Noliprel Bee bụ ọgwụ na-agwakọta ihe abụọ na - arụ ọrụ - perindopril arginine na ebepamide. N'ihi ihe ndị a ejikọtara ọnụ, ọ ga-ekwe omume idozi ọbara mgbali elu na ndabere nke mmetụta diuretic dị nwayọọ. Emebeghi ogwu a ka o jiri mee umu aka na ndi di ime.
International Nonproprietary Aha
Perindopril + Indapamide.
Noliprel Bee bụ ọgwụ na-agwakọta ihe abụọ na - arụ ọrụ - perindopril arginine na ebepamide.
ATX
C09BA04.
Ha weputara udi ya na ihe mebere ya
Ọgwụ dị n'ụdị mbadamba biconvex ọcha nwere akwa mkpuchi. Ngalaba nke ogwu nwere arginine ma ọ bụ nnu tert-butylamine, 10 mg nke perindopril na 2.5 mg nke ebepamide. Otu ndi ozo mejuputara:
- silica colloidal dehydrogenated;
- mmiri ara ehi shuga;
- stodi sodium carboxymethyl;
- maltodextrin;
- stereta magnesium.
Ihe nkiri dị na mpụta nke mbadamba ihe mejupụtara macrogol 6000, titanium dioxide, glycerol, magnesium stearate na hypromellose.
Omume ọgwụ
Ọgwụ nwere mmetụta hypotensive na diuretic na ahụ. Ọgwụ a jikọtara aka na-enyere aka belata enzyme angiotensin (ACE). A na-enweta ihe ndị a na-eji ọgwụ ahụ eme ihe n'ihi mmetụta nke onye ọ bụla n'ime ihe ndị ahụ na-arụ ọrụ. Nchikota ebepamide na perindopril na-abawanye mmetụta antihypertensive.
N'ihi mmetụta diuretic nke ọgwụ ahụ, ọbara mgbali ọbara onye ọrịa na-ebelata.
Ngwunye Perindopril tertbutylamine na-egbochi mgbanwe nke angiotensin I n'ime ụdị angiotensin II site na igbochi kinase II (ACE). Nke ikpeazụ bụ peptidase nke dị na mpụga, nke na-etinye aka na mmebi nke bradykinin vasodilating bradykinin na heptapeptide, metabolite na-adịghị arụ ọrụ. ACE na-egbochi nnwogha nke ụdị M angitensin ogige mmiri n'ụdị vasoconstrictor.
Indapamide bụ ndị otu sulfonamides. Ngwá ọgwụ dị iche iche bụ otu ihe na usoro nke thiazide diuretics. N'ihi igbochi reabsorption nke mkpụrụ ndụ sodium na glomerulus nke akụrụ, mwepu nke klorine na sodium ion na-abawanye, mwepu nke magnesium na potassium na-ebelata. Enwere ịbawanye na diuresis. N'ihi nsị, ọbara ọgbụgba na-ebelata.
Mlọ ọgwụ
Mgbe ejiri ya were ọnụ, tebụl etisasịwara mbadamba ihe. A na - ahapụ Perindopril na ebepamide n'ime obere eriri afọ mgbatị ahụ, ebe villi pụrụ iche na-abanye ihe ndị ahụ. Mgbe ha batara n’akụkụ akwara, akwara abụọ na-arụ ọrụ na-erute ogo plasma kachasị n’ime otu elekere.
Mgbe perindopril batara na arịa ọbara, ọ na-agbasa perindoprilat site na 27%, nke nwere mmetụta antihypertensive ma gbochie ịmepụta angiotensin II. Ọ dị mkpa icheta na iri nri na-ebelata mgbanwe nke perindopril. Ngwaahịa nke metabolic na-ebute oke plasma ịta n'ime awa 3-4. Ọkara ọkara nke perindopril bụ minit 60. A na-ekepụ ogige mmiri ahụ site na sistem.
Ngwaahịa nke metabolic na-ebute oke plasma ịta n'ime awa 3-4, ọkara ndụ bụ nkeji 60.
Indapamide na-ejikọ albumin site na 79% na n'ihi mmalite nke ogige ahụ ka ekesara n’akwara niile. Iwepu ọkara ndụ na-eruchaghị awa iri na anọ ruo awa iri abụọ na anọ. Site na nchịkwa ugboro ugboro, a naghị ahụ nchịkọta nke ihe na-arụ ọrụ. 70% nke ebepamide n'ụdị nke ngwaahịa metabolic na-ahapụ ahụ site na akụrụ, 22% - na ọnya.
Ihe ngosi maka ojiji
A na-ezube ọgwụ a iji belata ọbara mgbali n'ihu ọnụnọ ọbara dị mkpa na ndị ọrịa chọrọ ọgwụ ọgwụ na ebepamide na dose nke 2.5 mg na 10 mg perindopril.
Ihe ngbanwe
Edeghị ọgwụ a n'ihe ndị a:
- nchịkwa nke oge ọgwụ nke na-abawanye oge QT, yana ọgwụ nwere lithium na ion potassium, megide ndabere nke hyperkalemia;
- mmetụta nke ihe ndị mejupụtara ọgwụ ahụ;
- ụdị nke lactose ekweghị ibe nọrọ, galactosemia, ụkọ lactase, malabsorption nke monosaccharides;
- mwepụ nke creatinine (Cl erughị 60 ml / min) - ọdịda akwara siri ike;
- ọrịa obi na-adịghị ala ala na usoro decompensation;
- n'okpuru afọ 18.
Ekwesịrị ịkpachara anya mgbe ị na-ewere Noliprel na ọnụnọ nke usoro pathologies na anụ ahụ na - ejikọta ya (lupus erythematosus, sclerodermaem), mmegbu nke akụkụ ahụ na-akpụ ọbara, ọrịa obi obi, hyperuricemia.
Uzo esi aga na Noliprel Bi
A ga-ewererịrị mbadamba okwu ọnụ, 1 otu ugboro n'ụbọchị. A na-atụ aro ị drinkụ ọgwụ ahụ n'ụtụtụ tupu nri ụtụtụ, n'ihi na iri nri na-ebelata njigide ma belata bioavailability nke ihe ndị nọ n'ọrụ.
Etu esi agwọ ọrịa shuga 2
Ọgwụ ahụ anaghị emetụta mmiri ọgwụ homonụ nke mkpụrụ ndụ beta nke pancreatic ma ọ gbanweghị ịta shuga na plasma ọbara, yabụ, ndị ọrịa nwere ọrịa shuga na-adịghị insulin na-achọghị mmezi dose.
Nsonaazụ nke noliprel bi
Mmetụta ọghọm na-ebute nzụlite nke usoro dosing na-ezighi ezi ma ọ bụ n'ihu ọnụnọ anụ ahụ na - abawanye uru nke akụkụ ahụ.
Ọkpụkpụ afọ
A na-eji mmeghachi omume na-adịghị mma na ngha nke diges.
- ọnụ kpọrọ nkụ
- ọgba aghara;
- ihe mgbu epigastric;
- agụụ riri;
- vomiting, afọ ọsịsa, dyspepsia na afọ ntachi.
N'ọnọdụ ndị a na-adịghị ahụkebe, ọdịdị nke pancreatitis, cholestatic jaundice megide ndabere nke hyperbilirubinemia, angioedema nke eriri afọ.
Ahụhụ Hematopoietic
Na ọbara na lymph, mbelata nke ọnụ ọgụgụ na mgbochi nke ịmalite platelet, a na - ahụbe ihe neutrophils na leukocytes. Na enweghi ụkọ ọbara ọbara, anaemia aplastic na ụdị haemolytic pụtara. Ọdịdị nke agrenulocytosis ga-ekwe omume. N'okwu ndị pụrụ iche: ndị ọrịa ịba n'ọbara, oge ịkpụzigharị mgbe agbatịchara akụrụ - ndị na - egbochi ACE na - akpalite mmepe nke anaemia.
Sistemụ akwara Central
Site na imebi usoro akwara ozi, ihe mere:
- vertigo;
- isi ọwụwa;
- paresthesia;
- Dizziness
- nsogbu ndị a na-ehi ụra na ọnwụ nke mmetụta uche.
N'ọnọdụ ndị pụrụ iche, 1 onye ọrịa n'ime ndị ọrịa 10,000 nwere ike ịnwe ọgba aghara na ọnwụ nke mmụọ.
A na-ahụta nsonaazụ ndị a na-ahụ na bọl bọọlụ site na mbelata n'ọdịdị anya, ebe ntị ntị ka a na-egosipụta n'ụdị mgbanaka na ntị.
Site na usoro urinary
N’ọnọdụ ndị a na-adịghị ahụkebe, akụrụ afọ na nrụrụ etolite etolite.
Site na sistem iku ume
Na-emegide usoro ọgwụgwọ ọgwụ, ndị na - egbochi ACE nwere ike ịmalite ụkwara akọrọ, mkpụmkpụ ume, bronchospasm, imi mkpọchi imi na akpukpo iku ume nke eosinophilic.
Ahụhụ
Enwere ọnya, akpukpo na itching na akpukpo ahu. N'ụfọdụ, angioedema nke ihu na akụkụ ya na-amalite, edeke nke Quincke, urticaria, vasculitis. Karịsịa na ọnụnọ nke a ga - egbochi mmeghachi omume anaphylactoid. Na ọnụnọ nke lupus erythematosus systemic, ọrịa ahụ banyere ọrịa ahụ kawanyere njọ. N'ime usoro nlekọta ahụike, edekọwo banyere ọnọdụ ọrụ na neoprolysis necrolysis nke abụba subcutaneous.
Mmetụta ikike ịchịkwa usoro
Ọgwụ a anaghị emetụta ikike itinye uche ma ọ belatara ngbanwe ọsọ ọsọ, mana n'ihi ọghọm nke nsonaazụ na sistemụ akwara, a ga-elebara anya mgbe ị na-arụ ọrụ na ngwaọrụ ndị siri ike, egwuregwu dị egwu, ịnya ụgbọ ala.
Ntụziaka pụrụ iche
Drugakingụ ọgwụ ejikọtara anaghị egbochi mmepe nke hypokalemia, gụnyere ndị ọrịa nwere ọrịa ezumike n’akuku na ọrịa shuga. N'ọnọdụ a, achọrọ nlebara anya nke ịta potassium na plasma.
N'oge ọgwụgwọ, mbelata nke ọdịnaya sodium ahụ dị na ahụ ga - ekwe omume n'ihi mmepe nke hypotension. Ihe ọghọm nke hyponatremia na-abawanye site na nkwụgharị akwara nke akụrụ, yabụ n'ọnọdụ ndị a ọ dị mkpa ịgwa dọkịta banyere akpịrị ịkpọ nkụ, ọgbụgbọ na afọ ọsịsa. Mbelata ọbara mgbali ugboro ugboro anaghị egbochi nchịkwa Noliprel.
Jiri na agadi
Ndị ọrịa karịrị afọ iri isii na ise nwere ọrụ akụrụ ha adịghị achọ mgbatịkwu dose ọzọ. N'aka nke ọzọ, a na-ahazi usoro onyonye ọgwụ na oge ọgwụgwọ dabere n'afọ, ogo ahụ na okike nke onye ọrịa.
Crib na-edezi ụmụaka
N'ihi ụkọ data na nsonaazụ nke ihe ndị na-arụ ọrụ na uto na mmepe na nwata na etolite, a machibidoro ọgwụ ahụ maka ụmụaka ndị gbara afọ 18.
Jiri n'oge ime na lactation
Thenara ọgwụ ahụ n'oge agba nke abụọ na nke III nke etolite etolite nwere ike akpalite ịdọ akụrụ na ọkpụkpụ nke okpokoro isi, oligohydramnios, ma na-emekwa ka ohere nke hypotension na mkpịsị akụrụ nwa bụrụ nwa ọhụrụ. Ya mere, amachibidoro iji Noliprel n'ime ụmụ nwanyị dị ime.
N'oge ọgwụgwọ, kwụsị ịsa ahụ.
Ngwa maka ọrụ ezughi oke ọrụ
Site na mwepụ nke creatinine karịa 60 ml / min, ọ dị mkpa iji nyochaa ọkwa nke creatinine na potassium ion na plasma mgbe niile.
Jiri maka ọrụ imeju na-arụ ọrụ
Amachibidoro ọgwụ a maka iji ndị ọrịa nwere oke imeju daa.
Nwepu nke Noliprel Bi
N'inwe otu ụdị ọgwụ dị elu, a na-ahụ ihe osise banyere ịdoụbiga mmanya ókè:
- mbelata nke ọbara mgbali elu, ya na ọgbụgbọ na ọgbụgbọ so ya;
- ogwe akwara;
- Dizziness
- oliguria na mmepe nke anuria;
- imebi nguzore nke nnu-mmiri;
- mgbagwoju anya, adighi ike.
Onye a metụtara chọrọ nlekọta ahụike ozugbo chọrọ iji gbochie ịptionụ ọgwụ ọzọ. N ’ụlọ ọgwụ, a na-asa onye ọrịa ahụ ube ya n’afọ, a na-enye carbon dị ọcha ọrụ. Site na mbelata ọbara mgbali elu, a na-akwali onye ọrịa ka ọ kwụ ọtọ ma bulie ụkwụ ya elu. Site na mmepe nke hypovolemia, a na-achịkwa ihe ngwọta sodium chloride 0.9% na ntanetị.
Mmekọrịta na ọgwụ ndị ọzọ
Site na nhazi otu oge nke ọgwụ antipsychotic na antidepressants, ọ ga-ekwe omume ịbawanye mmetụta antihypertensive, nke na-eme ka ohere nke nkwụghachi ụgwọ orthostatic hypotension. Glucocorticosteroids na tetracosactides na-eme ka mmiri na njigide sodium, na-akụda mmetụta diuretic. N'ihi ya, mmụba nke ọbara mgbali amalite. N'aka nke ihe na - eme ka izuta akwara dịkwuo elu, na - amụba mbelata nke mgbali ọbara na akwara.
Jiri nlezianya
A na-ad ị ilezi anya mgbe ị na-ede akwụkwọ ndị a:
- Ọgwụ mgbochi mkpali na - adịghị mma, acetylsalicylic acid nwere usoro ọgwụ kwa ụbọchị nke ihe karịrị 3000 mg. Enwere mbelata na mmetụta antihypertensive, megide nke ọdịda akụrụ na hyperkalemia ọbara.
- Cyclosporin. Ihe ọghọm nke ịbawanye ọkwa nke creatinine na-enweghị ịgbanwe mkpokọta cyclosporine na ọdịnaya mmiri nkịtị.
- Baclofen nwere ike ịkwalite mmetụta ọgwụgwọ ahụ nke ọgwụ ahụ, yabụ mgbe edepụtara ya, ọ dị mkpa iji nyochaa ọnọdụ ọbara yana ọnọdụ akụrụ. Ọ bụrụ na ọ dị mkpa, a na-ahazigharị usoro usoro ọgwụ abụọ ahụ.
Agaghị atụ aro maka ịgwakọta ọnụ
Mgbe ị na-ewere ngwaahịa ndị nwere lithium tinyere Noliprel Bi-Forte, a na-achọpụta ịkpa ike ọgwụ. Site na ọgwụgwọ ọgwụ nke oge a, mkpokọta plasma nke lithium na-abawanye nwa oge na ihe ize ndụ nke egbu egbu na-abawanye.
Mmanya ndakọrịta
Amachibidoro ị toụ mmanya na-aba n'anya n'oge ọgwụ. Mmanya ethyl na-eme ka ọnọdụ nke imeju dịkwuo mma ma na-ebelata ọgwụgwọ nke ọgwụ ahụ, na-eme ka mmetụta inhibitory na ụjọ na sistemụ ịba ọcha n'anya pụta.
Analogs
Ndị nọchiri anya ụdị arụmọrụ gụnyere:
- Ko-perineva;
- Noliprel A;
- Noliprel A-Forte;
- n'otu oge ahụ na-ewere Perindopril na Indapamide, nke a na-ere dị ọnụ ala karịa mkpụrụ ndụ ihe nketa.
Can nwere ike gbanwee na ọgwụ ọzọ mgbe nyochachara ahụike.
Ahịa ọgwụ na-ahapụ okwu
Na-ere ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ
A na-ere ire ere anaghị akwụ ụgwọ n'ihi ihe nrịfere oke yana nsonaazụ ya mgbe ewere ya n’ebighi ndenye ọgwụ.
Ọnụ maka noliprel bi
Ọnụ ego ọgwụ ọjọọ bụ 540 rubles., Na Ukraine - 221 UAH.
Ọnọdụ nchekwa maka ọgwụ
A na-atụ aro ịchekwa ya na okpomọkụ + 15 ... + 25 Celsius.
Bọchị mmebi
36 ọnwa.
Emeputa
Slọ nyocha Labs Servier, France.
Nyocha banyere Noliprel Bi
Na nzukọ ntanetị enwere nyocha dị mma nke ndị na-ere ọgwụ na ndị ọrịa banyere ọgwụ.
Ndi Okacha Cardio
Olga Dzhikhareva, dibia bekee, Moscow
M na-ewere ọgwụ ọgwụ jikọtara ọnụ dị ka usọbọ dị irè. Ogwu ahụ na -ebelata ọbara mgbali n’ezie maka ebepamide nwere mmetụta diuretic. Edinyere ọgwụ a ka ndị ọrịa oge 1 kwa ụbọchị n'ụtụtụ. A na-eme ka usoro ọgwụgwọ ya dabere n'otu n'otu.
Svetlana Kartashova, dibia bekee, Ryazan
Ezigbo ọgwụ maka ọgwụ mgbochi izizi na-esote usoro mmụcha usoro usoro onunu ogwu. Ọgwụ a na-enyere aka belata obubu umeji aka ekpe ma na - eme ka akwara anụ ahụ na akwara vaskụla rụọ ọrụ. Nke a bụ ọgwụ izizi maka ọgwụgwọ ọbara mgbali elu.
Ndị ọrịa
Anastasia Yashkina, 37 afọ, Lipetsk
Edere ọgwụ ahụ maka ọbara mgbali elu. Ewelighị nrụgide ahụ nke ukwuu, yabụ na mbụ agaghị m dọkịta. Mgbe nsogbu ọbara ọgbụgba pụtara, nrụgide ahụ ruru 230/150. Tinye n'ụlọ ọgwụ. Mbadamba mbadamba Noliprel Bi-Fort. Daysbọchị iri na anọ ị regularụchara nri, nsogbu ahụ lọghachiri na nkịtị. Onweghi ahu anataghi, ogwu abiara aru. Nrụgide kwụsịrị ike ruo afọ 3.
Sergey Barankin, 26 afọ, Irkutsk
Otu afọ gara aga, nrụgide ahụ gbagoro ruo 170/130. Ọ chọrọ enyemaka ahụike - dọkịta nyere 10 mg nke Noliprel ma kwuo ka ọ were mbadamba 1 n'ụtụtụ n'ụtụtụ afọ. Na mbụ, ahụ erughị m ala ma atedụọ ọ sweụ nke ukwuu. Ekpebiri m iri ọkara mbadamba. Ọnọdụ na nrụgide laghachiri na nkịtị. Onu ogugu a ruru 130/80.
