Iji nweta ụgwọ ọrụ ogologo oge maka ọrịa shuga, a na-eji ọtụtụ insulin analogues dị iche iche. Insulin Lizpro bụ ọgwụ ọgbara ọhụrụ na - adịchaghị mma, nke na - adị gara gara nke na - egbochi glucose metabolism.
Enwere ike igosi ngwa a maka ndị ọrịa shuga nke ndị dị afọ dị iche iche. Enwere ike ịnye insulin Lizpro maka ụmụaka nwere ọrịa shuga.
E jiri ya tụnyere insulins ndị dị mkpụmkpụ, Insulin Lizpro na-eme ngwa ngwa, n'ihi oke oriri ya.
Omume ọgwụ na ihe ngosi
Emere insulin Lizpro biphasic site na iji teknụzụ DNA recombinant. Enwere mkparịta ụka na nnata nke akpụkpọ ahụ cytoplasmic nke mkpụrụ ndụ, a na-emepụta insulin-receptor complex, nke na-akpali usoro dị n'ime sel, gụnyere njikọ nke enzymes dị mkpa.
A na-akọwa mbelata mgbanye aka na ọbara ọbara site na mmụba na mmegharị ọbara ya, yana ịba ụba na nnabata nke mkpụrụ ndụ. Sugar nwere ike ibelata n'ihi mbelata nke ọnụego ya na-emepụta site na umeji ma ọ bụ site na mkpali nke glycogenogenesis na lipogenesis.
Lyspro insulin bụ ihe ndọghachi azụ nke DNA nke dị iche na usoro nke lysine na ntụgharị amino acid na ọkwa nke 28 na 29 nke insulin B yinye. Ọgwụ ahụ nwere nkwarụ protamine 75% na insulin lispro 25%.
Ọgwụ nwere mmetụta anabolic na nhazi nke metabolism metabolism. Na anụ ahụ (ewezuga akwara ụbụrụ), mgbanwe nke glucose na amino acids n’ime sel na - eme ngwa ngwa, nke na - enyere aka ịmepụta glycogen site na glucose n’imeju.
Ọgwụ a dị iche na insulins ndị a na-eme na ngwa ngwa mmalite nke anụ ahụ na obere nsonaazụ ya.
Ọgwụ na-amalite ime ihe mgbe nkeji iri na ise gasịrị, nke a na-akọwa site na nnukwu mmịpụta. Ya mere, enwere ike inye ya nkeji iri na ise tupu nri. Ana etinye insulin kwa ụbọchị na erughị ọkara otu elekere.
Site na nbiputa ya na ihe ndi ozo bu ihe anakpo onu ya. A na-ahụ oke ọrụ na oke nke 0,5 - awa 2.5. Insulin Lizpro na-arụ ọrụ ruo awa anọ.
A na-egosi ntụgharị ọgwụ Lizpro maka ndị nwere ụdị ọrịa shuga 1 nke ọrịa mellitus, ọkachasị bụrụ nke ekweghị na insulin ọzọ. Na mgbakwunye, a na-eji ya n'ọnọdụ ndị a:
- postprandial hyperglycemia,
- Nlegide ọgwụ insulin na-atụgharị anya n'ụdị dị njọ.
A na-ejikwa ọgwụ ahụ maka ụdị ọrịa shuga 2 nke ọrịa mellitus na iguzogide ọgwụ mgbochi hypoglycemic.
Inwere ike inye ọgwụ insulin Lizpro maka nsogbu ịgba ọgwụ mgbochi.
Ntuziaka maka iji ọgwụ ahụ
Ntụziaka maka ị ofụ ọgwụ na-egosi na ekwesịrị ịgụta usoro dabere na ọkwa nke glycemia. Ọ bụrụ na ọ dị mkpa, a na-a drugụ ọgwụ ahụ yana insulins na-eme ogologo oge, ma ọ bụ site na ọgwụ a sulfụ ọgwụ sulfonylurea.
A na-eme usịbi ụzọ n'ime ụdị akụkụ ahụ nke onye ọrịa ahụ:
- hips
- afọ
- ike
- ubu.
Ekwesịrị ịgbanwere saịtị ndị agba agba ka ha ghara iji karịa karịa 1 oge kwa ọnwa. Enyekwala irigha ebe ebe obara ọbara di ezigbo nso.
Ndị nwere nsogbu ịba ọcha n'anya na akụrụ nwere ike ịnwe ihe insulin na-ekesa ma nwee obere mkpa maka ya. Nke a chọrọ nlebara anya mgbe niile nke glycemia na mgbazi oge nke usoro ị theụ ọgwụ ahụ.
Edemede mkpụrụ edemede Humalog (Humapen) dị ugbu a; ọ ka mfe iji. Enwere ọtụtụ nhọrọ maka otu a, ọnụ ọgụgụ dịkarịa ala na-agụsị akwụkwọ na nkeji 0,5.
Ndị dị otú ahụ na-ere:
- "Humapen Luxura". Ngwa a ka eji eji enyo eleputa nke n’egosiputa oge udiri nke ikpe azu ya na ogo nke onunu enyere.
- Humapen Ergo. Pen nwere uru kachasị mma maka ego.
A na-ere insulin Lizpro, na mkpịsị mkpụrụ ọgwụ Humapen na ọnụahịa dị mma ma nwee nyocha dị mma.
Nsonaazụ na contraindications
Insulin Lizpro nwere ọgwụ ndị a:
- onye anabataghi,
- hypoglycemia,
- insulinoma.
A na-egosipụta ịkpa aghara na mmeghachi omume nfụkasị dị otú a:
- urticaria
- anakpo fever na aru
- mkpụkpu ume
- na-ebelata ọbara mgbali elu.
Ọdịba nke hypoglycemia na-atụ aro na a họọrọ usoro ị ofụ ọgwụ ahụ na-ezighi ezi ma ọ bụ mmejọ ahụ bụ nhọrọ na-ezighi ezi nke ọnọdụ ma ọ bụ usoro ntụtụ. Ekwesighi iji ụdị insulin a eme ya intravenia, mana subcutaneously.
N'ọnọdụ ndị a na-adịghị ahụkebe, hypoglycemic coma nwere ike ime.
A na-ekepụta Lipodystrophy ma ọ bụrụ na emechiri mpe mpe akwa n'okpuru.
Ihe ama ama ndia bu ezigbo ogwu.
- iju
- ọsụsọ
- obi ike
- agụụ
- nchegbu
- paresthesia n'ọnụ,
- pallor nke anụ ahụ,
- isi ọwụwa
- ịma jijiji
- vomiting
- nsogbu ihi ụra
- ehighi ura
- Obi erughị ala
- mgbakasị ahụ
- omume na-ekwesịghị ekwesị
- ọhụhụ anya na ikwu okwu,
- glycemic coma
- ogwe.
Ọ bụrụ na mmadụ maara ihe, mgbe ahụ, dextrose inward ga-egosi. Enwere ike ijikwa Glucagon intravenously, subcutaneously na intramuscularly. Mgbe etolite hypoglycemic coma, a na-ahụ ihe ruru 40 ml nke ngwakọta 40% dextrose. Ọgwụ na-aga n'ihu rue mgbe onye ọrịa ahụ si na Coma.
Ọtụtụ mgbe, ndị mmadụ na-anabata insulin Lizpro na-enweghị nsonaazụ ọjọọ.
N'ọnọdụ ụfọdụ, nnabata nwere ike ịdị iche na arụmọrụ belata.
Nmekorita nke nmekorita ya na ogwu ndi ozo
E kwesịghị iji insulin Lizpro na ọgwụ ndị ọzọ. A na - eme ka mmetụta hypoglycemic nke ọgwụ ahụ dịkwuo mma:
- Ndị na - egbochi MAO
- androgens
- ACE
- mebendazole,
- sulfonamides,
- carbonic anhydrase,
- theophylline
- anabolic steroid
- nkwadebe lithium
- Ndị NSAID
- chloroquinine,
- bromocriptine
- tetracyclines
- ketoconazole,
- clofibrate
- fenfluramine,
- quinine
- cyclophosphamide
- ethanol
- pyridoxine
- quinidine.
Mmetụta hypoglycemic na-ebelata site na:
- estrogens
- glucagon,
- heparin
- somatropin,
- danazol
- GKS,
- ogwu gboro ya
- diuretics
- homonụ thyroid
- Ndị na-emegide nnu
- nnabata ọmiko
- morphine
- clonidine
- tricyclic antidepressants,
- diazoxide
- wii wii
- nikotin
- ihe ndapụta
- BMKK.
Ihe omume a nwere ike imebi ma meziwanye:
- Octreotide
- ihe mgbochi beta,
- reserpine
- pentamidine.
Ozi Pụrụ Iche
Ọ dị mkpa iji nlezianya lelee ụzọ nchịkwa nke ọgwụ nke dọkịta guzobere.
Mgbe ị na-ebufe ndị ọrịa na insulin Lizpro na insulin na-eme ngwa ngwa, enwere ike ịchọ ndozi dose. Mgbe ubochi nke mmadu riri ihe kariri nari 100, nnyefe site n'otu ụdị insulin gaa na nke ọzọ ga-ebufere n'ọnọdụ ọnọdụ.
Enwere ike idozi mkpa maka ị doseụ ọgwụ insulin ọzọ n'ihi:
- ọrịa na-efe efe
- obi erughị ala
- na-abawanye ego nke carbohydrates na nri,
- mgbe ị na-a medicationsụ ọgwụ na-arụ ọrụ hyperglycemic: homonụ thyroid, thiazide diuretics na ọgwụ ndị ọzọ.
Mbelata mkpa ịchọrọ insulin nwere ike ịdị na umeji ma ọ bụ akụrụ, ịba ụba nke arụ ọrụ, ma ọ bụ mgbe ị na-a medicationsụ ọgwụ nwere ọrụ hypoglycemic. Ego ndị ahụ gụnyere:
- ndị na - abụghị ndị na - eme nhọrọ beta,
- Ndị na - egbochi MAO
- sulfonamides.
Ihe ọghọm hypoglycemia na-ebelata ikike mmadụ ịkwọ ụgbọ na idobere usoro dị iche iche.
Ndị na-arịa ọrịa shuga nwere ike wepu hypoglycemia dị nwayọ site na ị sugarụ shuga ma ọ bụ nri nwere oke carbohydrates.
Ekwesịrị ịgwa dọkịta dị ya nso banyere eziokwu hypoglycemia, ebe ọ bụ na a ga-agbanwe usoro ịha ahụ.
Akwụ ụgwọ na analogues nke ọgwụ
Ugbu a, a na-ere Insulin Lizpro na ọnụahịa nke 1800 ruo 2000 rubles.
Analogues nke ọgwụ insulin Lizpro bụ:
- Insulin Humalog Mix 25.
- Ngwakọta insulin Humalog 50.
Varietyzọ ọzọ insulin na-agba mmiri dịnụ bụ ọgwụ insulin nke nwere akụkụ abụọ.
Ọ dị mkpa icheta na ịnweghị ike iji insulin Lizpro dabere na mkpebi onwe gị. Ọgwụ a ga-ewere naanị mgbe emesịrị ya site na dọkịta na-abịa. Dos dos bụkwa ọrụ nke dibịa.
Nkọwa na iwu maka ị usingụ insulin Lizpro ka enyere na vidiyo dị n'isiokwu a.
