Torvacard bụ ọgwụ nke ọgwụ ọgwụ akpọrọ statins. A na-enweta ya n'ụdị mbadamba ọcha, nke nwere ntakịrị convex n'akụkụ abụọ, nke ekpuchiri ihe mkpuchi ihe nkiri na mpụga.
Torvacard mejuputara isi ihe nke Atorvastatin, yana otutu ihe inyeaka, nke gunyere magnesium oxide, magnesium stearate, hydrodroplosanose dochiri anya, silloon silicon dioxide, titanium dioxide, lactose monohydrate, talc, croxarmellose sodium.
Emere ọgwụ nke Torvacard
Torvacard bụ ọgwụ nke otu ọgwụ ọgwụ na-agbatị. Nke a pụtara na ọ na-ebelata ego nke lipids n'ime ọbara, nke mbụ, na-ebelata cholesterol.
A na-ekewa ọgwụ ndị na-eme ka Lible dị iche iche, n'aka nke ya, gaa n'ọtụtụ, Torvakard so n'ìgwè a na-akpọ statins. Ọ bụ ihe nhọta na-egbochi asọmpi HMG-CoA reductase.
HMG-CoA reductase bụ enzyme nke na-ahụ maka ntụgharị nke 3-hydroxy-3-methylglutaryl coenzyme A na mevalonic acid. Mevalonic acid bụ ụdị cholesterol precursor.
Usoro nke Torvacard bụ na ọ na-egbochi ya, yabụ, na-egbochi mgbanwe a site na isonye na igbochi HMG-CoA reductase. A maara na cholesterol, yana triglycerides, na-esonye n'ụdị nke lipoproteins dị ntakịrị, nke na-emesịa ghọọ lipoproteins dị ala, na-emekọ ihe na ndị na-anabata ha pụrụ iche.
Ihe na-arụ ọrụ nke Torvacard, atorvastatin, na-ahụ maka iwetulata cholesterol dị ala na nke dịkarịsịrị ala ma na - enyere aka ịba ụba nke nnabata lipoprotein na imeju, na mbara ala, nke na - emetụta ngwa ngwa ha na - ebili.
Torvacard na -ebelata mkpụkọ lipoproteins dị ala na ndị ọrịa na-arịa ọrịa dịka homozygous familial hypercholesterolemia, nke na-esikarị ike ịgwọ ya na ọgwụ ọdịnala.
Ọgwụ na - enyekwa aka ịbawanye ọnụ ọgụgụ nke ịdị elu lipoproteins nwere oke maka cholesterol dị mma ".
Pharmacokinetics na pharmacodynamics
Pharmacokinetics bụ mgbanwe ndị ahụ na - apụta na ọgwụ n'onwe ya na ahụ mmadụ. Nsonye ya, ya bụ, nnabata, dị elu. Ọzọkwa, ọgwụ a na - enweta ọsọ ọsọ n'obara ọbara, mgbe ihe dị ka elekere abụọ ruo awa abụọ. Ọzọkwa, n'ime ụmụ nwanyị, ọnụego iru ogo ịta bụ ngwa ngwa ihe dị ka 20%. N'ime ndị mmadụ na-arịa ọrịa imeju n'ihi ịhoụ mmanya, ịta ahụ n'onwe ya ji okpukpu iri na isii karịa ịdị elu ya, ọnụego ihe ọ rụzuru bụ ugboro iri na otu.
Ọnụego nnabata nke Torvacard bụ nri metụtara nri, n'ihi na ọ na-ebelata oriri, mana ọ naghị emetụta mbelata nke cholesterol dị obere. Ọ bụrụ na ị takeụọ ọgwụ na mgbede, tupu oge ụra, mgbe ahụ itinye uche ya na ọbara, n'adịghị ka usoro ụtụtụ, ga-agbadata ike. Achọpụtakwara ya na ọgwụ buru ibu karị, ọ na-agbakarị ọsọ ọsọ.
Ihe ndu biovvard nke Torvacard bu 12% n'ihi uzo ya site na mucous akpụkpọ ahụ nke usoro digestive na ngabiga site na imeju, ebe enwere akụkụ ya.
Ọgwụ dị ihe fọrọ nke nta ka ọ bụrụ 100% na protein protein. Mgbe ntụgharị akụkụ dị na imeju n'ihi ihe isoenzymes pụrụ iche, etolite metabolites na-arụ ọrụ, nke nwere isi Torvacard - ha na-egbochi HMG-CoA mbelata.
Mgbe mgbanwe ụfọdụ na imeju, ọgwụ nwere bile abanye na eriri afọ, site na ya wepụrụ ya kpamkpam n'ahụ ahụ. Ọkara ndụ nke Torvacard - oge ịta ọgwụ ọjọọ n’arụ na-ebelata ugboro 2 - bụ awa iri na anọ.
Mmetụta ọgwụ ahụ nwere ike ịhụ ihe dịka otu ụbọchị n'ihi ọrụ nke metabolites ndị ọzọ. Na mmamịrị, enwere ike ịchọpụta obere ọgwụ ọgwụ.
Ọ bara uru ịtụle na n'oge a na-egosipụtaghị ya n'ọbara.
Ihe ngosi maka iji ogwu
Torvacard nwere ọtụtụ ngosipụta dị iche iche.
Ekwesịrị iburu n'uche na ọgwụ ahụ nwere ndepụta zuru ezu nke iji ya, echebara ya mgbe ị na-ede ọgwụ ahụ.
Ntụziaka maka ojiji na-egosi ikpe ọgwụ niile.
N'ime ha, ndị bụ isi bụ ndị a:
- Edebere Torvacard iji belata ọkwa nke cholesterol zuru oke, yana jikọtara ya na lipoproteins dị ala, iji belata apolipoprotein B, na-emekwa triglycerides, na iwelie ego nke Lipoprotein cholesterol dị elu maka ndị mmadụ na-ata ahụhụ site na heterozygous ma ọ bụ hypercholesterolemia nke bụ isi II. . A na-ahụ nsonaazụ ahụ naanị mgbe ị na-eri nri.
- Ọzọkwa, mgbe ị na-eri nri, a na-eji Torvard eme ihe na ọgwụgwọ nke familial endogenous hypertriglyceridemia nke ụdị nke anọ dabere na Frederickson, yana maka ọgwụgwọ nke dysbetalipoproteinemia nke ụdị nke atọ, nke nri adịghị arụ ọrụ.
- A na - eji ọgwụ a ọtụtụ ndị ọkachamara iji belata ọkwa nke nchịkọta cholesterol na obere lipoproteins dị ala dịka ọrịa hyzycholesterolemia, homozygous familial hypercholesterolemia, ma ọ bụrụ na nri na ụzọ ọgwụgwọ ndị ọzọ na - abụghị ọgwụ enweghị mmetụta a chọrọ. Ọ kachasị dị ka ọgwụ nke abụọ.
Na mgbakwunye, a na-eji ọgwụ ahụ maka ọrịa obi na ọrịa vaskụla na ndị ọrịa ahụ nwere oke ihe ndị dị ize ndụ maka ịmalite ọrịa obi obi. Nke a karịrị afọ iri ise, ọbara ọgbụgba, ise anwụrụ, ọbara mgbali elu ventricular, ọrịa shuga mellitus, akụrụ, ọrịa vaskụla, yana ọnụnọ nke ọrịa obi na akwara na ndị hụrụ n'anya.
Ọ na-akachasị mma maka dyslipidemia concomitia, n'ihi na ọ na - egbochi mmepe nke nkụchi obi, ọrịa strok, na ọbụna ọnwụ.
Ihe mgbochi igbochi iji ogwu
Enwere ọtụtụ contraindications maka iji Torvacard.
Ọnụ ọgụgụ dị ukwuu nke contraindications na-akpata mmachibido iwu nchịkwa onwe onye nke ọgwụ.
Ọ bụ naanị dibia na usoro ga-ekpebi ma dọkịta ndị bịara njem ahụ nwere.
Ihe mgbochi:
- ọrịa ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba n'omume nke imeju ihe karịrị ugboro atọ maka ebumnuche amaghi;
- ụkọ nke ọrụ ịba ọcha n'anya;
- ọrịa ndị a ketara eketa nke ụdị lactose anagide ma ọ bụ enweghị lactase - enzyme nke na-akpata nbibi shuga mmiri ara ehi, nke a bụ n'ihi eziokwu ahụ na ọgwụ nwere lactose;
- ime
- oge ị breastụ ara;
- amachibidoro ị drugụ ọgwụ ọgwụ a nke ụmụ nwanyị toro afọ, mana esokwala ụzọ nchebe ọ bụla;
- ụmụaka na-erubeghị afọ 18, n'ihi arụmọrụ na nchekwa na-akọwaghị ya;
- Mmeghachi omume nfụkasị ahụ na akụkụ ọ bụla nke ọgwụ ahụ.
Ekwesịrị ilebara anya n'ọrịa ndị ọrịa, ọnọdụ na ọrịa ndị a:
- Mmanya na-egbu egbu
- Ọrịa ịba ọcha n'anya ọ bụla sitere.
- Mmebi nke mgbanwe mmiri na electrolytes.
- Hormonal ahaghị nhata.
- Ọrịa metabolism.
- Nrụgide na-akwụsịlata (hypotension).
- Sepsis bụ ọnụnọ nke nje na-aba ụba n'ọbara, otu n'ime nsogbu ndị kachasị njọ nke usoro nje.
- Akwụkwụ na-adọghị ya.
- Ihe ngbanwe nke usoro akwara.
- Ọrịa shuga mellitus nke ụdị nke mbụ na nke abụọ.
- O yigharịrị arụmọrụ buru ibu.
- Nsogbu merụrụ ahụ.
Okwesiri ichoputa ihe omuma nke iji Torvacard n’oge di ime na mgbe a na-enye nwa ara. N’ime oge izizi nke ịtụrụ ime, itinye usoro dị ezigbo mkpa n’akwara na ebu n’afọ na-eme. Maka usoro a, cholesterol na ihe ndị ahụ na - agwakọta site na ya dị ezigbo mkpa.
Ndị na-egbochi HMG-CoA reductase nwere mmetụta dị njọ na mmepe nwa ebu n’afọ, nke nwere ike ibute ọmụmụ nwa nwere nnukwu nsogbu, dị ka atresia (enweghị ya, nnabata) nke ahụ ike, nrụrụ ọkpụkpụ, fistula (n’ime oghere) n’etiti trachea na esophagus.
Ọ bụrụ na onye ọrịa na-ewere Torvacard nwere ime, mgbe ahụ ọgwụike ahụ kwesịrị ịkwụsị ozugbo. N'ọnọdụ nwanyị na-a breastụ ara, a na-atụ aro ka a kwụsị inye nri, n'ihi na anaghị enwe mmetụta dị mma na ụmụaka sitere na Torvacard.
Ekwesịrị ịgwa ụmụ nwanyị banyere ohere nke ọgwụ ọjọọ na nwa ebu n'afọ ma tụọ aro ka e jiri ụzọ dị ịtụnanya egbochi afọ ime.
Ntụziaka maka iji Torvacard
A ga-ejikọ ebumnuche ọgwụ a na usoro ọgwụgwọ nri iji belata kọlestrọl. Enwere ike iwere Torvacard n'oge ọ bụla n'ụbọchị, tupu nri ma ọ bụ mgbe nri ahụ gasịrị.
Amalite na usoro nke 10 mg kwa ụbọchị. Ogo ịba uru nke kachasị anabata bụ 80 mg kwa ụbọchị. Enwere ike ịhazigharị usoro ọgwụ kwa ụbọchị dabere na ihe ngosipụta cholesterol dị, triglycerides na obere lipoproteins dị ala, yana ichebara mmetụta onye ọ bụla maka onye ọrịa ọ bụla. Mgbe ị na-ewere Torvacard kwa izu abụọ ma ọ bụ anọ, ọ na-atụ aro ka ileba anya na profaịlụ.
Maka ọgwụgwọ nke ọrịa dị ka hypercholesterolemia bụ isi na hyperlipidemia agwakọta, a na-ejikarị usoro onunu ogwu 10 kwa ụbọchị. Mmetụta dị egwu na-amalite ịpụta mgbe izu abụọ gachara, ma kachasịa - ka izu anọ gachara. A na-atụ aro ọgwụgwọ ogologo oge.
Site na hyzycholesterolemia homozygous familialia, iji ọgwụ ahụ mee ihe na 80 mg kwa ụbọchị nwere ike belata ọkwa cholesterol na obere lipoproteins dị ala karịa pasent iri na ise.
Usoro onunu ogwu nke ndi oria na aru oria akaghi acho idozi ya, ya na ndi okenye.
Mmeghachi omume ọjọọ site na iji ọgwụ
Mgbe ị na-a theụ ọgwụ ahụ n’arụ onye ọrịa, ọrịa niile nwere ike ịdapụta.
Enwere ike ịtụle mmeghachi omume dị njọ mgbe ị na-ede ọgwụ.
Ọnụ ọgụgụ dị ukwuu nke nsonaazụ mgbe ị na-eji ọgwụ eme ihe na-akpata mmachi iwu nchịkwa onwe nke ọgwụ n'oge ọgwụgwọ. Naanị dọkịta nwere ikike ịkọ ọgwụ, na-eburu n'uche njirimara nke ahụ onye ọrịa.
Mgbe ị na-eji ọgwụ Torvakard, ụdị mmeghachi omume ndị a na-esote:
- Sistemụ akwara na akụkụ isi - isi ọwụwa, nkụda mmụọ, ike ọgwụgwụ, ehighị ụra nke ọma, ụra abalị, nrụrụ ebe nchekwa, belata ma ọ bụ nwee nsogbu oge, obi erughị ala, ataxia.
- Usoro nri - afọ ntachi ma ọ bụ afọ ọsịsa, mmetụta nke ọgbụgbọ, mmiri, oke flatulence, ihe mgbu na mpaghara epigastric, mbelata nke agụụ, na-eduga na anorexia, ọ bụ ụzọ ọzọ, mmụba ya, usoro mkpali na umeji na akwara, jaundice n'ihi stagnation nke bile;
- Usoro akwara - enwere oge enwere mgbu na akwara na nkwonkwo, myopathy, mbufụt nke uru ahụ, rhabdomyolysis, ihe mgbu na azụ, mgbu azụ nke akwara ụkwụ ụkwụ;
- Ngosiputa ihe anonye aru - itching na nchapu n’ahu, urticaria, mmeghachi ahu nfesa ozugbo (ujo anacticlactic), Stevens-Johnson and Lyell syndromes, angioedema, erythema;
- Ndị na-egosi ụlọ nyocha - mmụba ma ọ bụ mbelata ọbara glucose ọbara, mmụba na ọrụ nke creatiphosphokinase, alanine aminotransferase na aspartate aminotransferase, mmụba nke ọkwa hemoglobin glycated;
- Ndi ozo - obi mgbu, mbufụt nke ala na elu ikperechi, enweghi ume, alopecia focal, ibu di elu, ike adighi n'ogbako, pere mpe nke pere mpe, okpukpo nke ozo.
Amatakwa mmeghachi omume dị njọ nke ọgwụ ọgwụ statin niile:
- mbelata libido;
- gynecomastia - uto nke mammary glands na ụmụ nwoke;
- nsogbu nke usoro akwara;
- Obi erughị ala
- ọrịa ngụgụ na-adịghị ahụkebe na ogologo ọgwụgwọ;
- Ọrịa shuga.
Ekwesịrị ilebara anya pụrụ iche mgbe ị na-a Torụ Torvacard na cytostatics, fibrates, ọgwụ mgbochi na antifungal ọgwụ, ebe ọ bụ na ha anaghị ekwekọ oge niile. Nke a metụtakwara glycosides cardiac, karịchara Digoxin.
A na-emepụta ụdị analogues nke Torvacard dị ka Lovastatin, Rosuvastatin, Vasilip, Liprimar, Akorta, Atorvastatin, Zokor.
Nyocha banyere ọgwụ ahụ na-adịkarị mma, ebe ọ bụ na statins bụ ìgwè kachasị dị irè nke ọgwụ na-ebelata cholesterol.
Ndi okacha mara ga ekwu banyere ihe akuko a n’ime vidiyo n’isiokwu a.
