A na-eji Dilaprel agwọ ọrịa ọbara ọgbụgba na nnukwu myocardial infarction. Na-enye nsonaazụ na-adịgide adịgide na ọnụọgụ ọbara kachasị mma. Ọgwụ ahụ adịghị eri ahụ ma wepụ ya.
International Nonproprietary Aha
Ramipril (aha nke aha ihe na-arụ ọrụ).
A na-eji Dilaprel agwọ ọrịa ọbara ọgbụgba na nnukwu myocardial infarction.
ATX
Koodu ATX bu C09AA05.
Ha weputara udi ya na ihe mebere ya
Capsules
Ngwakọta nke Capsule gụnyere 2.5 mg nke ramipril, 0.143 g nke lactose.
Dị adịghị adị
Ere ọgwụ bụ ụdị ọgwụ na-adịghị taa.
Omume ọgwụ
N'okpuru mmetụta nke enzymes imeju na ahụ, a na-arụ ọrụ mkpokọta ihe omimi nke ihe omumu, ramiprilat. Na-ezo aka na ndị na - egbochi ACE ogologo oge - kininase. Na plasma, ACE na-eme ngwangwa mgbanwe nke angiotensin-1 na angiotensin-2, nke nwere mmetụta vasoconstrictor.
Site n'ọbara mgbali elu, mbelata ọbara mgbali elu na-ebilite n'ihi mgbasawanye nke arịa akwara ndị na - ebuputeghachi ọnụ ọgụgụ nke obi obi.
Ceptionmata Dilaprel na-akwalite njikọ nke bradykinin n'ime sel na anụ ahụ. Usoro a na - enyere aka n'ịbawanye akwara akwara na nrụgide dị ala. Ọgwụ na - enyere aka ichebe akwara obi site na ịba ụba ọdịnaya nke ion potassium dị n'ọbara na sodium na plasma. Ka ọdịnaya nke angiotensin-2 na-ebelata, ọkwa nke renin na-ebelata.
Site n'ọbara mgbali elu, mbelata ọbara mgbali elu na-ebilite n'ihi mgbasawanye nke arịa akwara ndị na - ebuputeghachi ọnụ ọgụgụ nke obi obi. Usoro a na - eme na - enweghị dysfunctions n'ọbara ọbara nke akụrụ na mkpo ya na-emebi emebi na renal glomeruli.
Mmalite nke ọgwụ ọgwụ oke ọnụ nke ọgwụ na-amalite nkeji 60 mgbe nchịkwa ọnụ. Mmetụta ọgwụgwọ zuru oke na-egosipụta onwe ya mgbe awa isii gachara ma nọkwa ogo n'ogologo ụbọchị. N'ime usoro ọgwụgwọ, mmetụta a na-aga n'ihu maka izu 4 mgbe ịwepu gasịrị, mgbe ahụ belata ntakịrị ma na-adịgide ogologo oge.
Terkwụsị ọgwụ a na-atụghị anya ya anaghị ebute mmụba, i.e. mwepu ọrịa anaghị etolite.
Ọgwụ na-ebelata ibu na obi ma na-eme ka ụda nke venous dịkwuo elu. Na-emegide ndabere nke iji Dilaprel, olu nke mmepụta obi na-abawanye. Ndị ọrịa na-a thisụ ọgwụ a yikarịrị ka ha ga-ahụ mmega ahụ.
Ọgwụ na-ebelata ibu na obi ma na-eme ka ụda nke venous dịkwuo elu.
Ngwá ọrụ ahụ na-ebelata mmepe nke akụrụ na-egbu oge ma na-egbu oge oge ọkwa ya, mgbe ọrụ dị oke mkpa na-akwado naanị site na mmịpụta akụrụ ma ọ bụ mmịnye akụrụ. Ihe mgbakwunye nke Dilaprel na ọgwụgwọ ijikọta na-ebelata ohere nke nkụchi obi, ọrịa strok, ọnwụ site na ọrịa obi na arịa ọbara. Mgbe o dechara ọgwụ banyere ọrịa obi ọgụ, ihe gbasara ọnwụ ga-ebelata.
Mlọ ọgwụ
Mgbe nchịkwa ime ahụ, a na-abanye ngwa ngwa ọgwụ ahụ na eriri afọ. Iri nri n’adịghị akwụsịlata usoro a. Ihe ndu a kariri 28% maka ramipril na 45% maka ramiprilat metabolite ya. Mkpụrụ plasma nke ramipril na-abawanye ngwa ngwa, na nrụgide nke enzymes imeju na-aghọ nke kachasị mgbe awa 4 gasịrị. Na-ejikọ protein ndị dị na plasma ihe dị ka 73%.
Mgbe nchịkwa ime ahụ, a na-abanye ngwa ngwa ọgwụ ahụ na eriri afọ.
Usoro metabolism na-apụta na anụ ahụ akwara, ebe a na-etolite ramiprilat. N'ime ahụ a, etolite nke ihe na - adịghị arụ ọrụ na - apụta - ramipril glucuronides ma ọ bụ diketopiperazine ether na acid, nke na - enweghị uru ọgwụgwọ.
Ọkara ndụ nke ihe ndị dị na nkwadebe ahụ bụ ihe dịka awa 5. Usoro ahụ na-agbadata na ọrịa akụrụ na-adịghị ala ala. A na - esite n'ọbara na - akarị n’ime eriri afọ ya ma nwee obere - na ure.
Ihe ngosi maka ojiji
A na-egosi ọgwụ ahụ maka ọrịa ndị dị otú a:
- Ọbara mgbali elu (edepụtara ka ọ bụrụ otu ọgwụ ọgwụ yana dịka akụkụ nke ọgwụgwọ mgbagwoju anya). A nwekwara ike ịkọwa ya mgbe ị na-a diụ ọgwụ metụtara ọbara ọgbụgba.
- Nephropathy nke ọrịa mamịrị, gụnyere ọ bu kwa n’aru ọria.
- Proteinuria (ọdịdị nke protein na mmamịrị) megide nzụlite ọbara mgbali elu dị ogologo oge.
- Ọrịa Ischemic, nkụchi obi (akụkọ ihe mere eme). Edere ya ndị ọrịa ahụ na-arịa ọrịa angioplasty ma ọ bụ akwara akwara ịwa ahụ.
- Ọrịa ụbụrụ na-akpata nnukwu ụbụrụ, gụnyere na anamnesis.
- Ọrịa shuga, ihe mgbagwoju anya site n’ilepụta anya na mmamịrị nke albumin, ọbara mgbali elu, mmụba n'ọbara plasma maka irighiri cholesterol niile n'ime ọbara.
- Ọnọdụ ndị dị njọ nke ọrịa obi na-adịghị ala ala.
Ihe ngbanwe
Amachibidoro ị medicineụ ọgwụ n'ọnọdụ ndị dị ka:
- Hypersensitivity na ACE inhibitor therapy.
- Ọkpụkpụ azụ angioedema edema (ihe nketa, nke enwetara ma ọ bụ idiopathic).
- Ibelata akwara akụrụ (jikọrọ ọnụ na abụọ) ka ha na-enwe naanị akụrụ na-arụ ọrụ.
- Mmụba na nrụgide systolic karịa 90 mm, ka ị na-enwe hemodynamics pathological.
- Oge imechi nke angiotensin-2 antagonists maka nephropathy nke ọrịa mamịrị.
- Ibelata obi valves.
- Mmụba na ego nke aldosterone n'ọbara.
- Okpu akwara gbasara oke na ikike idozi creatinine erughị 20 cm3 kwa nkeji.
- Dialysis.
- Nehropathy
- Decompensated obi na-adịghị ala ala.
- Ọgwụ metụtara ya na iwepu cholesterol dị ala n’ahụ.
- Na-eme ọgwụgwọ mgbochi nfụkasị ahụ na ndị mmadụ na-arịa hypersensitivity na nsị nke a beesụ, wasps na hymenoptera ndị ọzọ.
- Nnabata ọgwụ ọ bụla nwere aliskiren.
- Lactose anabataghị ya na lactase ọbara nke ezughi oke, gụnyere ya. malabsorption.
- Oge mmemme.
- Ọrịa obi dara oke na angina pectoris ejisighi ike.
- Ventricular dysfunction (enwere ihe ize ndụ na ndụ).
- Obi mkpọnwụ.
Jiri nlezianya
Ekwesịrị ilebara anya anya:
- n'otu oge eji ọgwụ ọjọọ eme ihe na Aliskiren;
- mmụba na mkpokọta nke potassium n'ime ọbara megide mmalite nke mmebi nke akụrụ na-aga n'ihu;
- ebumnuche nke mbulata na mberede;
- mbụ ụnwegirima unwoke;
- ileghara anya nke mmiri na electrolytes;
- mmepe nke imeju nke imeju, ascites (ọria);
- nsogbu akụrụ;
- ụfọdụ ọrịa autoimmune;
- nká.
Uzo esi ewere Dilaprel
Jiri ọnụ, jiri mmiri mmiri hichaa ya. Ọgwụ mbụ bụ 1 mbadamba ụtụtụ kwa ụbọchị. Ọ bụrụ na mgbe ụbọchị iri abụọ na abụọ agaghị ekwe omume ịhazi ihe na-egosi nrụgide, mgbe ahụ, a na-amụba kwa ụbọchị ruo 5 mg. Ọ bụrụ na nke a anaghị enyere aka, werezie Dilaprel gbakwunyere, a na-emezi usoro ọgwụgwọ ahụ ka 10 mg kwa ụbọchị na capsule abụọ iji bulie mmetụta antihypertensive.
Mgbe ụfọdụ, kama ịba ụba dose ahụ, a na-achịkwa ihe ọzọ na - egbochi ihe mgbochi.
Na-arịa ọrịa shuga
Na nephropathy mamịrị, a na-enye 2.5 mg ọgwụ. Onu ogwu ghari aro kariri 5 mg.
Nsonaazụ Dilaprel
Ejikọtara itinye ngwà na ihe ọghọm nke ngosipụta na-adịghị mma.
Na akụkụ ahụ akụkụ nke ọhụụ
Ọdịdị nke dysfunctions anya (eserese na-acha) na mmepe nke conjunctivitis ga-ekwe omume.
Site n'akụkụ akụkụ ahụ nke ọhụụ, ọdịdị nke dysfunctions visual (ihe na-acha ike).
Site na anụ ahụ na akwara
Ọtụtụ mgbe ọgwụ nwere ike ibute nkwarụ akwara, mgbu akwara.
Ọkpụkpụ afọ
Enwere ike mmepe nke nsogbu:
- mbufụt na afọ na eriri afọ;
- afọ ọsịsa
- dyspepsia
- ọgbụgbọ
- pancreatitis (na obere oge na nsonaazụ na-egbu egbu);
- mmụba nke enzymes pancreatic;
- mmetụta akpịrị ịkpọ nkụ.
Ahụhụ Hematopoietic
Na oge na-adịghị anya, mmepe nke ihe ga - ekwe omume:
- eosinophilia;
- mbelata nke ọnụ ọgụgụ ọbara ọcha;
- dobe na ọnụ ọgụgụ ọbara ọbara;
- mbelata na ịba ụba nke haemoglobin;
- mgbochi nke ịmịpụta ọbara na ụmị ọkpụkpụ.
Sistemụ akwara Central
Ihe puru omume mmepe:
- isi na isi;
- Dizziness
- nsogbu uche;
- uto nke uto nwa oge;
- ọgba aghara na mmetụta nke nguzozi;
- na - ebugharị dysfunctions ọbara n'ime obi;
- ọkụ na-enwu n’ime ahụ;
- akpụkpọ anụ nke ihu;
- isi nsogbu.
Site na usoro urinary
N’oge na-adịbeghị anya, arụ ọrụ na-arụ ọrụ n’akwara nwere nnukwu nsogbu nwere ike ịmalite.
Site na sistem iku ume
Iri afọ, mbufụt nke bronchi na sinus sinuses nwere ike ịpụta. Ọ na-adịkarị ụdọ akwara ozi na imi isi ala apụta.
Na anụahụ
Na anụ ahụ, ọdịdị ahụ:
- akpukpo anụ;
- angioedema;
- urticaria;
- mbibi nke efere ntu;
- hypersensitivity na ìhè;
- Ọrịa Stevens-Johnson;
- dermatitis dị ka psoriasis.
Site na usoro mkpụrụ ndụ ihe nketa
Mgbe ụfọdụ ụmụ nwoke nwere ike ịmalite nrụpụta mkpụkpụkpụ mkpụmkpụ mkpụmkpụ mkpụmkpụ mkpụmkpụ, belata libido.
Site na usoro akwara obi
Ikekwe imebi ọbara nye akwara obi, tachycardia, mmepe nke edema. Ndị ọrịa nwere ike inwe nchegbu banyere mbelata mgbanaka na-egosi ịdị mma, mbido nke hypotension na mgbanwe ọnọdụ nke ahụ, ọnya nke akwara vaskụla na ọrịa ndị ọzọ yiri ya.
Usoro endocrine
Mmepe nke syndrome nke hyper- ma ọ bụ hyposecretion nke ADH. N'ime ụmụ nwoke, gynecomastia nwere ike ịpụta.
N'akuku nke imeju na akụkụ biliary
Mmụba n'ọrụ enzyme, yana mmụba nke mkpokọta bilirubin dị n'ọbara. Jaundice adịkarịghị etolite n'ihi stagnation nke bile. Ọrịa ịba ọcha n'anya bụ oke obere.
Site na akwara na ọnya biliary, jaundice nwere ike ịpụta.
Site n'akụkụ nke metabolism
Theụ ọgwụ ahụ nwere ike ịkpalite ịrị elu nke mkpo potassium ion na plasma ọbara. N’oge na-adịghị anya, agụụ nwere ike ịna-agbada ruo nri nri.
Ahụhụ
Mmeghachi mmeghachi omume nke ndụ anaphylactic mgbe ụfọdụ na-etolite. Ihe egwu ha guzobe mgbe anu-agba ya na-abawanye.
Mmetụta ikike ịchịkwa usoro
Should kwesịrị ịkpachara anya na ịkwọ ụgbọ ala na ijikwa usoro mgbagwoju anya. N'iburu n'obi ikwu okwu nzuzu, ikwesiri ịhapụ ihe omume ndị a.
Ntụziaka pụrụ iche
E kwesiri iji nlezianya mee ọtụtụ ihe.
Jiri na agadi
Ọ dị mkpa iji belata ọgwụ ma ọ bụ gwọọ ndị ọrịa agadi n'ụlọ ọgwụ.
Ọ dị mkpa iji belata ọgwụ ma ọ bụ gwọọ ndị ọrịa agadi n'ụlọ ọgwụ.
Inye umuaka
A machibidoro iwu inye ụmụaka.
Jiri n'oge ime na lactation
Achọghị n'oge ime. Ọ bụrụ na mmekị ahụ emeela, mgbe ahụ ịkwesịrị iji mmiri dị mma dochie ọgwụ ahụ ozugbo, ma ọ bụghị ọrịa ndị na-esonụ nwere ike ịmalite:
- mmebi nke akụrụ nwata;
- agụụ oxygen na agụụ;
- mgbali mgbali;
- mmebi nke ọkpụkpụ cranial;
- ogwe aka nke ukwu;
- mmebi nke ngụgụ.
Achọghị n'oge ime.
Maka oge usoro ọgwụgwọ, amachibidola inye ara ara.
Dodoụbiga mmanya ókè nke Dilaprel
Ọ bụrụ n ’ịdoụbiga mmanya ókè, a na-achọpụta akara n’akụkụ.
Mmekọrịta na ọgwụ ndị ọzọ
Ngwakọta ndị amachibidoro
Amachibidoro iji ọgwụ analogues nke Aliskiren eme ihe bụ ihe amachibidoro ndị ọrịa ọrịa mamịrị na ọdịda akụrụ. A naghị atụ aro iji ndị nnọchianya yiri ya - angiotensin-2 inhibitors.
Ngwakọta anaghị atụ aro
Cangaghị eji ọgwụ nnu nwere ọgwụ potassium na - echekwa ya.
Shouldkwesighi ịme nchikota ọgwụ na ihe eji eme Telmisartan.
Mgwakọta chọrọ ịkpachara anya
Kpachara anya mgbe ị na-eji ọgwụ eji:
- nnu nke lithium;
- ọgwụ mgbochi tricyclic;
- cytostatics;
- izizi (etinyere ya n’olu ma ọ bụ maka ebumnuche niile);
- ọgwụ ịrahụ ụra;
- ọgwụ vasopressor sympathomimetic (Dobutamine, Epinephrine, wdg;);
- nhazi ọla edo;
- ọgwụ hypoglycemic ọ bụla (ihe ize ndụ nke ịmalite coma na-abawanye nke ukwuu);
- ọgwụ mgbochi-anaghị egbochi steroidal.
Should kwesịrị ịkpachara anya mgbe ị na-eji ọgwụ ọgwụ eji ehi ụra.
Mmanya ndakọrịta
Amachibidoro iji ya na ethanol.
Analogs
Ọgwụ ọgwụ ọjọọ gụnyere:
- Tritace;
- Pyramid;
- Hartil;
- Ramipril;
- Amprilan.
Ahịa ọgwụ na-ahapụ okwu
Ọ dị n’ụlọ ahịa ọgwụ naanị mgbe egosiri inye dọkịta akwụkwọ ọgwụ.
Enwere ike ịzụta ya na ụlọ ahịa ọgwụ naanị mgbe egosiri inye ya ọgwụ dọkịta.
Enwere m ike ịzụta na ndenye ọgwụ
Pharmfọdụ ụlọ ahịa ọgwụ na-enye ndị ahịa ha azụta Dilaprel n’enyeghị akwụkwọ ọgwụ. Actionsdị omume ndị a mebiri iwu. Ndị ọrịa na-a theụ ọgwụ ahụ n'ụzọ dị otú a na-etinye onwe ha n'ihe ize ndụ.
Ọnụahịa Dilaprel
Ofgwọ maka nkwakọ ngwaahịa bụ ihe dịka 200 rubles.
Ọnọdụ nchekwa maka ọgwụ
Chekwaa n’ebe gbara ọchịchịrị ma dị jụụ, n’ebe ụmụaka nọ.
Bọchị mmebi
Kwesịrị ekwesị maka ojiji n'ime ọnwa 24 site na ụbọchị a rụpụtara.
Emeputa
Emere ya na ụlọ ọrụ Russia "Vertex".
Nyocha nke Dilaprel
Ivan, gbara afọ 50, Kolomna: “Site n'enyemaka nke Dilaprel, enwere ike ịbelata nsogbu ọbara ọgbụgba na-eme ọsọ ọsọ, enwere nsogbu ọgbụgba mgbe nke mgbali ahụ dị obere ruo ihe dịka 180. Mmetụta ndị ahụ dị arọ. ọgwụgwọ ahụ ahụghị nsonaazụ ndị ọzọ. "
Svetlana, onye gbara afọ 49, Moscow: "Ha depụtara ọgwụ a maka ọgwụgwọ ọbara mgbali elu.Adọ aka na ntị nke otu dọkịta kwuru na ọrịa ọ na-agwọtaghị kpamkpam nwere ike kpalite nkụda mmụọ ma ọ bụ ọrịa strok. N'ihi ya, ọ kwenyere n'ụzọ dị mfe ị drugụ ọgwụ ike. N'agbanyeghi eziokwu na ntuziaka ahụ gosipụtara ọnụọgụ mmetụta dị ukwuu, ha abụghị. ”
Olga, dị afọ 58, St. Petersburg: "Ana m a medicineụ ọgwụ ahụ dị ka dọkịta si kwuo iji gbochie ihe ize ndụ nke nkụchi obi. Enwere m ọbara mgbali ogologo oge ejiri ọgwụ dị iche iche mee ihe iji kwalite mmetụta ọgwụgwọ ahụ. Enwere m ike ịnabata ọgwụ ahụ nke ọma ma soro usoro ọgwụ dọkịta niile." .
