A na-akpọ ọrịa shuga mellitus "ọrịa" nke narị afọ XXI. N'ihi ya, ị medicationụ ọgwụ bụ otu n'ime isi ihe na-agwọ ọrịa. Nkwadebe nke ntuziaka Pioglitazone nwere nkọwa zuru oke banyere ojiji ha.
Ọgwụ kachasị maka ọrịa shuga nke nwere ihe a bụ Aktos, Pioglar, Diab-norm, Diaglitazone. Pioglitazone n'onwe ya bụ ntụ ntụ nke na-acha ọcha, nke na-adịghị mma.
Ọ fọrọ nke nta ka ọ ghara ịgbaze na mmiri, mana a na-agwagbu ya nke ukwuu na dimethylformamide. Banyere ethanol na-eme nri, acetone na acetonitrile, ihe dị na ha nwere ntakịrị ntakịrị.
Pioglitazone bụ otu klas nke thiazolidinediones (glitazones); egosiri iji ya were belata shuga ọbara. Ebe ọ bụ na e ji ụdị ọrịa shuga nke abụọ mebie mmetụta nke mkpụrụ ndụ ahụ na insulin, glitazones na-eme ka ndị na-anabata ya dị na akụrụngwa ha. N'ihi ya, anụ ahụ na - emegharị insulin homonụ.
Ọtụtụ ndị ọrịa na-ajụ ajụjụ a, enwere ike ị drugụ ọgwụ nwere pioglitazone n'ụdị ọrịa mbụ? Glitazones bụ ọgwụ naanị maka ụdị ọrịa shuga nke abụọ. A na-eji ha dị ka ọgwụ bụ isi, yana mgbakwunye na metformin, sulfonamide ma ọ bụ insulin. Ndị ọrịa na-amalite ị theụ ọgwụ ma ọ bụrụ na mmega ahụ na nri kwesịrị ekwesị enweghị mmetụta achọrọ - shuga ọbara nkịtị.
Glitazones jiri ọgwụ ndị ọzọ na-eme ka okpete dichasị nke ọma kwụsị iwepụ insulin. Ha na-ebelata oke abụba n’ime ọbara mmadụ na imeghari anụ ahụ adipose site n’ọkpụkpụ nwa n’ime mpaghara subcutaneous. Na mgbakwunye, bekee belata triglycerides.
Ntuziaka maka iji ọgwụ ahụ
Isụ ọgwụ ahụ gosipụtara naanị mgbe ya na ndị dibia na-aga, bụ onye depụtara usoro ọgwụgwọ kwesịrị ekwesị, na-eburu n'uche njirimara onye ọrịa ahụ. N'ihe banyere iji Pioglitazone mee ihe, a ga-eji nlezianya mụọ ntuziaka maka iji zere nsogbu ọ bụla.
A na-egosi ọgwụ maka iji ya ma ọ bụrụ na usoro ọgwụgwọ mbụ sitere na 15 ruo 30 mg, yana kacha (kwa ụbọchị) bụ 45 mg. Ọ bụrụ na ijikọta ihe ahụ na ọgwụ ndị ọzọ, dose ahụ ekwesịghị ịkarị 30 mg. A na-egosi Pioglitazone maka otu ugboro kwa ụbọchị.
N'oge usoro ọgwụgwọ, ịkwesịrị ịnọgide na-agbaso nri na mmega ahụ. Ọ dị ezigbo mkpa ịlele ọkwa haemoglobin dị n'ọbara.
E gosipụtara Pioglitazone site na nlekọta pụrụ iche maka ndị ọrịa nwere ọria, imeju nwere ụba enzyme. Site na mmepe nke hypoglycemia n'oge ọgwụgwọ ngwakọta chọrọ mbelata usoro nke insulin ma ọ bụ sulfonamides. Ọ bụrụ na onye ọrịa nwere ọrịa jaundice, enwere ike ịgbatị mmetụta na-adịghị mma n'ahụ ahụ, yabụ a ga-akwụsị ọgwụgwọ. Ọrịa nwere ọrịa okike n’ebido oge ịhụ nsọ ga-adị ime ime, yabụ ekwesịrị iji ọgwụ mgbochi.
Ngwurugwu mgbochi na nsonaazụ ya
Tupu iji ọgwụ dabere na Pioglitazone, ịkwesịrị ịkpọtụrụ dọkịta gị. Ihe a nwere otutu contraindications: anabataghị Pioglitazone, ụdị ọrịa shuga mellitus 1, ọrịa ketoacidosis (metabolism na-akpata metabolism na-akpata n'ihi enweghị insulin), ọrịa ọrịa akwara na-arịa oke.
Etu ọkwa ALT (alanine aminotransferase) dị okpukpu abụọ karịa 2.5, nke nwere ike igosipụta mmepe nke ọtụtụ ọrịa ndị siri ike, afọ ruo afọ 18 (ekwenyebeghị ịdị mma nke ihe dị na ndị ọrịa nke afọ a), oge iko na inye nwa ara.
Ọ bụrụ na eji Pioglitazone eme nke ọma ma ọ bụ maka ihe ọ bụla ọzọ, onye ọrịa ahụ nwere ike ịnweta mmeghachi omume ọjọọ ndị a:
- hypoglycemia - mbelata nke glucose ọbara;
- ọzịza, yana ijikọ insulin na-eme ka ọghọm dị ihe ruru 15.3%;
- anaemia - haemoglobin dị ala n'ime ọbara mmadụ;
- ibelata larịị bilirubin;
- mbelata alanine aminotransferase (ALT) - enzyme hypogenic;
- iweda aspartate aminotransferase (AST) - enzyme nke na-ahụ maka njikọ nke amino asịd;
- mbelata nke alkaline phosphatase (ALP) - enzyme nke na-etisasị phosphates site na protein, alkaloids, wdg;
- transferase gamma glutamyl belatara.
Ọzọkwa, nkwadebe nwere ngwakọta nke sulfonamide, metformin, insulin, na-eduga n'ọrịa hypoglycemia.
Ọzọkwa, mgbe ejiri ya, ọ nwere ike ịgbalịsi ike iwelata ịdị irè nke ọgwụ mgbochi afọ.
Nyocha, uru na ọghọm ya
Nyocha nke ọtụtụ ndị ọrịa ji ọgwụ Aktos, Pioglar na ọgwụ ndị ọzọ, ọkacha mma. N’etiti uru dị, ọ ga-ekwe omume igosipụta ịdị irè nke iwetulata ọgwụ insulin n’etiti ọgwụ niile na --ebelata shuga a na -ewere ọnụ.
Mana enwere ụfọdụ ndọtị nke glitazones, nke egosiri na ihe ndị a: ha dị ala karịa ọgwụ ndị nwere metformin na sulfonylurea, haemoglobin na-agbada site na 0-1-1.5%, mgbe ị na-eji ihe dị ka kilogram 1 n'arọ na-achọpụta n'ihi ụba nke abụba. na njigide mmiri n’ime ahụ.
Ya mere, tupu ị glitazones, ịchọrọ ịkpọ dọkịta ma gụọ nyocha nke ndị ọrịa ririla ha.
Onye ọrịa ahụ na-a theụ ọgwụ Pioglitazone, ọnụahịa nke ọ dabere na ọgwụ ahụ, ga-ekpebi ụdị ọgwụgwọ ọ ga-eji mee ihe. Ọnụ ego nke mbadamba Pioglar (iberibe 30 nke 30 mg nke ọ bụla) bụ 1083 rubles, Actos (mkpụrụ ego 28 nke 30 mg nke ọ bụla) bụ 3000 rubles. Na ụkpụrụ, onye klas nwere ike ịzụta ọgwụ ndị a. Ọnụ ego ha dị elu bụ n'ihi eziokwu na ọgwụ ndị a na-ebubata, a na-emepụta Pioglar na India, Actos - na Ireland.
Ndị ọnụ na-adịghị ọnụ bụ ọgwụ ndị anwụpụtara na Russia. Ndị a gụnyere:
- Iwu Diab;
- Astrozone;
- Diaglitazone.
Mgbe etinyere ya, a ga-enye nsonaazụ hypoglycemic. Diaglitazone, nke na-efu nkezi 295 rubles, nwere ike ịbụ nnukwu ụzọ maka ọgwụ ndị ka ọnụ dị ọnụ. Astrozone na Diab-norm nwere otu contraindications na mmetụta dị n'akụkụ ya.
Diagnitazone nwere ike ibelata ịdị irè nke iji mgbochi afọ a, nke ekwesịrị iburu n'uche.
Pioglitazone analogues
N'ihi nnabata ọ bụla na nsonaazụ ya, enwere ike amachibido iji Pioglitazone. Ya mere, dọkịta ahụ depụtara ọgwụ ndị ọzọ nwere rosiglitazone.
A tinyekwara ihe a n’ime otu thiazolidinediones (glitazones). Mgbe ị na-eji ya, a ga-adọpụ otu mmetụta ahụ site na pioglitazone, ya bụ, mkpali nke ndị na-anabata ụyọkọ na ndị na-anabata anụ ahụ iji kpochapụ nguzogide insulin.
Ọgwụ ndị nwere rosiglitazone bụ:
- Avandia
- Roglit.
Tupu iji ha, ịkwesịrị ịgakwuru dọkịta ma gụọ ntuziaka maka ojiji.
Nhazi Biguanide na-ebelata insulin iguzogide. Metformin, nke bụ akụkụ nke ngwaahịa a, na-ebelata imeju glucose site na umeji. Jiri ọgwụ ndị a kpachara anya, ebe ọ bụ na biguanides nwere mmetụta dị njọ na-emetụta ọrụ obi ndị agadi, a na-enwe mmetụta na-adịghị mma na arụ ọrụ akụrụ na mmepe n'ihi lactic acidosis nwekwara ike ịgbalị. Nkwadebe na metformin ihe na-arụ ọrụ gụnyere Bagomet, Glucofage, Metformin-BMS, NovoFormin, Siofor na ndị ọzọ.
Ọzọkwa na-ebelata ọbara Acarbose shuga. Usoro nke ihe o mere bụ igbochi enzymes ndị na-enyere aka ịgbanye carbohydrates na ngha. Hypoglycemia ga-ekwe omume site na iji ọgwụ ndị ọzọ na insulin mee ihe ọzọ. Iji gbochie nhụsianya ndị metụtara nsonaazụ afọ, ọ ka mma ịmalite were obere usoro.
N'ịgwọ ụdị ọrịa shuga 2, enwere ike iji ọgwụ ọgwụ nwere pioglitazone ma ọ bụ analogues ya, ma Diaglitazone ma ọ bụ Metformin. Ebe ọ bụ na ọgwụ ndị a nwere ọnụ ọgụgụ buru ibu nke ọgwụ mgbochi na mmetụta ndị ọ na-akpata, a na-atụkarị aro ka ị jiri ha mgbe ịgachara ọrịa shuga. ya na dọkịta. Vidio dị n’isiokwu a chịkọtara mkparịta ụka a
