Nyocha nke usoro dị iche iche nke sulfonylurea

N'ihi enweghị ọgwụ insulin na-ezughị ezu, ha na-eme ka mgbakwunye ya dịkwuo elu. Ngwunye nke sulfonylureas so na ọgwụ ndị na-eme ka mmụba nke homonụ na-arụ ọrụ nke ọgwụ hypoglycemic sịntetik.

Ejiri mara ha akpọpụta nke ọma ma e jiri ya tụnyere ndị ọrụ ndị ọzọ nwere tebụl nwere otu mmetụta.

Na nkenke banyere ọgwụ nke otu ahụ

Nchịkwa Sulfonylurea (PSM) bụ otu ọgwụ agbadoro iji gwọọ ọrịa shuga. Na mgbakwunye na hypoglycemic, ha nwere mmetụta hypocholesterolemic.

Nkewa nke ogwu kemgbe iwebata:

1. Akpa emana Nke chlorpropamide bụ Tolbutamide nọchiri anya ya. Taa, a naghị eji ha eme ihe. Ejiri omume dị mkpụmkpụ gosipụta ha, iji rụpụta nsonaazụ edere ha na nnukwu olu.
2. Ọgbọ nke abụọ bụ Glibenclamide, Glipizide, Gliclazide, Glimepiride. Ha enweghị ngosipụta dị oke nhịahụ nke nsonaazụ dị n'akụkụ, ka edepụtara ya na obere ego.

Site n'enyemaka nke otu ọgwụ, enwere ike nweta ezigbo ụgwọ maka ọrịa shuga. Nke a na - enyere gị aka igbochi ma belata mmepe nke nsogbu.

Nnabata PSM na-enye:

• mbelata nke imeju glucose nke imeju;
• Mkpali β-cell na-eme ka ahụrụ aka na -emeziwanye usoro glucose;
• mụbara anụ ahụ uche na homonụ;
• igbochi nzuzo nke somatostatin, nke na - egbochi insulin.

Ndepụta nke nkwadebe PSM: Glibamide, Maninil, Glibenclamide, Teva, Amaril, Glisitol, Glemaz, Glisitol, Tolinase, Glibetik, Gliclada, Meglimid, Glidiab, Diabeton, Diazid, Reklid, Oziklid. Glibenez, Minidab, Movogleck.

Usoro nke ime ihe

Akụkụ bụ isi na-emetụta ụfọdụ ndị na-anabata ọwa ma gbochie ha. Enwere mbelata nke membranes nke mkpụrụ ndụ sel, yana n'ihi nke a, oghere nke oghere ndị nwere kalselik. Mgbe nke a gasịrị, Ca ion na-abanye na mkpụrụ ndụ beta.

Nsonaazụ bụ ịhapụ hormone ahụ site na granules intracellular yana mwepụta ya n'ime ọbara. Nsonaazụ nke PSM nọọrọ onwe onye n’oche glucose. Maka nke a, ọrịa hypoglycemic na-apụtakarị.

A na-etinye ọgwụ na ngwu, ma mmetụta ha na-amalite awa 2 mgbe nchịkwa gasịrị. Metabolized n'ime imeju, wepu, ewezuga Glycvidon, site na akụrụ.

Ndụ ndụ ọkara na oge ọ bụla nke ọgwụ ọ bụla na ìgwè ahụ dị iche. Bmegide protein ndị dị na plasma - site na 94 ruo 99%. Thezọ iwepu ya, ọ dabere na ọgwụ a, bụ gbasara akụrụ, healatic, na hepatic. Mwepu nke ihe di ike na-eji nri eji eme nri.

Ihe ngosi maka oge atọrọ

Nri nke sulfonylureas ka enyere n'iwu maka ụdị shuga 2 n'ụdị ndị a:

• na enweghi ike imeputa insulin;
• na mbelata nke inwe mmetụta nke homonụ nke anụ ahụ;
• site na adịghị ike nke usoro ọgwụgwọ nri.

Ngwurugwu mgbochi na nsonaazụ ya

Ngwurugwu ogwu contraraindications sulfonylurea gụnyere:

• Ọrịa shuga ;dị 1;
• mẹkpoo mkpụkpu;
• ime
• inye ara;
• mkpụkpu akụrụ;
• ketoacidosis;
• ihe mgbochi;
• hypersensitivity na sulfonamides na ngwa inye aka;
• anabataghị PSM;
• anaemia
• usoro na-efe efe;
• afọ ruo afọ 18.

Edeghị ọgwụ maka ọgwụ shuga dị elu karịa ihe karịrị 14 mmol / L. Ọzọkwa, etinyela akwụkwọ maka insulin kwa ụbọchị chọrọ karịa 40 nkeji. A naghị akwadoro maka ndị ọrịa nwere nnukwu ọrịa shuga 2 na ọnụnọ β-cell.

Mkpụrụ osisi Biguanide

Enwere ike inye glycvidone ndị mmadụ nwere obere ọrụ akụrụ. A na - eme mwepu ya (ihe dịka 95%) site na eriri afọ. Ojiji nke PSM nwere ike ịmalite nguzogide. Iji belata ihe ijuanya ndị dị otú a, enwere ike ijikọ ha na insulin na biguanides.

Otu ìgwè ọgwụ na-anabata nke ọma. N'ime mmetụta ndị na-adịghị mma, hypoglycemia bụ ugboro ugboro, hypoglycemia siri ike na-ahụ naanị 5% nke ikpe. Ọzọkwa, n'oge usoro ọgwụgwọ, a na-achọpụta ibu dị arọ. Nke a bụ n'ihi secretion nke insulin insulin.

Nsonaazụ ndị a abụghị ihe a na-ahụkarị:

• ọrịa dyspeptik;
• ọla n ’ọnụ;
• hyponatremia;
• hemolytic anaemia;
• arụ ọrụ ezumike;
• mmeghachi omume nfụkasị ahụ;
• imebi imeju;
• leukopenia na thrombocytopenia;
• jalestice cholestatic.

Usoro onunu ogwu na nhazi

Ejiri usoro onyonyo nke PSM ka dọkịta depụtara ya. Ekpebiela n’iburu n'uche nyocha nke steeti metabolism.

Ọ bụ ihe amamihe dị na ịmalite ọgwụ na PSM site na ndị na-esighi ike, na enweghị mmetụta, gbanwee gaa ọgwụ siri ike. Glibenclamide nwere mmetụta dị ala karịa okpomoku karịa ihe ndị ọzọ na-egosi hypoglycemic ọnụ.

Akingnara ọgwụ a enyere ndị otu a na-amalite site na obere doses. N'ime izu abụọ, ọ na-eji nwayọọ nwayọọ na-abawanye. Enwere ike ịnye insulin na insulin na ndị ọzọ ọgwụ nchekwa hypoglycemic.

Usoro onodu ogwu ndi ozo di nma, a na-ahọpụta ya karie. Mgbe enwere ụgwọ nkwụghachi ụgwọ, ịlaghachi usoro ọgwụgwọ a na-ejikarị eme. Ọ bụrụ na ọgwụ insulin chọrọ erughị nkeji iri / ụbọchị, dọkịta na-agbanye onye ọrịa ka ọ bụrụ ihe eji eme mmanụ sulfonylurea.

Ọrịa shuga 2dị 2

Usoro ọgwụgwọ nke otu ọgwụ ka akọwapụtara na ntuziaka maka ojiji. A na-atụle usoro ọgbọ na njiri mara ọgwụ ahụ n'onwe ya (ihe na-arụ ọrụ). Ọgwụ kwa ụbọchị maka chlorpropamide (ọgbọ nke 1) - 0.75 g, Tolbutamide - 2 g (ọgbọ nke abụọ), Glycvidona (ọgbọ nke abụọ) - ruru 0.12 g, Glibenclamide (ọgbọ nke abụọ) - 0.02 g. mmalite usoro ịbelata.

A na-ewere ego niile nke otu PSM ọkara ọkara ma ọ bụ otu awa tupu nri. Nke a na-enye nnabata ọgwụ ka mma ma, n'ihi ya, mbelata nke glycemia postprandial. Ọ bụrụ na enwere nsogbu dyspeptik pụtara ìhè, a na-ewere PSM mgbe nri.

Nchedo nchekwa

N’ime ndị okenye, nsogbu nke ibute hypoglycemia dị elu karịa. Maka ụdị ndị ọrịa a, a na-enye ọgwụ ndị nwere obere oge iji gbochie nsonaazụ na-adịghị mma.

A na-atụ aro ka ịhapụ ọgwụ ndị na-eme ogologo oge (Glibenclamide) wee gbanwee gaa na obere ihe (Glycvidone, Glyclazide).

Inweta usoro sulfonylurea na-akpata ihe ize ndụ nke hypoglycemia. N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọkwa shuga. A na-atụ aro ka ị soro usoro ọgwụgwọ nke dọkịta gị guzobere.

Site na ntụgharị ya, ọnụọgụ glucose nwere ike ịgbanwe. N'ihe banyere mmepe nke ọrịa ndị ọzọ n'oge ọgwụgwọ PSM, ọ dị mkpa ịgwa dọkịta.

N'ime usoro ọgwụgwọ, a na-enyocha ihe ndị a gosipụtara:

• mmamịrị ọkwa shuga;
• haemoglobin nke glycosylated;
• ọbara shuga
• laahu;
• ule imeju.

A naghị akwado ya ka ị gbanwee usoro onunu ogwu, gbanwee na ọgwụ ọzọ, kwụsị ọgwụgwọ na-enweghị nyocha. Ọ dị mkpa iji ọgwụ n'oge edepụtara.

Inggafe usoro enyere n'iwu ga-eduga hypoglycemia. Iji kpochapụ ya, onye ọrịa na-ewere 25 g glucose. A kọọrọ dọkịta na ọnọdụ ọ bụla yiri ya banyere mmụba nke usoro ọgwụ.

Na nnukwu hypoglycemia, nke ọnwụ ya na-akpata, ọ dị mkpa ịchọ enyemaka ahụike.

A na-elekọta glucose n'ọbara. May nwere ike ịchọ injelo ọzọ nke glucagon na / m, in / in. Mgbe enyemaka mbụ gachara, ị ga-eji ọkwa shuga nyochaa oge niile ruo ọtụtụ ụbọchị.

Vidio gbasara ọgwụ shuga nke 2:

Mmekọrịta nke PSM na ọgwụ ndị ọzọ

Mgbe ị na-a medicinesụ ọgwụ ndị ọzọ, enwere ike ịdabere na ndakọrịta ọ bụla na usoro sulfonylurea. Homonụ anabolic, antidepressants, beta-igbochi, sulfonamides, clofibrate, nwoke homonụ, coumarins, ọgwụ tetracycline, miconazole, salicylates, ndị ọzọ hypoglycemic na insulin na-abawanye mmetụta hypoglycemic.

PSM na-ebelata nsonaazụ corticosteroids, barbiturates, glucagon, laxatives, estrogens na gestagens, nicotinic acid, chlorpromazine, phenothiazine, diuretics, homonụ thyroid, isoniazid, thiazides.