Nkwadebe ejikọtara nke nwere ihe abụọ na - arụ ọrụ, ihe ndị ọzọ na - arụ ọrụ na - eme ka ọgwụ na - agwọ ọbara mgbali elu.
Aha
Noliprel (Bi) Forte bụ ọgwụ nwere ọgwụ ọnụọgụ abụọ nke ọgwụ na-arụ ọrụ (Perindopril 4 mg + Indapamide 1.25 mg). Ọ bụrụ na ọ dị mkpa iji ọgwụ kacha ike na ndị ọrịa nwere oke ọrịa (ọrịa shuga, ise anwụrụ, hypercholesterolemia), Bi-Forte (Perindopril 10 mg + Indapamide 2.5 mg).
Nkwadebe ejikọtara nke nwere ihe abuo 2 na-arụ ọrụ nke na-emeju mmetụta ọgwụ.
ATX
C09BA04 Perindopril na mgbakwunye.
Weputara udi ya na ihe mebere ya
Mbadamba ihe mkpuchi.
Nri arụ ọrụ: Perindopril 2 mg + Indapamide 0.625 mg.
Omume ọgwụ
Na-enyere aka ịgbanye ọbara mgbagha ma systolic na diastolic ọbara (BP) n'ime awa 24. A na-ahụta nsonaazụ zuru oke mgbe ọnwa gachara. Mmecha nke nchịkwa anaghị eduga na mmepe nke akara mgbapụta
Ọgwụ na-ebelata ọsọ nke usoro ndọghachi azụ myocardial, na-ebelata nguzogide nke akwara akwara na-enweghị emetụta ogo lipids na glucose ọbara.
Perindopril na-egbochi ọrụ nke enzyme, nke na-atụgharị angiotensin nke m n'ime enzyme angiotensin nke nọ n'ọrụ, nke bụ vasoconstrictor dị ike. ACE na-ebibikwa bradykinin, vasodilator na-arụ ọrụ n'ihe metụtara biolog. N'ihi vasodilation, mmegide vaskụla na-ebelata ma mgbali ọbara na-ebelata.
Mbadamba ihe mkpuchi.
Indapamide bụ diuretic sitere na otu thiazide. A na-ahụta ihe mmerụ ahụ na akụrụngwa hypotensive site na ibelata ntụgharị azụ nke sodium ion na akụrụ. Enwere mmụba dị na mmamịrị nke sodium, n'ihi nke nguzo nke akwara mbelata na olu ọbara na - ebupute na obi na-abawanye.
Ihe jikọtara ọnụ na perindopril na indapamide na-akwalite arụmọrụ nke ọgwụgwọ maka ọbara mgbali elu, na-ebelata ihe ize ndụ nke hypokalemia (nsonaazụ nke ị diụ diuretics).
Mlọ ọgwụ
Aclọ ọgwụ ọgwụ nke ihe ndị dị ike adịghị iche na ojiji ha jikọtara ọnụ ma ọ bụ iji ya iche.
Mgbe ejiri ya were ọnụ, ihe dịka 20% nke ngụkọta nke perindopril bụ metabolized n'ụdị arụmọrụ. Uru a nwere ike ibelata mgbe ejiri ya na nri. Edere ọdịnaya kachasị na ọbara n'ime awa 3-4 mgbe nchịkwa gasịrị. Otu obere akụkụ nke perindopril na-egbochi ihe nchebe ọbara. Ọ na-apụta ya na mmamịrị.
Enwere ike igbu oge nke perindopril na ọdịda akụrụngwa, ọkachasị ndị ọrịa merela agadi.
Indapamide na-aracha ahụ site na eriri afọ, mgbe nkeji 60 gasịrị, a na-edobe ọdịnaya kachasị nke metabolite nọ n'ọrụ n'ime plasma ọbara. 80% nke ọgwụ na-ebugharị ya na albumin ọbara. A na - ekepụta ya site na ntucha site na akụrụ ya na mmamịrị, 22% dị na feces.
Ihe ngosi maka ojiji
Ọbara mgbali elu (ọbara mgbali ike).
Edinyere ọgwụ ọgwụ maka ọbara mgbali elu.
Ihe ngbanwe
- nnabata onwe onye nye thiazide diuretics, ndị na - egbochi ACE;
- ọkwa ọbara na-erughị 3.5 mmol / l;
- nnukwu nsogbu gbasara akụrụ na mbelata nke mkpocha ọnụ nke na-erughị 30 ml / min;
- atherosclerotic stenosis nke akwara akwara nke akụrụ ma ọ bụ stenosis nke akwara na-arụ ọrụ;
- arụ ọrụ na-arụ ọrụ nke ukwuu;
- n'otu oge nchịkwa ọgwụ nwere proarrhythmogenic mmetụta;
- ime
- oge ị breastụ ara.
Etu ị ga-esi
Tupu ịmalite usoro ọgwụgwọ, ọ dị mkpa ịgụ ntuziaka maka ojiji ma kpọtụrụ ọkachamara.
A na-ewere ọgwụ 1 mbadamba ọgwụ 1 oge kwa ụbọchị, ọkacha mma n'ụtụtụ na afọ efu.
Enwere m ike ị nweta ọgwụ
Nwere ike ịkekọrịta, ogwu nwere ihe ize ndụ n'akụkụ abụọ.
Ofdị ọgwụ ahụ na prefix "forte" enweghị ihe ọghọm ma kpuchie ya na fim. Enweghi ike ikewa ha.
Otu esi agwọ gị maka ọrịa shuga 2
Ọ naghị emetụta metabolism glucose, na-anọpụ iche na metabolism. Maka ndị ọrịa nwere ọrịa shuga, ojiji ahụ ga-ekwe omume dịka usoro ọkọlọtọ si dị.
Nsonaazụ
Ọkpụkpụ afọ
Mgbu afọ, tinyere ọgbụgbọ na ọgbụgbọ; nsogbu ọgbụgba; ọnụ kpọrọ nkụ ọdịdị nke ụcha akpụkpọ ahụ; mmụba na paradaịs imeju nke akwara na pancreas n'ime ọbara; site na nsị nsị na-ezukọkọtara, mmepe nke encephalopathy ga-ekwe omume.
Ahụhụ Hematopoietic
Ọria (na ndị ọrịa nwere nnukwu akụrụ concomitant) ibelata ọnụ ọgụgụ haemoglobin, platelet, leukocytes, granulocytes; mbelatawo ọbara ọbara; hemolytic anaemia; nsogbu ọbara ọgbụgba; hypofunction ọkpụkpụ.
Maka ndị ọrịa nwere ọrịa shuga, ojiji ahụ ga-ekwe omume dịka usoro ọkọlọtọ si dị.
Sistemụ akwara Central
Isi ọwụwa, dizzness, adịghị ike, ike ọgwụgwụ, ahụ erughị ala, anya mmiri, enweghị ike mmetụta uche, nsogbu nke auditory na nyocha nyocha, ehighị ụra nke ọma, na -ekwuwanye nsogbu mpaghara.
Site na sistem iku ume
Ughughụ ọgwụ na-egosi na mbido iji ya, na-adịgide oge niile ị takingụ ọgwụ ahụ wee pụọ mgbe ọ kwụsịrị; iku ume ike okuku ikuku; adịkarịghị - mpụta mmamiri nke imi.
Site na usoro urinary
Mbelata ọrụ akụrụngwa; ọdịdị protein n’ime mmamịrị; n'ọnọdụ ụfọdụ, nnukwu mmebi akụrụngwa; mgbanwe na electrolyte ọkwa: mbelata nke potassium na plasma ọbara, tinyere hypotension.
Ahụhụ
Akpụkpọ isi, ọnya nke ụdị urticaria; Ire Quincke; vasculitis ọbara ọgbụgba; adịkarịghị - erythema multiforme.
Ntụziaka pụrụ iche
Mmanya ndakọrịta
Ojiji nkwonkwo ethanol nwere ike iso kpata oke ọgbụgba ọbara, ọgbụgba vaskụla. A naghị akwado iji ihe oriri ike.
Mmetụta ikike ịchịkwa usoro
Na mbido ị theụ ọgwụ ahụ, ị kwesịrị ịkpachara anya mgbe ị na-anya ụgbọ ala ma na-arụ ọrụ chọrọ nlebara anya na mmeghachi omume ngwa ngwa.
Site na ịrụ ọrụ ọrụ imeju
Ọ nwere ike ibute mmepe nke ọrịa cholestatic jaundice na mmụba dị nkọ na ọrụ enzymes imeju. Mgbe ọnọdụ a mere, ọ dị mkpa ịkagbu ọgwụ ahụ ma gakwuru dọkịta.
N'ime ndị ọrịa nwere ọrịa cirrhosis, ọ dịghị mkpa maka ndozi dose.
Na okukpu okpu
Na ọnụnọ nke ọrịa nke urinary sistemụ na-enwe ọfụma na arụ ọrụ filtration, mmụba nke ọdịnaya nke creatinine, uric acid na urea na plasma, mmụba nke ọdịnaya potassium ga-ekwe omume.
N'ime ndị ọrịa nwere ọrịa cirrhosis, ọ dịghị mkpa maka ndozi dose.
Site na mbenata nhichapụ nke creatinine erughị 30 ml / min. ekwesịrị ịhapụ ọgwụ ahụ na usoro ọgwụgwọ.
N'oge ime na lactation
A na - eji ọgwụ ahụ eme ihe na enweghị ọmụmụ banyere nsonaazụ ọgwụ a na nwa ebu n'afọ. Mụ nwanyị nọ n’oge nke abụọ na nke atọ kwesịrị ịkpachapụ anya.
N’oge agadi
Tupu ịmalite nnabata, ọ dị mkpa iji nyochaa ndị na-egosi ọrụ akụrụngwa (creatinine, urea), enzymes imeju (AST, ALT), electrolytes. Usoro ọgwụgwọ ahụ na-amalite site na usoro onyonyo dị ala ma ahọpụtara ya n'otu n'otu na-eburu mbelata ọbara mgbali elu.
Nhọpụta Noliprel nye ụmụaka
A na - enye ya ụmụaka maka ụmụaka na ụmụaka nọ n'afọ iri na asatọ n'ihi ụkọ data maka nchekwa ya na ndị ọrịa.
Dodoụbiga ya ókè
Ihe ịrịba ama nke ịdoụbiga mmanya ókè: nnukwu hypotension, ọgbụgbọ, vomiting, convulsive syndrome, anuria, heart pressure.
Nlekọta ihe mberede: lavage gastric, nchịkwa nke carbon na-arụ ọrụ, mmezi nke electrolytes ọbara. Site na iji hypotension, a ga-enye onye ọrịa ọnọdụ nwere ụkwụ dị elu.
Mụ nwanyị nọ n’oge nke abụọ na nke atọ kwesịrị ịkpachapụ anya.
Mmekọrịta na ọgwụ ndị ọzọ
Jiri nlezianya
Mgbe ejikọtara ya na antidepressants ma ọ bụ ọgwụ mgbochi, mmụba na nsonaazụ ọbara ọbara yana mmepe nke hypotension nwere ike ime.
Glucocorticosteroids belata mmetụta antihypertensive.
Na-emegide usoro ị backgroundụ ọgwụ, ọ ga-ekwe omume ịkwalite mmetụta mbelata nke insulin na usoro sulfonylurea.
Njikọ ya na glycosides cardiac chọrọ nlezianya nyocha nke ọkwa potassium na ECG, yana mmezi nke hypovolemia.
Site na nyocha X-ray nke ezubere, ọ dị mkpa igbochi mmiri ịkpa mmiri.
Site n'otu oge iji ọgwụ ụfọdụ (Erythromycin, Amiodarone, Sotalol, Quinidine), ohere nke ventricular arrhythmias na-abawanye.
Agaghị atụ aro maka ịgwakọta ọnụ
Anaghị anabata ịkekọrịta na lithium n'ihi nnukwu ihe egwu lithium riri oke.
Site na ọrụ mkpolata mbelata, ijikọ ya na diuretics, nke na-enyere igbu oge electrolytes, na infusions nke potassium chloride kwesịrị izere.
Site na nchịkwa ọnụ nke oge a na NSAIDs megide mmalite nke akpịrị ịkpọ nkụ, ọ nwere ike ibute ọrịa na-efe efe nke gbasara mkpụkọ akụrụ.
Analogs
Ko-Perineva, Ko-Parnawel, Perindapam, Perindid.
Ahịa ọgwụ na-ahapụ okwu
Relelị site na ndenye ọgwụ.
Noliprel ọnụahịa
Ọnụ ego nke otu ngwungwu ọgwụ (30 mbadamba), gbakọọ n'ọnwa ọgwụgwọ, na-amalite site na 470 rubles.
Ọnọdụ nchekwa nke ọgwụ Noliprel
Mee ka ụmụaka ghara iru. Enweghị ọnọdụ nchekwa pụrụ iche achọrọ.
Bọchị mmebi
Afọ 3
Nyocha na Noliprel
Ndi Okacha Cardio
Zafiraki V.K., Krasnodar: "Nchikota dị mma nke gosipụtara onwe ya ọ bụghị naanị n'ihe metụtara mbelata ọbara mgbali elu, kamakwa n'ihe banyere ibelata ihe omume obi, na nkụchi obi."
Nekrasova GS, Krasnodar: "Nhọrọ kachasị mma maka ndị ọrịa nwere ọbara mgbali elu."
Ndị ọrịa
,Hụnanya, Moscow: "Ọgwụ dị mma, ọ na-enyere aka."
Alexander, Oryol: "Nrụgide ahụ adịghị njọ."
