Gịnị bụ C-peptide
Sayensị sayensị na-enye nkọwa a:
- Nchọpụta ọrịa shuga mellitus na ọdịiche nke ụdị m na ọrịa shuga II;
- Nchoputa nke insulinoma (oke ma obu oke ibu nke akwara);
- Ificationmata ọnya nke anụ ahụ dị n’ime ya mgbe ewepụchara ya (maka ọrịa kansa nke anụ ahụ);
- Nchoputa nke oria oria;
- Nchoputa nke polycystic ovary;
- Nyochapụta ọkwa insulin na ọrịa ọrịa imeju;
- Ntụle ọgwụgwọ maka ọrịa shuga.
Kedu ka esi ejikọ C-peptide n'ime ahụ? Proinsulin, nke emepụtara na pancreas (nke ka nke ọma, n'ime mkpụrụ ndụ sel nke pancreatic) bụ nnukwu polypeptide silite nwere nsị amino acid 84. N’ụdị a, a napụrụ ihe ndị ahụ mmebi homonụ.
Mgbanwe nke proinsulin na-adịghị arụ ọrụ n’ime insulin na-apụta n’ihi ngagharị nke proinsulin site na ọgịrịga nke dị n’ime mkpụrụ ndụ ruo n’ọkpụkpụ mkpụrụ ndụ bụ́ site n’otu akụkụ mmebi nke irighiri akwara ahụ. N'otu oge ahụ, nsị amino acid 33, nke a maara dị ka peptide na-ejikọta ma ọ bụ C-peptide, na-apụ n'anya site n'otu njedebe nke yinye.
Kedu ihe kpatara m ji chọọ nyocha C-peptide?
Iji nweta nghọta zuru oke banyere isiokwu ahụ, ịkwesịrị ịghọta ihe mere ndị na-eme ụlọ nyocha ji eme nnyocha nyocha na C-peptide, ọ bụghị na insulin n'ezie.
- Ndụ ọkara nke peptide na n'ọbara ogologo ndụ karịa nke insulin, yabụ ihe ngosi mbụ ga-akwụsikwu ike;
- Nnyocha nyocha nke C-peptide na-enye gị ohere ịlele mmepụta insulin ọbụlagodi nzụlite nke ọnụnọ ọgwụ ọgwụ sịntetik n'ọbara (na usoro ahụike - C-peptide anaghị 'agafe insulin' na insulin);
- Nnyocha nke C-peptide na-enye nyocha zuru oke nke ọkwa insulin ọbụna na ọnụnọ nke ọgwụ mgbochi autoimmune n'ime ahụ, nke na-eme na ndị ọrịa nwere ụdị ọrịa shuga.
Na ịba ụba nke ọrịa shuga mellitus (ọkachasị ụdị)), ọdịnaya nke C-peptide n'ime ọbara dị ala: nke a bụ ihe akaebe zuru oke nke erughi insulin nke endogenous (esịtidem). Ọmụmụ nyocha nke mkpokọta peptide na - eme ka nyocha nke insulin insulin na ọnọdụ ụlọ ọgwụ dị iche iche.
Kedu ka nyocha nke C-peptide dị
A na-enyocha ọbara maka C-peptide na afọ efu, belụsọ na enwere nduzi pụrụ iche site na endocrinologist (a ga-agakwuru ọkachamara a ma ọ bụrụ na ị na-enyo ọrịa metabolic). Oge ibu ọnụ tupu inye ọbara bụ elekere 6-8: oge kachasị mma maka inye ọbara bụ ụtụtụ mgbe ị tetara.
Nnyocha ọbara onwe ya adịghị iche na nke mbụ: akwara akwara aka, a na-anakọta ọbara n'ime ọkpọ efu (mgbe ụfọdụ, a na-eji eriri gel). Ọ bụrụ na hematomas etolite mgbe a na - esochi ya, dọkịta kọwaa mmakọ ọkụ. Ọbara e weghaara na-agafe na centrifuge, nke na-ekewa ọbara ya na friji, wee nyocha ya n'ụlọ nyocha n'okpuru iji mikroskopu.
Dị ka ihe na-akpali akpali, a pụrụ itinye usoro ndị a:
- Jectiongba ọgwụ mgbochi antulinist - glucagon (maka ndị nwere ọbara mgbali elu, a machibidoro usoro a);
- Nri ụtụtụ nkịtị tupu nyocha (rie naanị 2-3 "achịcha achịcha").
Nhọrọ kacha mma maka nchọpụta ọrịa bụ ịme nnwale abụọ:
- nyocha nke ibu ọnụ
- kpaliri.
Mgbe ị na-enyocha afọ efu, a na-ahapụ gị ị drinkụ mmiri, mana ị kwesịrị ịhapụ ị takingụ ọgwụ ọ bụla nwere ike imetụta izi ezi nke nsonaazụ nyocha ahụ. Ọ bụrụ na ọgwụ enweghị ike ịkagbu maka ọgwụ na ahụike, a ga-egosipụta eziokwu a n'ụdị akwụkwọ ndekọ.
Kedu ihe bụ ihe ngosipụta nke nyocha maka C-peptides
Mgbanwe dị na ọkwa nke C-peptide na serum kwekọrọ na ume insulin na ọbara. Ọdịnaya nke peptide na-ebu ọnụ sitere na 0.78 ruo 1.89 ng / ml (na sistemụ SI, 0.26-0.63 mmol / l).
Maka nchoputa nke insulinoma na ihe di iche na hypoglycemia ugha (eziokwu), a na-ekpebi oke nke C-peptide n’ogo insulin.
Ọ bụrụ na rashọn ahụ bụ otu ma ọ bụ ihe na-erughị uru a, nke a na-egosi iwulite insulin n'ime. Ọ bụrụ na ndị na - egosi ihe karịrị 1, nke a bụ ihe akaebe nke iwebata insulin nke mpụga.
Ọkwa dị elu
- Ọrịa shuga IIdị nke Abụọ;
- Insulinoma;
- Ọrịa Hisenko-Cushing (ọrịa neuroendocrine kpatara site na hyperfunction adrenal);
- Ọkpụkpụ akụrụ;
- Ọrịa imeju (cirrhosis, ịba ọcha n'anya);
- Polycystic ovary;
- Oke oke ibu nwoke;
- Ogologo oge eji estrogens, glucocorticoids, ọgwụ homonụ ndị ọzọ.
Ihe dị elu nke C-peptide (ya mere insulin) nwere ike igosi iwebata nke ndị na - eweda mmanụ glucose dị n’ala. O nwekwara ike ịbụ nsonaazụ akwara ma ọ bụ ntụgharị mkpụrụ ndụ akwara beta.
Obere dị ala
Dị ala ma e jiri ya tụnyere ọkwa nkịtị nke C-peptide mgbe:
- Ọrịa shuga ;dị 1;
- Hypoglycemia Artificial;
- Surgerywa ahụ a na-ewepu pesọre.