Basal nwere insulin kwekọrọ na insulin mmadụ na ahaziri ya wee nweta site na ụdị usoro eji arụ ọrụ mkpụrụ ndụ bụ Escherichia Coli K12 135 pINT90d.
Usoro nke insulin na-arụ:
- na-ebelata ọbara shuga, na-ebelata catabolic mmetụta, na-akwalite mmeghachi nke anabolic;
- na-abawanye usoro glycogen n'ime imeju, akwara na ịmịkọ glucose n'ime sel;
- na-egbochi glyconeogenesis na glycogenolysis;
- na - eme ka ojiji nke pyruvate rụọ ọrụ;
- na-egbochi lipolysis;
- na-abawanye lipogenesis na anụ ahụ na adipose;
- na-akwalite njikọta protein na amino acid na sel.
- na-abawanye usoro nke potassium n'ime sel.
Insuman Bazal GT na-ezo aka insulins na-eme ogologo oge nwere mmalite na-egbu oge. Mgbe iwebata ọgwụ ahụ, nsonaazụ nke iweda glucose dị ala na-apụta n'ime otu awa, ọnụ ọgụgụ kachasị elu nke ihe Insuman Bazal GT pụtara mgbe awa 3-4 gachara. Ogologo nke mmetụta ahụ sitere na awa 11 ruo 20.
Mlọ ọgwụ
N’ime ndị ahụ zuru oke, T ½ plasma insulin bụ ihe dị ka nkeji isii na isii. N'ebe ndị ọrịa na-arụ ọrụ ezughi oke ọrụ, ọ toro ogologo.
Ọ bụ ezie na ekwesịrị iburu n'uche na ọgwụ ọgwụ nke insulin anaghị emepụtaghachi mmetụta metabolic ya. A na-akwado insulin maka ọgwụgwọ insulin chọrọ ọrịa mellitus.
Ihe ndị na-egbochi ọgwụ ọgwụ Bazal
- Ntinye obi mmadu na insulin ma obu ihe ndi ozo inye aka nke Insuman Bazal GT. Ihe ndị a bụ ndị ahụ bụ mgbe enweghị ike ime n’agaghị insulin.
- Hypoglycemia.
Cakpachapụ anya, ị ga-a drugụ ọgwụ:
- ndị ọrịa agadi, ebe ọ bụ na mbelata afọ na ọrụ akụrụ na-ebute mbelata mkpa nke insulin, njirimara a na-aga n'ihu;
- ọdịda akụrụngwa (n'ihi mbelata metabolism metabolism na ndị ọrịa, mkpa nke insulin na-ebelata);
- ọdịda nke imeju (n'ihi mbelata metabolism metabolism na mbelata ike nke gluconeogenesis, mkpa insulin nwere ike ibelata);
- nsogbu siri ike nke akụkụ akwara na akwara obi (na ndị ọrịa nwere ọrịa a, hypoglycemic nke ọma na-enwetara ihe puru iche gbasara ọgwụgwọ, nke a bụ n'ihi na enwere ohere dị na ọrịa ụbụrụ ma ọ bụ ọrịa obi nke hypoglycemia);
- ndị ọrịa nwere protinerative retinopathy, ọkachasị ndị na-enwetabeghị ọgwụgwọ na ọgwụgwọ laser (photocoagulation). Ndị ọrịa a nwere hypoglycemia nọ n'ihe ize ndụ transient amaurosis (kpuru ìsì zuru oke);
- ndị ọrịa nwere nsogbu mgbochi, n'ọnọdụ ndị a, ndị ọrịa na-amụba insulin ike.
Maka ọrịa ọ bụla nke ndị edepụtara n'elu, tupu ịmalite iji ọgwụ ahụ, ịkwesịrị ịchọ ndụmọdụ dọkịta.
Basal n’oge ime na lactation
Ọbụlagodi na ịtụrụ ime, ị nweghị ike igbochi ọgwụgwọ ya na Insuman® Bazal GT. Nke a dị mma, ebe ọ bụ na insulin enweghị ike ịbanye n'ihe mgbochi placental.
Maka nwanyị nke nwere ọrịa shuga tupu ọ tụrụ ime ma ọ bụ onye nwere ọrịa mellitus nke afọ ime, ogo njigide njikwa metabolism n'oge mmegharị ahụ dị oke mkpa.
N’ime oge izizi nke ịtụrụ ime, mkpa insulin nwere ike belata, n’ime oge nke abụọ na nke atọ nke afọ ime, ọ na - etokarị. Mkpa insulin na-ebelata ma ozugbo ịmụ nwa, nwanyị nwere ohere dị ukwuu nke ịmalite hypoglycemia.
N’oge ime ime ya na mgbe amuchara nwa, a ga-enyocha ọkwa nke suga ọbara. Mgbe ị na-eme atụmatụ ịtụrụ ime na mmalite ya, nwanyị ga-agwa dibia bekee banyere nke a.
N'oge ị na-enye nwa ara, enweghị mgbochi ọ bụla na usoro insulin, ọ bụ ezie na enwere ike ịhazigharị dose.
Nsonaazụ ọgwụ
Hypoglycemia
Ihe kachasị akpata mmetụta insulin na-arụ bụ hypoglycemia. Ọ nwere ike itolite ma ọ bụrụ na ọgwụ insulin na-akari mkpa ọ dị. Ugboro ugboro ugboro nke ajọ hypoglycemia na-eduga mmepe nke mgbaàmà akwara ozi: coma, convulsions.
Ọnọdụ siri ike na ogologo oge hypoglycemia nwere ike ibute ndụ ndị ọrịa nnukwu ọrịa. Tupu onye ọrịa ebido mepụta ihe mgbaàmà nke neuroglycemia, o nwere ngosipụta nke mmegharị ahụ nke sistemụ ọmịiko. Nke a bụ nzaghachi nye hypoglycemia.
Ọtụtụ mgbe, site na mgbanye ọsọ ọsọ ma na-ekwusi ike na ịta ọbara shuga, a na-egosipụta ihe mgbaàmà nke ịgbatị ume ahụ nke sistemụ ọmịiko na ihe omume ya ka ukwuu.
Site n'ibelata shuga dị n'ọbara, hypoglycemia ma ọ bụ ụbụrụ nwere ike ịmalite. Edepụtara ebe a bụ ihe ojoo nwere ike ime na ndị ọrịa. Ejiri klaasị akụkụ ahụ klaasị ha
- a maghị ugboro ole a (dịka data dị adị si dị, ọ gaghị ekwe omume ịchọpụta ihe mmetụta ọ bụla dị na ya);
- di obere (<1/10000);
- ụkọ (≥1 / 10000 na <1/1000);
- ugboro ugboro (≥1 / 1000 na <1/100);
- ugboro ugboro (≥1 / 100 na <1/10);
- ugboro ugboro (≥1 / 10).
Site na usoro ahụ ji alụso ọrịa ọgụ
- Ngosiputa ihe omimi nke udiri ya na insulin ma obu ndi aru oru ogwu - amaghi ugboro ole.
- Bronchospasms - amaghi ugboro ole.
- Mmeghachi omume anụ ahụ mepụtara - ugboro ole amaghi.
- Mbelata ọbara mgbali elu - ugboro ole amaghi.
- Ọkpụkpụ Angioneurotic - amabeghị ugboro ole a.
- Nkịtị anaphylactic bụ mmeghachi omume na-enweghị oge.
- Inje insulin ga - eme ka ọgwụ mgbochi ọgwụ dị na insulin - a maghị ugboro ole a.
Ihe ndị a niile nwere ike ibute ndụ onye ọrịa nnukwu, yabụ, ha chọrọ enyemaka ozugbo. Ọnụnọ nke ọgwụ mgbochi ndị a n'ọnọdụ ndị a na-adịghị ahụkebe maka mmezi nwere ike ịchọ ịgbanwe insulin.
Na nri nke nri na metabolism
Site na njikwa metabolic dị mma (nke na-ezitabeghị na mbụ) site na iji ọgwụ insulin na-arụsi ọrụ ike:
- ọzịza nwere ike ime - ọtụtụ mgbe;
- njigide sodium na - eme - amabeghị ugboro ole a.
Site na akụkụ ahụ anya
- Ọgba aghara nke na - adịru nwa oge nwere ike ịpụta n'ihi mgbanwe nke njikwa glycemic - amabeghị ugboro ole a. Nsogbu a na-ebilite n'ihi nbibi nke oghere anya na nwa oge.
- A na - ewere ọgwụ insulin nke ukwuu na njikwa glycemic nwere ike ịda ka mbibi na - adị nwa oge nke ọrịa mamịrị retinopathy na - arịa amaghi ugboro ole.
- N'ime ndị ọrịa nwere ọrịa retinopathy na-abawanye uru (ọkachasị maka ndị na-anaghị enweta ọgwụgwọ ziri ezi site na ọgwụgwọ laser), nnukwu ihe hypoglycemic nwere ike ime ka mpụsị ọhụụ zuru ezu (transient amaurosis) - amabeghị ugboro ole a.
Site na anụ ahụ na akpụkpọ anụ
N’inye ọgwụ insulin ọ bụla, o nwere ike ịbụ na lipodystrophy na-etolite n’ebe a na-agba ya ma na-ebelata insulin nke ime obodo - a amaghị ugboro ole a Mmeghachi omume ndị dị otú a nwere ike ifu ma ọ bụrụ na a na-agbanwe saịtị ntanetị mgbe niile n'ime mpaghara akwadoro.
Mgbakasị ahụ na saịtị ịgba ahụ yana nsogbu niile
Mmeghachi omume dị nwayọ na-abụkarị n'ebe ndị a na-agba agba ọgwụ. Ha gụnyere:
- ihe mgbu na mpaghara nchịkwa - amabeghị ugboro ole a;
- acha ọbara ọbara na mpaghara nchịkwa - amabeghị ugboro ole a;
- urticaria na mpaghara nchịkwa - amabeghị ugboro ole a;
- itching na mpaghara nchịkwa - amabeghị ugboro ole a;
- mbufụt ke mpaghara nchịkwa - amaghi ugboro ole;
- ọzịza n’ebe a na-agba agba mmadụ - amabeghị ugboro ole a.
Ọbụna mmeghachi omume siri ike na insulin homonụ na saịtị ịgba ntụtụ na-apụkarị n'anya mgbe ụbọchị ole na ole ma ọ bụ izu.
Ntụziaka maka ojiji
Nkwadebe insulin ga-eji mee ihe; mkpokọta ọbara shuga; Usoro insulin nke usoro insulin (oge igba ntụtụ na dose) kwesịrị ka edobe ma dozie ya n’otu n’otu. Nke a dị mkpa iji soro:
- ndu nke onye ọrịa;
- larịị nke mmega ahụ;
- nri.
Enweghị iwu dị mma maka ọgwụ insulin. Agbanyeghị, enwere insulin dose bụ 0.5-1 IU / kg / s. Ọ bụ ihe e ji mara na ọ̀tụ̀tụ̀ insulin na-arụ ọrụ ogologo oge na-akpata 40% ruo 60% nke insulin kwa ụbọchị nke mmadụ chọrọ.
Dọkịta kwesịrị inye onye ọrịa ndụmọdụ na ndụmọdụ ndị dị mkpa:
- gbasara mgbanwe ọ bụla na usoro ọgwụgwọ insulin;
- gbasara mgbanwe n’ime nri;
- site ugboro ole ị na-ekpebi ịta shuga n’ọbara.
Ntugharị sitere na Bazal
Mgbe ị na-ebufere ndị ọrịa n’otu insulin na insulin ọzọ, mgbazi nke usoro onunu ogwu ga-adị mkpa. Ọ nwere ike ịbụ:
- ntughari insulin nke mmadu si na insulin nke sitere na anumanu puta;
- mgbanwe nke otu ọgwụ insulin na-agbanwe na nke ọzọ;
- ma ọ bụ mgbe ị na-agbanwe site na ọgwụ insulin na-arịa mmadụ na-agbanye na usoro nke metụtara ojiji nke insulin na-eme ogologo oge.
Mgbe ị na-agbanwe insulin nke anụmanụ sitere na insulin mmadụ, ọ nwere ike ịdị mkpa belata ya.
Nke a bụ eziokwu karịsịa maka ndị ọrịa ahụ:
- nọbu n'ọbara shuga dị ala;
- n'ihi ọnya ọgwụ dị iche iche iji nwee insulin, a na-eji ya ọgwụ ndị dị elu emeburu ya;
- nwere ihe ga - eme ka ịbawanye hypoglycemia.
Mkpa maka mbelata ọgwụ nwere ike apụta ozugbo ịbanye na ụdị insulin ọzọ, ma nwee ike ịmalite nwayọ (ọtụtụ izu). N'oge mgbanwe site n'otu insulin gaa na nke ọzọ, yana n'izu ole na ole sochirinụ, achọrọ ịchịkwa shuga shuga ọbara.
Ndị ọrịa bụ, n'ihi ọnụnọ ọgwụ nje, na-eji insulin dị ukwuu, kwesịrị ịgbanye ụdị insulin ọzọ naanị n'ụlọ ọgwụ n'okpuru nlekọta ahụike siri ike.
Usoro onunu ogwu
Mmụba insulin na-aba ụba nwere ike ịrụpụta site na nchịkwa metabolic dị mma. N'ihi ya, mkpa anụ ahụ insulin nwere ike ibelata.
Mgbanwe dose nwere ike ịdị mkpa n'okpuru ọnọdụ ndị ọzọ:
- mgbanwe n’arụ ahụ onye ọrịa;
- ụdị ndụ na-agbanwe, gụnyere ogo arụ ọrụ na nri;
- ọnọdụ na-enye aka na mmepe nke hyper- na hypoglycemia.
Usoro usoro onunu ogwu maka otu ndi oria puru iche
- Ndị okenye - na otu a, ka oge na-aga, mkpa insulin nwere ike belata. Ya mere, bido kwalite insulin, họrọ mmezi ma ọ bụ iwelie usoro ọgwụgwọ nke ndị ọrịa agadi na-arịa ọrịa shuga kwesịrị ịkpachapụ anya. Ma ọ bụghị ya, enwere ike iwe iwe hypoglycemic.
- Ọrịa nwere akụrụ. Ndị a, nwekwara ike ịchọ insulin na-erughị.
Ọgwụ ọgwụ
A na-ahụkarị Basal n'ụzọ miri emi, minit 45-60 tupu nri. Oge ọ bụla, a na-atụ aro ịgbanwe saịtị ntụtụ n'ime otu mpaghara. Dịka ọmụmaatụ, afọ na-agbanwe mpaghara mpaghara hip. Mana mgbanwe a ga - ekwe omume naanị mgbe gị na dọkịta kpachara anya tupu ị gwaa ya.
Nke a dị mkpa n'ihi na adsorption insulin, yabụ na mmetụta nke iwetulata ọkwa shuga dị ala, nwere ike ịgbanwu dabere na ebe a na-etinye insulin (dịka ọmụmaatụ, apata ụkwụ ma ọ bụ afọ).
A naghị eji Bazal n'ọtụtụ nfuli insulin (gụnyere nfuli mmanụ). Nlekọta ọgwụ mgbochi ọbara nke ọgwụ ahụ bụ ihe anabataghị! Ọ gaghị ekwe omume ịhapụ ịgwakọta Bazal na insulin analogues, insulin nke sitere anụmanụ, insulin nke ịta na ọgwụ ndị ọzọ.
Enwere ike ịgwakọta Bazal na nhazi insulin ọ bụla nke mmadụ nke Sanofi-aventis Group mepụtara. Ma na insulin, nke emebere maka paịlị insulin, ekwesighi ịgwakọta Bazal.
I kwesiri icheta oge niile na mmonye nke insulin di na nha nke 100 IU / ml (maka carridges 3 ml ma ọ bụ vials 5 ml. Ọ bụ ya mere ị ga-eji jiri mkpụrụ osisi sirinji KlikSTAR ma ọ bụ OptiPen Pro1 mee ihe (ma ọ bụrụ na ejiri cartridges), ma ọ bụ plates plastik emebere maka ịta a.
Na sirinji rọba enweghị ike ịbụ ọgwụ ọ bụla ọzọ ma ọ bụ nsị. Mgbe ị na-anakọta insulin na vial ahụ na nke mbụ, ịkwesịrị iwepu okpu plastik site na nke ikpeazụ. Ọnụnọ ya na-egosi na emeghebeghị karama ahụ tupu mgbe ahụ.
Ihe mgbaàmà nke oke ị ofụ ọgwụ
Mmeghe nke insulin ngafe, ya bụ, ịdoụbiga ya oke ókè ma e jiri ya tụnyere ụgwọ ọrụ ike ma ọ bụ nri riri, ọ nwere ike ibute hypoglycemia ogologo oge, nke siri ike ma na-eyi ndụ egwu.
Ọgwụgwọ
Ọ bụrụ na onye ọrịa maara, nke a na - egosi ntakịrị hypoglycemia. A na-akwụsị usoro ndị dị otú ahụ site na ịgesụ carbohydrates. Ma mmezi nke insulin dose, mmega ahụ na iri nri ka nwere ike ịchọrọ.
Ọnọdụ hypoglycemia dị njọ karị, nke onye ọrịa dabara na Coma, nkwarụ akwara ma ọ bụ nkwarụ na-apụta, nwere ike ịkwụsị ya site na intramuscular ma ọ bụ subcutaneous management nke glucagon ma ọ bụ site na ntụtụ ọnya ọgbụgba dextrose.
Ego ole dextrose na-ahụ maka ụmụaka ka edobere nha ahụ nwatakịrị. Mgbe itinye glucose na ọbara bilitere, enwere ike inwe mkpa maka mmezi nke carbohydrates. Ekwesịrị ilebara nwatakịrị ahụ anya, nke mere na mgbe ọpụpụ ahụike dị omimi pụtara, ịmaliteghachi hypoglycemia nwere ike ime.
N'ihe banyere hypoglycemia ogologo oge ma ọ bụ nnukwu nnwale mgbe nchịkwa glucagon ma ọ bụ dextrose, ọ dị mkpa iji zụpụta usoro dextrose dị mkpụmkpụ. Nke a dị mkpa iji gbochie ịmaliteghachi hypoglycemia.
Ọ dị mkpa iji nlezianya nyochaa oke nke glucose na ọbara n'ime ụmụaka, nke a ga - enyere aka igbochi mmepe nke hyperglycemia siri ike.
