Zilt bụ ọgwụ antiplatelet dị irè nke na-ebelata nchịkọta platelet. Ndị ọkachamara na-edepụtara ya ndị ọrịa iji gbochie thrombosis, ọrịa strok na nkụchi obi.
Aha
Aha Latin bụ Zyllt. INN ọgwụ: clopidogrel.
Zilt bụ ọgwụ antiplatelet dị irè nke na-ebelata nchịkọta platelet.
ATX
B01AC04.
Ha weputara udi ya na ihe mebere ya
A na-emepụta ọgwụ ahụ na mbadamba 75 mg nke ihe na-arụ ọrụ (clopidogrel hydrosulfate). Ihe ndi ozo gunyere:
- MCC;
- prolylene glycol;
- talc;
- ụcha ígwè;
- pregelatinized iche iche nke stachi;
- titanium dioxide;
- macrogol-6000;
- ụdị nke lactose;
- hydrogenated castor oil;
- hypromellose.
A na-emepụta ọgwụ ahụ na mbadamba 75 mg nke ihe na-arụ ọrụ (clopidogrel hydrosulfate).
Erere ọgwụ na ngwugwu nke 14, 28, 30, 56, 84 na 90 PC.
Omume ọgwụ
Ọgwụ a bụ otu nke Clopidogrel prodrugs. Ọ na - egbochi usoro njikọ nke ADP na ndị na - anabata platelet yana ịgbalitekwu ọrụ nke GPIIb / IIIa complex (glycoprotein), nke na - akpasu mchichi nke nchịkọta platelet.
Usoro a na-aga n'ihu maka izu 1-1.5. Metabolite nọ n'ọrụ na-apụta dị ka nsonaazụ nke CYP450 isoenzymes. Agbanyeghị, ọ bụghị onye ọrịa ọ bụla nwere mmeghachi omume zuru oke, n'ihi na ụfọdụ isoenzymes nwere polymorphism, gbanwee n'okpuru mmetụta nke ọgwụ ndị ọzọ, ma ọ bụ nwee ogo mgbochi ọzọ nke ADP.
Ọgwụ a na-egosi ịdị mma na mgbochi nke nsonaazụ atherothrombotic na ndị ọrịa nwere mmebi nke arịa ọbara dị iche iche, ọkachasị na pathology nke mpaghara, akwara na akwara akwara.
Ọgwụ ahụ gosipụtara ịdị mma na mgbochi nke atherothrombotic pụta na ndị ọrịa nwere mmebi nke arịa ọbara dị iche iche.
Mlọ ọgwụ
A na-etinye ọgwụ ahụ ngwa ngwa mgbe nchịkwa ọnụ gasịrị. A na-enweta mkpokọta plasma kachasị nke ihe ndị nọ n'ọrụ na-enweta nkeji iri anọ na anọ iri anọ na ise mgbe ị nwesịrị 75 mg.
Ihe mejupụtara ọgwụ dị n'ime imeju bụ metabolized. Ọkara ọkara bụ ihe dịka awa 6. 46% nke ọgwụ ahụ bụ eriri afọ ga-ahapụ, ihe ndị ọzọ bụ akụrụ.
Ihe ngosi maka ojiji
Ejiri ogwu a gbochie nsogbu atherothrombotic n’ime ndị okenye toro eto achọpụtala ụdị ọrịa a:
- infarction myocardial;
- afọ ischemic;
- akwara obi;
- ọrịa anwansi (ọrịa akaji);
- nnukwu ọrịa coronary syndrome (ya na mmụba na mpaghara ST na enweghị ya).
Na mgbakwunye, a na-eji ọgwụ ahụ egbochi ọgwụ thromboembolic na atherothrombotic nke atrial fibrillation, ọrịa strok.
Ihe ngbanwe
- hypersensitivity nke ihe ogwu ahu;
- afọ ime na lactation;
- ọbara ọgbụgba (nnukwu);
- ọrịa shuga na-arịa ọrịa siri ike;
- afọ erughị afọ 18;
- Ọrịa GGM, enweghị ndidi nke lactose, enweghị lactase.
Jiri nlezianya
- nsogbu nsogbu imeju dị nfe;
- arụ ọrụ ezumike;
- ọnọdụ enwere nnukwu ọbara ọgbụgba;
- ngwakọta na Heparin, Warfarin na glycoprotein na-egbochi ndị ọrụ;
- anabataghi ndi ozo di iche (Prazogrel, Ticlopidine, wdg).
Etu esi ewere Zilt?
Ọgwụ kwesịrị ị drunkụ mmanya 1 oge kwa ụbọchị. Nri anaghị emetụta ọrụ yana nnabata nke ọgwụ.
Na ischemia, infarction na myocardial infarction na ọrịa vaskụla artvable akwara, nkezi bụ 75 mg (1 pill) otu ugboro n'ụbọchị.
Maka ndị ọrịa nwere ọrịa ọgbụgba na -akpata ọrịa, a na-edenye ọgwụ ahụ na usoro onunu ogwu nke 75 mg. Oke kachasị kwa ụbọchị bụ 300 mg. N'okwu a, a na-eji acid acetylsalicylic acid mgbe ụfọdụ.
Ọ bụrụ n’ikpebie iji ọgwụ eji eme ọgwụ ọzọ, ị nwere ike were ya n’ime awa iri na abụọ. Mgbe nke a gasịrị, a gaghị emebi usoro ọgwụgwọ ọgwụgwọ. Ekwula ya okpukpu abụọ.
Ọgwụ kwesịrị ị drunkụ mmanya 1 oge kwa ụbọchị.
Na-a drugụ ọgwụ maka ọrịa shuga
Ọ bụrụ na ị nwere ọrịa shuga, kwesịrị ịgakwuru onye ọkachamara n’ịgwọ ọrịa tupu ị theụọ ọgwụ.
Ogologo oge ole ka ị ga-ewe?
Ogologo oge ọgwụgwọ ọgwụ agaghị agafe afọ 1.
Nsonaazụ
Ọgwụ nwere ike ibute mmeghachi omume achọghị. Ọ bụrụ na ndị a apụta, ịkpọtụrụ dọkịta gị ozugbo.
Ọkpụkpụ afọ
- mgbu n'ime afọ;
- afọ ọsịsa na afọ ntachi;
- ọnụ;
- ọria aru
- ọbara ọgbụgba na eriri afọ (ọbara ọgbụgba azụ);
- ọgbụgbọ
- vomiting
- dyspepsia.
Ahụhụ Hematopoietic
- leukopenia;
- anaemia
- agranulocytosis;
- granulocytopenia;
- thrombocytopenia;
- neutropenia (na obere oge).
Sistemụ akwara Central
- isi ọwụwa
- ahụ ọkụ
- mẹ iphe dụ ẹji;
- auditory na visual hallucinations;
- Dizziness
- ịma jijiji.
Site na usoro urinary
- glomerulonephritis (n'ọnọdụ ndị na-adịghị ahụkebe);
- hematuria;
- arụ ọrụ ezumike;
- ụba plasma creatinine ịta.
Site na sistem iku ume
- ọbara site na imi;
- ọgbụgbọ na ọnya ọgbụgbọ na ọnya na - efe efe;
- ụdị ọzọ nke oyi ịba ọcha n'anya;
- ihe nchara.
Na akụkụ ahụ nke ọhụụ
- mbelata nke nghọta;
- ụba intraocular mgbali;
- ọhụụ.
N'akuku nke imeju na akụkụ biliary
- iwe iwe na ọrụ imeju ndị ọzọ na - arụ ọrụ;
- ịba ọcha n'anya.
Site na anụ ahụ na akwara
- ọbara ọgbụgba akwara;
- hemarthrosis;
- myalgia;
- arthralgia;
- ọrịa ogbu na nkwonkwo.
Na mgbakwunye, mmeghachi anaphylactoid nwere ike ime mgbe ị na-ewere mbadamba.
Ntụziaka pụrụ iche
Ọrịa dị iche iche a na-eme ọfụma na arụmọrụ chọrọ nlezianya anya mgbe ha na-a theụ ọgwụ iji zere nsogbu n'ihi ọbara ọgbụgba na mberede.
Ọgwụ na-agbatịkwu oge ọbara ọgbụgba dị. Ya mere, ejiri nlezianya debe ya ndị ọrịa nwere nnukwu ihe dị otú ahụ.
Tupu arụ ọrụ ezubere, mgbe a chọghị ihe mgbochi antiplatelet, a ga-akwụsị ọgwụ ahụ ma ọ dịkarịa ala ụbọchị 5-6 tupu ịwa ahụ. Nke a gụnyere usoro eze.
Mmanya ndakọrịta
Njikọ ọgwụ na mmanya nwere ike ịkpalite ọgba aghara obi, mmepe nke tachycardia na bradycardia. Ya mere, site na iji ọgwụ ogwu, ụdị ọgwụ ndị a kwesịrị izere.
Njikọ ọgwụ na mmanya nwere ike ịkpalite ọgba aghara obi, mmepe nke tachycardia na bradycardia.
Mmetụta ikike ịchịkwa usoro
Ọgwụ ahụ enweghị mmetụta ọ bụla na ike ịkwọ ụgbọ ala yana ihe omume chọrọ mmeghachi omume na nlebara anya ngwa ngwa.
Jiri n'oge ime na lactation
N'oge mmegharị ahụ, a na-enye ọgwụ ahụ naanị n'ọnọdụ ebe atụ anya uru ga-akacha n'ihe ize ndụ.
Mgbe ị na-actụ mmiri na ị theụ ọgwụ, a ga-atụfu ara.
Oge emere Zilt na ụmụaka
Ebumnuche ogwu a abụghị maka ọgwụgwọ nke obere ndị ọrịa.
Jiri na agadi
Maka ndị ọrịa meworo agadi, a naghị agbanwe usoro ọgwụgwọ ahụ. Agbanyeghị, ha kwesịrị ịtụfu etu esi etinye ego.
Maka ndị ọrịa meworo agadi, a naghị agbanwe usoro ọgwụgwọ ahụ.
Dodoụbiga ya ókè
N'ime oke oke ọnụọgụ, ọgwụ nwere ike ibute ogologo oge nke ọbara ọgbụgba na nsogbu ọbara ọgbụgba. Iji mee ka ọnọdụ onye ahụ dị ọcha dị mma, a na-enye ọgwụ mmịnye platelet. Ọgwụ enweghị ọgwụ mgbochi.
Mmekọrịta na ọgwụ ndị ọzọ
Ekwesighi ikpokọta ogwu a na ọgwụ anticoagulants n'ihi na ihe ike nwere ike ịbawanye ike nke ọbara ọgbụgba.
Nke pụtara na gbochie ọrụ nke mgbapụta proton nwere obere ntakịrị ihe na isobezyme CYP2C19 - Lansoprazole na Pantoprazole. Enwere ike ijikọ ha na ọgwụ ịchọrọ.
Akụkụ ike nọ n'ọrụ nke ọgwụ ahụ anaghị emetụta Njirimara ọgwụ nke warfarin. Mana ngwakọta dị otu a na -eme ka ọnwe ọbara na-aga n'ihi ịba ụba nke coagulation.
Mgbe ejikọtara ọgwụ na Theophylline na Digoxin, ọgwụ ọgwụ ha anaghị agbanwe agbanwe.
A na-atụ aro ka ọ ghara iji omeprazole mee ihe n'otu oge.
Ekwesighi ikpokọta ogwu a na ọgwụ anticoagulants n'ihi na ihe ike nwere ike ịbawanye ike nke ọbara ọgbụgba.
Analogs
- Aterocardium;
- Areplex;
- Agrel;
- Brilinta;
- Deplatt;
- Avix;
- Diloxolum;
- Jendogrel;
- Clopact;
- Klopigrel.
Ahịa ọgwụ na-ahapụ okwu
Enwere m ike ịzụta na ndenye ọgwụ?
Onweghi ike inweta ọgwụ n’enweghi ọgwụ.
Ọnụ ahịa zilt
Ọnụ ego ọgwụ na-amalite site na 120 rubles maka mbadamba 14 nke 75 mg nke ihe na-arụ ọrụ n'ime igbe kaadi.
Onweghi ike inweta ọgwụ n’enweghi ọgwụ.
Ọnọdụ nchekwa maka ọgwụ
Ọ bụ ihe amamihe dị na ya ịchekwa ọgwụ ahụ na-ekpo ọkụ na-erughi + 20 Celsius C, n'ebe dị jụụ ma kpọọ nkụ ebe ìhè anyanwụ anaghị enweta.
Bọchị mmebi
24 ikp.
Nyocha maka Sylt
Ndi dibia
Igor Kvashnin (onye na-agwọ ọrịa), gbara afọ 40, Barnaul.
Agentlọ ọrụ dị mma ma dị ike site na otu nke ndị na-ahụ maka antiplatelet. Ihe na-arụ ọrụ n'ime ihe mejupụtara ya nwere ike belata AT. Jiri ọgwụ ndị a naanị maka ebumnuche ọgwụ yana dịka ntuziaka dọkịta si dị. Ọ bụrụ na eleghara nke a anya, mgbe ahụ mmadụ ga-ezute mmeghachi omume na nsogbu dị oke egwu.
Ndị ọrịa
Anton Wigman, 45 afọ, Moscow.
Ọtụtụ afọ tara ahụhụ si na angina pectoris. Ihe dị ka afọ 3 gara aga, enwere m stenting. Mgbe usoro ahụ gachara, ana m ewere mbadamba ọgwụ 1 kwa ụbọchị. Na nso nso a, ọ gafere ule, dọkịta ahụ ekpugheghị mmebi ọ bụla, na ntụle, kwuru na enwere ọganihu na ọnọdụ izugbe. Ahụike ya gbasikwara ike, ọrịa angina apụtaghị.
Vladimir Dubov, onye gbara afọ 47, Lipetsk.
Ọ tụrụ m n'anya nke ukwuu nke ọkachamara nke ndị ọkachamara n'ụlọ ọgwụ anyị bụ ndị nyochapụtara ọnọdụ m tupu ọrịa strok wee zọọ ndụ m. Ekwesịrị m ịgakwuru ndị dọkịta ihe dị ka ọnwa iri na abụọ. Ọkpụkpụ akwara gwara m okwu banyere ihe ọghọm dị n'iji ụyọkọ ọgwụ wee tụrụ aro ka m becauseụọ ọgwụ a n'ihi na anụ ahụ na-ahụ ya nke ọma, ọ na-esikwa ike iwe iwe. Ugbu a arịa m na akwara akwara dị mma.
