Ndị ọkà mmụta sayensị nọ n'ọnụ ụzọ ịmepụta ọgwụgwọ maka ọrịa shuga 1

Ndị nyocha Russia emepụtara ihe ndị eji eme ọgwụ iji weghachi ma dokwa ahụike akwara ọrịa shuga nke 1.

Ihe ohuru nke ndi sayensi Russia meputara na-enwe ike idozi pancreas mebiri site na oria shuga

Na pancreas, enwere mpaghara pụrụ iche akpọrọ Langerhans Islands - ha bụ ndị na - eme ka insulin dị n'ahụ. Homonụ a na - enyere sel aka inweta glucose n’ọbara, na enweghị ya - akụkụ ma ọ bụ n’ozuzu oke - na - ebute mmụba nke ọkwa glucose, na - eduga n’ọrịa shuga.

Ọgwụ glucose na -eme ka nguzị kemịkal dị n'ahụ ahụ, nrụgide oxidative na-ebilite, yana ọtụtụ radicals na - etolite na sel, nke na - akpaghasị nguzosi ike nke mkpụrụ ndụ ndị a, na - akpata mbibi na ọnwụ.

Ọzọkwa, ahụ glycation na-eme ahụ, nke glucose na-ejikọ ya na protein. N'ime ahụike mmadụ, usoro a na-aga n'ihu, mana nwayọ karịa, na ọria mamịrị ọ na - eme ngwa ngwa ma mebie ọnya.

Ndi mmadu nwere oria 1. Ya, mkpụrụ ndụ nke Langerhans Islets na-amalite ịnwụ (ndị dọkịta kwenyere na nke a bụ n'ihi mwakpo autoimmune nke anụ ahụ n'onwe ya), na n'agbanyeghị na ha nwere ike kee, ha enweghị ike iweghachi ego mbụ ha, n'ihi mmụba nke glucose na oxidative kpatara oke glucose na-akpata. nwụọ ngwa ngwa.

Daybọchị ọzọ, akwụkwọ akụkọ Biomedicine & Pharmacotherapy bipụtara otu isiokwu na nsonaazụ nke ọmụmụ ọhụrụ nke ndị ọkà mmụta sayensị si Mahadum Ural Federal (Ural Federal University) na Institute of Immunology and Physiology (IIF UB RAS). Ndị ọkachamara achọpụtala na ihe ndị emepụtara na ntanetị nke 1,3,4-thiadiazine na-ebelata mmeghachi omume autoimmune dị n’elu n'ụdị mbufụt, nke na-emebi mkpụrụ ndụ insulin, ma, n'otu oge ahụ, na-ewepụ mmetụta nke glycation na oxidative stress.

Na ụmụ oke nwere ọrịa shuga nke 1, nke a nwalere usoro dị 1,3,4-thiadiazine, ọkwa nke protein na-egbochi mkpali na ọbara belatara nke ukwuu na haemoglobin glycly adịkwaghị. Mana ihe kachasị mkpa bụ na ụmụ anụmanụ, ọnụ ọgụgụ insulin na - arụ ọrụ n'ime akwara mụbara ugboro atọ ma ọkwa insulin n’onwe ya mụbara, nke belatara mgbanye glucose n’ọbara.

O yikarịrị ka ọgwụ ọhụrụ ndị a mepụtara na-adabere na ọgwụ ndị a kpọtụrụ aha n'elu ga-agbagha usoro ọgwụgwọ nke ọrịa shuga 1 ma nye ọtụtụ nde ndị ọrịa olileanya dị ukwuu maka ọdịnihu.