Thioctic acid bụ ihe vitamin-yiri ya, antioxidant endogenous. Sdị usoro ị isụ ọgwụ bụ ọgwụ nhọrọ maka ọgwụgwọ endothelioneural dysfunction (arụ ọrụ na ọnọdụ nke anụ ahụ ụjọ n'ihi mbelata ọbara ọkọnọ n'ihi akwara endothelial pathologies) na nrụgide oxidative.
Aha
Lipoic acid, alfa lipoic acid, thioctacid bụ okwu nke thioctic acid.
Na Bekee, a na-akpọ ihe ahụ Thioctic acid. Na Latin - Acidum thiocticum (genus Acidi thioctici). Aha ahia nwere ike di iche (Oktolipen, Berlition 600, wdg).
Thioctic acid bụ ihe vitamin-yiri ya, antioxidant endogenous.
ATX
Koodu ATX bu A16AX01.
Weputara udi ya na ihe mebere ya
Dị ka:
- ọgwụ
- ihe ngwọta maka injection, 1 ml nke nwere 25 mg nke α-lipoic acid;
- tinye uche maka ihe maka ngwakọta.
Thioctacid dị n'ụdị mbadamba mkpuchi.
Ere ọgwụ
Thioctacid dị n'ụdị mbadamba mkpuchi dị na usoro nke 200 na 600 mg nke ihe arụ ọrụ.
Ntụ ntụ
N'ọdị ntụ ntụ, a naghị eji ihe maka ọgwụgwọ agwọ ọrịa, n'ihi soluble naanị na ethanol.
Omume ọgwụ
N'ịbụ ọgwụ antioxidant sitere n'okike, thioctacid na-egbochi mbo nke ihe nuklia kappa-bi n'ihi radicals n'efu. Imebi iwu ya na - akpata ọrịa autoimmune, ngbanwe sel nke cell na apoptosis (ọnwụ) nke mkpụrụ ndụ.
Nosological mmetụta bụ n'ihi ya Njirimara:
- isonye na mmeghachi nke decarboxylation nke alpha-keto acid - na-ahụ na mgbanwe mgbanwe cellular na mgbochi nke DKA;
- ike iwetulata abụba abụba, cholesterol;
- antioxidant - njikọ nke radicals na-adịghị mma, ụfụ na iku ume, mweghachi nke glutathione;
- mwepu nke njikọ nke nitric oxide site na mkpụrụ ndụ imeju - mgbochi na enyemaka nke phlebopathy;
- radioprotective.
Site n'ime ihe endothelium nke arịa ọbara, acid lipoic (thioctic) na-ebelata mmebi nke akwa dị n'ime ha, na-ebelata lumen, iberibe yana ihe egwu nke ọbara ọgbụgba.
Site na Njirimara nke thioctacide, ogwu nwere otutu uzo na aru:
- na - eme ka ọbara ọgbụgba na - arụ ọrụ;
- na - egbochi mwepu nke NO synthetase, nke na - egbochi ischemic mbibi anụ ahụ nke sistem ụjọ;
- na-eme ngwa ngwa nke akwara ozi;
- na-edozi ọrụ nke glutathione;
- na-egbochi mmebi sel.
Nsonaazụ nke usoro nke onye ọrụ ahụ bụ:
- normalisation nke cholesterol;
- ibelata nguzogide insulin;
- njikwa glycemic mụbara;
- nchebe nke islet pancreatic na-emepụta insulin;
- mbelata nke ogo mmanu mmanu, nke na akowaputa ihe oma di nma banyere ọgwụgwọ oke ibu;
- mgbochi nke mkpụrụ ndụ ụrọ n’ihi oke nke sorbitol n’ime ha;
- mmelite nke ihe na-agbanwe agbanwe na microcirculation nke akwara ọbara;
- mbelata ihe ndị na-egbochi mmebi na plasma ọbara;
- rụọ ọrụ detoxification nke imeju, imepụta nke bile asịd na ichebe akpụkpọ ahụ nke anụ ahụ na mmebi.
Site n'ime ihe endothelium nke akwara ọbara, acid lipoic (thioctic) na-ebelata mmebi nke ala dị n'ime ha, na-ebelata lumen, ọnya na ọnya nke ọbara ọgbụgba, usoro mkpali.
Ihe acid a n’agha meriri ihe mgbochi obara nke obara, nke n’ikpebi oru ya na ọgwụgwọ nke encephalopathy na oria akwara obi: Alzheimer na Parkinson’s.
Mlọ ọgwụ
Mgbe a na -ewere ya ọnụ, ọgwụ na-agbakasị ahụ kpamkpam na ngụgụ nri. Nchịkwa nke ọgwụ nri nwere ike ime ka ọ ghara ịdịkwa mma. A na-ahụ ọrụ kachasị elu (Cmax) nke ọgwụ a nkeji iri na ise nke otu elekere ma ọ bụ otu elekere gachara. N'ime imeju, biotransformation nke alfa lipoic acid na-apụta n'oge akụkụ mbụ site na mgbidi nke eriri afọ, imeju, akpa ume, nke na-eme ka bioav adị nke ihe ahụ ruo 30-60%.
Mgbe a na -ewere ya ọnụ, ọgwụ na-agbakasị ahụ kpamkpam na ngụgụ nri.
Vp ya (olu nkesa) dị ihe dịka 450 ml / n'arọ, nke na-egosi nkesa ọgwụ sara mbara na akwara nke ahụ. Ọkara ndụ (T1 / 2), ma ọ bụ oge mfu nke ọrụ 50%, nke lipoic acid bụ nkeji 20-50, nke kpatara mkpochapu ngwaahịa nke mgbanwe nke ihe na - eme n’ime imeju site na akụrụ. Ọnụego ịsacha ọbara plasma ọbara (Cl plasma) sitere na ọgwụ bụ 10-15 ml / min.
Ihe achoro maka
A na-eji Thioctacid na ọgwụgwọ nke ọrịa kpatara nrụgide oxidative, hyperinsulinemia, insulin resistance, endothelial dysfunction. Eji ya na ọgwụgwọ nke:
- Ndị ọrịa nwere ọrịa shuga na nsogbu ya, dịka:
- polyneuropathy na-arịa ọrịa shuga;
- encephalopathy na-arịa ọrịa shuga;
- ọrịa imeju na-egbu egbu na ndị ọrịa nwere ọgwụ insulin;
- ọrịa mamịrị retinopathy;
- cardiovascular autonomic neuropathy;
- oke ibu
- Polycystic ovary syndrome dị na ụmụ nwanyị.
- Ọrịa imeju nke ị withụbiga mmanya ókè, ọla dị arọ, nsí nje; ntinye nke onye nje na-arịa ya (ọrịa ịba ọcha n'anya C, B).
- Mmanya na-egbu egbu.
- Ọrịa ogbu na nkwonkwo.
A na-eji ihe ahụ, ya na ikike ịchịkwa carbohydrate na abụba metabolism, dịka akụkụ nke nri iji belata ibu ma na-agwọ oke ibu.
Na cosmetology, a na-eji acid eme ihe maka:
- kpochapu oria;
- nchebe pụọ na nsonaazụ nke ihe ndị dị na mpụga na-akpata wrinkles, na-ete anụ ahụ;
- ịkọwapụta, nchedo UV;
- nhazi anụ ahụ;
- ihe mgbochi glycation - usoro “gluing” fiberg collagen with glucose;
- rejuvenation.
Ihe a na - akwalite nsonaazụ na anụ ahụ nke vitamin D, ascorbic acid na tocopherol.
Ngwaọrụ ịchọ mma enweghị ihe karịrị 10% lipoic acid dị ka Iwu EU si dị. E gosipụtara ojiji ha jiri ụmụ nwanyị nwere agadi, hyperpigmentation, ọchịchọ nke iwe, iwe. Ọzọkwa, a na-eji ihe ịchọ mma nke nwere thioctacid ma ọ bụrụ na akpụkpọ ahụ nwere mmanu mmanu, yana oke pores na otutu.
Ihe ngbanwe
Ebe ọ bụ na a na-ejikọ lipoleic acid n'ime ahụ chọrọ, ọ fọrọ nke nta ka ọ bụrụ na enweghị nzube. Isi contraindication bụ hypersensitivity na ihe. Jiri ọgwụ jiri nlezianya jiri:
- afọ ime na lactation;
- afọ onye ọrịa dị afọ 6.
Isi contraindication bụ hypersensitivity na ihe.
Ihe mgbochi bụ n'ihi enweghị ahụmịhe banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nke otu ndị a na enweghị ọnụ ọgụgụ nchekwa zuru ezu.
Na usoro ọgwụgwọ ọgwụ, a ga-atụle ọnụnọ nke lactose dị ka ihe nzacha. Ebumnuche nke ihe ndị dị otú ahụ bụ contraindicated na ndị ọrịa nwere ọrịa malabsorption - enweghị nkwekọrịta lactose.
Etu esi ewere thioctic acid
A malitere usoro ọgwụgwọ site na iji ọgwụ thioctic acid site na nchịkwa intravenous ma ọ bụ nchịkwa nke ọgwụ. Mgbe ọnọdụ ahụ kwụsịrị, a na-edenye ọgwụgwọ mmezi na mbadamba ihe.
N'ime imepụta ihe ngwakọta site na itinye uche na ampoules, a na-eji mmiri nnu wee gwakọta ha - ngwọta nke NaCl.
Maka nchịkwa enteral (site n'ọnụ), usoro ndị a na-esochi:
- were ya tupu i rie nri otu ugboro n’ụbọchị;
- awụla, ilo, a ,ụ mmiri buru ibu;
- mgbe ọkara elekere kwesịrị ị rie nri ụtụtụ;
- ọnụọgụ ọgwụ kachasị elu kwa ụbọchị ọtụtụ oge anaghị agafe 600 mg nke thioctacide;
- usoro ọgwụgwọ ahụ bụ ọnwa 3, dịka ihe gosiri na-egosi, enwere ike ịgbatị oge nke ọgwụgwọ ahụ.
A na - amalite usoro ọgwụgwọ site na iji thioctic acid site na nchịkwa ọgbụgba nke onye nnọchite.
Edere ya na mbadamba ọgwụ ka ekwesịrị izu izu 2-4 nke ọgwụ mgbochi ma ọ bụ nchịkwa nke ọgwụ.
N'ime obi, a na-eji ọgwụ ahụ nwayọ nwayọ iji zere mmetụta ndị ọzọ. A na-achịkwa onye na-eri anụ ahụ na mmalite nwayọ. Olu ahụ bụ 300-600 mg.
A na - ejikwa Thioctic acid maka nchịkwa intramuscular. Iji zere mmeghachi omume na-adịghị mma, a naghị atụ aro ka ịgbanye ihe karịrị 2 ml nke ihe ngwọta n'otu ebe.
Thioctic acid dị n’ịrụ ahụ
N'ịzụ ahụ, ọzụzụ ike na egwuregwu ndị ọkachamara, a na-eji thioctacid belata nrụgide oxidative mgbe mgbatị ahụ siri ike. Ike iji belata ọrụ glucose na ịnyefe ya na ogige nwere ume dị ukwuu na-arụkwa ọrụ dị mkpa: ihe a nke ọgwụ na-enyere aka inye ume ọkpụkpụ aka ma nweta nsonaazụ kachasị na ọzụzụ. Na mgbakwunye, acid na-eme ka thermogenesis dịkwuo mma, na-enyere aka wepu abụba na mpaghara nsogbu, ya mere, etinyere ya ọ bụghị naanị n'egwuregwu, kamakwa maka oke ibu.
N'ịzụ ahụ, ọzụzụ ike na egwuregwu ndị ọkachamara, a na-eji thioctacid belata nrụgide oxidative mgbe mgbatị ahụ siri ike.
E gosipụtara ndị na-eme egwuregwu toro eto nke 50 mg 3-4 ugboro n'ụbọchị ọkara otu awa mgbe nri gasịrị. Site na ọzụzụ kpụ ọkụ n'ọnụ, ọnụego ọgwụ na-abawanye 300-600 mg kwa ụbọchị.
Na-a drugụ ọgwụ maka ọrịa shuga
Na ọrịa shuga mellitus, a na-amalite inye ọgwụ ọgwụ parenterally (na-agbanye eriri afọ). A na-etisasị mkpokọta na 100-250 mg nke 0.9% sodium chloride na olu nke 600 mg na-achịkwa ntụgharị uche intravenously maka ụbọchị 15. A na-enye ọgwụ ahụ n’usoro ngagharị nke ụbọchị 5 na izu-ike nke ụbọchị n’etiti ha. Na mkpokọta, a na-eji ampoules iri na ise maka ọgwụgwọ.
Mgbe emechara ọgwụ ịgba ọgwụ mgbochi, a na-ebugharị onye ọrịa na mbadamba thioctacid, 1 pc. otu ụbọchị tupu nri ụtụtụ.
Na ọrịa shuga mellitus, a na-amalite inye ọgwụ ọgwụ parenterally (na-agbanye eriri afọ).
Mata glucose na ime ka insulin nke gị rụọ ọrụ nwere ike ịchọ ndozi insulin na ọgwụ na-ebelata shuga. Na nsogbu ndị siri ike, usoro ọgwụgwọ ga-abụ ọnwa 3-5.
Nsonaazụ
A na-ahụta mmetụta ọjọọ n'ọnọdụ 1 n'ime ndị ọrịa 10,000. Egosiputa n'ụdị:
- akpụkpọ anụ ahụ;
- hypoglycemia;
- site na iji ọnụ, ọgba aghara dyspeptik, obi mgbawa, ihe mgbu epigastric kwere omume;
- ya na iv, ihe na-ama jijiji, ịrị elu na ọbara mgbali elu na mgbali intracranial, ọhụụ okpukpu abụọ, nsogbu nke mkpịsị ọbara, ọbara ọgbụgba na ọbara ọbara nwere ike ibilite.
Ihe ngosi putara na mgbe obula bekee ma obu mgbe ejesiri ikwusi nke ihe ahu.
Ntụziaka pụrụ iche
Ndị ọrịa na-arịa ọrịa shuga kwesịrị ilebara ọkwa glucose anya. Ngwọta a kwadebere bụ foto na-enweghị atụ, yabụ a na-eji ya ozugbo dilution ma ọ bụ jiri enyo mkpuchi na-echebe ya.
Mmanya ndakọrịta
Ogwu a ekwekorita na mmanya, n’ihi ethanol belata ịdị irè nke ikpughe.
Mmetụta ikike ịchịkwa usoro
Ọ naghị emetụta ọnụego mmeghachi omume neuromuscular, mana ngosipụta na-adịghị mma nwere ike ịchọ nlezianya n'oge ọgwụgwọ.
Jiri n'oge ime na lactation
Ọ bụ ihe a nabatara iji nye ọgwụ ka ọ bụrụ oge a na-eme mmekpa ahụ ma ọ bụrụ na uru ọgwụgwọ a ga-enye gị nwere ike ibute ya. N'okwu mgbe ọgwụgwọ dị mkpa mgbe a na-enye nwa ara, ọ dị mkpa ka ịnyefe nwa ahụ na inye mmadụ nri.
Ọ bụ ihe a nabatara iji nye ọgwụ ka ọ bụrụ oge a na-eme mmekpa ahụ ma ọ bụrụ na uru ọgwụgwọ a ga-enye gị nwere ike ibute ya.
Cribdebere ụmụaka ụmụaka thioctic acid
Ntụziaka maka iji ọgwụ ahụ akwadoghị ojiji o jiri ụmụaka gbara afọ 6. Agbanyeghị, dị ka ihe gosiri, enwere ike ịkọ ọgwụ a na ego ole:
- 0.012 g 2-3 ugboro n'ụbọchị maka ụmụaka na-erubeghị afọ asaa;
- 0.012-0.024 g ugboro abụọ n'ụbọchị maka ụmụaka karịrị afọ asaa.
Dodoụbiga ya ókè
Ohere inweta oke inye mmadụ nsogbu karịrị akarị, ma ọ bụrụ na iji uche ya mee ihe ma ọ bụ mebie ụkpụrụ nchịkwa, ihe ndị a nwere ike ime:
- isi ọwụwa
- ọgbụgbọ na ọgbụgbọ.
Ọ bụrụ na mmanya na-egbu egbu, a na-eme ọgwụgwọ iji kwụsị ọrịa.
N'ihi ịdoụ ọgwụ gabigara ókè, isi ọwụwa na-apụta.
Mmekọrịta na ọgwụ ndị ọzọ
Acid ekwekorita na:
- Ngwọta Ringer na ndị ọzọ na-ebu calcium na magnesium;
- nhazi ọla;
- ethanol.
Ọgwụ a na - akwalite nsonaazụ insulin na ọgwụ nke hypoglycemic.
Analogs
Analogues nke Acidum thiocticum bụ ọgwụ:
- Alfa lipon;
- Mkpụkpu;
- Thioctacid;
- Thiogamma;
- Oktolipen;
- Lipoic acid, aha a na-akpọkarị bụ vitamin N;
- Lipothioxone;
- Neuroleipone;
- Ntuli aka.
Ahịa ọgwụ na-ahapụ okwu
Site na ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ
Ee e.
Pricegwọ nke thioctic acid
Dabere na onye nrụpụta na ụdị ntọhapụ, ọnụahịa ọgwụ dị na 40 (mbadamba 50) ruo 2976 (mbadamba 100) rubles. Thioctacid 600 na ampoules na-efu 1,539 rubles. maka mbukota. Na Ukraine, ọnụahịa ahụ sitere na 92 ruo 292 UAH.
Ọnọdụ nchekwa
Ndepụta B - Chekwaa n’ebe dị jụụ ma gbaa ọchịchịrị.
A na-ahapụ ọgwụ ahụ naanị ma ọ bụrụ na onye ọrịa ahụ edepụtara ọgwụ.
Bọchị mmebi
Afọ 3
Nyocha nke Thioctic Acid
Ọgwụ ahụ anọbeghị na-akpata arụmụka n'etiti ndị ọrụ na ndị ọkachamara. Ọdịdị nke ụdị ọgbara ọhụrụ nwere ntakịrị ihe ọ bụla na-eduga na nyocha dị mma.
Ndi dibia
Elena Sergeevna, onye na-ahụ maka ọgwụgwọ, Kiev: "Abụ m onye ọrịa mamịrị ma hụ na arụmọrụ nke thioctic acid, ya mere, enwere akọ na uche dị ọcha, m na-edegara ndị ọrịa Thioctacid BV."
Inga Olegovna, endocrinologist, Kostroma: "N'ihe gbasara dọkịta, ọ dị mkpa ijide n'aka ịdị irè na nchekwa nke ọgwụ. Ekwenyela m ike ugboro ugboro ole nsonaazụ ọgwụgwọ na ọgwụ Thioctacid BV ka ekwuputara."
Ndị ọrịa
Mirra, dị afọ 45, Krivoy Rog: "Ọnwa isii gara aga, amalitere m inwe ahụ mkpịsị aka na aka. Dọkịta ahụ kwuru na ihe kpatara ya bụ ọrịa shuga, na-atụkwa mbadamba ọgwụ Thioctacid BV. A Iụrụ m nanị ọkara, ahụike m kawanyere nke ukwuu."
Oksana, onye gbara afọ 31, Odessa: "Ntụziaka ahụ na-egosi na enwere ike ịnwere nfụkasị ahụ, mana ọgwụ ahụ emeghị ka ọ bụrụ ihe mgbaàmà dị nro, n'agbanyeghị na abụ m onye nfụkasị nwere ahụmịhe."
Anna, dị afọ 40, Kazan: “Na mgbakwunye na ọrịa shuga, enwere nnukwu nsogbu na ọkpụkpụ azụ. M na-a theụ ọgwụ ahụ ihe karịrị ọnwa 3. N'agbanyeghị eziokwu na m na-a manyụ ọtụtụ ọgwụ ndị ọzọ ma e wezụga ya, enweghị mmetụta ọ bụla, ogo ahụ belatara obere ntakịrị n'agbanyeghị nri adịghị. "
