Vasilip bụ ọgwụ nke otu ndị na-emetụta Lipid. Isi ihe dị n’ọrụ ya bụ na ebum n’obi ya bụ iwetulata ọkwa lipids (abụba) n’ime ọbara. Vasilip dị n'ụdị mbadamba ọcha n'ime ihe nkiri ahụ, okirikiri, dị ntakịrị convex n'akụkụ abụọ ahụ.
Ihe kachasị dị mkpa n'ọrụ ọgwụgwọ a bụ simvastatin. O tinyekwara ihe ndi ozo dika lactose monohydrate, sitri pregelatinized, acid anhydrous, vitamin C, stachi ọka, magnesium stearate na celclolose microcrystalline. Mpekere mbadamba onwe ya nwere talc, propylene glycol, hypromellose na titanium dioxide.
Usoro ị ofụ ọgwụ ahụ nwere ụdị abụọ - 20 na 40 mg nke ọ bụla.
Usoro nke vasilip
Ebe ọ bụ na Vasilip bụ ọgwụ ọgwụ na-eme ka ọ dị ala, usoro ọrụ ya dabara adaba. Nke mbu, vasilip na - ebelata oke mkpoko cholesterol n'ime obara. E nwere ụdị cholesterol abụọ - “jọrọ njọ” na “nke ọma.” Onye “jọrọ njọ” nwere obere lipoproteins pere mpe, ma “nke ọma” bụ nke ukwuu ana –eme ntaramahụhụ.
Vasilip nwere mmetụta na mmalite nke cholesterol guzobere. Ọ gụnyere ntụgharị nke HMG-CoA (hydroxymethylglutaryl-coenzyme A) na mevalonic acid. Mgbanwe a na-eme n'okpuru ike nke enzyme HMG-CoAreductase. Vasilip nwere mmetụta na-akụda mmụọ na enzyme a, n'ihi nke cholesterol enweghị akpụ. Ọgwụ na-emetụtakwa cholesterol, nke dị n’ahụ. Ọ na-ebelata oke cholesterol na-emetụta obere lipoproteins dị ala, ma na-ebelata ịta nke triglycerides.
Ọ bụ ihe ndị a sitere n'okike nke oke nwere ọrụ maka ihiwe onyonyo atherosclerotic na lumen nke akwara. Mana ọgwụ ahụ na-abawanye ụba nke cholesterol dị mma "nke metụtara oke lipoproteins. A na - ebelata ọkwa nke apolipoprotein B - protein pụrụ iche na - ebu maka cholesterol n'ahụ niile.
Na mgbakwunye na iwelata ọkwa nke ụdị mmiri ụfọdụ, isi ihe Vasilip na-arụ ọrụ na-enwe mmetụta n'ahụ mgbidi arịa ọbara na ọbara onwe ya. Ọgwụ ndị ahụ dị ka macrophages, bụ ndị na-ebute ụzọ na izobe nkwakọba cholesterol, na ọgwụ ndị ahụ na-ebelata ya, a na-ebibikwa ngwugwu ndị ahụ. Ọzọkwa, njikọ nke ihe ndị a na-akpọ isoprenoids, nke na-ahụ maka uto mkpụrụ ndụ nke akwara olu nke arịa ahụ, na-ebelata nke ọma, n'ihi nke mgbidi arịa anaghị ebido, ma oghere ya adịghị warara. Na mgbakwunye, Vasilip na-atọpụ arịa ọbara dị mma ma na-eme ka ọbara na-aga n'ihu.
A na-ahụ mmetụta kachasị ukwuu mgbe ọnwa na ọkara gasịrị.
Njirimara nke pharmacokinetics nke vasilip
Vasilip na-egbu egbu. A na-etinye ya nke ọma site na mgbidi nke obere eriri afọ. A na-ahụta oke ọgwụ ahụ otu ugboro ka elekere abụọ ma ọ takingụrụ ya, mana mgbe awa iri na abụọ gasị, ọ na-agbadata 10%. Enwere ike iburu ọgwụ a na nri, nke a agaghị emetụta nsonaazụ ya. Ọzọkwa, ọ naghị agbakọ n'ime ahụ na iji ogologo oge. Ọgwụ ahụ nwere njikọ aka na protein protein, ihe fọrọ nke nta ka ọ bụrụ 100%.
A gbanwee Vasilip ka ọ bụrụ ogige na-arụ ọrụ. A na-akpọ ogige a beta hydroxy acid. A na-ewepụta mgbatị ya (mkpochapụ) site na nnukwu eriri afọ. A na-ewepụ ọgwụ ahụ n'ụdị metabolites (ngwaahịa ntụgharị).
Akụkụ obere akụrụ ahụ na-ewepụ ya, akụrụ, mana n'ụdị akụrụngwa na-apụ apụ site na akụrụ.
Kpochapu ọkara ndụ - oge itinye uche nke ọgwụ n’ọbara na - agbada ugboro abụọ - dabara n ’otu elekere na nkeji iri ise na anọ.
Ihe ngosi na contraindications maka ojiji
Ndị dọkịta na-edekarị ọgwụ vasilip maka ọrịa dịka atherosclerosis. Ebumnuche ya na hypercholesterolemia nke bụ ma ọ bụ dyspidemia agwakọtara (imebi oke ọbara dị n'ọrịa dị iche iche), yana mmega ahụ mgbe niile, oke ibu, na-agbaso nri etinyere, ma ọ bụ na enweghị ọgwụ nke ọgwụ ndị ọzọ.
Ihe ozo gosiputara bu hyzycholesterolemia homozygous. Dị ka o kwesịrị ịdị, na myirịta, nri na oriri nke ọgwụ ndị ọzọ antiatherosclerotic ga-agbaso. Edere Vasilip maka igbochi ọrịa nke akwara obi na atherosclerosis ma ọ bụ ọrịa shuga dị ugbu a, ebe ọ bụ na enwere nnukwu nsogbu nke nkụchi obi, ọrịa strok na ọrịa vaskụla dị iche iche. Nke ikpeazu bu cholesterol di elu ma obu na ekpughi ngosiputa ogwu.
Vasilip bụ contraindicated na ọnọdụ ndị dị ka:
- ọrịa imeju na ọkwa ma ọ bụ na-arụ ọrụ;
- mmụba dị ogologo na enzymes imeju na-enweghị ezigbo ihe kpatara ya;
- afọ ime na lactation;
- obere afọ;
- Mmeghachi ahụ nfụkasị na simvastatin ma ọ bụ ihe ọ bụla ọzọ nke ọgwụ ahụ.
Ekwesịrị ị paida ntị na ndị ọrịa ahụ nwere ọrịa ndị na-esonụ ma ọ bụ ụfọdụ ọnọdụ akọwapụtara:
- Consumption alcoholụbiga mmanya ókè.
- Ọnụnọ nke ọrịa na-emetụta imeju.
- Ọnụnọ nke echiche ezighi ezi na ahụ.
- Nnukwu mmebi nke usoro endocrine na metabolism.
- Nrụgide na-akwụsịlata (hypotension).
- Ahụhụ anụ arụ.
- Ọrịa nke usoro akwara.
- Akwụkwụ na-adọghị ya.
- Nnukwu ịwa ahụ ma ọ bụ mmerụ ahụ.
- Enweghi lactase, enzyme nke na etiwapu lactose (mmiri ara ehi).
- Mmebi nke usoro nke oriri nke lactose.
Ojiji nke oge ọgwụ dika cyclosporine, fenofibrate, amiodarone, verapamil, diltiazem, nicotinic acid, gemfibrozin, yana mkpụrụ osisi grape, chọkwara ịkpachara anya mgbe ị na-eji vasilip.
Ntuziaka maka iji ọgwụ ahụ
Tupu ị anyụ ọgwụ ọ bụla, ị ga-agakwuru dọkịta gị banyere otu esi a drinkụ ya nke ọma, marakwa nkọwa ahụ. Usoro ọkọlọtọ kwesịrị iwere otu ma ọ bụ karịa mbadamba otu ugboro n'ụbọchị.
A na-atụ aro ka ị theụọ ọgwụ ahụ n’abalị, n’ihi na n’abali na-eme ihe na-eme ka kọlestrọl buru ibu, a na-ekwukwa mmetụta ọgwụ ahụ ka ọ na-ekwu. Na-ebido na ọgwụ nke 10 mg. Ogo ịba uru nke kachasị anabata bụ 80 mg kwa ụbọchị. Edere ya maka ndị ọrịa nwere ụdị ọrịa dị elu yana yana nnukwu ihe egwu nke nsogbu site na obi na akwara ọbara. A họọrọ oke chọrọ n'ọtụtụ oge n'ime ọnwa. A na-ahọrọ dọkịta oge ọ ga-agwọ ọrịa iche maka onye ọrịa ọ bụla site na dọkịta na-aga ya.
Ekwesịrị icheta na mgbe ị na-ewere Wazilip, onye ọrịa ahụ n'otu n'otu na-eme nri, nke ọ ga-agbaso. N'ọnọdụ ụfọdụ, a na-enyekwa ọgwụ ndị ọzọ na-akụda Lipid. Maka ndị ọrịa nwere ọrịa dịka hypercholesterolemia, ọgwụgwọ na-amalite site na ntụtụ 10 mg, mana enwere ike ịbawanye ya ruo 40 mg iji nweta nsonaazụ kachasị akpọpụta. Maka ụdị ọrịa a ọrịa, a na-ekewa Vazilip ụzọ ugboro atọ ma ọ bụrụ na enyere ọgwụ kachasị (80 mg), ma ọ bụ etinyere 40 mg nke ọgwụ otu ugboro n'ụbọchị tupu ụra.
Vasilip nwere mmetụta achoro ya na ma otu iji ya na njikọ yana ndị ọzọ na - eso ọgwụ acid. Ndị a bụ ọgwụ dịka colestyramine, colestipol.
Site na iji cyclosporine, gemfibrozil, acid nicotinic ma ọ bụ ọgwụ sitere na otu nke fibrates, ha na-amalite site na 5 mg, na oke kachasị anabata bụ 10 mg. N'okwu a, ị ga-agafe ọgwụ a. Ọ bụrụ na onye ọrịa ahụ na-a drugsụ ọgwụ ike megide arrhythmia na ọbara mgbali elu, dịka Amiodarone na Verapamil, mgbe ahụ, ọgwụ Vasilip ekwesịghị ịbụ ihe karịrị 20 mg kwa ụbọchị, ebe ọ bụ na e nwebeghị ndakọrịta ha.
Ọ bụrụ na mmadụ na-ata ahụhụ n'ọdịdị siri ike nke akụrụ, nke oke mkpochasị ụwa na-erughi 30 ml / min., Edere Vasilip na ọgwụ erughi 10 mg kwa ụbọchị. Ekwesiri ịbawanye dose ahụ nke ọma, na nke a, a ga-enyocha onye ọrịa ahụ mgbe niile.
Ọ bụrụ na -achọkwa azụmaahịa na-alụkwaghịm yana, usoro ọgwụgwọ agaghị agbanwe. Otu ihe a na-aga ndị agadi.
Nsonaazụ vasilip na ịdoụbiga mmanya ókè
Dị ka ọtụtụ ọgwụ, Vasilip nwere ike kpalite ọdịdị nke mmetụta ụfọdụ n'akụkụ ahụ onye ọrịa.
Mmeghachi omume ọjọọ site na iji vasilip adị ụkọ.
Enwere mmetụta dị iche iche sitere na sistemụ anụ ahụ dị iche iche.
Usoro nri: nhịahụ imebi ihe, ihe mgbu n’ime afọ, imetọ gas, oke afọ, ọgbụgbọ, ọgbụgba oge ụfọdụ, ọnya afọ, mgbanwe nke imeju na umeji, ịbawanye ime ụlọ nyocha nke enzymes imeju, alkaline phosphatase na creatine phosphokinase.
Usoro ụjọ na akwara anụ ahụ: mgbu n’isi, nkụda mmụọ, mmetụta na-adịghị mma, neuropathy, nsogbu ịrahụ ụra, ngosipụta nkwarụ, ọhụhụ na anya.
Usoro akwara: myopathies (pathologies nke usoro akwara), mkpo nke akwara, mgbu akwara na ntagide.
Ngosiputa ihe omimi: ihe omuma zuru oke banyere oke nlebara anya nke ogwu, nke ihe oputara n’azu, ngosiputa nke lupus, oke olu mgbu, dermatomyositis, mbelata onu ogugu platelet, mmụba nke eosinophils, vasculitis, osooso nke erythrocyte sedimentation rate, mgbu na usoro mkpali na nkwonkwo, urticaria mmetụta ọkụ, ahụ ọkụ, ọbara ọbara nke ihu, adịghị ike nke izugbe, iku ume.
Ngosiputa akpụkpọ: rashes, itching, isi nkwọcha isi (alopecia).
Na mgbakwunye, enwere ike ịbelata ọnụ ọgụgụ mkpụrụ ndụ ọbara uhie na haemoglobin (anaemia), nnukwu akụrụ na-ada ada, mbelata libido, na palpitations.
A na-ahụta oke ọgwụ Vasilip mgbe pasent nke 3.6 g N'ime nke a, ọ dị mkpa ka ịsaa afọ ahụ, were unyi na-arụ ọrụ ma ọ bụ ọgwụ laxative ka ọgwụ ndị fọdụrụnụ ghara inwe oge ị ga-eji nweta ya, wepụtakwa nke ahụ natara ngwa ngwa. Ekwesịrị inyocha onye ọrịa ahụ mgbe niile.
Enwere ụdị analogues nke Vasilip dịka Atorvastatin, Krestor, Lovastatin, Rosuvastatin, Akorta. Ha niile bụ otu nke otu akpụ. Enwere ike ịzụta ọgwụ ahụ n'ụlọ ahịa ọgwụ ọ bụla site na ndenye ọgwụ. Vasilip dị ọnụ ala - na 250 rubles. Tupu iji ya, dị njikere ịgụ akwụkwọ ntuziaka.
Ọkachamara na vidiyo dị n'isiokwu a ga-ekwu maka simvastatin na ọgwụ ndị dabere na ya.
