Etu esi eji ọgwụ Biosulin P eme ihe.

Biosulin P bụ ihe nnọchianya nke glycemic based on the insulin nke mmadụ mere. A na-ejikọ nke abụọ ahụ na teknụzụ maka mkpụrụ ndụ ihe nketa. N'ihi nhazi dị ka homonụ nke pancreas, a pụrụ iji Biosulin mee ihe maka ụdị 1 na ụdị shuga 2. Akụkụ dị ike anaghị agafe Plasenta, yabụ, enyere ọgwụ a maka nchịkwa n'oge atụrụ ime.

International Nonproprietary Aha

Insulin mmadu Na Latin - insulin mmadụ.

Biosulin P bụ ihe nnọchianya nke glycemic based on the insulin nke mmadụ mere.

ATX

A10AB01.

Ha weputara udi ya na ihe mebere ya

A na-egosipụta mmiri ntụtụ ahụ dị ka mmiri na-enweghị mmiri, nke doro anya. Dị ka ogige na-arụ ọrụ, 1 ml nke nkwusioru ahụ nwere 100 IU nke insulin na-arụ ọrụ mmadụ. Iji dozie pH nke mmiri mmiri ma mee ka bioavailability dịkwuo elu, a na-agbakwunye ihe ndị na-arụ ọrụ n'ime ihe ndị a:

• metacresol;
• mmiri mmiri;
• Ngwọta soda 10%;
• ihe ngwọta nke hydrochloric acid nke ịta 10%.

A na-enweta biosulin n'ime karama iko ma ọ bụ katridges na olu nke 3 ml, nke edepụtara maka iji ya na sirinji Biomatic Pen. Iko kaadiboodu nwere ngwongwo 5 na ngwugwu ogbe.

Omume ọgwụ

Insulin na-agbaso nhazi nke homonụ nke mmadụ site na imegharị DNA. Mmetụta hypoglycemic bụ n'ihi na njikọ nke ihe ike dị n'ọrụ nye ndị na-anabata ndị nọ n’elu mmiri nke sel ahụ. Site na ogige a, e mepụtara otu sel nke nwere insulin, nke na-eme ka enzymatic na-arụ ọrụ nke hexose-6-phosphotransferase, glycogen synthesis na mmebi glucose. N'ihi ya, a na-ahụta mbelata nke ọbara glucose ọbara.

Biosulin P na-eme ka glucose na protein nke abụba si na glucose na-eme ka usoro gluconeogenesis belata.

A na - enweta ọgwụgwọ ọgwụgwọ site na ịba ụba nke nnabata shuga site na uru ahụ. Ọ na - ebulite njem n’ime sel ya. Formationmepụta glycogen na abụba sitere na glucose na-abawanye, usoro gluconeogenesis na imeju na-ebelata.

A na-agbakọ oge hypoglycemic mmetụta dabere na ọnụego insimilation, nke, n'aka nke ya, dabere na ebe na usoro nchịkwa nke insulin, njirimara nke ndị ọrịa mamịrị. Mgbe nchịkwa subcutaneous gasịrị, a na-ahụta ọgwụgwọ ahụ mgbe ọkara elekere gachara ma nwee ike kachasị ike n'etiti awa atọ na anọ mgbe ịrechara klọọkụ ahụ. Mmetụta hypoglycemic dịruru maka awa 6-8.

Mlọ ọgwụ

Bioavailability yana mmalite nke usoro ọgwụgwọ na-adabere n'ihe ndị a:

• usoro nke ngwa - a na-ahapụ iruu subcutaneous ma ọ bụ intramuscular;
• ego homonụ nke gbara arụ;
• saịtị ịgba irighiri (rectus abdominis, apata ụkwụ nke ihu, gluteus maximus);
• ịta insulin.

A na-ekesa homonụ na-akpụ akpụ akpụ akpụ n'ime ahụ. A na-ebibi ogige ahụ nọ n'ọrụ na hepatocytes na akụrụ. Nkeji ọkara bụ nkeji 5-10. Ihe dị n’ọrụ na-ahapụ ahụ na 30-80% na mmamịrị.

Short ma ọ bụ ogologo

Insulin nwere mmetụta dị mkpirikpi.

A na-agbakọ oge nke mmetụta hypoglycemic dabere na ọnụego insimilation.

Ihe ngosi maka ojiji

Enwere ike ịnye ọgwụ ahụ na ọnọdụ ndị a:

• shuga na-akpata insulin;
• ọrịa shuga na-abụghị insulin na ndabere nke ịdị ala ọgwụgwọ ọgwụ, mmega ahụ na usoro ndị ọzọ iji belata ibu;
• Ọnọdụ mberede na ndị ọrịa nwere ọrịa mellitus nke ọrịa shuga, bụ nke e ji mara mmebi nke metabolic saccharide.

Ihe ngbanwe

Amachibidoro iji ọgwụ ahụ maka hypoglycemia na ekweghị ibe nọrọ n'ihe ndị na-arụ ọrụ na inyeaka.

Jiri nlezianya

Ọ dị mkpa iji nyochaa ọkwa glucose oge niile ma gakwuru dọkịta na ọnọdụ ndị a:

• ọdịda nke akụrụ siri ike n'ihi mbelata nke enwere ike inwe insulin megide mmalite nke metabolism ya na - emejọ;
• ime agadi, ebe ọ bụ na ihe karịrị afọ na-arụ ọrụ nke akụrụ mbelata;
• ọrịa obi na-adịghị ala ala;
• ọrịa ma ọ bụ ọdịda imeju na-eduga na mbelata gluconeogenesis;
• nnukwu stenosis nke akwara na akwara;
• merie site na protinerative retinopathy na-enweghị ọgwụgwọ nkwado na photocoagulation, ọrịa ahụ na mmepe nke hypoglycemia na-amụba ohere nke ikpu ìsì zuru oke;
• ọrịa ndị ọzọ na-eme ka ọrịa shuga na-agbagha ma na-abawanye mkpa insulin.

Na ọdịda akụrụngwa siri ike, ekwesịrị iji nlezianya mee ọgwụ ahụ.

Ọrịa obi na-ekweghị ala ala bụ ihe kpatara eji eji ọgwụ Rinsulin R eme ihe nke ọma.

Maka ọrịa ma ọ bụ ọdịda imeju, a na-eji nlezianya jiri Rinsulin P.

Ejiri nlezianya Rinsulin P mee ihe ma ọ bụrụ na onye ọrịa ahụ nwere stenosis nke akwara ọbara na akwara.

Ekwesịrị iji nlezianya Rinsulin P mee agadi.

Etu ị ga - ewere Biosulin P

Ọ bụ ọkachamara n’ọrụ ahụike kpebiri n’otú insulin si arụ ọrụ, dabere n’ihe ndị gosiri shuga dị n’ọbara. Ekwenyere biosulin ka a na-elegharị anya na subcutaneously, na ebe nwere akwa akwara dị omimi na ntinye. N’ihe dị iche iche a na-atụ aro ka onye toro eto na-eme kwa ụbọchị bụ 0-1-1 IU kwa 1 n'arọ.

Ndị ọkachamara n'ịgwọ ọrịa na-enye ndụmọdụ n'ịchịkwa ọgwụ ahụ nkeji iri atọ tupu mmalite nke nri nwere carbohydrate. N'okwu a, ọnọdụ okpomọkụ nke ọgwụ a na-achịkwa kwesịrị ịdị ka ọnọdụ okpomọkụ. Site na monotherapy na Biosulin, a na-elekọta hypoglycemic na-elekọta mmadụ ugboro atọ n'ụbọchị, n'ihu nri dị n'etiti nri, ugboro ole nke injections na-abawanye ruo ugboro 5-6 kwa ụbọchị. Ọ bụrụ na usoro onodu ogwu a kariri 0.6 IU kwa 1 n'arọ nke anụ ahụ, ọ dị mkpa ịme 2 injections n'akụkụ dị iche iche nke ahụ ọ bụghị n'otu mpaghara mmegharị ahụ.

Ọ dị mkpa ịgbanye ọgwụ n’akpụkpọ ụkwụ ya n’ọkpụkpụ akpụ ụkwụ nke azụ, na-eso usoro alụlụ gị etolite:

1. N'ebe ntinye okwu a chọrọ, ị ga-eji aka ya na isi ya were chikọta anụ ya na crease. A ga-etinye yarịrị mpe mpe akwa n’akpụkpọ anụ ya na akụkụ 45 Celsius ma piston belata.
2. Mgbe iwebata insulin gasịrị, ịkwesịrị ịhapụ agịga n'okpuru anụ ahụ maka sekọnd isii ma ọ bụ karịa iji jide n'aka na a na-enye ọgwụ ahụ kpamkpam.
3. Mgbe ewepụsịrị agịga, ọbara nwere ike pụta na ntụtụ. Ekwesịrị iji mkpịsị aka ma ọ bụ ajị anụ mee mmanya ahụ mmanya.

Ọzọkwa, a ga-emerịrị ntụtụ ọ bụla n'etiti oke mpaghara mpaghara anatomical, na-agbanwe saịtị ịgba ntụtụ. Nke a dị mkpa iji belata ohere nke lipodystrophy. Ọ bụ naanị ndị ọkachamara na-ahụ maka ahụike ka a na-ebu ntụtụ isi ya. A na - ejikọ insulin na-eme obere ihe na ụdị insulin ọzọ nwere mmetụta ọgwụgwọ ogologo.

Site na monotherapy na Biosulin, a na-elekọta hypoglycemic n'ụlọnga ugboro atọ n'ụbọchị.

Nsonaazụ nke Biosulin P

Ọdịdị nsonaazụ bụ nsonaazụ nke anụ ahụ maka ịme ọgwụ, ọgwụ usoro ezighi ezi ma ọ bụ iwebata ntụtụ.

Site n'akụkụ nke metabolism

Ọrịa hypoglycemic syndrome e ji mara:

• cyanosis;
• ịsụsọ ọnụ;
• tachycardia;
• ịma jijiji;
• agụụ;
• mụbaa excitability;
• detụ paresthesia;
• isi ọwụwa;
• hypoglycemic coma.

Ahụhụ

N'ime ndị ọrịa nwere njiri anụ ahụ na nhazi nke ọgwụ, angioedema nke akpịrị na mmeghachi omume anụ ahụ nwere ike ịmalite. N'ọnọdụ ndị a na-adịghị ahụkebe, ujo anafilactic nwere ike ime.

Ọsụsọ mụbara bụ mmetụta dị n'akụkụ ọgwụ ọgwụ Rinsulin R.

Rinsulin P nwere ike ibute ọrịa tachycardia.

Mgbe ụfọdụ Rinsulin P na-akpata isi ọwụwa.

Ejiri ọbara hypoglycemic bụ ọrịa hypoglycemic na-eme mgbe a na-ewere Rinsulin R.

N'ọnọdụ ndị na-adịghị ahụkebe, ujo ihe ụjọ nwere ike isite na iwere Rinsulin P.

Mmetụta ikike ịchịkwa usoro

Ogwu a emetụtaghi ikike ijikwa usoro mgbagwoju anya. Yabụ, n'oge usoro ọgwụgwọ glycemic, ịnya ịnya ma ọ bụ ya na ngwaọrụ ngwaike amachibidoro.

Ntụziaka pụrụ iche

Can nweghị ike ịbanye na igwe ojii, ọgwụ agbanweela agba ma ọ bụ nwee ahụ ndị si mba ọzọ siri ike. N'oge ọgwụgwọ insulin, ọ dị mkpa ijikwa ọkwa shuga dị n'ọbara.

Ọnọdụ nke hypoglycemic ọnọdụ na-abawanye n'ọnọdụ ndị a:

• ịgbanye aka na hypoglycemic onye ọzọ ma ọ bụ ụdị insulin ọzọ;
• nri mgbo la;
• akpịrị ịkpọ nkụ n'ihi ọgbụgbọ na afọ ọsịsa;
• ịba ụba arụ ọrụ;
• oria intercurrent;
• ibelata homonụ nke eriri afọ nke adrenal cortex;
• mgbanwe na mpaghara nchịkwa;
• nmekorita ya na ogwu ndi ozo.

Ọ bụrụ na emeghị ọgwụgwọ kwesịrị ekwesị, hyperglycemia nwere ike ibute ọnọdụ nke ketoacidosis mamịrị.

Usoro ntụpọ, ọkachasị nke ọrịa na-efe efe, ma ọ bụ ọnọdụ eji mara azụ, na-eme ka anụ ahụ chọrọ insulin. Ekwesịrị iji ọgwụ insulin biosulin nweta ụdị insulin mmadụ ọzọ n'okpuru ịchịkwa shuga ọbara ọbara.

Ihe egwu nke onodu hypoglycemic na-abawanye n’ihe gbasara mmekorita ya na ogwu ndi ozo.

Mustsụ ọgwụ ọ mustụ mustụ ga-akpachara anya dozie ọnọdụ ndị a:

• arụ ọrụ dị ala nke gland thyroid;
• ọrịa imeju ma ọ bụ akụrụ;
• Ọrịa Addison;
• afọ karịrị afọ 60;
• ịba ụba na mmega ahụ ma ọ bụ mgbanwe nri.

Ọgwụ na-ebelata nnabata nke anụ ahụ na nsonaazụ ethanol.

Jiri n'oge ime na lactation

Insulin nwere injinia meghere adịghị agafe ihe mgbochi Placental, nke anaghị emebi mmepe ẹmbrayon eke. Ya mere, amachibidoro ọgwụ insulin n'oge ime. Ọgwụ anaghị abanye glands mammary ma na-apụtaghị ya na mmiri ara, nke na-enye ụmụ nwanyị na-actụ nwa ohere ịbanye na Biosulin n'atụghị egwu.

Jiri na agadi

Ndị okenye n'ihi ịda afọ na ọrụ akụrụ na-ejikarị ike ijikwa ọkwa shuga ọbara.

Na-edeba ụmụaka Biosulin P

Na nwata, a na-atụ aro iwebata 8 nkeji ọgwụ.

Nmefere nke Biosulin P

Site n'iji insulin insulin dị elu, hypoglycemia nwere ike ime. Enwere ike iwepu ntakịrị ntakịrị na ịba uru glucose site na ị eatingụ shuga ma ọ bụ nri nwere carbohydrate. N'ihi nke a, a na-adụ ndị ọrịa nwere ọrịa shuga ụdị 2 ka ha buru ntụ ma ọ bụ ihe ịchọ mma, ihe ọfectionụ fruitụ mkpụrụ osisi, na shuga.

Ọ bụrụ na onye ọrịa ahụ tụfue uche, mgbe ahụ enwere nnukwu ọrịa hypoglycemia. N'okwu a, nchịkwa ozugbo 40% glucose ma ọ bụ usoro dextrose, 1-2 mg nke glucagon intravenously, subcutaneously ma ọ bụ intramuscularly dị mkpa. Mgbe ị nwetaghachiri, ọ dị mkpa ịnye onye ahụ ihe oriri nri na carbohydrates dị elu iji belata ihe ize ndụ nlọghachị.

Ọ bụrụ na onye ọrịa ahụ tụfue uche, mgbe ahụ enwere nnukwu ọrịa hypoglycemia.

Mmekọrịta na ọgwụ ndị ọzọ

Mmanya ndakọrịta

Mmanya Ethyl na-emetụta sistemụ mgbasa yana ọrụ akwara na akụrụ. N’ihi nke a, a na - akpaghasị usoro ọgwụ insulin, nke a nwere ike ibute njikwa nke glycemic. Ohere inweta hypoglycemia na-abawanye. Ya mere, n’oge ịgwọ ọgwụ ahụ, amachibidoro ịholicụ mmanya na-aba n’anya.

Analogs

Enwere ike dochie ọgwụ a site na ụdị insulin na-eme ngwa ngwa:

• Insuman Rapid GT;
• Actrapid NM Penfill;
• Gensulin P;
• Humulin Regular.

Ahịa ọgwụ na-ahapụ okwu

Enwere ike ịzụta ọgwụ site na ndenye ọgwụ.

Enwere m ike ịzụta na ndenye ọgwụ

Usoro ezighi ezi nwere ike ibute mmepe nke hypoglycemia ruo mmalite nke ọrịa mamịrị, yabụ, a na-ere ọgwụ ahụ maka ebumnuche ọgwụ.

Ọnụ ego maka Biosulin P

Onu ogugu maka ichota na karama bu 1034 rubles.

Ọnọdụ nchekwa maka ọgwụ

Ọ na-atụ aro idobe katiriji na ampoules nwere insulin na temprechọ nke + 2 ... + 8 Celsius C n'ebe dịpụrụ iche site n'ìhè na iru mmiri dị ala.

Bọchị mmebi

24 ikp. Mgbe ịmepe ampoule nwere ike ịchekwa ya ụbọchị iri anọ na anọ, a na - echekwa katrik - ụbọchị iri abụọ na asatọ n ’ọnọdụ okpomọkụ nke + 15 ... + 25 Celsius.

Emeputa

Marvel LifeSines, India.

Nyocha banyere Biosulin P

Ọgwụ ahụ eguzobewo onwe ya na ahịa ọgwụ n'ihi nzaghachi dị mma sitere na ndị dọkịta na ndị ọrịa.

A na-atụle analọg Rinsulin P bụ Insuman Rapid GT.

Humulin mgbe nile anaeche ogwu Rinsulin R.

A na-ewere Actrapid NM Penfill dị ka analog nke ọgwụ Gensulin R.

Gensulin R - analog nke ọgwụ Rinsulin R.

Ndi dibia

Elena Kabluchkova, endocrinologist, Nizhny Novgorod

Ọgwụ insulin na-arụpụta nke ọma na - enyere aka na hyperglycemia mberede na ndị ọrịa mamịrị. Mkpịsị sirinji dị mma maka ndị ọrịa nwere nhazi oge ọrụ na ọrụ mgbanwe. Omume dị mkpirikpi na-enyere aka ịnagide nnukwu shuga ngwa ngwa. Site na inweta ihe ọgwụgwọ ngwa ngwa, ịnwere ike iji katriki tupu ị rie nri. A na - anabata biosulin iji ọgwụ ndị ọzọ dabere na insulin na - arụ ọrụ ogologo oge. Ndị ọrịa nwere ike ịnata ọgwụ n’erị ego.

Olga Atamanchenko, endocrinologist, Yaroslavl

N'ime omume ụlọọgwụ, m na-ede ọgwụ ahụ kemgbe ọnwa Machị 2015. Site na mmalite nke ụdị insulin na ndị ọrịa mamịrị, ogo ndụ na-akawanye mma, enwere ike ịbawanye hyperglycemia na hypoglycemia. Ewere ya ka o jiri ya mee ihe n’ebe ụmụaka na ụmụ nwanyị dị ime dị. N'ihi insulin na-adị mkpụmkpụ, onye ọrịa ahụ nwere ike ịnye ọgwụ ahụ n'ọnọdụ ọnọdụ mberede (nwere nnukwu shuga). Echere m na Biosulin bụ ọgwụ na-arụ ọrụ ọsọ ọsọ, ma dịkwa elu.

Ndị ọrịa mamịrị

Stanislav Kornilov, 53 afọ, Lipetsk

Insulin na-arụ ọrụ ngwa ngwa. Ejiri m Gensulin na Farmasulin, mana enwere m ike belata nke ọma na glucose naanị site na Biosulin. Ọgwụ ahụ egosila onwe ya na Insuman Bazal - insulin na-arụ ọrụ ogologo oge. Site na nsonaazụ ngwa ngwa, enwere m ike ịgbatị nri nke mkpụrụ osisi. Achọpụtara m na site na ọgwụ ọgwụ gara aga isi m na-emerụkarị ahụ, mana ahụghị mmetụta n'akụkụ a. Enwere m afọ ojuju na nsonaazụ ahụ, mana isi ihe bụ ịgbaso ntuziaka maka iji ya na usoro nri.

Oksana Rozhkova, 37 afọ, Vladivostok

Afọ ise gara aga, ọ nọ na nlekọta ahụike n'ihe metụtara oke ọrịa shuga shuga, nke ọ maghị banyere ya.Mgbe ọ nwetasịrị nchịkwa glycemic, dọkịta ahụ kwuru banyere nchoputa ya ma nyekwa Biosulin usoro na-aga n'ihu. O kwuru na ọ ka adaba adaba iji sirinji sirinji. Ọ bụ ezie na ọgwụ a gbanyere ọgwụ ọkụ, ọnụego shuga nọgidere na njedebe. Ma ụdị insulin a anaghị adị mkpụmkpụ, ọ dịkwa mkpa ịhọrọ ụdị ọzọ na-emetụta ogologo. Wasjọ tụrụ m na ọgwụ ndị ahụ agaghị ekwekọ, mana ekwenyeghị obi abụọ. Ọ dị mma maka ijikọ ya na ụdị insulin ọzọ.