Lisinopril Ratiopharm nwere mmetụta vasodilating n'ihi mkpesa nke njikọ nke angiotensin II. N'ihi inweta ọgwụgwọ ọgwụgwọ, a na-ahụ mmetụta dị mma nke ọgwụ ahụ na saịtị anụ ahụ ischemic. Ọgwụ na-enye gị ohere ịzụlite nguzogide nke akwara endothelium vaskụla na anụ ahụ na-ebukwu ibu n'oge ọgbụgba akwara ọbara. Ya mere, ndị dibia bekee jiri ọgwụ ahụ wee gwọọ ọbara mgbali elu, nnukwu nkụchi obi na nkụda obi.
International Nonproprietary Aha
Lisinopril.
Ọgwụ na-enye gị ohere ịzụlite nguzogide nke akwara endothelium vaskụla na anụ ahụ na-ebukwu ibu n'oge ọgbụgba akwara ọbara.
ATX
C09AA03.
Ha weputara udi ya na ihe mebere ya
Ọgwụ dị n'ụdị mbadamba maka iji ọnụ mee ihe.
Ere ọgwụ
Dabere na usoro onodu ogwu eji eme ihe - lisinopril, mbadamba ihe di iche na agba:
- 5 mg bụ ọcha;
- 10 mg - light pink;
- 20 mg - pink.
Iji meziwanye ọgwụ pharmacokinetics, isi mbadamba ihe nwere ihe ndị ọzọ:
- steeti magnesium;
- phocium hydrogen phosphate;
- pregelatinized stachi;
- mannitol;
- sodium croscarmellose.
Ibepu
Dị adịghị adị.
Omume ọgwụ
Lisinopril na-egbochi ọrụ ọrụ nke angiotensin na-agbanwe enzyme (ACE). N'ihi ya, ọkwa nke angiotensin II na-ebelata, na-ebelata lumen arịa ahụ ma belata njikọta nke aldosterone. Ngwakọta ọgwụ na-arụ ọrụ nke ọgwụ ahụ na-egbochi ndakpọ nke bradykinin, peptide nwere mmetụta vasopressor.
Lisinopril na-ebelata ọkwa nke angiotensin II, nke na-ekwupụta oghere nke arịa ahụ.
Na-emegide usoro vasodilation, ọbara ọgbụgba na-ebelata, nguzogide arịa arịa. Ibe dị na myocardium belatara. Site na iji Lisinopril ruo ogologo oge, iguzogide akwara endothelium vaskụla na akwara obi na-abawanye ibu, mgbasa microcirculatory na mpaghara ischemia na-akawanye mma. Ọgwụ ahụ na-enyere aka belata ihe dị n’iru mmepe ọdịda ventricular ọdịda.
Mlọ ọgwụ
Mgbe a na -ekwu ya n’onu, ọkwa Plasa nke lisinopril ruru n’iru ya ka ọ gachara awa 6-7. Inye nri n’otu ihe emetụtaghị mmụba na bioav adị nke akụkụ ahụ na - arụ ọrụ. Lisinopril, mgbe ọ banyere n'ọbara ọbara, emebeghi ihe mgbagwoju anya na protein plasma ma ọ dịghị agbanwe mgbanwe n'ime mkpụrụ ndụ imeju. Ya mere, ihe dị arụ ọrụ na-ahapụ ahụ ahụ site na akụrụ. Iwepu ọkara ndụ bido awa iri isii na isii.
Ihe ngosi maka ojiji
A na-eji ọgwụ ahụ eme ihe n’ịgwọ ọrịa n’etiti:
- nkụda mmụọ obi na-adịghị ala ala site na mgbakwunye mkpụrụ akụkụ ventricular ejection erughị 30%;
- ọbara mgbali elu;
- nnukwu myocardial infarction na ndị ọrịa na-enweghị akwara ọdịda.
Ihe ngbanwe
Amachibidoro ị theụ ọgwụ ahụ n'ọnọdụ ndị a:
- ọnye ọ bụla na-eme ka uru ahụ dị na ọgwụ ahụ ike;
- stenosis akwara akụrụ;
- ndị ọrịa nwere ọrịa akụrụ na nhichapụ creatinine n'okpuru 30 ml / min;
- mitral valve stenosis na aorta;
- ọbara systolic nke 100 mm Hg na ala;
- hemodynamics a na-ejigideghị agbagha megide mmalite nke nnukwu ọrịa nke nkụchi obi;
- womenmụ nwanyị dị ime na ndị na-actụ nwa;
- hyperaldosteronism;
- oge ndozigharị mgbe akụrụ gbasasịrị.
Jiri nlezianya
A na-atụ aro ka ọ gaa usoro ọgwụgwọ ọgwụ n'ọnọdụ nlekọta n'okpuru nlekọta nke dọkịta na ọnọdụ ndị a:
- hypovolemia;
- sodium ọbara dị ala erughị 130 mmol / l;
- ọbara mgbali elu (BP);
- nhazi oge nke ihe gbasara diuretics, ọkachasị usoro dị elu;
- obi ada ada;
- ọrịa akụrụ
- ọgwụ vasodilator dị elu;
- ndị ọrịa karịa afọ 70.
Otu esi ewere lisinopril ratiopharm?
Ogologo oge ọgwụgwọ bụ izu isii. Ndị ọrịa nwere nkụda obi kwesịrị iburu Lisinopril na-aga n'ihu. A na-anabata nchịkwa nkwonkwo na Nitroglycerin.
Kedụ nsogbu m kwesịrị ị ?ụ?
Edere ọgwụ a maka ndị ọrịa nwere oke ọbara mgbali elu karịa RT/80 mm RT. Art. Na nrụgide dị ala n'oge systole - erughị 250 mm RT. Art. tupu ịmalite iji onye na - egbochi ACE ma ọ bụ n'ime ụbọchị 3 mbụ nke ọgwụgwọ, ọ bụ naanị 2.5 mg nke ọgwụ ahụ ka a ga-ewere. Ọ bụrụ na egosi systolic ihe karịrị nkeji 60 anaghị ebili karịa 90 mm Hg. Art., Ikwesighi iju ogwu a.
Na-a drugụ ọgwụ maka ọrịa shuga
Ọrịa shuga adịghị mkpa mgbazi nke usoro onunu ogwu nke ACE inhibitor.
Ọgwụ Mgbali Ọbara
Ndị ọrịa nwere ọbara mgbali elu kwesịrị iwe 5 mg nke ọgwụ n'ụtụtụ maka izu 3. Site na ezigbo nnabata, ị nwere ike ịbawanye ọgwụ kwa ụbọchị ruo 10-20 mg nke ọgwụ. Oge dị n’etiti ịba ụba usoro onunu ogwu kwesiri ibu opekata mpe 21. Ọnụ ego kachasị mma maka otu ụbọchị bụ 40 mg nke ọgwụ. E kwesịrị iburu mbadamba otu ugboro n'ụbọchị.
Ọrịa shuga adịghị mkpa mgbazi nke usoro onunu ogwu nke ACE inhibitor.
Usoro ọgwụgwọ nkụchi obi
Ndị ọrịa nwere nkụchi obi na-a drugụ ọgwụ ọgwụ n’otu oge ya na diuretics Digitalis. Ya mere, ọgwụgwọ dị na usoro ọgwụgwọ mbụ bụ 2.5 mg n'ụtụtụ. E guzobere usoro mmezi ahụ yana mmụba nwayọ nke 2.5 mg kwa izu 2-4. Ọkwa onodu a zuru oke sitere na 5 ruo 20 mg, dabere n'ogo ịnabata naanị otu ọgwụ kwa ụbọchị. Mkpụrụ kachasị maka ya bụ 35 mg.
Nnukwu myocardial infarction
Edere ọgwụ ogwu n'oge ụbọchị site na mgbe mbụ akara nke oke obi ọgụ. A na-anabata ọgwụgwọ naanị ma ọ bụrụ na akụrụ akwụghị ọtọ ma na systolic mgbali dị elu karịa 100 mm Hg. Art. A na - ejikọ Lisinopril na ọgwụ thrombolytic, ọgwụ mgbochi beta-adrenergic, nitrates na ọgwụ na-ete ọbara. Ọgwụ nke mbụ bụ 5 mg, mgbe awa 24 jiri ọnọdụ kwụsie ike nke onye ọrịa ahụ, ọnụọgụ ahụ na-abawanye ruo oke kwere - 10 mg.
Nsonaazụ
A na-ahụta mmetụta na-adịghị mma n'ihi ịperụ ya n'ụzọ na-adịghị mma ma ọ bụ mmeghachi omume anụ ahụ n'otu akụkụ nke ọgwụ ahụ.
Ọkpụkpụ afọ
A na-egosipụta mmeghachi omume na-adịghị mma maka ọgwụ ahụ na sistem nri.
- afọ ntachi, afọ ọsịsa;
- gag reflexes;
- agụụ
- mgbanwe na uto;
- jalestice cholestatic, nke nkpalite nke hyperbilirubinemia kpasuru iwe.
Ahụhụ Hematopoietic
A na-ahụ nsogbu akwara hemolytic na ndị ọrịa nwere ụkọ glucose-6-phosphate dehydrogenase. Site na mgbochi nke ụmị ọbara ọbara, a na-ebelata ọnụ ọgụgụ sel ọbara.
Sistemụ akwara Central
Ihe ọghọm nke mpaghara nsogbu yana akwara ozi nọ n'etiti ndị ọzọ bụ ihe ama ama:
- isi ọwụwa;
- ike ọgwụgwụ;
- Dizziness
- mfu nke nghazi na itule na ohere;
- na-anụ ntị na ntị;
- ọgba aghara na enweghị uche;
- paresthesia;
- ogwe akwara;
- ọnwụ nke mmetụta uche: mmepe nke ịda mba, ụjọ jijiji;
- polyneuropathy.
Ogwu nwere ike bute oke mgbu.
Site na sistem iku ume
N'ọnọdụ ụfọdụ, ọnya na-egbu mgbu na ọdịdị nke ụkwara na-ata ahụhụ.
N’akụkụ anụ ahụ na anụ ahụ dị n’okpuru ala
N'ọnọdụ ụfọdụ, mmepe nke urticaria, rashes, Stevens-Johnson syndrome, erythema, ịba ụba na-eto eto, iwe iwe psoriasis ga-ekwe omume. Ntutu nwere ike ịpụ n’isi.
Site na usoro akwara obi
Enwere ihe ize ndụ nke ịmalite hyperension orthostatic na bradycardia, mmetụta nke okpomọkụ.
Na akụkụ akụrụ na urogenital
O nwere ike ịrụ ọrụ na-ezighi ike na-arụ ọrụ, iwepụ ọdịda akụrụ, ụba urination.
Site n'akụkụ nke metabolism
N'ọnọdụ ụfọdụ, hypernatremia ma ọ bụ hyperkalemia na-amalite.
Ntụziaka pụrụ iche
Site n'iji lisinopril na mkparịta ụka n'otu oge nwere lipoproteins dị ala, enwere ihe ize ndụ nke ịma jijiji anaphylactic.
Site n'iji lisinopril na mkparịta ụka n'otu oge nwere lipoproteins dị ala, enwere ihe ize ndụ nke ịma jijiji anaphylactic.
N'ime ndị ọrịa amụrụ na mmepe nke allergies, angioedema nwere ike ime. Ọ bụrụ n ’ihu ọhụụ na egbugbere ọnụ kwuru, ekwesịrị ị shouldụ ọgwụ mgbochi. Site na mgbochi nke ikuku dị elu megide azụ azụ nke ire na glottis, a chọrọ ọgwụgwọ mberede site na ntụtụ nke Epinephrine subcutaneously 0,5 mg ma ọ bụ 0.1 mg intravenously. Site na nsụ nke akwara, ọ dị mkpa iji nyochaa elektrọnikọn yana ọbara mgbali.
Mmetụta ikike ịchịkwa usoro
N'oge ọgwụgwọ na Lisinopril, ọ dị mkpa ịchịkwa ụkpụrụ nke ọbara mgbali elu, n'ihi na dabere na njirimara nke ndị ọrịa, mmepe nke hypotension arterial bụ omume. N'ihi nrụda ọbara dị ala, enwere ike imebi ikike ịchịkwa ngwaọrụ ndị dị mgbagwoju anya na ịnya ụgbọ ala.
Jiri n'oge ime na lactation
Anaghị anabata ọgwụ maka ụmụ nwanyị dị ime n'ihi enweghị ozi banyere nsonaazụ kemịkalụ nke ACE inhibitor na mmepe nwa ebu n'afọ. N'oge omumu ihe omimi, ekpughere ikike nke ihe di n’ime ya n’abia n’ime ala. Na ngwụcha ọnwa atọ nke mmepe nwa ebu n'afọ, ọgwụ nwere ike kpasuo oke nzu eto.
Mgbe ị na-ede akwụkwọ Lisinopril n'oge ị na-a breastụ ara, ịkwesịrị ịkwụsị inye nwa ahụ ma gbanye ya na nri na-enweghị isi.
Cribdebere Lisinopril Ratiopharm ụmụaka
Amachibidoro ọgwụ a maka ụmụaka yana ndị ntorobịa erubeghị afọ 18.
Amachibidoro ọgwụ a maka ụmụaka yana ndị ntorobịa erubeghị afọ 18.
Jiri na agadi
Maka ndị ọrịa agadi, a na-edozi usoro usoro onunu ogwu dabere na nhichapụ ihe. A na-agbakọ nke ikpeazụ site n'ụkpụrụ Cockroft:
| Maka ụmụ nwoke | (140 - afọ) × ibu (kg) /0.814 × serin creatinine (μmol / L) |
| Womenmụ nwanyị | E mepụtara nsonaazụ site na 0.85. |
Dodoụbiga ya ókè
Ofụbiga ọgwụ ike ókè nwere ike ịkpalite mmepe nke mgbaàmà nke ịdoụbiga mmanya ókè:
- mgbada nke ọbara ọgbụgba;
- kadiogenic ujo;
- mẹ iphe dụ ẹji, ẹphe meru;
- bradycardia.
A ga-ebugharị onye ọrịa ahụ na ngalaba nlekọta ahụike, ebe a na-achịkwa ọkwa ọbara nke electrolytes na creatinine. Ọ bụrụ na ewere mbadamba ndị ahụ n'ime awa 3-4 gara aga, mgbe ahụ a ga-enye onye ọrịa ọgwụ na-anabata ihe, hichaa oghere afọ. Enwere ike wepu Lisinopril site na hemodialysis.
Mmekọrịta na ọgwụ ndị ọzọ
Na ntinye aka na mbadamba ụrọ Lisinopril na ọgwụ ndị ọzọ, a na-ahụta mmeghachi omume ndị a:
- Mgbu na-egbu mgbu na ọgwụ mgbochi na - abụghị steroidal na - egbochi ọrịa hypotension.
- Baclofen na - akwalite ọgwụgwọ ọgwụgwọ nke lisinopril. N'ihi nke a, mmepe nke hypotension akwara kwere omume.
- Ọgwụ antihypertensive, sympathomimetics, Amifostin na-akwalite ọgwụgwọ ọgwụgwọ nke ọgwụ ahụ, na-eduga n'ọganihu mmepe nke hypotension akwara.
- Prekwadebe maka ịkụnwụ ahụ izugbe, ọgwụ ịrahụ ụra na ọgwụ na-eduga na mbelata ọbara mgbali elu.
- Immunosuppressants, ọgwụ cytostatic na anticancer na-abawanye ihe ize ndụ nke leukopenia.
- Ọgwụ hypoglycemic ọgwụ nke izu mbụ nke usoro ọgwụgwọ dị mgbagwoju anya nwere ike ịkwalite mmetụta antihypertensive nke lisinopril.
- Ihe antacids na-ebelata bioavailability nke ihe eji arụ ọrụ.
Amifostine na - akwalite ọgwụgwọ ọgwụgwọ nke ọgwụ ahụ, na - eduga n'ọganihu mmepe nke hypotension akwara.
Ọgwụ sodium chloride na-ebelata ike ọgwụgwọ ahụ ma na-akpalite mmepe nke akara nke nkụda obi.
Mmanya ndakọrịta
Ndị na - egbochi ACE nwere ike iwelie toxicity nke ethyl mmanya na hepatocytes, anụ ahụ nke obi na sistem. N'ihi ya, n'oge ọgwụ mgbochi, ị ga-akwụsị ị alcoholụ mmanya.
Analogs
A na-eme ọgwụ mgbochi ọgwụ n'okpuru nlekọta nke dibịa bekee na-enweghị mmetụta dị mkpa hypotensive na ntinye nke otu ọgwụ ndị a:
- Dapril;
- Aurolyza;
- Vitopril;
- Diroton;
- Zonixem;
- Amapin-L;
- Amlipin.
Ọnọdụ ezumike Lisinopril Ratiopharm sitere na ụlọ ahịa ọgwụ
Enwere ike ịzụta ọgwụ site na ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ?
Theakingụ ọgwụ ahụ na-enweghị ndụmọdụ ahụike ọ bụla nwere ike iduga n'ọbara ọbara, nke nwere ike iduga mmepe nke bradycardia, mwepu nke mmụọ, nkụchi obi, coma, ọnwụ. Maka nchekwa ndị ọrịa, ereghị ọgwụ ahụ n'ofe.
Ọnụahịa
Ọnụ ego otu ọgwụ dị ihe dị ka ruble 250.
Ọnọdụ nchekwa maka ọgwụ
A na-echekwa ọgwụ a na okpomọkụ nke erughị + 25 Celsius C n'ebe dịpụrụ adịpụ site na ọrụ anyanwụ.
Bọchị mmebi
Afọ 4
Onye na-emeputa Lisinopril Ratiopharm
Merkle GmbH, Germany.
Nyocha maka Lisinopril Ratiopharm
Site na ntinye anya nke nkwenye nke ndi okacha mara, enwere ike inweta ndu ogwu di nkpa.
Ndi dibia
Anton Rozhdestvensky, urologist, Yekaterinburg
Ọrịa a na-anabata ndị ọrịa nke ọma. Ọ na-eduga na ngosipụta nrụgide kwụsiri ike, dị ọnụ ala karịa Diroton. N'otu oge ahụ, anaghị m ede ọgwụ siri ike na ya na ya. Lisinopril anaghị emetụta ọrụ arụ ọrụ. Mbadamba a ga-ewere naanị n'ụtụtụ 1 oge kwa ụbọchị. Nrụgide na-ekwusi ike ruo awa 24.
Vitaliy Zafiraki, dibia bekee, Vladivostok
Ọgwụ adịghị mma maka monotherapy. Ana m enye ndị ọrịa ọgwụ na ọgwụ mkpirisi. Ọzọkwa, n'oge usoro ọgwụgwọ, a chọrọ nlezianya nyocha nke ikpocha akụrụ dị n'ụwa. Ọgwụ ahụ agafewo ule ndị dị mkpa maka ọgwụgwọ ma kwe ka ndị ọrịa nwere ọbara mgbali elu mee ihe maka ya.
Amlipin bụ analogue nke ọgwụ.
Ndị ọrịa
Barbara Miloslavskaya, gbara afọ 25, Irkutsk
Site na nhọrọ ọgwụ ọfụma maka nrụgide, ọ nweghị ihe nyeere aka. Agara m n'ụlọ ọgwụ na-arịa ọrịa shuga, bụ́ ebe e depụtara ọgwụ ọgwụ ọnụ maka ọbara mgbali elu. Onye dọkịta ahụ tụrụ aro ka e jiri mbadamba Lisinopril-Ratiopharm dochie ọgwụ a. Ana m ewere ya maka afọ 5 na 10 mg kwa ụbọchị. Ndọghachi ahụ laghachiri na 140-150 / 90 mm Hg. Art. ebiliteghịkwa ọzọ. BP a dabara na m. Ọ bụrụ n’ youaraghị ọgwụ ahụ, mgbe ahụ gafee mgbede, nrụgide na-ebili, ahụike gị na-akawanye njọ.
Immanuel Bondarenko, onye gbara afọ 36, St. Petersburg
Dọkịta tiri 5 mg nke lisinopril kwa ụbọchị. Ana m anabata n'ụtụtụ ike nke ọma na ntuziaka n'otu oge ahụ.Cliniclọ ọgwụ ahụ dọrọ aka ná ntị na ebughị mbadamba nkume ndị ahụ iji mee ihe ngwa ngwa. Mmetụta ọgwụgwọ ahụ agbakọtara, mgbe ọnwa gasịrị, nrụgide ahụ agafeghị 130-140 / 90 mm Hg. Art. N'oge gara aga, a hụrụ nlebara anya 150-160 / 110 mmHg. Art. Ya mere, ahapụrụ m nyocha nke ọma. Ahụbeghị m mmetụta ọ bụla.
