Fenofibrate bụ ogige kemịkal nwere mmetụta hypoglycemic. So na ogwu ufodu. Emere ọgwụ a iji gwọọ hyperlipidemia na hypercholesterolemia. A na-eji ya dị ka ihe mgbochi iji gbochie guzobe palesterol plaques ma ọ bụ mgbanwe atherosclerotic na vaskụla vaskụla.
International Nonproprietary Aha
Na Latin - Fenofibrate.
Aha ahia bu Tricor.
Fenofibrate bụ ogige kemịkal nwere mmetụta hypoglycemic.
ATX
C10AB05.
Ha weputara udi ya na ihe mebere ya
Emere ọgwụ a n'ụdị mbadamba membrane. Ngalaba ọ bụla n’ime nkwadebe ahụ nwere fenfibrate nke 145, 160 ma ọ bụ 180 nke micronized. Dika eji eme ihe ndi ozo:
- mmiri ara ehi shuga;
- microcrystalline cellulose;
- crospovidone;
- hypromellose;
- silikoni dioxide dioxide dehydrogenated;
- chia;
- sulfur lauryl na sodium scus;
- stereta magnesium.
Emere ọgwụ a n'ụdị mbadamba membrane.
Ihe mpụga ahụ bụ nke talc, xanthan gum, titanium dioxide, polyvinyl na mmanya na soya nke lecithin. Mbadamba ụcha nwere ọdịdị dị ogologo nke nwere ihe osise na akụkụ abụọ nke usoro onunu ogwu, na-egosi mkpụrụedemede mbụ nke ihe na-arụ ọrụ na usoro onunu ogwu.
Usoro nke ime ihe
Mbadamba ụrọ Fenofibrate bụ otu nke ndị ọrụ hypoglycemic ma bụrụ ihe ewepụtara na fibroic acid. Ihe a nwere ikike imetụta ọkwa nke lipids n’ahụ.
Ngwongwo ogwu bu ihe sitere na RAPP-alpha na-aru oru (onye nnabata nke onye na - eme ngagharị peroxisis). N'ihi mmetụta na-akpali akpali, usoro metabolic nke mmebi nke abụba na mwepu nke plasma lipoproteins dị ala (LDL) na-abawanye. A na - eme ka nguzobe nke apoproteins AI na AH wee pụta, n'ihi nke a na - abawanye nke lipoproteins densens (HDL) dị elu site na 10-30% na - eme ka lipoprotein lipase na - arụ ọrụ.
N'ihi mweghachi nke metabolism abụba n'ihe banyere mmebi nke nguzobe nke VLDL, ihe fenofibrate na-eme ka mpụta nke LDL belata, belata ọnụ ọgụgụ irighiri ihe nke obere lipoproteins dị ala na obere nha.
A na-abawanye ọkwa LDL n’ebe ndị ọrịa nọ n’ihe ize ndụ nke ibute ọrịa obi.
Ọgwụ na-enyere aka belata cholesterol site na 20-25% na triglycerides site na 40-55%. Na ọnụnọ nke hypercholesterolemia, ọkwa cholesterol metụtara LDL na-agbadata ruo 35%, ebe hyperuricemia na atherosclerosis belatara na mkpokọta uric acid n'ime ọbara site na 25%.
Mlọ ọgwụ
Mgbe a na -ekwu ya ọnụ, a na-etinye micronized fenofibrate n'akụkụ proximal nke obere eriri afọ site na iji microvilli, site na ebe ọ na-abanye n'ime arịa ọbara. Mgbe ọ banye n’ime eriri afọ, akụrụngwa nọ n'ọrụ mebie ozugbo nye fenofibroic acid site na hydrolysis na esterases. Ngwaahịa ire ere na-erute ọkwa plasma kachasị n'ime awa 2-4. Nri ọnụego nnabata na bioavailability anaghị emetụta n'ihi nanoparticles.
Mgbe ọ banye n’ime eriri afọ, akụrụngwa nọ n'ọrụ mebie ozugbo nye fenofibroic acid site na hydrolysis na esterases.
N'ime usoro ọbara, akụrụngwa na-arụ ọrụ na-ejikọ plasma albumin site na 99%. Ọgwụ a anaghị etinye aka na metabolism metabolism. Nkeji ọkara ndụ dị ka elekere iri abụọ. N'oge ule nke ụlọ ọgwụ, enweghi ọnọdụ nke ịchịkọta ma otu ma ọ bụ ịchịkwa ọgwụ ogologo oge. Ọkpụkpụ anụ ahụ adịghị arụ ọrụ. A na-ewepụ ọgwụ ahụ n'ụdị fenofibroic acid kpamkpam n'ime ụbọchị 6 site na usoro urinary.
Ihe ngosi maka ojiji
Edere ọgwụ a n'ihu kọlestrọl dị elu yana ya na ụdị hypertriglyceridemia agwakọta ma ọ bụ nke dịpụrụ adịpụ. Na-enyere aka na ọrịa ogbu na nkwonkwo nke rheumatoid. Ọ dị mkpa icheta na ọgwụ ezubere maka ọgwụgwọ megide ndabere nke adịghị ike ọgwụgwọ ọgwụgwọ, mmega ahụ na ihe omume ndị ọzọ metụtara arọ. Karịsịa na ọnụnọ nke ihe ndị dị ize ndụ (ọbara mgbali elu, àgwà ọjọọ) na dyslipidemia.
A na-eji ọgwụ ahụ eme ihe iji kpochapụ hyperlipoproteinemia nke abụọ naanị mgbe a na-ejide ntụpọ lipoprotein n'ọkwa dị elu megide ndabere nke usoro ọgwụgwọ dị mma nke usoro pathological isi.
Dyslipidemia na ọrịa shuga mellitus nwere ike ịbụ nke ikpeazụ.
Ihe ngbanwe
Edeghị ọgwụ ahụ n'ihi ọgwụ mgbochi siri ike:
- hypersensitivity na fenofibrate na ihe nhazi ozo nke ogwu ahu;
- ọrịa imeju
- nnukwu nshịkọ akụrụngwa;
- galactosemia na akụrụngwa, ụkọ nke lactase na sucrose, ịmịkọrọ glucose na galactose;
- akụkọ banyere ọrịa akwara ọrịa;
- ịma mma maka ọkụ mgbe ejiri ya Ketoprofen ma ọ bụ fibrates ndị ọzọ;
- usoro ọnya na ọnya mmanụ.
Ndị nwere mmeghachi omume anaphylactoid na ahụekere na ahuekere ekwesịghị ị takeụ ọgwụ.
Jiri nlezianya
Ekwesịrị igosipụta ịkpachara anya na akwara akwara na ọrịa ịba ọcha n'anya, ị withdrawalụbiga mmanya ókè, ọrịa akwara akụrụngwa, hypothyroidism.
Uzo esi ewere Fenofibrate
A na-ewere mbadamba n'echeghị ata. Ọ dị ndị ọrịa toro eto mgụọ ọgwụ ọgwụ 145 n'ime ụbọchị. Mgbe ị na-agbanwe site na usoro onyunyo nke 165, 180 mg gaa na ọgwụ kwa ụbọchị nke 145 mg, ọ dịghị achọ mgbazi nke ụkpụrụ kwa ụbọchị.
A na-atụ aro ị theụ ọgwụ ahụ ogologo oge megide ndabere nke usoro ọgwụgwọ nri kwesịrị ekwesị. Ekwesịrị ka ndị dibịa bekee nyochaa ọgwụ ịgwọ ọrịa ga-arụ ọrụ nke ọma dabere na ọdịnaya nchịkwa ọbara ahụ.
A na-ewere mbadamba n'echeghị ata.
Na-a drugụ ọgwụ maka ọrịa shuga
Tupu ị were Fenofibrate, ọ dị mkpa iji kpochapụ hypercholesterolemia nke abụọ megide ụdị ọrịa shuga na-arịa insulin na-abụghị insulin. Mgbe nke a gasịrị, a na-eji ọgwụ ahụ eme ihe n’usoro ọkọlọtọ.
Nsonaazụ
Nsonaazụ na-etolite site na iji usoro ezumike ezighi ezi ma ọ bụ mgbe ekpughere ya ihe ndị dị na mpụga: ọrịa ndị ọzọ nke akụkụ ahụ na sistemụ, nsogbu nke usoro ihe omimi, ike mmadụ nwere na fenofibrate.
Ọkpụkpụ afọ
Ihe mgbu Epigastric, vomiting, na ụkwara ume ọkụ na-adịte aka. A kọwo ọrịa nke ọrịa ogbu egbu.
Ahụhụ Hematopoietic
Nsogbu vaskụl nwere ike imepụta gụnyere thromboembolism venous. N'ọnọdụ ndị a na-adịghị ahụkebe, mmụba nke mkpokọta nke leukocytes na ọkwa nke hemoglobin n'ọbara ga-ekwe omume.
Sistemụ akwara Central
Ehihie na isi ọwụwa nwere ike ibute nsonaazụ nsị na akwara.
Site na usoro akwara
N’ọnọdụ ndị na-adịghị ahụkebe, inye mgbasa olu, ọrịa ogbu na nkwonkwo, adịghị ike na ihe na-adọ adọ, na-enwe nsogbu nke ibute akwara necrosis
Site na usoro mkpụrụ ndụ ihe nketa
Onweghi mgbanwe na-adighi mma n’omume nke usoro olulu.
Ahụhụ
Ọtụtụ mgbe, ọnya anụ ahụ, ọnụnọ (nwute ọkụ), itching ma ọ bụ hives nwayọ nwayọ ruo obere. N'ọnọdụ ndị a na-adịghị ahụkebe, ntutu na-emebi, ọdịdị nke erythema, blisters ma ọ bụ nodules anụ ahụ na-ejikọta n'okpuru radieshon ultraviolet.
Mmetụta ikike ịchịkwa usoro
Ceptionnabata Fenofibrate anaghị emetụta ịta ahụhụ, mmeghachi omume anụ ahụ na nke uche, ya mere, n'oge ọgwụgwọ Lipid na-ebelata, ịnya ụgbọ ala na ịrụ ọrụ na ngwaọrụ ndị dị mgbagwoju anya.
N'ime oge ị theụ ọgwụ ahụ, a na-anabata ịnya ụgbọ ala na ngwaọrụ ndị nwere mgbagwoju anya.
Ntụziaka pụrụ iche
A na-enyocha ọkwa nke ọgwụgwọ ọgwụgwọ na ndabere nke ndị gosipụtara ọdịnaya lipid: serum LDL, cholesterol na triglycerides. Ọ bụrụ na enweghị mmeghachi anụ ahụ na ọgwụ ahụ n'ime ọnwa 3 nke ọgwụgwọ, ọ dị mkpa ka ịkpọtụrụ dọkịta banyere nhọpụta nke usoro ọgwụgwọ ọzọ.
Ọnọdụ nke hyperlipidemia nke abụọ mgbe ewere ọgwụ estrogens, ọgwụ homonụ na mgbochi afọ ndụ nke dabere na homonụ mmekọahụ nke ụmụ nwanyị nwere ike jikọtara ọkwa nke estrogen. Fibrinogen na-ebelata.
Mmụba dị ukwuu nke hepatocytic transaminases n'ọtụtụ oge bụ asymptomatic nwa oge. Ọnwa iri na abụọ mbụ ọgwụgwọ na ọnọdụ a, a na-atụ aro ka ọ nwalee nnwale maka ọkwa nke ịba ọcha n'anya transrans kwa ọnwa atọ. Site na mmụba na mkpokọta transaminases site ugboro atọ ma ọ bụ karịa, ọ dị mkpa ịkwụsị ị Fụ Fenofibrate.
N'ime oge ọgwụgwọ, edepụtara okwu banyere mmepe nke ọrịa pancreatitis. N'ime ihe ndị nwere ike ibute ọrịa ọnya, enwere:
- cholelithiasis, sote cholestasis;
- nrụpụta dị ala nke ọgwụ maka nnukwu hypertriglyceridemia;
- nguzobe ya na otite.
N'ime oge ọgwụgwọ ya na ọgwụ ahụ, e dekọtara okwu banyere mmepe nke pancreatitis.
Ikekwe mmepe nke mmetụta ọgwụ ọjọọ ọgwụ na akwara, na-eduga n'ọrịa rhabdomyolysis. Ihe ọghọm nke ibute ọrịa na nsogbu ya na-abawanye n ’usoro nke ọdịda akụrụ na mbelata nke albumin na plasma. Ọ dị mkpa iji duzie nchọpụta iji chọpụta nsonaazụ Fenofibrate na akwara ọkpụkpụ na mkpesa nke adịghị ike, mgbu olu, myositis, cramps, cramps muscle, mmụba na ọrụ nke creatine phosphokinase ugboro ise ma ọ bụ karịa. Ọ bụrụ na nsonaazụ nyocha ahụ dị mma, ọgwụ ga-akwụsị.
Site na mmụba na ọkwa creatinine karịa 50% nke ụkpụrụ, a na-atụ aro ka ọ kwụsịtụ usoro ọgwụgwọ Fenofibrate. Site na usoro ọgwụgwọ ọgwụ na-aga n'ihu, a na-atụ aro ka nyochaa nyocha nke creatinine maka ụbọchị 90.
Jiri n'oge ime na lactation
Na omumu ihe omumu nke anumanu na anumanu, achoputaghi oria teratogenic. Na nyocha ndị a kapịrị ọnụ, edekọtara oke ihe nwatakịrị ahụ na ihe ize ndụ nye nwa ebu n’afọ, yabụ, ọgwụ a ka ewere ya naanị ma ọ bụrụ na mmetụta ọma ọ dịịrị nwanyị dị ime karịrị ihe ize ndụ intrauterine dị n’ime nwata ahụ.
A na-ahapụ ị Breastụ ara ara n'oge ọgwụgwọ.
Cribdebere Fenofibrate Childrenmụaka
A naghị akwado ọgwụ ahụ maka ụmụaka na ndị na-eto eto na-erubeghị afọ 18 n'ihi enweghị ozi gbasara mmetụta Fenofibrate na uto na mmepe nke anụ ahụ.
Jiri na agadi
Ndị dị ihe karịrị afọ 70 ekwesịghị imezi usoro usoro usoro onunu ogwu.
Dodoụbiga ya ókè
Onwebeghi ọnọdụ ịdoụbiga mmanya ókè n'ihi ị drugụ ọgwụ ọjọọ. Onweghi kompịlị doro anya. Yabụ, ọ bụrụ na onye ọrịa nwere otu oke ọgwụ ọgwụ malitere ịrịa ahụike, ịka njọ ma ọ bụ nsonaazụ ya, ọ dị mkpa ịchọ enyemaka ahụike. N ’ụlọ ọgwụ, a na-ewepụ ihe ngosipụta nke usoro ị overụbiga mmanya ókè.
Mmekọrịta na ọgwụ ndị ọzọ
Mgbe ị na-ejikọ fenofibrate na ọgwụ anticoagulants maka nchịkwa ọnụ, ịdị irè nke ọgwụ a na-atụle na-abawanye. Site na mmekorita a, ihe ize ndụ ọbara ọgbụgba na-abawanye n'ihi nchụpụ nke anticoagulant site na protein protein plasma.
Site n'iji ihe ndị na-egbochi HMG-CoA reductase na-egbochi, ihe egwu nke nsonaazụ nsí na akwara olu na-abawanye, yabụ ọ bụrụ na onye ọrịa ahụ ewere statins, ọ dị mkpa ịkagbu ọgwụ ahụ.
Cyclosporine na-eme ka akụrụ na-emebi emebi, yabụ mgbe ị na-ewere Fenofibrate, ị ga-enyocha ọnọdụ nke anụ ahụ mgbe niile. Ọ bụrụ na ọ dị mkpa, a ga-akagbu idozi ọgwụ ịba ụba mmadụ.
Mmanya ndakọrịta
Ekwesiri ị withụ mmanya na-egbu egbu n'oge ọgwụgwọ ya. Mmanya Ethyl na-ebelata mmetụta ọgwụgwọ nke ọgwụ ahụ, na-eme ka ihe ndị na-egbu egbu ghara ịdị na mkpụrụ ndụ imeju, akwara ndị dị n’ahụ na mgbasa ọbara.
Analogs
Analogues nke ọgwụ ahụ gụnyere ọgwụ nwere otu ụdị arụmọrụ:
- Ihe omumu
- Atorvacor;
- Lipantyl;
- Ciprofibrate;
- Mbadamba Canon Fenofibrate;
- Livostor;
- Ẹse;
- Trilipix.
A na-agbanye ya na ogwu ozo emechaa mgbe nyochachara ogwu.
Usoro ọgwụ ezumike Fenofibrate
A naghị ere ọgwụ a na-enweghị ndenye ọgwụ na Latin.
Enwere m ike ịzụta na ndenye ọgwụ
N'ihi ọghọm dị na rhabdomyolysis, amachibidoro ire fenofibrate n'efu.
Ego ole
Maka mbadamba nke 145 mg, iberibe iri atọ kwa mkpọ, ọnụahịa nkezi bụ 482-541 rubles.
Ọnọdụ nchekwa maka ọgwụ
Ọ na-atụ aro ịchekwa ọgwụ ahụ na okpomọkụ ruo 25 + Celsius C n'ebe nkụ, adịghị anya site na ìhè anyanwụ.
Ọ na-atụ aro ịchekwa ọgwụ ahụ na okpomọkụ ruo 25 + Celsius C n'ebe nkụ, adịghị anya site na ìhè anyanwụ.
Bọchị mmebi
Enwere ike ịchekwa mbadamba 145 na 160 mg maka afọ 3, 180 mg maka afọ 2.
Onye na-emeputa Fenofibrate
Fournier Laboratories, Ireland.
Nyocha Fenofibrate
Enwere okwu na-agba ume sitere na ndị na-ere ọgwụ na ndị ọrịa.
Ndi dibia
Olga Zhikhareva, dibia bekee, Moscow
Irè n'ọgụ megide elu triglycerides. Ana m akwado iji ụdị IIa, IIb, III na IV maka hyperlipoproteinemia. N'ime usoro ọgwụgwọ, ana m edepụta oge nchịkwa na usoro onunu ogwu n'otu oge. Enweghị mmetụta ọ bụla a hụrụ. Ọ nweghị mmetụta akpọsa na belata cholesterol.
Afkasy Prokhorov, onye na-ahụ maka nri na-edozi ahụ, Yekaterinburg
Site na oke ibu na cholesterol dị elu, fenofibroic acid na-enyere aka nke ọma. Karịsịa na arụmọrụ mmega na nri dị ala. N'oge usoro ọgwụgwọ, ana m akwado ịhapụ omume ọjọọ na ịgbaso ndụmọdụ ndị dọkịta na-agbaso iji nwekwuo arụmọrụ.
Ndị ọrịa
Nazar Dmitriev, onye gbara afọ 34, Magnitogorsk
Ezi usọbọ. Lipids bụ 5.4.Site n'iji Fenofibrate mee ihe mgbe niile, ogo abụba belatara ruo 1.32. Borderline dị 1.7. Enweghị mmetụta ọ bụla akọwapụtara.
Anton Makaevsky, onye gbara afọ 29, St. Petersburg
O were ihe dị ka otu afọ kama Torvacard n'ihi ọdịnaya dị ala nke HDL. Mgbe ọnwa 4-5 gachara, mwakpo ọgbụgbọ na mgbu n'ime akwara dị elu malitere ịpụta. Mgbe ọnwa 8-9 gachara, ha rụrụ ọrụ ịwa ahụ iji wepu ọnya afọ. A hụrụ viscous bile na okwute rụrụ arụ. Mgbe ọgụ ahụ mechara, ọgụ ahụ kwụsịrị.
Mikhail Taizhsky, 53 afọ, Irkutsk
Ọgwụ dụrụ mmanya iji mee ka mgbidi vaskụla sikwuo ike, mana enweghị m ike ikwu banyere ihe ahụ. A naghị enwe mmetụta olu. Site n'enyemaka nke ọgwụ ahụ, ịdị arọ belatara n'ihi agụụ, mana akpụkpọ ama ama nke ukwuu. Chọgharị ọrụ achọrọ. Enwere m afọ ojuju n'ihe si na ya pụta.
