Ruo taa, ụlọ ọrụ ọgwụ na-emepụta ọgwụ insulin dị iche iche maka ndị ọrịa mamịrị, bu n’obi ịgba ntụtụ. Ọgwụ a dị iche iche nwere ike ịnwe aha, ogo na ọnụ ahịa dị iche iche. Otu n’ime ha bụ insulin Humalog.
Mlọ ọgwụ
Humalog insulin bu nnuku ihe ana - eme na - eme ka anyi mata ihe banyere mmiri n’ile anya. Ihe dị iche n'etiti Humalog na insulin nke anụ ahụ bụ usoro amino acid nke dị na ọnọdụ 29 na 28 nke insulin B yinye. Isi mmetụta o nwere bụ usoro glucose metabolism
Humalog nwekwara mmetụta anabolic. N'ime akwara mkpụrụ ndụ, ọnụọgụ nke abụba abụba, glycogen na glycerol na-abawanye, mmepụta protein na-abawanye, ọkwa nke iji amino acid na-abawanye, mana ike nke glycogenolysis, gluconeogenesis, na mwepụta nke amino acid na-ebelata.
N'ime ahụ ndị ọrịa nwere ọrịa shuga nke ụdị abụọ a n'ihi ojiji Humalog, ịba ụba hyperglycemia nke na-apụta mgbe nri belatara ruo n'ókè dị ukwuu n'ihe banyere insulin mmadụ na -akpata.
Maka ndị ọrịa na-anata ụdị insulin n’otu oge na obere oge, ịkwesịrị ịhọrọ usoro nke insulin abụọ iji mezuo ọdịnaya glucose ziri ezi ụbọchị niile.
N'otu aka ahụ na nhazi insulin ndị ọzọ, oge mmetụta nke ọgwụ Humalog dịgasị iche na ndị ọrịa dị iche iche ma ọ bụ n'oge dị iche iche na otu onye ọrịa. The pharmacodynamics nke Humalog na ụmụaka kwekọrọ na ọgwụ pharmododynamics ya na ndị okenye.
N'ime ndị ọrịa nwere ụdị shuga nke 2 na ị largeụ nnukwu usoro ọgwụgwọ sulfonylurea, ojiji nke Humalog na-akpata mbelata nke ọkwa haemoglobin dị elu. Mgbe Humalog jiri ụdị ọrịa shuga abụọ mee, a na-agbadata ọnụ ọgụgụ nke hypoglycemic nke ọma n'abalị.
Esemokwu glucodynamic na Humalog enweghị ezughi oke nke ọrụ ịba ọria na akụrụ. E guzobelarịrị ọgwụ ahụ maka insulin mmadụ, mana nsonaazụ nke ọgwụ a ngwa ngwa ma na-adịgide obere.
A na-ahụ Humalog na mmetụta ya na-amalite ngwa ngwa (ihe dị ka nkeji iri na ise) n'ihi nnukwu nnabata, nke na-eme ka o kwe omume iwebata ya tupu nri (na nkeji 1-15), ebe insulin nkịtị, nke nwere obere ihe, enwere ike ịchịkwa na 30 -45 nkeji tupu eri.
Mlọ ọgwụ
Site na nsị subcutaneous, nnabata nke insulin lyspro na-eme ngwa ngwa, Cmax ya na-enweta mgbe awa 1-2 gachara. Vd nke insulin na mejupụtara ọgwụ na mmadụ nkịtị insulin bụ otu, ha sitere na 0.26 ruo 0.36 lita kwa n'arọ.
Ihe ngosi
Ofdị shuga na-adabere na ọrịa shuga: mmadụ ịghara ịnabata insulin ndị ọzọ; postprandial hyperglycemia, nke nkwenye insulin na-enweghị ike idozi ya.
Diabetesdị nke ọrịa shuga na-abụghị insulin: iguzogide ọgwụ mgbochi ọrịa shuga were ọnụ (malabsorption nke usoro insulin ndị ọzọ, hypglycemia postprandial, ọ bụghị mgbazi); ihe ogwugwo na oria aru (nke neme ka ihe otiti di nma).
Ngwa
Usoro onunu ogwu Humalog kpebisiri ike n’otu n’otu. A na-edozi humalog n'ụdị vials ma subcutaneously na intravenously na intramuscularly. Humalogue n'ụdị katridges bụ naanị subcutaneous. A na-ebu ụzọ inje 1 ruo 15 tupu nri.
N'ọdị ọcha ya, a na-a drugụ ọgwụ ahụ ugboro isii n'ụbọchị, yana insulin na-eji ya eme ogologo oge, ugboro atọ kwa ụbọchị. Ọkwa otu karama kariri nkeji iri anọ. Enwere ike ịgwakọta Humalog na vials na ngwaahịa insulin na-enwe mmetụta dị ogologo n'otu sirinji.
Emebeghi kaadi ihe ahu maka igwakọta Humalog na nkwado insulin ndi ozo n'ime ya na kwa ozo.
Mkpa nke iwetulata insulin nwere ike ibilite ma ọ bụrụ na mbelata ọdịnaya nke carbohydrates na ngwaahịa nri, nnukwu ahụ ike anụ ahụ, ị additionalụ ọgwụ ndị ọzọ nwere oke hypoglycemic - sulfonamides, ndị na-abụghị nhọrọ beta-blockers.
Nsonaazụ
Isi mmetụta nke ọgwụ a na-akpata nsonaazụ ndị a: mmụba ọsụsọ, nsogbu ihi ụra, coma. N'ọnọdụ ndị a na-adịghị ahụkebe, allergies na lipodystrophy nwere ike ime.
Ime
Ka ọ dị ugbu a, enwebeghị mmetụta ọjọọ Humalog nwere banyere ọnọdụ nwanyị dị ime na nwa o bu n’afọ amatala. Enwebeghị ọmụmụ ọ bụla metụtara.
Nwanyị ịmụ nwa nke na-arịa ọrịa shuga kwesịrị ịgwa dọkịta banyere atụmatụ dị ime ma ọ bụ nke na-abịanụ. Maka ndị ọrịa na-arịa ọrịa shuga, mgbe ụfọdụ ịwa ahụ chọrọ idozi ya na insulin insulin ma ọ bụ nri ya.
Dodoụbiga ya ókè
Ngosiputa: omumu nke glucose ọbara, bu nke oke ure, iyi, otutu ihe n’iru, ihe mgbu, isi.
Ọgwụ: n'ụdị dị nro, enwere ike ịkwụsị hypoglycemia site na oriri glucose dị n'ime ma ọ bụ ihe ọzọ sitere na shuga, ma ọ bụ ngwaahịa nwere shuga.
Hypoglycemia ruo obere oge ka enwere ike idozi ọbara intramuscular ma ọ bụ subcutaneous nke glucagon na inwekwu carbohydrates n'ime mmiri mgbe enwere ike ịkwụsị ọnọdụ onye ọrịa ahụ.
A na-enye ndị ọrịa na-anabataghị glucagon, na-enye ọgwụgwọ glucose na-emetụta ọbara. N'ihe banyere coma, a na-eduzi glucagon subcutaneously ma ọ bụ intramuscularly. N'iburu na glucagon ma ọ bụ mmeghachi omume na ntụtụ nke ihe a, a ga-arụ ọrụ nhazi nke ọgwụgwọ glucose.
Ozugbo onye ọrịa mechara nwetaghachi mmụọ, ọ kwesịrị iri nri nwere carbohydrates. May nwere ike ịchọrọ ị carbohydụ carbohydrates n'ọdịniihu, ị ga-achọkwa nyochaa onye ọrịa, ebe ọ bụ na enwere ihe ọghọm ịlaghachi hypoglycemia.
Nchekwa
Ekwesịrị idobe Humalog na okpomọkụ nke +2 ruo +5 (na friji). A naghị anabata mmanị. Kabetị ma ọ bụ karama nke ebidolarị nwere ike ịdịru ụbọchị 28 n'ụlọ okpomọkụ. Kwesiri ichebe Humalog site na ìhè anyanwụ.
Anabataghị iji ya mee ihe n ’ikpe ahụ mgbe o nwere igwe ojii, yana oke ma ọ bụ nke na-acha odo odo, ma nwee ọnụnọ siri ike na ya.
Mmekọrịta nke ọgwụ ọgwụ
A na-ebelata hypoglycemic mmetụta nke ọgwụ a mgbe ị na-a contraụ ọgwụ mgbochi mkpị, ọgwụ na-adabere na homonụ thyroid, beta2-adrenergic agonists, danazole, tricyclic antidepressants, thiazide ụdị diuretics, diazoxide, chlorprotixen, isoniazid, nicotinic acid, carbonhi litateum.
Mmetụta hypoglycemic nke Humalog na-abawanye na beta-blockers, mmanya ethyl na ọgwụ ndị nwere ya, fenfluramine, steeti anabolic, tetracyclines, guanethine, salicylates, ọgwụ hypoglycemic ọgwụ, sulfonamides, AC inhibitors na MAO na octre.
Enwere ike iji Humalog (dabere na nlekọta nlekọta ahụike) yana insulin mmadụ, nke nwere mmetụta na-adịgide adịgide, ma ọ bụ yana ọnụ ọgwụ hypoglycemic nke bụ ọgwụ sitere na sulfonylurea.
