi nwayọ nke cholesterol na nri, otu ọgwụ a nwere ike belata ịta ya. Nke kachasị dị irè ga-abụ guar. Ihe mgbakwunye nri a bụ nchekwa kpamkpam ma esite na mkpụrụ nke agwa hyacinth. Ngwakọta nke ngwaahịa a gụnyere polysaccharide, nke, na kọntaktị mmiri mmiri, na-agbanwe n'ime jelii.

Guarem nwere ike wepu molekil cholesterol na mgbidi nke eriri afọ. Na mgbakwunye, ọgwụ ahụ:

• na-eme ka mwepu nke acid bile na-eme ngwa ngwa;
• kwusi nri;
• na-enyere aka belata nri ị na-eri.

Onye na - egbochi nnabata a dị n'ụdị nnyịnya iji tinye ya n'ihe ọ toụ .ụ. Enwere ike ijikọ ọgwụ a na ụzọ ndị ọzọ.

N'oge eji, nsonaazụ na - ọgaghị ekwe omume, dịka ọmụmaatụ, igbachapụ stool, mgbu na eriri afọ, ọgbụgbọ na bloating. Mgbaàmà ndị a pere mpe ma ọ na-esiri ike. Ọbụna na enweghị ọgwụgwọ, ha na-agafe ngwa ngwa, ebe enwere sistemụ sistemụ ọbara ọbara na-agbadata.

Nicotinic Acid

Nikotinic acid na usoro ya nile, dịka ọmụmaatụ:

1. arifimox
2. niceritrol
3. enduracin

Na nkenke, ha bụ vitamin B .. ọgwụ ndị a na - ebelata cholesterol dị ala ma na - emekwa ka sistem fibrinolysis, nke na - enyere aka belata ohere nke thrombosis. Uzo di nma karia ogwu ndi ozo na - ewedata mmanu ozo cholesterol n’ime obara ya.

Usoro ọgwụgwọ a na-eji nicotinic acid na-ewe ogologo oge iji mmụba na-akwụ ụgwọ na usoro onunu ogwu. Mgbe ịmechara nkwadebe ahụ, tupu nke ahụ ịghara ị drinkụ ihe ọ hotụ hotụ na-ekpo ọkụ, karịsịa kọfị eke.

Niacin nwere ike ịkpasu mgbidi nke afọ, na - ewepu ya iji ọnya afọ na ọnya afọ. N'ọtụtụ ndị ọrịa, enwere ike ịhụ nchapu ihu na mbido ọgwụgwọ, otu ihe mgbaàmà a ga-apụ n'anya ka oge na-aga. Iji gbochie ịcha ọbara ọbara, ịkwesịrị ị drinkụ 325 mg nke ọgwụ aspirin ọkara otu awa tupu ị usingụ ọgwụ ahụ.

Ihe ndị bụ isi contraindications maka nicotinic acid gụnyere:

• ịba ọcha n'anya;
• gout
• obi obibia nsogbu.

Enwere ọgwụ nke nwere ike ibute obere ntakịrị ihe ọ na-akpata ma na-anọ ogologo oge - nke a bụ enduracin.

Probucol

Probucol anaghị emetụta triglycerides, mana ọ na-edozikwa nguzozi nke cholesterol dị mma na nke ọjọọ. Mbadamba ụbụrụ na-egbochi peroxidation nke abụba ma gosipụta ọgwụ mgbochi atherosclerotic, na-emetụta mbelata nke cholesterol ọbara.

Enwere ike ịnweta nsonaazụ ọgwụgwọ na Probucol mgbe ọnwa 2 gasịrị ma nwee ike ịdịru ọnwa 6 mgbe ịkwụsị iji ya. Enwere ike ijikọ ngwaọrụ ahụ n'ụzọ zuru oke na ọgwụ ndị ọzọ na-ebelata cholesterol.

N'oge usoro ọgwụgwọ, enwere ike ịgbatị oge nke mkpụrụ obi obi ya na mmepe nke obi arrhythmias. Iji gbochie ọnọdụ a, ọ dị mkpa iji nyocha elektrokiogram dịkarịa ala 1 n'ime ọnwa isii.

Agaghị enwe ike ịkọpụta probucol n'otu oge na cordarone.

Mmetụta ndị ọ na-enwe n'ahụ ahụ gụnyere mgbu n'ime oghere afọ, ọgbụgbọ na afọ ọsịsa.

Ekwesighi iji ọgwụ a:

• arrhythmias ventricular;
• oge ihe ana - eme ugboro ugboro maka ischemia myocardial;
• HDL dị ala.

Fibrates

Fibrates nwere ike ịnagide ọkwa nke triglycerides, yana ntinye nke LDL na VLDL. Enwere ike iji ha na nnukwu hypertriglyceridemia. A pụrụ ịkpọ nke kachasị ewu ewu mbadamba nkume ndị dị otú a:

• gemfibrozil (lopa, gevilon);
• fenofibrate (Tipantil 200 M, Tricor, Exlip);
• cyprofibrate (lipanor);
• choline fenofibrate (trilipix).

Enwere ike ịpụta nsonaazụ ọjọọ nke oriri, na mgbu na akwara, ọgbụgbọ na mgbu n'ime oghere afọ. Fibrates nwere ike ime ka ihe akụrụ na akwara jupụta ya na akụrụ. N’oge na-adịghị anya, enwere ike ịhụ mgbochi nke hematopoiesis.

Enweghị ike ịkọ ọgwụ ndị a maka ọrịa nke akụrụ, eriri afọ na nsogbu ọbara.

Ọnọdụ

Statins bụ ọgwụ kachasị cholesterol na - agbadata ọgwụ. Ha na-enwe ike igbochi enzyme pụrụ iche nke na-aza maka mmepụta nke abụba dị ka abụba na imeju, ma na-ebelata itinye uche ya na ọbara. N'otu oge ahụ, ọnụọgụ nke ndị na-anabata LDL na-abawanye, nke na-enye nkwado maka mmụba ngwa ngwa nke cholesterol dị ala.

Dịka iwu, usoro ọgwụ ndị a ka edepụtara:

• simvastatin (vasilip, zokor, aries, simvageksal, simvakard, simvakor, simvastatin, simvastol, simvor, simlo, sincard, holvasim);
• lovastatin (kadiostatin, choletar);
• pravastatin;
• atorvastatin (anvistat, atocor, atomax, ator, atorvox, atoris, vazator, lipoford, lypimar, liptonorm, novostat, torvazin, torvakard, tulip);
• rosuvastatin (akorta, obe, mertenyl, rosart, rosistark, rosucard, rosulip, roxer, rustor, tevastor);
• pitavastatin (livazo);
• fluvastatin (leskol).

A na-eji Simvastatin, yana lovastatin mee ihe. Ọgwụ yiri ya maka mbadamba cholesterol dị elu na-abanye metabolites na-arụ ọrụ. Pravastatin bụ mkpụrụ osisi fungal nke bụ n'onwe ya ihe na - arụ ọrụ.

Enwere ike ịkwado Statins otu ugboro kwa abalị. A na-akọwa usoro ọgwụgwọ a site n'eziokwu ahụ bụ na ọnụ ọgụgụ kachasị elu nke cholesterol ọbara na-apụta n'abalị. Ka oge na-aga, enwere ike ịbawanye ụba nke statins, na arụmọrụ ya ga-enweta mgbe ụbọchị ole na ole mbụ nke nchịkwa, na-erute karịa n'ime otu ọnwa.

Statins adịghị mma maka ụmụ mmadụ, mana ọ dị ezigbo mkpa ka ị ghara iji nnukwu doses, karịsịa na fibrates, nke jupụtara na nsogbu imeju.

Patientsfọdụ ndị ọrịa nwere ike ịnwe ike na mgbu n’ahụ. N'ọnọdụ ụfọdụ, ọnya afọ, afọ ntachi, ọgbụgbọ, yana agụụ nri zuru oke, ehighị ụra nke ọma na isi ọwụwa.

Ọgwụ ndị a iji belata cholesterol enweghị ike imetụta carbohydrate na purine metabolism, nke na-enye ha ohere iji ha maka ogo oke ibu, gout na ọrịa shuga. Rịba ama na ọ bụrụ na achọpụta cholesterol dị elu n'oge afọ ime, ọ dị mkpa ịkpọtụrụ dọkịta na ọgwụ.

Ọ bụrụ na anyị na-atụle usoro ọgwụgwọ oge gboo, mgbe ahụ enwere ike ijikọ statins na ọgwụgwọ nke atherosclerosis dị ka monotherapy ma ọ bụ yana ọgwụ ndị ọzọ.

Pharmacology na-enye nkwakọ ndị mere eme nke sitere na:

1. lovastatin na acid nicotinic;
2. ezetimibe na simvastatin;
3. pravastatin na fenofibrate;
4. rosuvastatin na ezetimibe.

Enwere ike ịhapụ mgbanwe nke statins na acetylsalicylic acid, atorvastatin na amlodipine.

Ojiji nke ọgwụ eji eme nkwalite abụghị naanị uru na usoro ịchekwa ego, kamakwa ọ na-akpata opekempe nsonaazụ ya.