Ọ bụrụ na achọpụtara ọkwa cholesterol dị elu n'oge nnwale ọbara, dọkịta ga-enyerịrị ọgwụ pụrụ iche iji gbochie ọrịa obi na ọrịa vaskụla. Ọgwụ ndị a bụ nke otu statins.
Onye ọrịa ahụ kwesịrị ịmara na ọ ga-anara ọgwụ ahụ oge niile. Statins, dị ka ọgwụ ọ bụla ọzọ, nwere ụfọdụ nsonaazụ ya, dọkịta ga-agwa onye ọrịa banyere ha.
Onye ọ bụla nsogbu nke cholesterol dị elu na-eche: enwere ọgwụ ọ bụla iji mezie ọkwa nke ogige a ma ị ga-ewere ya.
E kee ọgwụ cholesterol ụzọ abụọ:
- Ọnọdụ
- Fibrates
Dika adjuvants, lipoic acid na omega-3 fatty acids nwekwara ike iri ha.
Statins - cholesterol belata ọgwụ
Statins bụ ihe kemịkal nke na-eme ka anụ ahụ belata mmepụta nke enzymes dị mkpa maka ịmepụta cholesterol n'ime ọbara. Ọ bụrụ na ị gụọ ntuziaka maka ọgwụ ndị a, mgbe enyere iwu ndị a ebe ahụ:
- Statins belata cholesterol ọbara n'ihi mmetụta mgbochi nke HMG-CoA mbelata na iwelata njikọta imeju.
- Statins na-enyere aka belata cholesterol dị elu n’ime ndị nwere ọgwụ hyzychous hypercholesterolemia, nke enweghị ike iji ọgwụ ndị ọzọ belata cholesterol.
- Statins belata cholesterol zuru ezu site na 30-45%, yana ihe akpọrọ "ajọ" cholesterol - site na 45-60%.
- Concentta nke cholesterol bara uru (oke njupụta lipoproteins) yana apolipoprotein A na-abawanye.
- Statins site na 15% belata ihe ize ndụ nke ịmalite ọrịa ischemic, gụnyere infyoction myocardial, yana ohere nke angina na-etolite na ngosipụta nke ischemia myocardial site na 25%.
- Ha abụghị carcinogenic yana mutagenic.
Mmetụta akụkụ nke statins
Ogwu di otu a nwere otutu nsogbu ndi ozo. Themfọdụ n’ime ha bụ:
- - Ọtụtụ mgbe, isi ọwụwa na mgbu mgbu, ehighị ụra nke ọma, ọgbụgbọ, ọrịa asthenic, afọ ọsịsa ma ọ bụ afọ ntachi, flatulence, olu mgbu;
- - site na usoro ụjọ ahụ enwere paresthesia, dizzness na malaise, hypesthesia, amnesia, neuropathy akụkụ;
- - site na ngba nri - ịba ọcha n'anya, afọ ọsịsa, anorexia, vomiting, pancreatitis, cholestatic jaundice;
- - site na usoro akwara - azụ na mgbu mgbu, akpụ ụkwụ, ogbu na nkwonkwo nke nkwonkwo, myopathy;
- - ngosipụta nfụkasị - urticaria, ọnya ọnya, itching, erythema exudative, ọrịa Lyell, ọrịa anaphylactic;
- - thrombocytopenia;
- - nsogbu nke metabolic - hypoglycemia (iwetulata glucose ọbara) ma ọ bụ ọrịa shuga;
- - ibu dị oke ibu, oke ibu, enweghi ike, ụbụrụ oke.
Needsnye kwesịrị iji statins
Advertisingkpọsa ọgwụ na-ekwu na ọ dị mkpa iwetulata cholesterol, na statins ga - enyere aka na nke a, ha ga - eme ka ndụ ha ka mma, belata ihe ize ndụ nke ịmalite ọrịa strok na nkụchi obi.
Ọtụtụ nnyocha gosipụtara na ọgwụ bụ ụzọ dị irè iji gbochie ihe mberede vaskụl ma mee ka ọ nwee mmetụta dị ole na ole. Mana ịkwesịrị ịkpachara anya banyere nkwupụta dịka "onye ọ bụla na-a statụ statins nwere kọlesterol dị mma na cholesterol dị mma." Enweghị nkwenye, a gaghị atụkwasị obi ụdị amamịghe a.
N’ezie, a ka na-arụ ụka gbasara mkpa ọ dị iji statins n’oge agadi. Ka ọ dị ugbu a, ọnweghị ọgwụ ịkpa oke enweghị ụdị otu ọgwụ a. Ihe omumu emere gosiputara na mgbe cholesterol di elu, ihe ha kwesiri ime bu iji belata ohere obi na oria.
Ndị sayensị ndị ọzọ kwenyere na ọgwụ nwere ike imerụ ahụike nke ndị agadi ma na-akpata oke nsonaazụ, na abamuru ha na nzụlite a adịghị oke.
Iwu Statin Nhọrọ
Onye ọ bụla, dabere na ndụmọdụ dọkịta, ga-ekpebiri onwe ya ma ọ ga-ewere statins. Ọ bụrụ na emere mkpebi dị mma, mgbe ahụ dọkịta kwesịrị ịkọwa mbadamba cholesterol dị iche iche, na-eburu n'uche ọrịa ndị na-eso ya.
Can enweghị ike ị takeụ ọgwụ iji wedata cholesterol n'onwe gị. Ọ bụrụ na enwere mgbanwe ma ọ bụ nsogbu ọ bụla na-achọpụta ihe gbasara metabolism na nyocha ahụ, ị ga-akpọtụrụ onye ukwu na-ahụ maka ọrịa obi ma ọ bụ usoro ọgwụgwọ. Naanị ọkachamara nwere ike nyochaa n'ụzọ ziri ezi ihe ize ndụ nke ịnwe statins maka onye ọ bụla, na-eburu n'uche:
- afọ, okike na ịdị arọ;
- ọnụnọ nke àgwà ọjọọ;
- Ọrịa obi na akụrụngwa ọbara yana ọrịa dị iche iche, ọkachasị ọrịa shuga mellitus.
Ọ bụrụ na edepụtara statin, mgbe ahụ ịkwesịrị ị were ya nke ọma na usoro onunu ogwu nke dọkịta nyere. N'okwu a, a ga-enyocha ọbara nke mmiri ọgwụ dị kwa ụbọchị. N'ihe banyere oke ọnụ ahịa ọgwụ a na-atụ aro, ọ dị mkpa iji otu ọnụọgụ nwere ike dochie ya ga-ekwe omume ịnọchi ya.
Ọ bụ ezie na ọ ka mma ị drugsụ ọgwụ ọgwụ mbụ, ebe ọ bụ na mkpụrụ ndụ ihe nketa, ọkachasị nke ndị sitere na Russia, ka njọ karịa mma karịa ọgwụ mbụ, ma ọ bụ ọgwụ ọgwụ ndị esi esi.
Fibrates
Nke a bụ otu ọgwụ ọgwụ iji belata cholesterol ọbara. Ha bụ usoro nke fibroic acid ma nwee ike kegide na bile acid, wee si otú ahụ belata ọrụ cholesterol na-arụ ọrụ. Fenofibrates belatara mkpo nke cholesterol dị elu n'ihi eziokwu ahụ bụ na ha na-agbadata mkpokọta lipids n'ime ahụ.
Ọmụmụ nyocha ahụike gosipụtara na iji fenofibrates na-eduga n'eziokwu ahụ na ngụkọta cholesterol na-agbadata site na 25%, triglycerides na 40-50%, ezi kọlesterol na-abawanye site na 10-30%.
N'ime ntuziaka maka fenofibrates na ciprofibrates, e dere na ojiji ha na-eduga n'ịbelata nkwụnye extravascular (tendon xanthomas), ọnụego nke triglycerides na cholesterol na ndị ọrịa nwere hypercholesterolemia na-agbadata.
Ekwesịrị icheta na ọgwụ ndị a, dị ka ọtụtụ ndị ọzọ, na-akpata ọtụtụ azịza. Nke mbu, nsogbu a bu nsogbu nri diges, na adighi enye ya igba cholesterol n’oge di ime.
Mmetụta ndị metụtara fenofibrates:
- Usoro nri - afọ mgbu, ịba ọcha n'anya, ọrịa gallstone, pancreatitis, ọgbụgbọ na ọgbụgbọ, afọ ọsịsa, flatulence.
- Ọkpụkpụ akwara - mee ka myalgia ghara ịdị ike, adịghị ike anụ ahụ, rhabdomyolysis, nsogbu ahụ ike, myositis.
- Ọkpụkpụ akụrụngwa - akwara umeji ma ọ bụ thromboembolism venous.
- Sistemụ ụjọ - imebi ọrụ mmekọahụ, isi ọwụwa.
- Ngosiputa ihe ekpom - ekpomkpukpo aru, itching, hives, hypersensitivity to light.
Ejikọtara ojiji nke statins na fibrates mgbe ụfọdụ iji belata usoro nke statins kwa. ya mere, mmetụta ha na-arụ.
Meanszọ ndị ọzọ
Na ndụmọdụ nke dọkịta, ị nwere ike iji mgbakwunye nri, dịka ọmụmaatụ, Tykveol, mmanụ linse, Omega 3, lipoic acid, nke jikọtara ya na ọgwụgwọ bụ isi na-enye aka mbelata cholesterol.
Omega 3
Ndị Ọkpụkpụ Obi America na-adụ ndị ọrịa niile nwere oke ọbara ume ị tabletsụ mbadamba mmanụ azụ (Omega 3) iji chebe onwe ha pụọ n'ọrịa obi na igbochi ịda mba na ọrịa ogbu na nkwonkwo.
Ma a ghaghi iji nlezianya mee mmanụ azụ, n'ihi na ọ nwere ike ịkpalite mmepe nke ọrịa pancreatitis na-adịghị ala ala, ebe a kwa ọgwụ kọlestrọl agaghị enyere aka.
Tykveol
Nke a bụ ọgwụ mere na mmanụ ugu. Edere ya ndị nwere atherosclerosis nke arịa ụbụrụ, cholecystitis, ịba ọcha n'anya.
Phytopreching a nwere ọrịa mgbochi, hepatoprotective, choleretic na mmetụta antioxidant.
Lipoic acid
A na - eji ya dịka onye na - agwọ ọrịa na onye na - ahụ maka ọrịa na - arịa ọrịa atherosclerosis, dịka ọ na - emetụta antioxidants endogenous.
Ọ nwere mmetụta dị mma na metabolism nke carbohydrates, na-abawanye mmepụta nke glycogen na imeju, na-eme ka nri nke neurons dị mma, enwere ike iburu nchịkọta nke imeju na nchịkọta, nyocha nke ndị dị mma.
Usoro ọgwụgwọ vitamin
Ha na - enyere aka ịbelata cholesterol nkịtị. Vitamin B6 na B12, folic acid, vitamin B3 (nicotinic acid) dị ezigbo mkpa.
Mana ọ dị ezigbo mkpa na vitamin bụ ihe dị ndụ ma ọ bụghị sịntetik, yabụ nri kwesịrị ịnwe nnukwu nri nke ike.
SievePren
Nke a bụ mgbakwunye nri a na-ewepụta nke nwere ntụpọ fir. O nwere beta-sitosterol na polyprenols. A na-eji ya maka ọbara mgbali elu, atherosclerosis, cholesterol ọbara mgbali elu na triglycerides.
Ekwesiri iburu n'uche na mmeju nke nri abụghị ọgwụ, yabụ, site na echiche ahụike, ha enweghị nnukwu ike karịa statins na-egbochi ọnwụ na oge ọghọm.
Ugbu a enwerekwa ọgwụ ọhụrụ maka iwetulata cholesterol ọbara - ezetemib. Ihe o mere sitere na iwetulata cholesterol site na eriri afọ. The doseụ ọgwụ kwa ụbọchị bụ 10 mg.
