ISOFAN INSULIN: NKỌWA, NYOCHA, ỌNỤAHỊA ELEKTRỌN

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Ọgwụ a bụ nke insulins. N’ezie, nke a bụ insulin mmadụ, nke enwetara n’ihi teknụzụ njikọ DNA.

Omume ọgwụ

Insulin insulin nwere mmetụta hypoglycemic. Ọ na - emekọ ihe ọnụ na ndị na - anabata ndị pụrụ iche na sel nke cytoplasmic membrane ma mepụta usoro insulin-receptor nke na - akpali usoro intracellular, nke gụnyere njikọ nke isi nke enzymes isi (pyruvate kinase, hexokinase, glycogen synthetase).

Mmụba dị na ebu intracellular na-ebute glucose na-eme ka mbelata ọkwa ya n’ọbara. Ọ na - enye aka na mbelata mbelata nke glucose site na imeju, ịba ụba na nnabata site na anụ ahụ. Na-akpali glycogenogenesis, lipogenesis, njikọ protein.

Nkwekorita nke obi, n'ihi ogwu ndi ahu nwere otutu ndu, dabere na otutu ihe n'otu oge: ebe na uzo ochichi ya si di. N'akụkụ a, ihe insulin nwere ike ịgbanwu n'ọtụtụ. Ọzọkwa, enwere ike ịhụ mgbanwe ndị a ọ bụghị naanị na ndị dị iche iche, kamakwa n'otu ọrịa ahụ.

Mgbe ogwu ogbugba gasịrị, na nkezi, ọgwụ amalite ịrụ ọrụ ma awa 1.5 gachara, oke kachasị na-apụta na etiti oge dị n’agbata awa anọ na iri na abụọ. Mmetụta nke ọgwụ ahụ na-adịgide ruo awa 24.

Mmalite nke mmetụta ahụ na izu oke nke nnabata insulin dịgasị:

site na saịtị ịgba ahụ (afọ, isi ụkwụ, apata ụkwụ);
na ịta ahụ homonụ na ọgwụ ahụ;
na ego ole insulin na-achịkwa.

Njirimara ndị ọzọ:

Odighi n'ime mmiri ara.
N'esepụghị aka kesaa anụ ahụ.
Ọ dịghị adaba site na ihe mgbochi placental.
30-80% kpụrụ akụrụ.
Site na insulinase mebiri emebi na akụrụ ya na imeju.

Mgbe ị ga-ewere insulin isofan

Ọrịa shuga mellitus ụdị nke m.
Oge iguzogide ọgwụ mgbochi hypoglycemic.
N'oge ejikọtara ọgwụgwọ, ịkwụ ụgwọ nke ọgwụ mgbochi otu a.
Ọrịa shuga IIdị nke abụọ n’ime ụmụ nwanyị dị ime.
Ọrịa.

Ihe ngbanwe

Hypoglycemia, hypersensitivity, yana hypoglycemia n'oge ime.

Nsonaazụ nke ọgwụ insulin isofan

Yiri nsonaazụ na metabolism metabolism:

Hypoglycemia:

nkwalite ọsụsọ na-agba agba
agụụ
pallor nke anụ ahụ
jijiji, tachycardia,
obi uto
isi ọwụwa
paresthesia na ọnụ;
nnukwu ọrịa hypoglycemia, nke juputara na mmepe nke hypoglycemic coma.

Ihe ekpughere ekpughe

Isi okwu Quincke,
akpukpo aru
nsogbu anaphylactic.

Ndị ọzọ:

ọ na-abụkarị na mmalite ọgwụgwọ ọgwụgwọ njehie na-ezighi ezi;
ọzịza.

Mmeghachi omume mpaghara:

ọzịza na itching na ntụtụ ebe;
hyperemia;
lipodystrophy na mpaghara ịgba agba (yana iji ogologo oge).

Mmekorita

Mee ka mmetụta inspoglycemic dị na insulin:

Ndị na - egbochi MAO;
ọgwụ ọgwụ hypoglycemic;
bromocriptine;
carbonic anhydrase inhibitors;
sulfonamides;
fenfluramine;
nkwadebe nwere ethanol;
Ndị na - egbochi ACE;
ndị na - achọghị beta-mgbochi;
mebendazole;
nkwadebe lithium;
tetracyclines;
ketoconazole;
steroid anabolic;
cyclophosphamide;
octreotide;
pyridoxine;
clofibrate;
theophylline.

Wepu mmetụta hypoglycemic nke insulin:

thiazide diuretics;
mẹ ụnwunna iya;
diazoxide;
homonụ thyroid;
morphine;
glucocorticoids;
danazole;
heparin;
BKK;
ọgwụ mgbochi tricyclic;
nikotin;
ihe nnabata;
clonidine;
ihe ndapụta.

Ma salicylates na reserpine nwere ike ibelata ma welie ọrụ insulin.

Dodoụbiga ya ókè

N'ihe banyere ịdoụbiga mmanya ókè, hypoglycemia nwere ike ime.

Ọgwụ hypoglycemia

Onye ọrịa ahụ nwere ike ịnagide hypoglycemia dị nwayọ site na iri otu shuga, swiiti ma ọ bụ nri nwere carbohydrate. Ya mere, ndị na-arịa ọrịa shuga kwesịrị ịnwe shuga, kuki, Grava ma ọ bụ ihe ọ fruitụ fruitụ mkpụrụ osisi mgbe niile.

N'ihe banyere hypoglycemia siri ike, mgbe onye ọrịa kwụsịrị ịmara, 40% nke dextrose ma ọ bụ glucagon ka a na-abanye n'ime.

Enwere ike ịlekọta insulin ikpeazụ nke mkpụrụ ndụ ihe ọmụmụ intramuscularly na subcutaneously. Mgbe nsụhọ laghachikwute mmadụ, ọ kwesịrị iri nri nwere carbohydrate, nke a ga - egbochi ịmalite ịmalite hypoglycemia.

Usoro onunu ogwu na nhazi

Ọ bụ ọkachamara n’otu n’otu n’otu n’otu n’otu si ekpebi ya. Ọ dabere n'ọkwa glucose dị n'ọbara onye ọrịa. Nkezi ọgwụ kwa ụbọchị dị iche site na 0,5 ruo 1 IU / n'arọ, ọ dabere n'ihe ọkwa glucose dị n'ọbara yana n'omume nke onye ọrịa ahụ, etu o siri meghachi omume na insulin isenji mmadụ.

Isofan insulin, dị ka ọgwụ mmadụ na mkpụrụ ndụ ihe nketa, na-abụkarị ọgwụ subcutaneously n'ime apata ụkwụ, mana enwere ike itinye ntụtụ n'ime buttock, mgbidi nke akụkụ ihu, yana uru ahụ dị n'ubu. Okpomọkụ dị iche iche nke ọgwụ a na-ahụ maka ụlọ kwesịrị ịbụ okpomoku ụlọ.

Nchedo nchekwa

N'ime mpaghara anwansi, a na-atụ aro ịgbanwe mpaghara sirinji. Nke a ga - egbochi mmepe nke lipodystrophy. N'ịgwọ insulin, ịkwesịrị ilebara shuga ọbara oge niile.

Na mgbakwunye na eziokwu ahụike insulin nke mmadụ na nke mkpụrụ ndụ ihe gafere gafere, ihe na - akpata hypoglycemia nwere ike ịbụ:

mẹ nri nri;
afọ ọsịsa, ọgbụgbọ;

Ọrịa na -ebelata mkpa maka insulin homonụ (pituitary, pituitary, corenex adrenal, thyroid gland, ọrụ akụrụ na ọrụ ịba ọcha);

ọgwụ nchịkwa;
mgbanwe mpaghara injection;
ịba ụba arụ ọrụ;
nmekorita ya na ogwu ndi ozo.

Ọ bụrụ na etinye insulin na-amụ mmadụ na mkpụrụ ndụ ihe ọmụmụ na-apụtaghị ìhè ma ọ bụ na usoro ọgwụgwọ ahụ ezughị oke, hyperglycemia nwere ike ime, ihe mgbaàmà nke na-amalitekarị nwayọ nwayọ (ọtụtụ awa ma ọ bụ ọbụna ụbọchị). Hyperglycemia na-esonyere:

ọdịdị nke akpịrị ịkpọ nkụ;
ọnụ kpọrọ nkụ
ugboro urination;
ọgbụgba, vomiting;
ụnwụ nri;
anya ntughari
akpukpo aru na akpukpo aru nke akpukpo aru;
isi acetone si n'ọnụ ya.

Ọ bụrụ na ọgwụgwọ oge maka hyperglycemia agaghị ekwe omume na ọrịa shuga m, ọrịa shuga na-eyi ndụ egwu, ketoacidosis, nwere ike ịmalite.

Na ọrịa Addison, ọrịa thyroid, ọrụ imeju na akụrụ, hypopituitarism na ọrịa shuga mellitus n'ime ndị agadi, ọ dị mkpa ịgbanwe ọgwụ ahụ ma jiri nlezianya dezie insulin mmadụ na mkpụrụ ndụ ihe nketa.

Enwere ike ịchọ mgbanwe nrịbama na ọnọdụ ebe onye ọrịa gbanwere ụdị nri ọ na-emebu ma ọ bụ nwekwuo ike nke mmega ahụ.

Insmalite insulin na-eme ka mmadụ mara ihe na ihe na-ebelata ndidi ị alcoholụ mmanya. Na njikọta mgbanwe nke ụdị insulin, ebum n’uche ya, enwere ike dị elu na mbelata ikike ị na-anya ụgbọala ma ọ bụ na-ejikwa usoro dị iche iche.