Ọrịa shuga mellitus bụ ọrịa dị ize ndụ nke nwere ike ịdabere na insulin (ụdị 1) ma ọ bụ nke na-abụghị insulin (ụdị 2). N'okwu nke ikpeazụ, a na-agwọ ọrịa ahụ nke ọma site na enyemaka nke ndị na - ahụ maka hypoglycemic na nri pụrụ iche. Mana n'ụdị ọrịa mbụ na ọrịa shuga nke 2 malitere, a gaghị enyefe insulin ọgwụgwọ.
Ọtụtụ mgbe, ndị ọrịa na-enwekarị mgbanye shuga n'ọbara bụ ka a na -enye insulin Glulizin. Nke a bụ azịza ọcha maka ịgba ntụtụ, ihe bụ isi bụ ya bụ analogue nke insulin mmadụ na -akụkọ, mepụtara site na iji mkpụrụ ndụ ihe nketa.
Ọgwụ nwere mmetụta dị mkpirikpi iji gbadata ọsọ ọsọ na mkpokọta glucose na ọbara. Apidra SoloStar na Apidra bụ nke aka, nke jikọtara insulin Glulisin.
Mmetụta ọgwụ na ọgwụ ọgwụ
Ngwọta ahụ nwere obere hypoglycemic mmetụta. Na mgbakwunye, ọ na-eme ka usoro nke ịmịkọta glucose site na nsị anụ ahụ (ọdụdụ, akwara ọkpụkpụ), na-egbochi usoro mmepụta glucose na imeju.
Ọzọkwa, ọgwụ ahụ na-akpali njikọ protein, na-egbochi proteolysis na lipolysis na adipocytes. Mgbe nchịkwa subcutaneous, ibelata ọkwa shuga na-apụta mgbe nkeji 10-20 gachara.
N'ihe banyere ochichi iv, mmetụta hypoglycemic dị ka ọrụ insulin nke mmadụ. Yabụ, n'ihe gbasara ịdị irè, 1 IU nke insulin Glulisin bụ 1 IU nke insulin na-arụ ọrụ mmadụ.
E jiri ya tụnyere insulin nke mmadụ, a na-amịkọrọ Glulisin ugboro abụọ. Nke a bụ n'ihi ntụgharị amily acid asparagine amino acid (ọnọdụ 3B) na lysine, yana lysine (ọnọdụ 29B) nwere acid glutamic.
Absorption mgbe sc nchịkwa:
- n'apata apata - ọkara;
- na mgbidi ime - ngwa ngwa;
- n'ubu - n'etiti.
Ezigbo bioavailability bụ 70%. Mgbe etinyere n’ime ebe dị iche iche, ọ dị otu ma nwee obere mgbanwe n’etiti ndị ọrịa (mgbanwe nke 11%).
Mgbe ejiri ụdị shuga 1 na-achịkwa subcutaneously, 0.15 U / kg TCmax bụ 55 min., Cmax n'arọ bụ 80.7-83.3 μU / ml. Thedị ọrịa nke abụọ, mgbe sc nke ọgwụ a na 0.2 PIECES / n'arọ, Cmax bụ 91 mcU / ml.
N’ime sistemụ sistemụ, oge ikpughere oge ya bụ 98 min. Na ntinye aka / na ntinye, olu nke nkesa bụ 13 lita, T1 / 2 - 13 nkeji. AUC - 641 mg x h / dl.
Ndị ọgwụ pharmacookinetics na ndị ọrịa mamịrị n’agbata afọ iri na isii nwere ụdị ọrịa mbụ dịkwa otu ndị okenye. Na sc nchịkwa T1 / 2 sitere na 37 ruo 75 nkeji.
Ntuziaka maka iji ọgwụ ahụ
A na - edozi insulin Glulisin subcutaneously, a na-ahọrọ usoro onyonyo otu n'otu n'otu maka onye ọrịa ọ bụla. A na-eme ọgwụ mgbochi na nkeji 0-15. tupu ma ọ bụ mgbe ị risịrị nri.
A na-eji Glulisin mee ihe na usoro ọgwụgwọ, gụnyere iji insulin na-ajụ ma ọ bụ ogologo oge, ma ọ bụ analogues ha. Ọzọkwa, enwere ike iji ọgwụ ahụ jikọta ya na ọgwụ ndị nwere mmetụta hypoglycemic, nke a na-eji ọnụ.
A na-achịkwa azịza ya n'ụdị ọgwụ ntụtụ ma ọ bụ infusion site na iji insulin. A na-eme inje na mpaghara ubu, apata ụkwụ, ogwe n’afọ. Na iwebata ego site na infusion na-aga n'ihu na-eme na peritoneum.
A ga-agbanwe mpaghara maka injections na infusus oge ọ bụla. Ihe iche iche (ihe mmega ahu, ebe ochichi) bu nke anakpo osiso nke mmata, nmalite na oge onyonye ya. Maka nnabata ngwa ngwa, ọgwụ ahụ ga-abanyerịrị n ’ebe n'ihu mgbidi akụkụ ahụ.
Ọ dị mkpa ịkpachara anya na insulin Glulisin abanyeghị arịa ọbara. Ya mere, ọrịa mamịrị ọbụla kwesịrị ị were were ghee insulin. Mgbe ogwu ogbugba, a machibidoro uzo ogwu ịhịa aka.
A na-ahapụ Glulisin ka agwakọta ya na Isofan (insulin) mmadụ, mana a ga-ebu ụzọ Glulisin banye sirinji. Ekwesịrị ịme nlekọta nchịkwa nke SC ozugbo ozugbo agwakọchara ụzọ. N'ụdị nke a, amachibidoro ngwakọta nke Isofan na Glulisin ka edobere ya n'usoro.
Ọ bụrụ na a na-eji insulin Glulisin arụ ọrụ, a ga-agbanwe kit ahụ kwa elekere 4 ọ bụla, na-agbaso iwu antiseptik. Site na usoro nchịkwa infusion ya, ekwesighi ịgwakọta ọgwụ ahụ na ngwọta ma ọ bụ insulins ndị ọzọ.
N'ihe banyere iji pọmpụ na-adịghị mma ma ọ bụ mebie ọrụ ya, ketoacidosis ọrịa mamịrị, hyperglycemia ma ọ bụ ketosis nwere ike ịmalite. Iji gbochie ọnọdụ nke ọnọdụ ndị dị otú a, tupu ịme usoro ahụ, ịkwesịrị iji nlezianya mụọ iwu maka iji sistemụ ahụ ma jiri nlezianya gbakọọ usoro ahụ.
Tupu iji edozi ahụ, ịkwesịrị ịlele nsonaazụ ya, ụcha ya na gbaa mbọ hụ na enweghị mpempe mba ọzọ na ya. Ọ bụrụ na ngwaahịa a dị urukpuru, na-acha ma ọ bụ nwee adịghị ike, mgbe ahụ, amachibidoro iji ya.
Contraindications, mmetụta dị n'akụkụ, ị ,ụbiga mmanya ókè
Ejighị insulin Glulizin na-emeso ụmụaka na-erubeghị afọ isii, yana hypoglycemia na hypersensitivity na akụkụ ya. Nsonaazụ kachasị emetụta bụ hypoglycemia. A na - ahụ mgbanwe mmekpa ahụ nke anụ ahụ yana ọrịa metabolic.
Mgbe ụfọdụ, mgbaàmà ọria akwara na-apụta, dị ka ụra, ike ọgwụgwụ, ike adịghị agwụ, ihe mgbu, na ọgbụgbọ. Isi ọwụwa, enweghị itinye uche, nsụhọ na ọgba aghara na-apụta.
Ọtụtụ mgbe, tupu nkwarụ akwara ozi, ihe mgbaàmà nke ihe mgbochi adrenergic na-apụta. Nke a bụ agụụ, ahụ erughị ala, tachycardia, obi uto, ọsụsọ oyi, nchekasị, akpachapụ akpụkpọ ahụ na ịma jijiji.
Ọ dị mma ịmara na mwakpo siri ike nke hypoglycemia, nke a na-eme ugboro ugboro, na-eduga na mbibi nke NS. Ọzọkwa, n'ọnọdụ ụfọdụ, nke a nwere ike ịnwụ.
Na mgbakwunye na ọnụego shuga dị ala, mmeghachi omume na-emetụta obodo nwere ike ịme n'akụkụ ebe ejiri ọgwụ ahụ. Ihe ndị a gụnyere hyperemia, ọzịza na itching, mgbe mgbe, ngosipụta ndị a na-apụ n'anya n'onwe ha n'oge ọgwụgwọ ọzọ. Site n'oge ufodu, nihi na ekwenyeghi ntughari nke uzo ochichi nke insulin, onye oria n’iru nwere ike imeputa lipodystrophy.
Ihe mgbaàmà nke hyperistitivity nwekwara ike:
- itching
- urticaria;
- nfụkasị ahụ akpịrị;
- imechi obi;
- igbochi.
Ahụ nwere ike igbu mmadụ.
N'ihe banyere ịdoụbiga mmanya ókè, hypoglycemia nke ike dị iche iche nwere ike ime. Site na ntakịrị mbelata shuga ọbara, onye ọrịa ahụ kwesịrị ị drinkụ ihe ọveraụveraụ ma ọ bụ ngwaahịa nwere shuga.
N'ọnọdụ dị njọ karị na mwepu nke mmụọ, s / c ma ọ bụ na / m na-achịkwa Dextrose ma ọ bụ Glucagon. Mgbe onye ọrịa nwetaghachiri onwe ya, ọ kwesịrị ị consumeụ carbohydrates, nke a ga-ezere nlọghachi.
Nmekorita ya na ogwu ndi ozo na ntuziaka puru iche
Mgbe ejikọtara insulin Glulisin na ndị na-egbochi ACE / MAO, Disopyramide, fibrates, sulfonamides, salicylates na Propoxyphene, a na-eme ka mmetụta hypoglycemic dịkwuo elu ma nwee ike hypoglycemia na-abawanye.
Nchikota nke insulin na ndi na - egbochi nchebe, Danazole, antipsychotics, Salbutamol, Terbutaline, isoniazids, Epinephrine, Diazoxide, diuretics, Somatropin na ihe ndi ozo bu phenothiazine ga - eme ka mmetụta hypoglycemic ghara ikwuputa. Clonidine, beta-mgbochi, ethanol na nnu nke lithium na-ebelata ike nke insulin Glulisin. Iji ọgwụ a jikọtara ọnụ na Pentamidine nwere ike ịkpasu ma hypoglycemia na hyperglycemia.
Nyocha nke ndị na-arịa ọrịa shuga na-ekwu na mgbe ị na-eji ndị na-egosi ọrụ ọmịiko, enwere ike ịchịkwa ihe mgbaàmà nke ịgbado ọkụ nke adrenergic. Ọgwụ ndị dị otú ahụ gụnyere clonidine na guanethidine.
Ọ bụrụ na ebugharị onye ọrịa ahụ na ụdị insulin ọzọ ma ọ bụ ọgwụ site n'aka onye nrụpụta ọhụụ, mgbe ahụ a ga-eme nke a n'okpuru nlekọta ahụike. Ọ dị mma icheta na usoro ị incorrectụ insulin na-ezighi ezi ma ọ bụ ịkwụsị ịgwọ ọrịa insulin nwere ike ịmalite ọrịa ketoacidosis na ọrịa hypoglycemia.
Ọzọkwa, ọnọdụ ụfọdụ nwere ike ịgbanwe ma ọ bụ mee ka ihe ngosipụta hypoglycemia belata. Ihe omume ndi di otua gunyere:
- ọrịa ogologo oge nke ọrịa shuga;
- ike nke insulin;
- ibugharị onye ọrịa site na anụmanụ gaa na homonụ nke mmadụ;
- ị certainụ ọgwụ ụfọdụ;
- ọrịa mamịrị na-arịa ọrịa mamịrị.
Mgbe ị na-agbanwe nri ma ọ bụ mmega ahụ ọ dị mkpa ịgbanwe usoro nke insulin. Agbanyeghị, ọ bụrụ na a na-enye ọgwụ ọgwụ ozugbo egwuregwu, mgbe ahụ, ohere nke hypoglycemia dị elu.
Banyere ojiji nke insulin Glulisin n'oge ime, a ghaghị iji nlezianya na-agakwuru usoro ọgwụgwọ ahụ, n'ihi na glycemia nwere ike ịmalite n'ụdị shuga nke mbụ na nke mbụ. Ọzọkwa, n'ime ọnwa atọ mbụ nke ịtụrụ ime yana mgbe amuchara nwa, a na-ebelata dose nke insulin. N’oge ị na-enye nwa ara, enwere ike ịchọ mgbanwe iji dozie ya.
Ọnụahịa nke ihe ngwọta maka nchịkwa sc dabere na insulin Glulisin sitere na 1720 ruo 2100 rubles.
Vidiyo dị n’isiokwu a gosipụtara otu esi abanye insulin subcutaneously.
