Atorvastatin-Teva bụ ọgwụ hypoliplera. Usoro nke ị actionụ ọgwụ belata belata belata cholesterol “ọjọọ” yana oke nke triglycerides na lipoproteins dị ala. N'aka nke ha, ha na-abawanye mmụba nke lipoproteins dị elu na cholesterol dị mma.
Atorvastatin-Teva dị n'ụdị mbadamba ihe nkiri na-acha ọcha. Edere ihe odide abụọ na elu ha, otu n'ime ha bụ "93", nke abụọ dabere na usoro ị theụ ọgwụ ahụ. Ọ bụrụ n ’usoro onodu ogwu ahụ bụ 10 mg, yabụ edetu a na-akpọ“ 7310 ”, ma ọ bụrụ na 20 mg, ya bụrụ“ 7311 ”, ọ bụrụ na 30 mg, yabụ“ 7312 ”, ma ọ bụrụ na 40 mg, yabụ“ 7313 ”.
Ngwakọta bụ isi nke Atorvastatin-Teva bụ calcium atorvastatin. Ọzọkwa, ihe mejupụtara ọgwụ ahụ gụnyere ọtụtụ ihe ndị ọzọ, ihe inyeaka. Ndị a gụnyere, dịka ọmụmaatụ, lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.
Usoro nke Atorvastatin-Teva
Atorvastatin-Teva, dị ka ekwuputara na mbido, bụ ihe nnọchianya na-egbusi ike. Ike ya niile bụ iji gbochie, ya bụ, igbochi ọrụ enzyme n'okpuru aha HMG-CoA reductase.
Ọrụ bụ isi nke enzyme a bụ ịhazi nhazi nke cholesterol, ebe ọ bụ na nguzobe ya, mevalonate, sitere na 3-hydroxy-3-methyl-glutaryl-coenzyme A. na-ebido. A na-eziga cholesterol, yana triglycerides, na imeju, ebe ọ na-ejikọ ọnụ na obere lipoprote. . Akụrụngwa kpụpụtara na-abanye na plasma ọbara, ma were nke ugbu a nyefe akụkụ ahụ na anụ ahụ ndị ọzọ.
A na-agbanwe lipoproteins dịkarịsịrị ala dị ntakịrị site na ịkpọtụrụ ndị na-anabata ha. N'ihi nsonaazụ a, nnuku ha na-eme, ya bụ, ire ere.
Ọgwụ na-ebelata oke cholesterol na lipoproteins n'ọbara nke ndị ọrịa, na-egbochi mmetụta nke enzyme ma na-abawanye ọnụ ọgụgụ nke ndị na-anabata ya na imeju maka obere lipoproteins dị ala. Nke a na - eme ka nnata na mkpofu ha kakwuo mma. A na - ebelatakwa usoro nke lipoproteins atherogenic. Na mgbakwunye, mkpokọta nke protein dị ukwuu nke lipoprotein cholesterol na-abawanye ma triglycerides belata yana protein apolipoprotein B.
Ojiji nke Atorvstatin-Teva na-egosi nsonaazụ dị elu na ọgwụgwọ nke ọ bụghị naanị atherosclerosis, kamakwa ọrịa ndị ọzọ metụtara metabolism lipid, nke usoro ọgwụgwọ Lipid belata adịghị mma.
Achọputara ya na ihe ọghọm oria ọrịa na - emetụta obi na akwara ọbara, dịka nkụchi obi na ọrịa strok, belatara nke ukwuu.
Pharmacokinetics nke Atorvastatin-Teva
A na-etinye ọgwụ a ngwa ngwa. N'ihe dị ka awa abụọ, edekọwo ọgwụ kachasị elu na ọbara onye ọrịa. Mwepu, ya bụ, nnabata, nwere ike ịgbanwe ọsọ ya.
Dịka ọmụmaatụ, ọ nwere ike ibelata mgbe ị na-ewere mbadamba nri. Ma ọ bụrụ na itinye uche n'ụzọ dị otú a na-agbada, mgbe ahụ ọ naghị emetụta mmetụta nke Atorvastatin n'ụzọ ọ bụla - cholesterol na-aga n'ihu na-ebelata dabere na usoro onunu ogwu. Mgbe ị na-abanye n'ahụ ahụ, ọgwụ ahụ na-enwo usoro mgbanwe dị iche iche na eriri afọ. Ọ jikọtara ya nke ọma na protein plasma - 98%.
Mgbanwe mgbanwe metabolism bụ isi na Atorvastatin-Teva na-adị na imeju n'ihi ikpughe iche iche. N'ihi nsonaazụ a, etolite metabolites na-arụ ọrụ, bụ nke na-ahụ maka mgbochi nke HMG-CoA reductase. 70% nke nsonaazụ ọgwụ niile na-apụta kpọmkwem n'ihi metabolites ndị a.
A na - ahụpụ Atorvastatin site na ahụ ya na hepatic bile. Oge oge ị theụ ọgwụ na ọbara ga-abụ ọkara nke mbụ (nke a na-akpọ ọkara ndụ) bụ awa iri na anọ. Mmetụta enzyme ahụ na-ewe ihe dị ka otu ụbọchị. Ọ nweghị ihe karịrị pasent abụọ nke ego anabatara nwere ike kpebisie ike site na inyocha mmamịrị onye ọrịa. Maka ndị ọrịa nwere ezughi oke gbasara akụrụ, ekwesiri icheta na n’oge hemodialysis Atorvastatin anaghị ahapụ ahụ.
Oke kachasị nke ọgwụ a karịrị ogo 20% na ụmụ nwanyị, ọnụego mkpochapu ya belata 10%.
N'ime ndị ọrịa na-arịa mmebi imeju n'ihi ị alcoholụbiga mmanya ókè na-egbu egbu, mkpokọta kachasị na-abawanye site na ugboro iri na isii, ọnụego ntụpọ ahụ na-agbadata ugboro iri na otu, na-agbaso ụkpụrụ.
Ihe ngosi na contraindications maka ojiji
Atorvastatin-Teva bụ ọgwụ a na-eji n'ọtụtụ ọgwụ.
A na-eme ọgwụgwọ nke ọrịa ọ bụla na ọrịa a dị n'elu ebe a na-enwe nri na - enyere aka belata cholesterol ọbara (nke dị elu na akwụkwọ nri na mkpụrụ osisi, mkpo, mkpị osisi, tomato, azụ, anụ ọkụkọ, akwa), yana enweghị nsonaazụ sitere na mbụ. etinyere ọgwụgwọ.
E nwere ọtụtụ ihe ngosi ndị gosipụtara na ọ rụpụtara ezigbo ọrụ:
- atherosclerosis;
- isi hypercholesterolemia;
- heterozygous ezinụlọ na hypercholesterolemia na-abụghị nke ezinụlọ;
- ụdị hypercholesterolemia agwakọta (ụdị nke abụọ dabere na Fredrickson);
- triglycerides dị elu (ụdị nke anọ dịka Fredrickson);
- ahazighi ezi nke lipoproteins (ụdị nke atọ dabere na Fredrickson);
- Hyzycholesterolemia homozygous familial.
Enwere ọtụtụ contraindications maka iji Atorvastatin-Teva:
- Ọria imeju na ọkwa nọ n'ọrụ ma ọ bụ n'oge ọnọdụ iwe.
- Mmụba na ọkwa nke ọrịa ịba ọcha n'anya (ALT - alanine aminotransferase, AST - aspartate aminotransferase) karịrị ugboro atọ, n'enweghị ezigbo ihe kpatara ya;
- Imeju imeju.
- Ime na lactation.
- Ofmụaka dị obere.
- Ngosiputa ekpughere mgbe obula nke ihe ogwu ahu.
N'ụfọdụ oge, ọgwụ ndị a kwesịrị iji nlezianya debe ọgwụ ndị a. Ndị a bụ ikpe dịka:
- ị excessiveụbiga mmanya ókè;
- kẹle ẹphe gude ẹhu-ụtso;
- enweghi ike ịba uru nke homonụ;
- ahaghioke nke electrolytes;
- nsogbu nke metabolic;
- ọbara mgbali ala;
- nnukwu ọnya ọnya;
- Akwụkwụ na-adọ adọ;
- arụmọrụ buru ibu na mmerụ ahụ;
Na mgbakwunye, ịkpachara anya mgbe ị na-a theụ ọgwụ ahụ kwesịrị iji ya na ọnụnọ nke pathologies nke usoro akwara.
Ntuziaka maka iji ọgwụ ahụ
A na-ekpebi usoro ị drugụ ọgwụ ahụ site na ọrịa mbụ chọrọ ọgwụgwọ, ọkwa nke cholesterol, lipoproteins na triglycerides. Ọzọkwa, mmeghachi omume nke ndị ọrịa na usoro ọgwụgwọ na-aga n'ihu na-eburu n'uche. Oge ị theụ ọgwụ ahụ anaghị adabere na nri oriri. Should ga-ewere otu mbadamba ma ọ bụ karịa (dabere na ndenye dọkịta) otu ugboro n'ụbọchị.
Ọtụtụ mgbe, ojiji nke Atorvastatin-Teva na-amalite site na usoro nke 10 mg. Agbanyeghị, ụdị usoro ọgwụgwọ a anaghị adịkarị mma, ya mere enwere ike ịbawanye dose ahụ. Nke kacha nyere ohere bụ 80 mg kwa ụbọchị. Ọ bụrụ na a ka chọrọ mmụba nke ọgwụ ahụ, yabụ na usoro a, a ga-eme nyocha nke profaịlụ egbugbere ọnụ oge niile na ịchọrọ ịgwọ ọrịa dabere na ha. Gbanwee usoro ọgwụgwọ ọ dị mkpa karịa otu ugboro n'ọnwa.
Ebumnuche bụ isi nke ọgwụgwọ bụ belata kọlestrọl ka ọ dị mma. Usoro nke cholesterol zuru oke n'ime ọbara bụ 2.8 - 5.2 mmol / L. Ekwesịrị icheta na maka ndị ọrịa na-arịa ọrịa imeju, ọ nwere ike ịdị mkpa iji belata ọgwụ ahụ ma ọ bụ kwụsị kpamkpam iji ọgwụ ahụ.
Nsonaazụ ọgwụ
N'oge eji Atorvastatin-Teva, mmeghachi omume ọjọọ dị iche iche sitere na akụkụ ahụ na sistemụ anụ ahụ nwere ike ịmalite. Effectsfọdụ nsonaazụ na-akachasị njọ.
Sistemụ akwara na akụkụ ụbụrụ: nsogbu ụra, isi ọwụwa, nrụrụ ụbụrụ, adịghị ike, belatara ma ọ bụ nwee uche agbagọ, neuropathy.
Ọkpụkpụ afọ: mgbu afọ, ọgbụgbọ, afọ ọsịsa, ịkpụ gas na-ebu oke, afọ ntachi, afọ mgbu, usoro mkpali na umeji na akwara, jaundice metụtara na mgbagide nke bile, ike ọgwụgwụ.
Usoro akwara: mgbu n'ime akwara, karịsịa na akwara nke azụ, ọnya azụ nke akwara, mgbu nkwonkwo, rhabdomyolysis.
Ngosiputa ihe anwansị: site n’ụdị akpịrị anụ ahụ n’ụdị urticaria, mmetụta nke itching, mmeghachi ahụ nfụkasị ozigbo n ’ụdị anaphylactic ujo, ọzịza.
Usoro nke Hematopoietic: mbelata ọnụ ọgụgụ platelet.
Usoro metabolism: mbelata ma ọ bụ mmụba na glucose ọbara, mmụba na ọrụ nke enzyme a na-akpọ creatine phosphokinase, edema nke akụkụ elu na nke ala, oke ibu.
Ndị ọzọ: nwere mbelata, ihe mgbu n'obi, ezughi oke ọrụ ọrụ mkpo ya, isi nkwọcha, ike ọgwụgwụ.
Maka ụfọdụ ọrịa na ọnọdụ, ekwesịrị iji nlezianya dezie Atorvastatin-Teva, dịka ọmụmaatụ:
- Abuse abuseụbiga mmanya ókè;
- Pathology nke imeju;
- Ule ọrụ imeju na-abawanye n’enweghị ihe pụtara ìhè;
A chọkwara ịkpachara anya mgbe ị na-a otherụ ọgwụ ndị ọzọ na-egbu egbu, ọgwụ nje, immunosuppressants, na ụfọdụ vitamin.
Mmekọrịta na ọgwụ ndị ọzọ
Atorvastatin-Teva juputara na mmepe nke myopathy - ike na-egbu ike, dịka ọgwụ niile dị na otu nke HMG-CoA reductase inhibitors. Site na ijiri ọtụtụ ọgwụ, enwere ike ịbawanye ọrịa a. Ndị a bụ ọgwụ ọgwụ dịka fibrates (otu n'ime ọgwụ anticholesterolemic otu), ọgwụ nje (erythromycin na macrolides), ọgwụ antifungal, vitamin (PP, ma ọ bụ nicotinic acid).
Ndị otu a na-eme ihe na enzyme pụrụ iche akpọrọ CYP3A4, nke na-arụ nnukwu ọrụ na metabolism Atorvastatin-Teva. Site n'ụdị ọgwụgwọ njikọta a, ọkwa nke atorvastatin dị n'ọbara nwere ike ịbawanye n'ihi mmachi nke enzyme ahụ a kpọtụrụ aha na mbụ, ebe ọgwụ adịghị metabolized nke ọma. Nkwado nke ndị otu ahụ dị, dịka ọmụmaatụ, Fenofibrate, gbochiri usoro mgbanwe nke Atorvastatin-Teva, n'ihi ọnụ ahịa ya na-abawanye.
Atorvastatin-Teva nwekwara ike iduga mmepe nke rhabdomyolysis - nke a bụ ọrịa mara mma nke na - apụta dịka nsonaazụ nke myopathy ogologo oge. N'ime usoro a, akwara anụ ahụ na-aga mbibi dị ukwuu, a na-ahụta oke ha na mmamịrị, nke nwere ike ibute oke gbasara akụrụ. Rhabdomyolysis na-etolitekarị site na iji Atorvastatin-Teva na otu ọgwụ ọgwụ dị n'elu.
Ọ bụrụ n’ịdee ọgwụ n ’ụzọ kachasị anabata kwa ụbọchị (80 mg kwa ụbọchị) yana Digoxin cardiac, mgbe ahụ enwere mmụba nke mkpokọ Digoxin ihe dị ka otu ụzọ n’ime ụzọ ise nke ọgwụ a were.
Ọ dị ezigbo mkpa ijikọta ojiji Atorvastatin-Teva n'ụzọ ziri ezi yana ọgwụ mgbochi afọ ime nke nwere estrogen na usoro ya, ebe enwere mmụba nke ọkwa homonụ nwanyị. Ọ dị ndị inyom gbara afọ aka.
N’ihe nri, a na-atụzi anya ka ọ belata ihe ọ juiceụpeụ mkpụrụ osisi grepu, ebe o nwere ihe karịrị otu ihe na-egbochi enzyme ahụ, n’okpuru nke isi metabolism nke Atorvastatin-Teva pụtara na ọkwa ya na ọbara na-abawanye. Enwere ike ịzụta ọgwụ a n'ụlọ ahịa ọgwụ ọ bụla nwere ndenye ọgwụ.
Enyere ozi banyere ọgwụ Atorvastatin ọgwụ na vidiyo dị n'isiokwu a.
