N'ihi ọtụtụ ọmụmụ na ụlọ ọrụ ọgwụ, ugbu a enwere ọgwụ ndị dị irè megide ọrịa shuga. Site n'enyemaka nke ọgwụ ụfọdụ, ịnwere ike ịnwe ọkwa insulin n'ime ọbara.
Otu ebe pụrụ iche n'etiti ọgwụ ọjọọ bụ ọgwụ ndị ọgbara ọhụrụ nwere iji dochie anya insulin dị n'ime. Enwere ike iji insulin Glargin dị ka ihe eji eme onwe ya, mgbe ụfọdụ ọ na-adị na ọgwụ ndị ọzọ, dịka ọmụmaatụ, Lantus ma ọ bụ Solostar. Nke ikpeazụ a nwere ihe dịka 70% nke insulin, Lantus - 80%.
Emebeghi ihe omuma nke ogwu ndia n’oge ime, ya mere, obu na dibia bekee kwesiri ime mkpebi banyere nnabata. Ọzọkwa, a ga-eji ego dọọ ụmụaka na-erubeghị afọ asaa aha maka ego.
Nkọwapụta ọrịa shuga
Ọrịa shuga bụ ọrịa na-efe efe nke na - enweghị insulin njikọ. Site na ọrịa a, ọrụ nke ọtụtụ akụkụ na sistem nke ahụ na - emebi emebi, ebe ọ bụ na mgbanwe na nguzozi metabolic na - apụta.
N'ime pasent 90%, ọrịa ahụ enweghị ụkọ insulin, dịka iwu, a na-edenye ụdị shuga dị na ndị buru oke ibu. 10% nke ikpe metụtara ejikọtara glucose na insulin, nke a bụ n'ihi usoro akwara.
E nwere ọtụtụ ihe nwere ike ibu provocateurs nke ọrịa:
- mkpụrụ ndụ ihe nketa
- mmeghari nke usoro autoimmune,
- nsogbu ndị metụtara oke ibu na ndị ọzọ.
Usoro autoimmune na-echebe anụ ahụ n'ọrịa dị iche iche, nje na nje. Nke a gụnyere sel nke onwe ya na nke ndị mba ọzọ nwere nnukwu nsogbu.
Ogwu ohuru amaghi ihe kpatara oge ufodu ji emehie udiri oria ma bido iwere akwara na akwara maka mba ofesi, na-anwa ikpochapu ha, weputa ihe ogwu di iche.
Dịka iwu, ụdị mbibi a na-aga nke ọma, mkpụrụ ndụ ndị gbanarịrị na mkpochapụ na-amalite imepụta homonụ, gụnyere insulin, n'ọnọdụ ngwa ngwa. Usoro a na-ewe oge, mgbe ahụ na-abịa oge mgbe olu insulin ga-amalite ịda, nke pụtara na ọkwa shuga na-ebili, nke enweghị ike ịkụda.
Ihe ngosi nke abuo nke oria shuga:
- Ọrịa pancreatic, dịka pancreatitis,
- ọrịa hormonal, na-agbasa goiter ugboro ugboro,
- ị hormonụ ọgwụ ọalụ hormonụ na-agwọ ọrịa ndị ọzọ.
Ihe ọ bụla kpatara ọrịa shuga, usoro ọrịa a ka agbanwebeghị. N'ihi ụkọ insulin, ahụ mmadụ anaghị anabata glucose ma ghara inwe ike ịchịkọta ya na akwara na umeji. Nnukwu ọnya shuga na-apụta, a na-ebugharị ya n'ọbara ma na-asa ahụ niile, na-enye ha nnukwu nsogbu.
Ọ bụ glucose bụ otu n’ime ihe ndị na-enye ike, ya mere, ihe ọzọ na-akwụghachi ụkọ ya. N'okwu a, anụ ahụ na-amalite ịhazi abụba, na-atụle ha dịka isi iyi nke ike.
“Ugwu” a nwere otutu nri enzymes nri, nke n’enweghi uzo ewepu ya n’ahu.
Enzymes ndị emebere ka ha gwuo nri nri na-agbadata ma ọria, na-ebute oke mbufụt, nke ọtụtụ mgbaàmà na-eso ya.
Njirimara ọgwụ
Ofkpụrụ nke ọrụ insulin, ọrụ ya bụ isi, gụnyere Glargin, bụ ịhazi metabolism metabolism. Insulin Lantus na-eme ka oriri glucose ike na akwara na adipose, yabụ, ọkwa shuga plasma na-ebelata. Ọgwụ a na-emekwa ka ọnụego ihe ịmịkọ glucose dị na belata.
Ọgwụ ndị a bụ analogues nke insulin mmadụ, nke a na-enweta site na nkwanye Escherichia coli bacteria DNA. Ejiri ya na obere nsogbu na mpaghara na-anọpụ iche.
Ọ na - ekekọta ndị na - anabata insulin ma na - eme ka bioeffect dị ka insulin nke dị n'ime (endogenous).
Enwere mmezi nke metabolism metabolism. Ọgwụ na analogues ya belata ọbara shuga, na - eme ka glucose na - arụ ọrụ site na anụ ahụ dị n'akụkụ (ọkachasị anụrị adipose na akwara), na - egbochikwa glucose na imeju. Insulin na-egbochi proteinolysis na lipolysis, ebe ha na-akwalite njikọ protein.
Mgbe nchịkwa ọgwụ ọgwụ subcutaneous gasịrị, a na-ahụta mmetụta ya ka ihe dị ka nkeji 40-60. Dịka iwu, a na-ahụ ihe ahụ awa iri abụọ na anọ, awa iri abụọ na anọ. N'iji otu irighiri ihe dị n'okpuru, a na-ahụta itinye uche n'ihe niile dị na ọbara mgbe ụbọchị 2-4 gachara.
A na-agwagbu insulin Glargin Lantus kpamkpam n'ihi usoro acidic pụrụ iche, yana nchịkwa subcutaneous, acid na-adọpụ ma mebe microprecipitate, site na nke wepụtara ọgwụ ahụ na obere oke oge.
N'ime plasma ọbara, ọ nweghị mgbanwe dị nkọ na olu insulin, ihe niile na-aga nke ọma. Ihe pụrụ iche na-eweta usoro nke ogologo oge.
Insulin Glargin 300 nwere mmetụta pharmacokinetic na ọgwụ ọgwụ. Enwere ike ịkwado dochie anya nke a ka insulin basal na ndị ọrịa nwere ọrịa shuga 1 na ụdị 2.
Ọ bụrụ na ị na-eji Insulin Glargin 300 IU / ml, nke a na-emepe ohere dị ukwuu maka ọgwụgwọ zuru oke nke ndị nwere ọrịa shuga.
Ntuziaka maka iji ọgwụ ahụ
Ndi dosiri nke ogwu a ka ahọrọ n’otu n’otu. A na-achịkwa ọgwụ n'okpuru subcutaneously 1 oge kwa ụbọchị n'otu oge. Mpaghara mpaghara mmeghe nwere ike ịbụ:
- anụ ahụ dị obere nke dị n'ime afọ,
- apata apata
- ubu.
M
Iri nri maka injers kwesiri ka agbanye ya na ntinye ogwu obula.
N'ime ụdị shuga 1, a na-enye ọgwụ ahụ ka ọ bụrụ insulin bụ isi. N'ime ụdị shuga 2, a na-eji ya dị ka monotherapy ma ọ bụ na njikọta ya na ndị ọzọ hypoglycemic.
Ọ bụrụ na onye ọrịa agbanweela site na insulin na-ajụ ma ọ bụ ogologo oge na insulin Glargin, mgbe ahụ, imezi insulin kwa ụbọchị nke insulin isi ma ọ bụ mgbanwe mgbanwe ọgwụgwọ dị mkpa.
Mgbe a na-ebugharị onye ọrịa site na insulin-isophan gaa naanị otu ọgwụ ọgwụ, ọ dị mkpa iji belata ọgwụ kwa ụbọchị nke insal insal kwa otu ụzọ n'ime izu mbụ nke ọgwụgwọ. Nke a dị mkpa iji belata ohere ọrịa hypoglycemia n'abalị. N'oge a, mbelata nke usoro onunu ogwu nwere ike weghachite ya site na mmụba nke insulin na-eme obere ihe.
Nsonaazụ
Hypoglycemia bụ nsogbu na-akpatakarị nsogbu nke usoro ahụ, dị ka ọgwụ insulin, ọ na-apụta ma ọ bụrụ na usoro insulin dị elu nke ukwuu ma e jiri ya tụnyere mkpa n'ezie. N'ihi iji ọgwụ ọjọọ eme ihe n'ụzọ na-adịghị mma, mmadụ nwere ike ịmalite ịnwe ọrịa hypoglycemia, nke na-edugakarị ịrụ ọrụ nke sistem ụjọ.
Ọrịa Neuropsychiatric n'ihi ọrịa hypoglycemia, dị ka a na-achị, bụ nke ihe mgbaàmà nke mgbochi imebi:
- agụụ
- mgbakasị ahụ
- tachycardia.
Mgbanwe dị ukwuu na nhazi shuga n'ọbara na-ebutekarị nsogbu anya mkpụrụ ndụ n'ihi ngbanwe anụ ahụ na ntụgharị nke anya anya. Sugar sugarụ shuga dị n'ọbara agbagote na-ebelata ihe ize ndụ nke ịmalite ọrịa mamịrị ọrịa retinopathy.
Mmeghachi omume mpaghara na mpaghara ịgba ahụ yana mmeghachi ahụ nfụkasị nwere ike ime:
- acha ọbara ọbara
- mgbu
- itching
- urticaria
- ọzịza.
Imirikiti obere mmeghachi omume na mpaghara nchịkwa insulin na-apụkarị n'izu ole na ole. Mmeghachi omume mmetụta insulin na-etolite n'ụdị ndị a na-adịghị ahụkebe.
Mmeghachi omume ndị dị na insulin ma ọ bụ ndị nwere ibu nwere ike ịpụta n'ụdị mmepe nke mmeghachi anụ anụ arụ. Na mgbakwunye, ihe ndị a nwere ike ịbụ:
- angioedema,
- bronchospasm
- hypotension akwara ozi ma obu ujo.
Mmebi iwu ndị a niile nwere ike itinye ndụ mmadụ n'ihe egwu.
Mgbe ụfọdụ ọnụnọ ọgwụ mgbochi ọgwụ na insulin na-ebute mgbanwe nke usoro iji wepu mmụba nke hyper-ma ọ bụ hypoglycemia. Ọzọkwa, insulin nwere ike ibute oge na mwepu sodium.
N'ihi ya, edema na - apụta, ọkachasị ma ọ bụrụ na ọgwụ insulin na - arụ ọrụ na - eduga n'ịhazi usoro metabolic dị mma.
Njikọ Ọgwụ
Ogwu a ekwekọghi na uzo ozo. Ọ dịghị mkpa ịgwakọta ya na ngwaahịa ndị ọzọ ma ọ bụ dil.
Ọtụtụ ọgwụ na-emetụta metabolism metabolism, nke chọrọ mgbanwe nke dose. Drugsdị ọgwụ ọjọọ ndị a gụnyere:
- onyiresị hypoglycemic wakiil,
- Ihe mgbochi ACE
- ndị na-enupụ isi
- fibrates
- fluoxetine,
- Ndị na - egbochi MAO
- pentoxifylline
- propoxyphene
- salicylates,
- ọgwụ sulfa.
Uzo nke puru iwenweta nnabata nke insulin gụnyere:
- diuretics
- estrogens
- isoniazid
- glucocorticoids,
- danazol
- diazoxide
- glucagon,
- clozapine.
- gestagens
- homonụ ibu,
- homonụ thyroid,
- epinephrine
- salbutamol,
- terbutaline
- ndị na-egbochi nchebe
- olanzapine.
Nwere ike mee ka ike gwụ hypoglycemic mmetụta nke insulin:
- ihe mgbochi beta,
- clonidine
- nnu nke lithium
- mmanya
Nhọrọ insulin
Ọ bụrụ na anyị atụlee ọgwụ ọgwụ nke ọgwụ ndị a na-atụle, mgbe ahụ, a ga-egosi nhọpụta ha dịka dọkịta maka ọrịa shuga nke ụdị nke mbụ na nke abụọ. Ugwu a na-eme ugbua adighi enye aka na oke ibu n'ihi ọgwụ. A na-ebelata ọnụ ọgụgụ nke mgbede n’abalị n’abali n’oche shuga.
Ọ nwere mkpa maka naanị otu ọgwụ insulin kwa ụbọchị. Maka ndị ọrịa, ọ dabara adaba. Amara dị elu nke anarol insulin na-eme mmadụ na metformin maka ndị ọrịa nwere ụdị shuga 2. Ihe omumu sayensi gosiputara na-ebelata nnukwu abali n’abali n’ogologo. N'ihi ya, a na-ahụkarị nhazi nke glycemia kwa ụbọchị.
Ọ dị mma arịba ama na njikọta nke insulin Glargin Lantus na ọgwụ ọnụ iji belata glucose ọbara n'ọbara ndị ọrịa ahụ na-enweghị ike ịkwụ ụgwọ maka ọrịa shuga. E kwesiri inye ndị ọrịa dị otu a Insulin Glargin n'oge mmalite ọrịa ahụ.
Enwere ike ịkwado ọgwụ a site na endocrinologist ma ọ bụ ọkachamara n'ozuzu. Ọgwụ ọgwụgwọ kpụ ọkụ n'ọnụ site na iji Lantus na-enye ohere iji chịkwaa glycemia na ndị nwere ọrịa shuga nke otu niile.
Efu
Thelọ ahịa ọgwụ na-enye nkwado insulin n'ụgwọ dị iche iche. Ọnụahịa ahụ dabere n'otú e si webata analogues nke ọgwụ Glargin Insulin. Ọnụ ego ọgwụ ahụ sitere na 2800 ruo 4100 rubles
