Elelesterol dị n'ọbara na - eduga n'ọzụ nke ọnọdụ dị ize ndụ. Site na hyperglycemia, usoro akwara na - agbagha, atherosclerosis na - apụta, ọnya na -emekwa abụba na veins na akwara.
Mgbe akwara ọbara mebiri emebi, mgbasa ọbara na-akawanye njọ na hypoxia. Nke a nwere ike iduga nkụchi obi, ọrịa strok, na thrombosis. Ihe a niile na - akpata ọnwụ.
Karịsịa n'ihe ize ndụ nke ịmalite ọrịa atherosclerosis bụ ndị ọrịa mamịrị, ndị, na-emegide nzụlite hyperglycemia, ahụ dum na-agbagha. N'ihi ya, ha kwesịrị iji nlezianya nyochaa ahụike ha ma ghara ikwe ka cholesterol na-emerụ ahụ bara ụba n'ime ọbara.
Taa, ụlọ ọrụ na-emepụta ọgwụ na-enye ọtụtụ ọgwụ cholesterol belata. Otu n'ime ọgwụ kachasị mma bụ simvastol. Mana tupu ị theụ ọgwụ ahụ, ị kwesịrị ịmara onwe gị na ntuziaka maka ọgwụ ahụ ma gaa hụ dọkịta.
Emeghachi ọgwụ ọgwụ, ihe mejupụtara na ụdị ntọhapụ
Simvastol na - egbochi mmepụta cholesterol ma na - egbochi ọrụ enzyme dị na njikọ mevalonate. Ihe a na - ebelata mkpokọta triglycerides, obere lipoproteins dị ala na nnukwu ume.
Ọgwụ nwere mmetụta ngụkọta, yabụ, a ga-ahụta nsonaazụ ya naanị mgbe mkpụrụ ụbọchị iri na anọ gachara. A na-etinye Simvastol ngwa ngwa n'ọbara ọbara, a na-enweta ntinye kachasị na nkeji iri abụọ na isii mgbe nchịkwa ya gasịrị.
N'ime imeju, a gbanwere ọgwụ ahụ, na-eme ka e guzobe beta-hydroxyl acid, nke nwere mmetụta ọgwụ ọgwụ dị ike. Iwepu ọkara ndụ nke metabolites bụ awa 2. Ha na-apụ n’ahụhụ n’ụzọ bụ isi n’ime eriri afọ.
Isi ihe dị na simvastol bụ simvastatin. Enwetara onyinye a site na gbaa akwụkwọ nke Aspergillus terreus molds.
Ngwa ndi ozo nke ogwu:
- macrogol;
- citric acid na lactose monohydrate;
- ụcha ígwè;
- butylhydroxyanisole,
- steeti magnesium;
- ụcha ígwè;
- titanium dioxide na ndị ọzọ.
Ọgwụ ahụ dị n'ụdị mbadamba. Otu ngwugwu nwere mbadamba 14 ma ọ bụ 28. N'ime okpu pink ahụ enwere 10 mg, na odo - 20 mg, na agba aja aja - 40 mg nke ihe na-arụ ọrụ.
Ihe ngosi na contraindications
E gosipụtara iji simvastatin maka ụdị hypercholesterolemia bụ isi nke IIa ma ọ bụ IIb nke nwere ike ịbawanye na atherosclerosis na adịghị ike nke usoro ọgwụgwọ nri na usoro mmega ahụ. Ọzọkwa, ọgwụ ahụ nwere ike inye aka na ischemia cardiac dị ka mgbochi nke ịdaba na ọrịa obi, nkụchi obi.
Edebere Simvastol maka cholesterol dị elu, jikọtara ya na hypertriglyceridemia. Edere ọgwụ ahụ n'oge nkwadebe maka ịlaghachi ọgwụ iji belata ohere enwere nsogbu.
Ihe mgbochi iji ojiji nke simvastatin - ọrịa imeju, myopathy, anabataghị akụkụ nke ọgwụ ahụ. Edeghị ọgwụ ahụ n’oge nwata na n’oge uto.
N'iji nlezianya, a na-eji simvastol mee ihe n'okwu ndị a:
- ọrịa imeju na-adịghị ala ala;
- alisụrụma;
- nsogbu nke mmiri-electrolyte nguzozi;
- ọbara mgbali ala;
- mmerụ ahụ
- ọdịda odida;
- atonicity nke akwara nke ọkpụkpụ;
- nsogbu endocrine;
- ọrịa na-efe efe siri ike;
- mmebi nke usoro metabolic;
- ime na ịba ọcha n'anya B.
Ọzọkwa, ekwesighi iburu mbadamba mgbe usoro ịwa ahụ ọ bụla. Karịsịa, ọgwụ ahụ nwere contraindicated na ntụgharị nke akụkụ ahụ dị n'ime mgbe eji immunosuppressants.
Ntuziaka maka mbadamba mbadamba
Akwụkwọ ntuziaka maka iji ọgwụ ahụ na-ekwu na ọ na-egbu mmanya otu ugboro n'ụbọchị na mgbede, jiri mmiri sachaa ya. Ọzọkwa, oge a na-ewere Simvastol agaghị ejikọ ya na iji nri.
Tupu ịmalite na n'oge ọgwụgwọ, ekwesịrị ịgbaso nri anticholesterol. Na usoro ọgwụgwọ mbụ, a na-atụ aro ị tabletsụ mbadamba mmiri n'ọtụtụ ọgwụ 10 na 20 mg.
Dabere na ogo hypercholesterolemia, dọkịta nwere ike ịgbanwe ego nke ihe na-arụ ọrụ site na 10 ruo 80 mg kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, ụbọchị iri abụọ na asatọ ọ bụla dọkịta na-emezi usoro ịgwọ gị. N'ime ọtụtụ ndị ọrịa, a na-enweta mmetụta ọgwụgwọ kachasị site na iwere 20 mg nke Simvastol kwa ụbọchị.
Site na hypercholesterolemia na-eketa ekesa (homozygous), ego ọgwụ kwa ụbọchị bụ 40 mg / ụbọchị ma ọ bụ 80 mg kwa ụbọchị, kewara n'ime usoro atọ (20/20/40 mg).
Site na ọrịa obi obi, usoro ọgwụgwọ a tụrụ aro ya bụ 20-40 mg kwa ụbọchị. Ọ bụrụ na ntinye uche nke LDL erughị 1.94 mmol / L, yana ọkwa cholesrol bụ 3.6 mmol / L, mgbe ahụ belata belata.
Na ọrịa akụrụ na-adịghị ala ala, na-ewere fibrates, nicotinic acid na Simvastol, ego a na-atụ aro maka nke ikpeazụ kwa ụbọchị adịghị karịa 10 milligrams.
Ndị ọrịa na-a Amụ Amiodarone ma ọ bụ Verapamil kwesịrị iwere Simvastol na ego ruru 20 mg kwa ụbọchị.
Nsonaazụ na mmekọrịta mmekọrịta ọgwụ
N'ime usoro ọgwụgwọ nke Simvastol, ọtụtụ mmeghachi omume na-adịghị mma nwere ike ịmalite. Yabụ, mgbe ị theụchara ọgwụ ahụ, akwara diges na-agbakarị nsogbu, nke na-egosipụta afọ ọsịsa, afọ ntachi, ọgbụgba, pancreatitis, ọgbụgbọ, ịba ọcha n'anya.
Mgbe ụfọdụ nsonaazụ ya na-emetụta sistemụ akwara. Ihe ga - esi na ya pụta bụ nkwonkwo akwara, myalgia, ịba, myopathy, rhabdomyolysis.
N'oge eji simvastatin, ekpughe ihe nfụkasị ahụ, dịka urticaria, polymyalgia, lupus, fever, vasculitis, angioedema, rheumatoid ogbu na nkwonkwo, mkpụmkpụ ume. Mmeghachi omume akpụkpọ ahụ nwekwara ike ịmalite - hyperemia na itching nke anụ ahụ, dermatomyositis, photoensitivity, alopecia.
Ojiji nke simvastol nwere ike imetụta ọrụ nke sistem na-adịghị mma:
- ntaramahụhụ;
- isi ọwụwa
- nsogbu neuropathy;
- ọrịa asthenic;
- ọrịa shuga;
- ehighi ura
- ogwe akwara;
- paresthesia.
Mmetụta na-adịghị mma nke na-eme mgbe ị nwusịrị Simvastol gụnyekwara mbelata ikike, nnukwu akụrụ gbasara ọrịa, anaemia, ọkụ ọkụ, na nkụchi obi. Simvastatin nwekwara ike imetụta paradaịs ụlọ nyocha, nke gosipụtara site na thrombocytopenia, mmụba na ESR, eosinophilia.
Banyere mmekorita nke ọgwụ, ọ bara uru ịmara na ọgwụ ahụ na-abawanye arụmọrụ anticoagulants, nke na-eme ka ohere ịwụ ọbara dị elu. Mmetụta ọgwụgwọ nke Simvastol na-abawanye na njikwa ya na mmiri mkpụrụ osisi grape.
Ọ bụrụ na i were mbadamba osisi na Verapamil, cytostatics, Erythromycin, nicotinic acid, Amiodarone, ndị na-egbochi antifungal, Diltiazem, nje na-egbochi nje HIV, Telithromycin, Clarithromycin, mgbe ahụ ị ga-enwe ike myopathy ga-abawanye.
Analogs, nyocha na ọnụahịa
Enwere ọtụtụ ọgwụ na-eme na ndabere nke simvastatin. Yabụ, ịnwere ike iji Simvastol dochie Simvastol - Simgal, Ariescor, Zovatin, Levomir, Zokor, Simvor, Actalipid.
Ihe ama ama nke Simvastol bu Avestatin. Onye ọzọ dochie ọgwụ bụ Vasilip. Enwekwara otutu ogwu a na-akpo ihe eji aru oru.
Ọgwụ ndị a gụnyere Simvastatin Alkaloid / Vero / SZ / Teva / Pfizer / Chaikafarm / Ferein. Ihe analogues ndị ọzọ na nnọchi maka ọgwụ Simvastol - Simvakol, Zorstat, Simlo, Sinkard, Aterostat.
Simvastatin nwere nyocha dị mma. Nke a bụ n'ihi oke ọgwụgwọ nke oke ọgwụ yana ntakịrị ihe ize ndụ nke ịmalite mmeghachi omume na-adịghị mma.
Agbanyeghị, ndị mmadụ na-ewere mbadamba ihe eji eme simvostatin na-achọpụta na ọgwụ nwere ike belata cholesterol dị njọ site na 20%. A ga-ewepụ LDL ndị ọzọ site n'ahụ ahụ site na usoro nri.
Patientsfọdụ ndị ọrịa na-akọ na Simvastol nyeere ha aka izere ịwa ahụ. Ma mgbe ọnwa isii nke ọgwụgwọ gasịrị, ọnọdụ obi na arịa ọbara ka ukwuu, nke emere nyocha site na nyocha ụlọ nyocha.
Ọnụahịa ọgwụ ahụ dabere na usoro ọ ga-esi. Ya mere, Simvastol Nke 28 10 mg na-efu ihe dịka 187-210 rubles, yana Simvastol 20 mg - ihe ruru 330 rubles.
Otu esi wedata cholesterol n'ime ọbara ga-agwa ndị ọkachamara na vidiyo ahụ n'isiokwu a.
