1 ampoule (12 ml) nke Berlition 300 nwere ihe ndị na-arụ ọrụ: nnu nke ethylenediamine nke α-lipoic (thioctic) acid 0.388 g (na of-lipoic (thioctic) acid) - 0.300 g na ihe inyeaka: mmiri maka injection, propylene glycol, etinne acid.
Mbadamba mkpuchi, nke ọ bụla n’ime ha nwere acid α-lipoic (thioctic) nke na - arụ ọrụ - 300 mg ma ọ bụ 600 mg;
Na mgbakwunye, enwere ihe inyeaka:
- steeti magnesium;
- lactose monohydrate;
- sodium croscarmellose;
- microcrystalline cellulose;
- silloidal anhydrous silica;
- povidone (uru K = 30);
Opadry OY-S-22898 "odo" na shei, mejupụtara:
- hypromellose,
- sodium dodecyl sulfate,
- titanium dioxide (E 171),
- acha odo odo-epe (E 110),
- acha ọbara ọbara nke quinoline (E 104),
- paraffin mmiri.
Ngwongwo ogwu
Mlọ ọgwụ Ngwakọta bụ isi nke ọgwụ ahụ bụ ọgwụ antioxidant sitere n'okike na-ejikọ radicals n'efu. A na-emepụta Acid site na nsonaazụ oxidative na α-keto acids.
Attentionaa ntị! Nyocha ndị dọkịta na-egosi na ọgwụ nwere mmetụta bara uru na iweda shuga dị ala, na-abawanye ọkwa glycogen na imeju insulin na-eguzogide.
Site na akụrụngwa kemịkalụ ha, mbadamba osisi 300 na 600 dị nso na vitamin B.
- Soro na mmezi nke carbohydrate na metabolism metabolism.
- Mee ka ọrụ imeju dịkwuo mma, na-akpali metabolism metabolism.
- Ha nwere hypoglycemic, hepatoprotective, hypocholesterolemic, mmetụta hypoliplera.
Ojiji Berlition 300 na 600 na infusions maka irighiri akwara ike belata ogo mmeghachi omume ọjọọ.
Mlọ ọgwụ Berlition 300 na mbadamba 600, n'ụzọ ziri ezi, ihe ndị ha na-arụ ọrụ, nwere ikike "ibufere" site na imeju. Thioctic acid na ihe ndị mejupụtara ya bụ ihe fọrọ nke nta ka ọ bụrụ kpam kpam (80-90%) akụrụ wepụrụ.
Ngwọta nke ịgba ntụtụ. Oge ị ga-eji nweta ntinye uche kachasị na ahụ gị na nhazi ngwa ngwa bụ nkeji 10-11. Mpaghara dị n'okpuru ebe a na-ere ọgwụ (oge ịta) bụ 5 μg h / ml. Ntinye uche kachasị bụ 25-38 mcg / ml.
Mbadamba ụma maka nchịkwa ọnụ na-abanye ngwa ngwa ma banye na ngwu. Mgbe ejiri nri, adsorption na-ebelata. A na-enweta mkpo ọgwụ kachasị anya mgbe nkeji 40-60 gasịrị. Bioavailability bụ 30%.
Nkeji ọkara bụ nkeji iri abụọ na ise. Mkpokọta plasma zuru ezu bụ 10-15 ml / min.
Ihe ngosi maka iji ogwu
Ọrịa mamịrị (polyneuropathy) nke ọrịa mamịrị na-akpata ọrịa shuga ma ọ bụ ahoụrụma. A na-ejikwa ọgwụ mgbochi ọgwụ. The doseụ ọgwụ kwa ụbọchị bụ 300 ma ọ bụ 600 mg. 1 ampoule nwere 300 mg.
A na-agbazeze mmiri na 0.9% sodium chloride solution ma nye onye ọrịa ahụ site na ịmịpụ ọbara intravenously. Oge iwebata dị ihe dị ka nkeji iri atọ.
Na mbido ọgwụgwọ, a na-enye Berlition maka izu 2-4. Mgbe nke ahụ gasịrị, ị nwere ike ịga n'ihu na nchịkwa ọnụ nke mbadamba ihe Berlition na ọnụọgụ 300-600 mg kwa ụbọchị.
A na-egosi mbadamba mkpụrụ osisi maka iji 600 mg otu ugboro kwa ụbọchị. Ndị a bụ mbadamba abụọ. Ọgwụ a ga-a onụ na ukpọk afo, ihe dị ka ọkara otu awa tupu nri.
A ga-elorịrị mbadamba ndị ahụ kpamkpam na-ata ata. Na-a plentyụ mmiri buru ibu. Naanị dọkịta na-ekpebi oge nke usoro ọgwụgwọ ahụ.
Featuresfọdụ atụmatụ nke ọgwụ
Nyocha nke ndị dọkịta na ndị ọrịa banyere Berlition na-adịkarị mma, mana, dịka ọgwụ ọ bụla ọzọ, o nwere njirimara nke ya. N'oge usoro ọgwụgwọ, ndị ọrịa kwesịrị ịhapụ ị beụ ihe ọholicụ alcoụ na-aba n'anya.
Ndị ọrịa mamịrị chọrọ nlebara anya maka ọkwa shuga plasma kwa ụbọchị. Nke a dị ezigbo mkpa na mmalite ọgwụgwọ. Mgbe ụfọdụ ọ nwere ike ịdị mkpa belata ntụtụ nke insulin ma ọ bụ ọgwụ hypoglycemic nke ndị ọrịa nọ n’ime ya were. N'ihi ya, a na-egbochi ihe ize ndụ nke hypoglycemia.
Ekwesịrị iji gbochie mgbochi nke 300 ma ọ bụ 600 na ụzarị UV. A na-eme nke a site na ikpuchi kalama na foil aluminom. A na-echekwa ihe ngwọta a n'ụzọ echekwara maka 7 awa.
Nsonaazụ
Ọtụtụ mgbe, ha anaghị eme eme, mana n'ọnọdụ adịghị obere, mgbe ịghasị ihe ngwọta, ọnya, obere ọbara ọgbụgba dị na akpụkpọ ahụ, ọnya ọgbụgba ọbara, thrombocytosis ga-ekwe omume. Site na nchịkwa ngwa ngwa, enwere ike ịnwe nrụgide intracranial na iku ume iku ume.
Nyocha ndị ọrịa na ndị dọkịta kwuru na mgbaàmà ndị a niile na-apụ n'enweghị nsogbu ọ bụla.
Enwere mmeghachi omume mpaghara na-egosi na mpaghara ịgba ahụ. Ọ nwere ike bụrụ ọrịa urticaria ma ọ bụ ekpughe ihe nfụkasị ọzọ, ruo ujo anaphylactic. Mmepe nke hypoglycemia, nke enwere ike ibute ya site na mmụba na nnabata glucose, apụtaghị.
A na-anabatakarị mbadamba mbadamba na-enweghị mmetụta ọjọọ. Ma mgbe ụfọdụ nsogbu ndị na-esonụ nwere ike:
- okpu iku ume;
- obi mgbawa;
- ọgbụgbọ
- vomiting
- hypoglycemia n'oge afọ ime;
- urticaria.
Mmekọrịta na ọgwụ ndị ọzọ
Mkpụrụ osisi "in vitro" na-emeghachi ihe na ionic metal ogige. Dịka ọmụmaatụ, enwere ike ịtụle cisplatin. Ya mere, iji siminti jiri cisplatin belata uto nke ikpeazụ.
Mana mmetụta nke ọgwụ hypoglycemic ọgwụ na insulin, Berlition 300 ma ọ bụ 600, na ntụle, na-eme ka ọ dịkwuo mma. Ethanol, nke a na-ahụ na mmanya na-egbu egbu, na-ebelata mmetụta ọgwụgwọ nke ọgwụ ahụ (gụọ nyocha).
Ọrụ ure nke Berlition, mgbe a na-emeghachi ya na shuga, a na-agwakọta ihe fọrọ nke nta ka ọ bụrụ mmiri. Site na nke a, enweghi ike ikpokọta ihe ngwọta nke thioctic acid yana infusion nke dextrose, Ringer, na ụdị ngwọta ndị ọzọ yiri ya.
Ọ bụrụ na apụrụ Berlition 300, mbadamba 600 n'ụtụtụ, ị nwere ike iji ngwaahịa mmiri ara ehi, magnesium na nkwado ígwè naanị mgbe nri ehihie ma ọ bụ na mgbede. Banyere ngwaahịa ara ehi, nke a bụ n'ihi eziokwu na ha nwere ọnụọgụ kalsel dị ukwuu.
Nkwekọrịta dịnụ
- Oge ime na inye nwa ara. Ọ bụ ezie na egosighi mmetụta ọjọọ nke ọgwụ ahụ, ebe ọ bụ na enweghị nyocha na ọmụmụ nke atụmatụ dị otú ahụ.
- Nnukwu uche banyere ihe nke Berlition.
- Edeghị ọgwụ ahụ maka ụmụaka (enweghị nyocha na nchekwa na arụmọrụ).
Enwere ike dogba Oria
- ọgbụgbọ
- vomiting
- isi ọwụwa.
Enweghị ọgwụgwọ ọ bụla akọwapụtara, ọ bụ ihe mgbaàmà a na-agwọ.
Nchekwa, oge ezumike, nkwakọ ngwaahịa
Ọgwụ a dị na listi B. Ọ ga - echekwa ya na ọnọdụ okpomọkụ agaghị akarị 25 Celsius C, n'ebe gbara ọchịchịrị ka ụmụaka ghara inweta.
Usoro eji abanye n'ụdị ntọhapụ:
- ihe ngwọta maka injection - afọ 3;
- ọgwụ - 2 afọ.
A na-ewepụta Berlition naanị site n'inye ọgwụ n'ụlọ ọgwụ. Ihe ngwọta maka injection dị na ampoules gbara ọchịchịrị nke 25 mg / ml. Igbe kaadiboodu (trays) nwere ampoules ise. Nke a bụ ntuziaka maka ojiji.
A na-eji mbadamba ụrọ ma ọ bụ ngwakọta mpempe akwụkwọ mejupụtara paịlị 10 n'ime blisters nke ejiri PVP opaque mee ma ọ bụ foil aluminom. Nkwakọ kaadiboodu nwere 3 blisters na ntuziaka maka ojiji.
