Kedu ihe nyocha c-peptide na-ekwu na ọrịa shuga?

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Site na ụdị ọrịa mellitus ọ bụla, nyochaa ọnọdụ ya dị ezigbo mkpa maka onye ọrịa.
Nke mbu, o na - elekota glucose na plasma. Enwere ike itinye usoro a site na enyemaka nke ngwaọrụ nchọpụta ọ bụla - glucometers. Mana ọ dịghị ihe dị mkpa bụ nyocha nke C-peptide - ihe na-egosi mmepụta insulin n’ime ahụ na metabolism metabolism. A na-eme nyocha dị otú ahụ naanị na ụlọ nyocha: ekwesịrị ịme usoro a mgbe niile maka ndị ọrịa nwere ọrịa shuga nke ụdị abụọ ahụ.

Gịnị bụ C-peptide

Sayensị sayensị na-enye nkọwa a:

C-peptide bụ ikwụsi ike nke ihe mejupụtara aru mmadụ - proinsulin.
A na - ekewapụta C-peptide na insulin n'oge nke ikpeazụ: yabụ, ọkwa nke C-peptide na - egosi ọkwa insulin.

Ọnọdụ ndị bụ isi ma ekwenye ịkwụ ụgwọ maka C-peptide bụ:

  • Nchọpụta ọrịa shuga mellitus na ọdịiche nke ụdị m na ọrịa shuga II;
  • Nchoputa nke insulinoma (oke ma obu oke ibu nke akwara);
  • Ificationmata ọnya nke anụ ahụ dị n’ime ya mgbe ewepụchara ya (maka ọrịa kansa nke anụ ahụ);
  • Nchoputa nke oria oria;
  • Nchoputa nke polycystic ovary;
  • Nyochapụta ọkwa insulin na ọrịa ọrịa imeju;
  • Ntụle ọgwụgwọ maka ọrịa shuga.

Kedu ka esi ejikọ C-peptide n'ime ahụ? Proinsulin, nke emepụtara na pancreas (nke ka nke ọma, n'ime mkpụrụ ndụ sel nke pancreatic) bụ nnukwu polypeptide silite nwere nsị amino acid 84. N’ụdị a, a napụrụ ihe ndị ahụ mmebi homonụ.

Mgbanwe nke proinsulin na-adịghị arụ ọrụ n’ime insulin na-apụta n’ihi ngagharị nke proinsulin site na ọgịrịga nke dị n’ime mkpụrụ ndụ ruo n’ọkpụkpụ mkpụrụ ndụ bụ́ site n’otu akụkụ mmebi nke irighiri akwara ahụ. N'otu oge ahụ, nsị amino acid 33, nke a maara dị ka peptide na-ejikọta ma ọ bụ C-peptide, na-apụ n'anya site n'otu njedebe nke yinye.

Ya mere, n’ime ọbara ahụ, enwere njikọ ọnụ n’etiti C-peptide na insulin na-arụ.

Kedu ihe kpatara m ji chọọ nyocha C-peptide?

Iji nweta nghọta zuru oke banyere isiokwu ahụ, ịkwesịrị ịghọta ihe mere ndị na-eme ụlọ nyocha ji eme nnyocha nyocha na C-peptide, ọ bụghị na insulin n'ezie.

Ọnọdụ ndị a na-esote aka na nke a:

  • Ndụ ọkara nke peptide na n'ọbara ogologo ndụ karịa nke insulin, yabụ ihe ngosi mbụ ga-akwụsikwu ike;
  • Nnyocha nyocha nke C-peptide na-enye gị ohere ịlele mmepụta insulin ọbụlagodi nzụlite nke ọnụnọ ọgwụ ọgwụ sịntetik n'ọbara (na usoro ahụike - C-peptide anaghị 'agafe insulin' na insulin);
  • Nnyocha nke C-peptide na-enye nyocha zuru oke nke ọkwa insulin ọbụna na ọnụnọ nke ọgwụ mgbochi autoimmune n'ime ahụ, nke na-eme na ndị ọrịa nwere ụdị ọrịa shuga.
Nkwadebe insulin ọgwụ adịghị nwere C-peptide, yabụ, mkpebi siri ike nke ogige a na ọbara ọbara na-enye anyị ohere ịtụle ọrụ nke mkpụrụ ndụ akwara pancreatic na ndị ọrịa na-eme ọgwụgwọ. Ọkwa basal nke C-peptide, na karịchaa ntinye uche nke ihe a mgbe ebighara glucose, na - eme ka ịchọpụta ọnụnọ nke nnabata (ma ọ bụ nguzogide) onye ọrịa ahụ na insulin. Ya mere, a na-ehiwe usoro mgbaghara ma ọ bụ iwe ọkụ na-edozi mmezi ọgwụgwọ.

Na ịba ụba nke ọrịa shuga mellitus (ọkachasị ụdị)), ọdịnaya nke C-peptide n'ime ọbara dị ala: nke a bụ ihe akaebe zuru oke nke erughi insulin nke endogenous (esịtidem). Ọmụmụ nyocha nke mkpokọta peptide na - eme ka nyocha nke insulin insulin na ọnọdụ ụlọ ọgwụ dị iche iche.

Oke nke insulin na C-peptide nwere ike gbanwee ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa imeju na akụrụ.
Insulin bụ metabolized kachasị na parenchyma imeju, A na - ekepụta C-peptide site na akụrụ. Ya mere, ndị na-egosi oke nke C-peptide na insulin nwere ike ịdị mkpa maka nkọwa ziri ezi nke data na ọrịa nke imeju na akụrụ.

Kedu ka nyocha nke C-peptide dị

A na-enyocha ọbara maka C-peptide na afọ efu, belụsọ na enwere nduzi pụrụ iche site na endocrinologist (a ga-agakwuru ọkachamara a ma ọ bụrụ na ị na-enyo ọrịa metabolic). Oge ibu ọnụ tupu inye ọbara bụ elekere 6-8: oge ​​kachasị mma maka inye ọbara bụ ụtụtụ mgbe ị tetara.

Nnyocha ọbara onwe ya adịghị iche na nke mbụ: akwara akwara aka, a na-anakọta ọbara n'ime ọkpọ efu (mgbe ụfọdụ, a na-eji eriri gel). Ọ bụrụ na hematomas etolite mgbe a na - esochi ya, dọkịta kọwaa mmakọ ọkụ. Ọbara e weghaara na-agafe na centrifuge, nke na-ekewa ọbara ya na friji, wee nyocha ya n'ụlọ nyocha n'okpuru iji mikroskopu.

Ọ na - eme na na enweghi afọ, ọkwa C-peptide dị n'ọbara kwekọrọ n'ụkpụrụ ma ọ bụ na mpaghara ala ya. Nke a enyeghi ndi dibia ihe ndabere maka ichota oria. N'ọnọdụ ndị dị otú ahụ nnwale kpaliri.

Dị ka ihe na-akpali akpali, a pụrụ itinye usoro ndị a:

  • Jectiongba ọgwụ mgbochi antulinist - glucagon (maka ndị nwere ọbara mgbali elu, a machibidoro usoro a);
  • Nri ụtụtụ nkịtị tupu nyocha (rie naanị 2-3 "achịcha achịcha").

Nhọrọ kacha mma maka nchọpụta ọrịa bụ ịme nnwale abụọ:

  • nyocha nke ibu ọnụ
  • kpaliri.

Mgbe ị na-enyocha afọ efu, a na-ahapụ gị ị drinkụ mmiri, mana ị kwesịrị ịhapụ ị takingụ ọgwụ ọ bụla nwere ike imetụta izi ezi nke nsonaazụ nyocha ahụ. Ọ bụrụ na ọgwụ enweghị ike ịkagbu maka ọgwụ na ahụike, a ga-egosipụta eziokwu a n'ụdị akwụkwọ ndekọ.

Oge nyocha ihe dị ntakịrị bụ awa 3. Enwere ike iji Archive whey echekwara na -20 Celsius C ruo ọnwa 3.

Kedu ihe bụ ihe ngosipụta nke nyocha maka C-peptides

Mgbanwe dị na ọkwa nke C-peptide na serum kwekọrọ na ume insulin na ọbara. Ọdịnaya nke peptide na-ebu ọnụ sitere na 0.78 ruo 1.89 ng / ml (na sistemụ SI, 0.26-0.63 mmol / l).

Maka nchoputa nke insulinoma na ihe di iche na hypoglycemia ugha (eziokwu), a na-ekpebi oke nke C-peptide n’ogo insulin.

Ọ bụrụ na rashọn ahụ bụ otu ma ọ bụ ihe na-erughị uru a, nke a na-egosi iwulite insulin n'ime. Ọ bụrụ na ndị na - egosi ihe karịrị 1, nke a bụ ihe akaebe nke iwebata insulin nke mpụga.

Ọkwa dị elu

Ọnọdụ ahụ mgbe ebuli ọkwa C-peptide nwere ike igosipụta ọrịa ndị a:

  • Ọrịa shuga IIdị nke Abụọ;
  • Insulinoma;
  • Ọrịa Hisenko-Cushing (ọrịa neuroendocrine kpatara site na hyperfunction adrenal);
  • Ọkpụkpụ akụrụ;
  • Ọrịa imeju (cirrhosis, ịba ọcha n'anya);
  • Polycystic ovary;
  • Oke oke ibu nwoke;
  • Ogologo oge eji estrogens, glucocorticoids, ọgwụ homonụ ndị ọzọ.

Ihe dị elu nke C-peptide (ya mere insulin) nwere ike igosi iwebata nke ndị na - eweda mmanụ glucose dị n’ala. O nwekwara ike ịbụ nsonaazụ akwara ma ọ bụ ntụgharị mkpụrụ ndụ akwara beta.

Obere dị ala

Dị ala ma e jiri ya tụnyere ọkwa nkịtị nke C-peptide mgbe:

  • Ọrịa shuga ;dị 1;
  • Hypoglycemia Artificial;
  • Surgerywa ahụ a na-ewepu pesọre.

Ọrụ C peptide

Ndị na-agụ akwụkwọ nwere ike inwe ajụjụ dabara adaba: gịnị kpatara anyị ji achọ C-peptides n’ahụ?
Ruo n'oge na-adịbeghị anya, e kwenyere na akụkụ a nke usoro amino acid bụ adịghị arụ ọrụ nke biolojiiki na ọ bụ ngwaahịa sitere na nguzobe insulin. Ma ihe omumu ohuru nke ndi endocrinologists na diabetologists mere ka nkwubi okwu bu na ihe a abaghị uru ọ bụla ma na-ekere òkè na ahụ, karịsịa maka ndị ọrịa nwere ọrịa shuga.

Dika akuko edeputaghi, ochicho ihe nke C-peptide n’oge ogwugwo insulin diri ndi oria oria oria na enye ohere izere udiri oria a dika nephropathy (akwara nke akwara), neuropathy na angiopathy (mbibi akwara na akwara obara, n’otu n’otu).
O kwere omume na n'oge dị nso a ga-eme nkwadebe C-peptide yana insulin na ndị ọrịa mamịrị, mana ka ọ dị ugbu a, e nwebeghi ihe ọghọm na ọghọm ọgwụ ndị dị etu ahụ. Nnyocha nyocha sara mbara n'isiokwu a ka ga-abịa.

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