Captopril-FPO bụ ọgwụ antihypertensive n'ihi mmetụta vasodilating. Mmetụta ọgwụgwọ bụ n'ihi mgbochi nke ACE na mgbochi na-egbochi nkwụsịtụ bradykinin. Ọgwụ na-egbochi oruru nke angiotensin 2. N'ihi mgbasawanye nke arịa na akụkụ ahụ, mgbasa ọbara na mpaghara ischemia na-eme ka ọ dịwanye mma, ọnọdụ onye ọrịa ahụ na-emeziwanye na ndabere nke ọrịa nke usoro akwara obi nke usoro dị iche iche. Ekwesịrị ị drugụ ọgwụ ahụ nke ọma dịka ntuziaka ndị dibịa na-aga.
International Nonproprietary Aha
Captopril.
Captopril-FPO bụ ọgwụ antihypertensive n'ihi mmetụta vasodilating.
ATX
C09AA01.
Ha weputara udi ya na ihe mebere ya
Ogwu a di n ’udiri mbadamba ocha nke nwere mmanu mmanu, nke nwere 25 ma obu 50 mg nke ihe ahu n’oru ike - captopril. Iji mee ka mmụba na bioav adị n'oge a na-emepụta ihe, a na-agbakwunye ogige inyeaka na akụkụ arụmọrụ:
- microcrystalline cellulose;
- ọka ọka;
- mmiri ara ehi shuga;
- steeti magnesium;
- aerosil.
Ulo ogwu nwere ike inwe udiri mara. A na-etinye mbadamba na paịlị dị mbadamba 5-10.
Omume ọgwụ
Ọgwụ a bụ nke otu ọgwụ ọgwụ antihypertensive, sistemu ahụ sitere na ya bụ nke gbochiri egbochi angiotensin na-agbanwe enzyme (ACE). N'ihi nsonaazụ ọgwụgwọ, mgbanwe nke angiotensin I n'ime Formdị II na-eji nwayọ nwayọ, nke na-eduga na vasoconstriction - spasm nke endothelium vaskụla. Site na iji mkpụchi nke arịa ahụ na-emegide ogo ụda nkịtị nke ọbara na-erugharị, ọbara mgbali elu. Ọgwụ na-egbochi spasm, si otú ahụ kwụsị nkwụsị nke bradykinin, enzyme nke na-eme ka akwara ọbara.
Captopril FPO na-agbadata mmepe nke nkụda obi.
N'ihi ya, ụgbọ ndị ahụ na-agbasa ma mgbali ahụ na-agbadata dị ka o kwesịrị, ma ọ bụrụ na olu nke ọkọnọ ọbara ezuru iji mejupụta ihe ọkpụkpụ. Ihe mgbochi ACE n'ihi nrụgide nrụgide nwere ọrụ ndị a:
- na-ebelata nguzogide n'ime akwara na akwara;
- na - eme ka iguzogide akwara na - ebuso ibu, na - ebelata ihe mgbapu nke mgbidi oruru ọbara;
- na-egbochi mmebi nke ọrụ nke ventricle ekpe, nke sitere na ọbara mgbali elu (BP);
- na-eji nwayọ nwayọ etolite etolite;
- na-ebelata itinye uche nke sodium na plasma ọbara megide mmalite nke ụdị ọrịa obi na-adịghị ala ala;
- ọ na - eme ka akwara a na - arụ ọrụ na oghere microcirculation na mpaghara ischemic.
Ọgwụ na-egbochi nrapado platelet.
Mlọ ọgwụ
Mgbe nchịkwa ọnụ gachara, captopril dị 75% abanye na mgbidi nke jejunum. N'ihe yiri nri, a na-ebelata mmịcha site na 35-40%. Akụkụ nọ n'ọrụ na-erute oke ogo na nkeji n'ime nkeji 30 ruo 90. Ogo nke ijikọ ya na plasma albumin mgbe ọ banyere n’ọbara akwara dị ala - 25-30%. Na ụdị dị mgbagwoju anya, a na-agwakọta ọgwụ ahụ na hepatocytes site na ịkpụpụta ngwaahịa biotransformation nke enweghị mmetụta ọgwụ.
Ihe kariri 95% nke captopril na-ahapụ ahụ site n'enyemaka nke akụrụ, ebe 50% na-apụ apụ n'ụdị mbụ ya.
Nkeji ọkara ndụ na-erughị awa 3. Oge na-abawanye megide mmalite nke ọdịda akụrụ site awa 1-29, dabere ogo ọrịa ahụ. Ihe kariri 95% nke captopril na-ahapụ ahụ site n'enyemaka nke akụrụ, ebe 50% na-apụ apụ n'ụdị mbụ ya.
Ihe na-enyere aka
A na-eji ọgwụ ahụ eme ihe na ahụike maka ọgwụgwọ na mgbochi nke usoro a na - esochi:
- ọbara mgbali elu, gụnyere ọbara mgbali ume ọhụrụ.
- dị ka akụkụ nke ọgwụgwọ zuru oke iji wepu ọrịa obi na-adịghị ala ala;
- ọghọm nke ọrụ aka ekpe ventricle mgbe nkụchi obi gasịrị, ọ bụrụhaala na onye ọrịa akwụsie ike;
- mmebi nke ngwa agha gloalular na akụrụ parenchyma n'ụdị shuga nke 1.
Ihe ngbanwe
Amachibidoro ọgwụ a maka ndị nwere nsogbu ọ bụla nye captopril na ihe ndị ọzọ mejupụtara ọgwụ ahụ. N'ihi ọnụnọ nke lactose monohydrate, akwadoghị Captopril maka ojiji ndị mmadụ nwere nsogbu na-arịa ọrịa monosaccharides, enweghị ndidi ma ọ bụ ụkọ lactase.
Usoro onunu ogwu
Owere usoro onunu ogwu weputara onodu mmadu site n'aka ndi dibia bekee, onye dabere na ihe nlere ulo uka na nbido idi nso. Ezubere ọgwụ a maka ndị ọrịa okenye n’agbata afọ 18. Usoro ọgwụgwọ akwadoro ịmalite bụ 12.5 mg 2 ugboro n'ụbọchị.
Na-arịa ọrịa shuga nephropathy
Maka igbochi na ọgwụgwọ nke nephropathy megide ndabere nke ọrịa shuga na-adabere insulin, ọ dị mkpa iji site na 75 ruo 100 mg ọgwụ ahụ kwa ụbọchị.
Na nkụda mmụọ obi na-adịghị ala ala
Ọkpụkpụ obi nkụji chọrọ ihe 25 mg ugboro atọ kwa ụbọchị na mmalite ọgwụgwọ. Site n'ọbara dị ala ma ọ bụ nke dị ala, yana ndị ọrịa nwere hypovolemia na sodium dị ala n'ọbara, a na-atụ aro ka ọ belata usoro onunu ogwu rue 6.25-12.5 mg yana oge nchịkwa ruo ugboro atọ kwa ụbọchị. Dịka ọgwụgwọ mmezi, ugboro atọ kwa ụbọchị ka a ga-ewere 12.5 ma ọ bụ 25 mg, dabere na ọkwa nke ịnagide ọgwụ.
N'okpuru nrụgide
Iji mee ka ọbara ọgbụgba nke ịdị nro ma ọ bụ agafeghị oke na mmalite ọgwụgwọ, a ga-agbanye 25 mg ugboro abụọ n'ụbọchị. Site na azịza ọgwụgwọ dị ala, ekwesịrị ịbawanye otu usoro ọgwụgwọ ahụ ruo 50 mg naanị ma ọ bụrụ na a nabatara ya nke ọma. Oke kachasị anabata ụbọchị ọ bụla bụ 150 mg.
Ọ bụrụ na enwetaghị ihe ngosipụta ọbara chọrọ chọrọ n'ime ụbọchị 14-21 nke ọgwụgwọ, thiazide diuretics na-agbakwunye na monotherapy captopril-FPO. A na-ahụta mmeghachi omume nke anụ ahụ maka izu 1-2. Iji wepu usoro ogwu siri ike, ị nwere ike iwelite otu usoro onunu ogwu rue 100-150 mg yana oge nchịkwa ruo ugboro 2-3 kwa ụbọchị.
Iji wepu nsogbu nke ọbara mgbali elu, ọ dị mkpa itinye ọgwụ ọgwụ n'okpuru ire yana ọgwụ nke 6.25-50 mg.
Iji wepu nsogbu nke ọbara mgbali elu, ọ dị mkpa itinye ọgwụ ọgwụ n'okpuru ire yana ọgwụ nke 6.25-50 mg. A na-ahụta ọgwụgwọ ahụ mgbe nkeji 15-30 gachara.
Site na infarction myocardial
Edere ọgwụ ahụ maka ụbọchị 3 mgbe infarction myocardial gasịrị. Ọgwụ na mbido ọgwụgwọ ọgwụ bụ 6.25 mg kwa ụbọchị. Site na mmeghachi omume dị mma nke anụ ahụ na ọgwụ, mmụba nke ụkpụrụ kwa ụbọchị ruo 12.5 mg yana ọtụtụ nchịkwa ruo ugboro atọ n'ụbọchị. N’ime izu ole na ole, a na-abawanye usoro onunu ogwu a ka anabatacha ya.
Uzo esi ewere Captopril-FPO
Mbadamba ụrọ a na -efere afọ efu 60 nkeji tupu nri, n'ihi na nri na-akwụsịlata ma ọ bụ na-egbochi nri nkịtị nke ọgwụ ahụ.
N’okpuru ire ma ọ bụ drinkụọ ihe ọ .ụ .ụ
A na-eji mkpụrụ okwu sọọsọ sụgharịa naanị iji mee ka ọgwụgwọ dị ngwa. Belata ọbara mgbali ọsọsọ dị mkpa ma ọ bụrụ na ọgba aghara oke ọbara.
Ogologo oge ole ka ọ na-ewe
Site na nchịkwa sublingual, a na-ahụ mmetụta hypotensive 15 nkeji iri na ise ka etisasịchara mbadamba nkume n'okpuru ire. Mgbe etinyere ya, a na-enweta ike ọgwụgwọ kachasị n'etiti awa 3-6, nke mbụ - mgbe awa 1-2 gachara.
Ugboro ole ka m nwere ike ị drinkụ
Otutu nke ngwa - 2-3 ugboro n'ụbọchị.
Nsonaazụ
Mmetụta ọjọọ na-etolite n'ihi usoro usoro usoro ọgwụgwọ adịghị mma. Mgbe ha gosipụtara, a na-atụ aro ibelata dose.
Ọkpụkpụ afọ
Mmetụta ndị dị na ọnya digestive na-egosipụta dịka:
- ọgbụgbọ
- agụụ riri;
- ọgba aghara;
- mgbu afọ;
- mụbara enzymatic ọrụ nke hepatic transaminases;
- hyperbilirubinemia;
- afọ ọsịsa, afọ ntachi;
- mmepe nke imeju abuba nke imeju.
N'ọnọdụ ndị a na-adịghị ahụkebe, ị nwere ike ịnya isi nke bile. Enweela ọnọdụ dị iche na mbufụt nke pancreas.
Ahụhụ Hematopoietic
A na-edepụtakarị ihe ike maka ụmị ọbara hematopoiesis:
- anaemia
- ibelata ọnụ ọgụgụ nke neutrophils;
- ibelata usoro e guzobere platelet.
N'ime ndị ọrịa nwere ọrịa autoimmune, agranulocytosis nwere ike ime.
Sistemụ akwara Central
Na mmebi nke usoro ụjọ ahụ, enwere nsogbu nke ọgbụgbọ, isi ọwụwa, ike ọgwụgwụ, paresthesias. Mayta nwere ike ghara igbochi ya.
Site na usoro urinary
N'ụfọdụ, enwere ike ịpụpụ protein na mmamịrị, ọdịnaya nke uric acid na creatinine n'ọbara plasma ọbara na-ebili, acidosis na-amalite.
Site na sistem iku ume
Ọdịdị nke ụkwara akọrọ.
Na anụahụ
Mmeghachi omume anụ ahụ na-apụta dịka ihe ọghọm ma ọ bụ itching. N'ime ndị ọrịa amalitere mmepe nke mmeghachi omume nfụkasị, ọrịa Stevens-Johnson syndrome, urticaria, ma ọ bụ kọntaktị dermatitis nwere ike ịpụta.
Site na usoro mkpụrụ ndụ ihe nketa
N'ime ụmụ nwoke, ịmụba ara ma ọ bụ mmepe nke nrụrụ etwapụta ga-ekwe omume.
Ahụhụ
A na-egosipụta ihe nhụjuanya n'ụdị mmeghachi omume anụ ahụ, bronchospasm nwere mgbochi ikuku, ụbụrụ Quincke, ujo anaphylactic, ọrịa ọbara, na ọnụnọ nke ọgwụ mgbochi antinuclear n'ime ọbara.
Mmetụta ikike ịchịkwa usoro
Ọgwụ a anaghị emetụta ọrụ nke ọma ịrụ ọrụ nke ọma, uche na ahụike nke onye ọrịa. Ya mere, n'oge usoro ọgwụgwọ ya na Captopril, ọ dịghị mkpa ịbelata oge ịkwọ ụgbọ ala ma ọ bụ jiri usoro ihe eji arụ ọrụ arụ ọrụ.
Ntụziaka pụrụ iche
A na-adụ ọdụ mgbe ị na-ewere ọnọdụ ndị a:
- stenosis akwara akụrụ;
- ọrịa obi;
- ọghọm nke ụbụrụ;
- na-ekwupụta ọrịa autoimmune;
- mmegbu nke ịmepụta ọbara;
- ọrịa shuga mellitus;
- oge ndozi mgbe akụrụ gbasasịrị;
- aortic stenosis;
- nri sodium dị ala
- ịka nká;
- olu dị ala nke na-ekesa ọbara, akpịrị ịkpọ nkụ.
N'oge ọgwụgwọ ọgwụ, ọ dị mkpa ịdọ ndị ọrụ ụlọ ọrụ aka ná ntị banyere ihe ga-ekwe omume nsonaazụ ụgha mgbe ị na-enyocha mmamịrị maka ọnụnọ acetone.
Jiri n'oge ime na lactation
Ojiji nke ogwu n'ime ogba nke abuo na nke III nke ẹmbrayon na-egosi nkwụpụta akpọrọ, n'ihi nke ịtọlite akụkụ ahụ na nwa ebu n’afọ. Ohere puru ime ịmụ nwa na-abawanye. Amachibidoro ụmụ nwanyị dị ime iji ọgwụ ahụ.
A na - ewepụ Captopril na mmiri ara ara, yabụ, n'oge a na-enye ya ara, ọ dị mkpa ịkwụsị ịsa ahụ.
Mmanya ndakọrịta
Amachibidoro ọgwụ a kpam kpam iji ihe ọ alcoụ alcoụ na-egbu egbu eme ihe, yabụ, n’oge ị drugụ ọgwụ, ịkwesighi ị alcoholụ mmanya ma ọ bụ were ngwaahịa ndị nwere ọgwụ ethanol. Mmanya ethyl na -eme ka mmetụta antihypertensive belata, na-abawanye ohere nke ọbara mkpụkọtara n'ihi nchịkọta nke platelet ma nwekwuo ohere ida.
Dodoụbiga ya ókè
Ọ bụrụ na ị drugụbiga ọgwụ ike ókè, enwere ike ịdalata ọbara mgbali elu. N'ihi ọbara ọgbụgba, mmadụ nwere ike tụfuo, daba na Coma ma ọ bụ Coma, njide obi ọ ga-ekwe omume. Site n'iji ọgwụ ọjọọ eme ihe n'ụzọ dị nro, isi na-amalite ịgba agba, ọnọdụ okpomọkụ dị na aka belata.
Iji megharia ọbara ọgbụgba, ọ dị mkpa ịmanye onye ahụ ọ dinara dinara ala na azụ ma bulie ụkwụ ya elu. N'ọnọdụ ọnọdụ, a na-enye usoro ọgwụgwọ symptomatic.
Mmekọrịta na ọgwụ ndị ọzọ
Yiri ojiji a na-ahụ captopril na ọgwụ ndị ọzọ na-egosipụta na mmeghachi omume ndị a:
- Ọgwụ cytostatic na ọgwụ immunosuppressive, azathioprine na-abawanye ohere nke ịmalite leukopenia. Azathioprine na-ebute iwelata mbelata ọkpụkpụ.
- Mkpụrụ ọgwụ a na-eme ka a Potụkọta mkpụrụ ọgwụ na-egbochi mkpali na-egbochi steroidal nwere ike ibute hyperkalemia. Ihe mgbochi ACE na-ebelata mkpụkọ nke aldosterone, n'ihi nke a na-egbu oge na ion potassium.
- N'iji ọgwụ eji eme ihe n'otu oge, enwere mmetụta hypotensive siri ike. N'ihi nke a, mmepe nke nnukwu akwara ike ọgwụgwụ, hyperkalemia, na ezughi oke akwara ga-ekwe omume. Ọzọkwa, a na-ahụta mbelata ọbara mgbali elu na ntinye ego maka ịkụnwụ ahụ izugbe.
- Allopurinol na - ebulite ohere nke ịzụlite mmeghachi omume nfụkasị na ọrịa hematological.
- Acetylsalicylic acid, ibuprofen na indomethacin belatara ọgwụgwọ ọgwụgwọ nke captopril.
- Captopril na - eme ka ịba ụba Plasma nke digoxin.
Ọgwụ nje cyclosporin nwere ike ịkpalite mmepe nke oliguria ma mebie ọrụ nke akụrụ.
Analogs
Mpempe akwụkwọ Captopril-FPO na-enweghị mmetụta antihypertensive nwere ike dochie ya na ọgwụ ndị a:
- Kapoten;
- Blockordil;
- Captopril Sandoz;
- Angiopril;
- Rilcapton;
- Captopril-STI;
- Captopril-Akos.
Kedu otu isi captopril-FPO si dị iche na isi mmalite
Dọta, n’adịghị ka ọgwụ mbụ, nwere mmetụta hypotensive na-enwe ma nwekwukwa mmetụta ọgwụgwọ.
Ọnọdụ ezumike maka captopril-FPO sitere na ụlọ ahịa ọgwụ
A na-ahapụ ya ịzụta maka ebumnuche metụtara ahụike.
Enwere m ike ịzụta na ndenye ọgwụ
N'ihi ojiji na-ekwesịghị ekwesị, ọ nwere ike ịmalite mmepe hypotension, yabụ na amachibido ịzụta Captopril na-enweghị ọgwụ ọgwụ.
Ọnụ ego maka captopril-FPO
Ọnụ ego dị na ụlọ ahịa ọgwụ bụ 128 rubles.
Ọnọdụ nchekwa maka ọgwụ
Ọ na-atụ aro idobe ọgwụ ahụ n'ebe dịpụrụ iche site na ìhè anyanwụ, na okpomọkụ agaghị akarị + 25 Celsius
Bọchị mmebi
Afọ 3
Captopril-FPO emeputa
CJSC FP Obolenskoye, Russia.
Nyocha nke ndị dọkịta na ndị ọrịa banyere Captopril-FPO
Olga Kabanova, dibia bekee, Moscow
Achọpụtara m na Captopril na mkpụrụ ndụ ihe ọmụmụ ya anaghị arụ ọrụ na ndị ọrịa niile. Enwere m ike ịkwado ọgwụ iji belata ọbara mgbali n'ọnọdụ ọnọdụ mberede. You nwere ike ị theụ ọgwụ ahụ ugboro atọ n'ụbọchị. N'ọnọdụ ụfọdụ, ndị ọrịa na-eme mkpesa nke ụkwara dị ukwuu. Jiri nlezianya jiri ya kpatara odida akwara.
Ulyana Solovyova, 39 afọ, Vladivostok
M na-ahapụ nyocha dị mma. A na-ekewa obere mbadamba ihe ọcha n'ime akụkụ 4 n'ụzọ dị mma maka ọkwa pụrụ iche. N'ọnọdụ m, dọkịta ahụ tụrụ aro itinye ọgwụ n'okpuru ire iji mee ngwa ngwa. Edere ya maka mbelata ihe mberede na ọbara mgbali elu. A na-ahụ ihe ahụ ruo nkeji 5. Ahụghị m ọghọm, ma e wezụga maka ilu uto. Ebughị m n’obi iji dochie ọgwụ. Enweghị mmetụta ọ bụla.
