Ndi mmadu a inara na ogwu ogbugba insulin nwere olile anya na ọgwụ insulin ga-egosi n’oge na-adighi anya. Ndị ọkà mmụta sayensị si Australia, India, Russia, Israel, na Denmark anọwo na-arụ ọrụ na nsogbu a ruo ọtụtụ iri afọ.
Mgbalị ndị ndu ndị sayensị ụwa n'ihe ọmụmụ a ga-emejupụta n'oge na-adịghị anya.
Ndị kacha mepụta insulin mbadamba ụbara bụ ndị mmepe nke India na Russia mebere.
Na -eme homonụ nke Tableted
Ihe ngosi uzo ato nke monoler insulin nke mmadu
Nchoputa nke ndi sayensi Russia mechiri mgbe eweputara insulin zuru oke site na aha mbu "Ransulin", nke na-anwale ule ozo.
Ihe bu ihe iteghete na mpaghara a bu okike ndi ihe nlere anya nke ndi sayensi America na Mahadum California. Ha ji shei nchebe meepụta ọmarịcha ihe ịtụnanya, nke na-echebe ihe ndị dị na nsonaazụ gastric ma jiri nwayọ na-ebuga ya na obere eriri afọ.
N'ime capsule bụ mucoadhesive pụrụ iche (polima pụrụ iche nke nwere ike ijide ihe ọ bụla) "patches" etinyere na insulin.
Ngwurugwu polymer nke esi eme ka ihe a na-ekwu na-enwe ikike ịrapara na mgbidi eriri afọ.
N'akụkụ mgbidi eriri afọ, ọ na-echebe insulin site na mmetụta mbibi nke enzymes n'otu akụkụ, na-abanyekwa homonụ ahụ n'akụkụ nke ọzọ banye n'ọbara.
Ciplekpụrụ nke ịrụ ọrụ
Insulin bụ homonụ nke pịrias na-emepụta. Site n’afere ọbara, ọ na-erute anụ ahụ na akwara ma na-ahụkwa n’ime ka ike carbohydrates banye n’ime ha.
N'ọnọdụ ọgba aghara nke metabolic, ego ekenyela nwere ike ọ gaghị ezu maka ebumnuche ndị a. Enwere ọrịa shuga. Enwere mkpa maka ọgwụgwọ insulin.
Provenzọ kachasị dị mma ma bụrụkwa nke a tụkwasịrị obi iji nọgide na-enwe shuga ọbara bụ iwebata ụfọdụ, akọwapụtara nke ọma maka onye ọrịa ọ bụla, usoro homonụ.
A na-amanye ndị ọrịa ịisterụ ọgwụ ọtụtụ oge n'ụbọchị iji sirinji pụrụ iche. Ọ bụghị ihe ijuanya na ha niile nwere nrọ maka oge a ga-eji ọnụ nweta ọgwụ ọjọọ.
Ọ ga - adị ka ọ na - ebunye ihe ahụ n'ụdị mbadamba - a na - edozi nsogbu ahụ. Mana ọ bụghị nke ahụ dị nfe. Afọ na-achọpụta insulin dị ka protein nkịtị nke kwesịrị ịgbari.
Ndị ọkà mmụta sayensị ji isi ike chọọ ihe ngwọta maka ajụjụ a - enwere ike ịme ya ka acid acid wee ghara ime ya?
Emere nyocha n'ọtụtụ usoro.
Nke mbu, odi nkpa ichota shei nke na anoghi egwuta ebe ikuku.
Anyị kpebiri itinye insulin na nke a na-akpọ liposome. Nke a bụ capsule abụba na - eme site na akpụkpọ membranes na - echebe ihe megide acid acid.
Ihe ozo nke ogugu ahiri na polyelectrolyte ghọrọ nchedo antienzyme. A kpọrọ ya "oyi akwa". Ọ ghaghi igbari, ogwu ya ewee. Ma absorption emeghị. O were ọtụtụ ọrụ na oge iji rụpụta ezigbo nsonaazụ.
Ndị ọkà mmụta sayensị Russia ewepụtala hydrogel maka ebumnuche ndị a. A gbakwunye polysaccharide, nke ebum n’obi ya bụ iji kpalie ndị na-anabata ya nọ n’elu mgbidi nke obere eriri afọ. Ejiri ọgwụ n'ime hydrogel nke mere na ọ naghị agwakọta ya na polysaccharide.
Usoro nanocoating nke microparticles nke insulin ma ọ bụ insulin na chitosan na kablales polysaccharide nanoengineered.
Ejiri Folic acid (vitamin B9) mee ihe dika polysaccharide, ihe ejiri mara amara na-abanye na obere eriri afọ. Ulo a bara ezigbo uru ebe a.
Nha niile nke gels na polymer ejiri nwayọ pụta ngwaahịa ngwaahịa ire ere. A nabatara insulin n'ime ọbara. Ọ na-anọgide ka gbakọọ ma gbakọọ usoro a chọrọ.
E guzobere ya na nnwale ka ịba ụba nke insulin na mbadamba ihe.
Uru nke ọgwụ a na mbadamba
Abamuru nke ị oụ ọgwụ ahụ bụ ihe doro anya.
Ike gwụrụ ndị ọrịa site na inje mgbe niile.
Ọgwụ a na-adịghị egbu mgbu nke ọgwụ na mbadamba nkume ga-eweta:
- na-ezere iwere oge niile na sirinji;
- nlekọta na-enweghị isi nke agịga na-akpali akpali;
- enweghị usoro maka ịhọrọ saịtị ntụtụ kwesịrị ekwesị;
- nhichapụ nke ntị siri ike mgbe ị na-ewebata agịga n'otu akụkụ.
Nwere ike ilo mbadamba mbido n’oge dabara adaba na ebe ọ bụla. Enweghị mkpa ịchọ ụlọ pụrụ iche. Nwere ike chekwaa ma bute gị n'etinyeghị mbọ gị. Ọ dị mfe nwatakịrị ị toụ ọgwụ ọ thanụ thanụ karịa imerụ ahụ na-enweghị mmerụ ahụ.
N'ime nyocha, a chọpụtara ya: na dose na mbadamba ọrụ dịịrị onye ọrịa, ọ ga-abawanye ihe dịka ugboro anọ. Achọpụtakwala na nchịkwa insulin nke ogologo oge na-akwalite mmetụta hypoglycemic.
Ndị ọrịa shuga nke ụwa niile ga-enwe obi ụtọ ịgbanye insulin na mbadamba. E bidobeghị ya mepụta oke ọnụ, enweghị aha. Ọ fọrọ nke nta ka ọ bụrụ enweghị ike ịnweta nkwadebe insulin na mbadamba - ọnụ ahịa ha ka dị oke.
Ma enwere olile anya nke iwepu inpa mgbu na-egbu mgbu pụtara.
