Liprimar 10 bụ ihe na - arụ ọrụ nke nwere mmetụta dị ala. Ọgwụ dị mkpa iji belata cholesterol na lipoproteins dị ntakịrị. N'ihi nke a, enwere ike imepụta onwarosclerotic plaques n’elu mgbidi nke akwara ọbara na-ebelata, ọkwa triglycerides na-ebelata ma na-eme ka abụba dị n’ahụ na-akawanye mma. Ndabere nke usoro nke ihe a bụ atorvastatin, nke dị mkpa iji kpochapụ hypercholesterolemia.
International Nonproprietary Aha
Atorvastatin.
Liprimar 10 dị mkpa iji cholesterol dị ala na obere lipoproteins dị ala.
ATX
C10AA05.
Ha weputara udi ya na ihe mebere ya
Ọgwụ ahụ dị na mbadamba mkpuchi-osisi. Ngalaba usoro onodu ogwu nwere ihe dika 10 mg nke calcium atorvastatin dika ihe na aru oru. Maka ọsọ nke nnabata na ụba bioavailability, mbadamba nkume nwere ihe ndị ọzọ:
- microcrystalline cellulose;
- steeti magnesium;
- mmiri ara ehi shuga;
- hyprolose;
- sodium croscarmellose;
- kaboneti a na-akpọ carbonate.
Ihe mejupụtara mbadamba nkume ndị ahụ bụ microcrystalline cellulose, magnesium stearate, shuga mmiri ara ehi, hyprolose, croscarmellose sodium, kabon kalsium.
Iri ihe nkiri ahụ nwere kandụl kandụl, hypromellose, polyethylene glycol, talc, simethicone, titanium dioxide. Na mbadamba ọcha nke ọdịdị nke elliptical, a na-etinye ihe osise "PD 155" na dose nke ihe na-arụ ọrụ.
Omume ọgwụ
Liprimar bụ ndị otu ọgwụ ọgwụ na-egbusi ike. Atorvastatin na-arụ ọrụ bụ ihe na-ahọrọ ihe mgbochi HMG-CoA, nnukwu enzyme dị mkpa maka mgbanwe nke 3-hydroxy-3-methylglutaryl coenzyme n'ime mevalonate.
Na ọnụnọ nke ụdị hypercholesterolemia (cholesterol mụbara), ngwakọta dyslipidemia, Liprimara na-arụ ọrụ ga-enyere aka belata mkpụkọ plasma nke mkpokọta cholesterol (Ch), apolipoprotein B, VLDL na LDL (lipoproteins dị ala) na obere nke triglycerides. Atorvastatin na-ebute mmụba dị elu lipoprotein (HDL)
Uzo a na - eme bu site na nnabata nke oru HMG-CoA reductase na igbochi nguzobe cholesterol na hepatocytes.
Atorvastatin nwere ike ịbawanye ọnụ ọgụgụ nke ndị na-anabata ihe mkpokọta lipoprotein dị ala na mpụta nke mkpụrụ ndụ imeju, nke na-eduga n'ịba ụba na mbibi nke LDL.
Ogwu ahụ nwere ike mee ka ọnụ ọgụgụ nke ndị na - anata mkpo lipoprotein dị ntakịrị nke dị n’elu elu nke imeju akwara.
Akụrụngwa na-arụ ọrụ na-ebelata njikọta LDL cholesterol na ọnụọgụ nke lipoproteins na-emerụ ahụ, n'ihi nke enwere mmụba na ọrụ nke ndị na-anabata LDL. N'ime ndị ọrịa nwere ụdị hypercholesterolemia nke homozygous na-eguzogide ihe nke ọgwụ Lipid, a na-ebelata mkpụrụ ndụ LDL. A na-achọpụta mmetụta ọgwụgwọ ahụ n'ime izu abụọ mgbe mmalite nke ọgwụ ọgwụ. Edere nsonaazụ kachasị mgbe ọnwa gasịrị ọgwụgwọ Liprimar.
Mlọ ọgwụ
Mgbe nchịkwa ọnụ gasịrị, mbadamba nkume ndị ahụ anaghị agbaze n'okpuru ọrụ hydrochloric acid n'ime afọ, na-adaba na jejunum proximal. N’akụkụ akụkụ nke ihe digestive ahụ, membrane ihe nkiri ahụ na-enyocha hydrolysis.
Mbadamba ụrọ ahụ mebiri emebi, nri na ọgwụ na-amalite ịdọrọ microvilli pụrụ iche.
Atorvastatin na-abanye n'ọbara ọbara site na mgbidi eriri afọ, ebe ọ na-eru ọkwa kachasị nke plasma n'ime awa 1-2. N'ime ụmụ nwanyị, ntinye uche nke ihe dị n'ọrụ dị pasenti 20 karịa nke ụmụ nwoke.
Bioavailability ruru 14-30%. Onu ogugu bu n'ihi nmezu nke metabolic nke atorvastatin na mkpo mucous nke eriri afọ na mgbanwe n’ime mkpụrụ ndụ akwara site na isoenzyme nke cytochrome CYP3A4. Ihe mejupụtara na-ejikọ albumin site na 98%, nke mere na hemodialysis anaghị arụ ọrụ. Iwepu ọkara ndụ na-erute awa iri na anọ. Mmetụta ọgwụgwọ na-adịgide ruo awa 20-30. Atorvastatin na-ahapụ ahụ nwa ahụ nwayọ site na sistemụ urinary - naanị 2% nke dose ka a na-ahụ na mmamịrị mgbe otu usoro gasịrị.
Ihe ngosi maka ojiji
A na-eji ọgwụ ahụ eme ihe na ahụike iji gwọọ:
- isi hypercholesterolemia nke ọrịa e ketara eketa ma ghara inweta ya;
- ogo dị elu nke triglycerides na-eguzogide ọgwụ ọgwụgwọ;
- hereditary homozygous hypercholesterolemia na nrụpụta nri dị ala na usoro ọgwụgwọ ndị ọzọ na-abụghị ọgwụ;
- ụdị jikọtara hyperlipidemia.
Edere ọgwụ ahụ ka ọ bụrụ ihe mgbochi nke ọrịa obi na-arịa ndị ọrịa na enweghị ihe ịrịba ama nke ọrịa obi, ma o nwere ihe ndị dị ize ndụ: ịka nká, omume ọjọọ, ọbara mgbali elu, ọrịa shuga mellitus. Ndị otu ahụ nwere nsogbu gụnyere hypercholesterolemia yana oke HDL.
Edere ọgwụ a ka ọ bụrụ ihe mgbochi maka ọrịa obi.
A na-eji ọgwụ ahụ eme ihe dị ka njikọta na usoro ọgwụgwọ nri maka mmepe nke dysbetalipoproteinemia. A na-eji Liprimar eme ihe iji gbochie mmepe nke nsogbu na ndị ọrịa nwere ischemia myocardial iji belata ihe egwu ọnwụ, nkụchi obi, ọrịa strok na ụlọ ọgwụ maka angina pectoris.
Ihe ngbanwe
Edeghị ọgwụ ahụ maka ịbawanye ike nke anụ ahụ na ihe nhazi Liprimar, yana n'ihe ndị a:
- ọrịa imeju siri ike;
- ụmụaka ndị gbara afọ 18;
- ịba ụba ọrụ plasma nke hepatic transaminases karịrị ugboro atọ.
Ekwesịrị ịkpachara anya mgbe ị na-a alcoholụbiga mmanya ókè.
Uzo esi ewere Liprimar 10
Mbadamba ụrọ ka edobere maka nchịkwa ọnụ, n'agbanyeghị oge ụbọchị ma ọ bụ nri. A na-eme ọgwụgwọ ọgwụ ọjọọ naanị na adịghị ike nke hypocholesterolemic nri, usoro ịbelata oke megide ihe ndabere nke oke ibu gabigara ókè, mmega ahụ. Ọ bụrụ na mmụba nke cholesterol bụ ihe kpatara ọrịa na-esite na ya, tupu ịpụ Liprimar, ịkwesịrị iwepụ usoro pathologies bụ isi. N'ime usoro ọgwụgwọ ọgwụ dum, ị ga-agbaso nri pụrụ iche.
Ọgwụ ọgwụ na Liprimar 10 ka a na-eme bụ naanị na adịghị ike nke nri hypocholesterolemic.
Usoro ubochi kwa ubochi bu 10-80 mg maka ijiri otu ma emeghari ya dabere na oru LDL-C na iweta nsonaazu ogwu.
Ihe kacha anabata ike ị nweta bụ 80 mg.
N'oge ọgwụgwọ Liprimar, ọ dị mkpa iji nyochaa nsị plasma nke lipids kwa izu 2-4, mgbe nke a gasịrị, ịchọrọ ịkpọtụrụ dọkịta gị banyere mgbanwe mgbanwe usoro usoro.
Iji kpochapụ ụdị hyperlipidemia, ọ dị mkpa iji 10 mg otu ugboro kwa ụbọchị, ebe hyzychous hereditary hypercholesterolemia chọrọ ọgwụgwọ ọgwụgwọ kachasị nke 80 mg. N'okwu ikpeazu, a na-ebelata cholesterol site na 20-45%.
Na-a drugụ ọgwụ maka ọrịa shuga
Ndị ọrịa nwere ọrịa shuga kwesịrị ịkpachara anya mgbe hypercholesterolemia mere. Ndị dị otú ahụ nọ n'ihe ize ndụ nke ibute ọrịa obi. A na-eji liprimar eme ihe dị ka ihe na-egbochi infarction myocardial. O were usoro dibia bekee kpebie usoro onodu a dabere n’otu ọkwa cholesterol.
Ndị ọrịa nwere ọrịa shuga kwesịrị ịkpachara anya mgbe hypercholesterolemia mere.
Ọ ga - ekewa na ọkara
Onweghi nsogbu di na mbadamba nkume, nke putara na enweghi ike ikesa udi usoro onodu ogwu.
Nsonaazụ Liprimara 10
Site n'iji ọgwụ eme ihe n'ụzọ na-adịghị mma, nsonaazụ ya nwere ike ịmalite nke na-agbanwe na mpaghara.
Ọkpụkpụ afọ
Ikekwe ọdịdị nke ọgbụgbọ, afọ ọsịsa, mgbu na mpaghara epigastric, afọ ntachi na flatulence. N'ọnọdụ ndị a na-adịghị ahụkebe, ọgwụgwọ Liprimar nwere ike ịkpasu anorexia, usoro mkpali na pancreas, ịba ọcha n'anya na jaundice.
Ahụhụ Hematopoietic
N'ọnọdụ ndị a na-adịghị ahụkebe, ụfụ ọkpụkpụ, na-esonyere thrombocytopenia.
Liprimar 10 nwere ike ibute ehighị ụra.
Sistemụ akwara Central
Mmeghachi omume na-adịghị mma na mmebi nke usoro akwara ozi dịka:
- ehighi ura
- oria ojoo;
- ọrịa asthenic;
- isi ọwụwa na ọgbụgbọ;
- ibelata ma nwezighi ezi uche zuru oke;
- sistemụ akwara azụ;
- amnesia.
Site na usoro urinary
N'ime ụmụ nwoke, ọgbụgba na ejidere urinary nwere ike ime.
Site na sistem iku ume
Dyspnea nwere ike ime.
Ahụhụ
Site n'igosipụta mmeghachi omume anaphylactic, rashes na anụ ahụ, redness, itching, exryative erythema, necrosis nke subcutaneous fatịlaịza nwere ike iputa. N'ọnọdụ siri ike, ụbụrụ Quincke na ụzụ anaphylactic.
Ogige ọgwụ a na-ajụ ajụjụ nwere ike ịkpasu ọdịdị nke rashes na anụahụ.
Mmetụta ikike ịchịkwa usoro
Ọgwụ ahụ anaghị egbochi ihe omume chọrọ nzaghachi ngwa ngwa na itinye uche. N'oge ọgwụgwọ ọgwụ ahụ, a na-anabata ịnya ụgbọ ala na njikwa nke ngwaọrụ ngwanrọ siri ike.
Ntụziaka pụrụ iche
Mgbe ị na-emeso Liprimar izu isii ọ bụla, ọ dị mkpa iji nyochaa nyocha nke imeju na ngosipụta nke ALT, AST. Ọ bụrụ na ọrụ aminotransferases karịa oke nke kwesịrị ka ọ karịa ugboro atọ, ọ dị mkpa ịkpọtụrụ dọkịta maka mbelata usoro onunu ogwu.
N'ihi usoro ọgwụgwọ hypocholesterolemic, n'ọnọdụ ụfọdụ, a hụrụ ngosipụta nke mgbu akwara megide ndabere nke myopathy. N'otu oge ahụ, ọmụmụ ụlọ nyocha gosipụtara mmụba okpukpu iri na ọrụ nke creatine phosphokinase ma e jiri ya tụnyere usoro.
Ọ bụrụ na onye ọrịa nwere adịghị ike na ihe mgbu na akwara nke ọkpụkpụ akwara, ọ dị mkpa ịkwụsị ị .ụ ọgwụ.
N'ọnọdụ ndị na-adịghị ahụkebe, rhabdomyolysis mepụtara - mmebi akwara necrotic na anụ ahụ, yana nnukwu ọdịda akụrụ.
Ekwesịrị ịkwụsị iji ọgwụ ahụ na mbelata ọbara mgbali elu.
Ọrịa n'ihi ọrịa myoglobinuria bụ ihe na - esite na myoglobinuria. Iji belata ohere ị ga-enwe rhabdomyolysis, ịkwesịrị ịkwụsị ị theụ ọgwụ ahụ n'ọnọdụ ndị a:
- n'oge ịwa ahụ na mbara ala;
- nnukwu mmebi nke akụrụ;
- mbelata nke ọbara mgbali elu;
- ọkpụkpọ ụbụrụ;
- akwara mgbu.
Ekwesịrị ịgwa onye ọrịa ahụ ihe ize ndụ nke rhabdomyolysis. Site na nkwenye ọgwụgwọ, iwu ji onye ọrịa ahụ ịchọ enyemaka ahụike na mmetụta nke adịghị ike anụ ahụ na ọdịdị nke ihe mgbu na-akọwaghị, yana ọkụ na ike ọgwụgwụ.
Cribdebere Liprimar ụmụ iri
Anabataghị ọgwụ a maka iji ọgwụ.
Mmanya ndakọrịta
Notgwakọta ọgwụ ekwesịghị ịgwakọta na ngwaahịa mmanya. Mmanya ethyl na-egbochi usoro ụjọ ahụ nke akwara, usoro hepatobiliary na mgbasa, yabụ belata ike hypocholesterolemic nke iji Liprimar eme ihe. Ihe gbasara nke puru iche banyere ihie atururosclerotic na akwara nke obara oburu ibu.
Notgwakọta ọgwụ ekwesịghị ịgwakọta na ngwaahịa mmanya.
Dodoụbiga mmanya ókè nke Liprimar 10
Mgbe ịdoụbiga ókè ókè, ọ na-emebi ihe ọ na-akpata. Egobeghi ihe eji egbo mkpa ya, ya mere, n'oge ụlọọgwụ, a na-eme ọgwụgwọ ọrịa.
Mmekọrịta na ọgwụ ndị ọzọ
Cimetidine, Phenazone, Azithromycin, antacids, Terfenadine, Warfarin, Amlodipine anaghị emetụta ọgwụ ọgwụ Liprimar ma ghara iso atorvastatin emekọrịta.
A naghị atụ aro maka nchịkọta
N'ihi ihe egwu nke ọrịa neuromuscular, a na-akwadoghị njikwa nsogbu nke Liprimar na:
- ọgwụ nje cyclosporin;
- usoro nicotinic acid;
- Erythromycin;
- ọgwụ antifungal;
- fibrates.
Agaghị akwado nchịkwa nke Liprimar na Erythromycin.
Njikọ ọgwụ ndị dị otú a nwere ike ibute myopathy.
Jiri nlezianya
A na-atụ aro ịkpachara anya mgbe ị na-eji Liprimar na ọgwụ ndị ọzọ:
- Atorvastatin nwere ike ịbawanye AUC nke mgbochi igbochi ọnụ site na 20-30%, dabere na homonụ ndị dị na nhazi ahụ.
- Atorvastatin nwere usoro onunu ogwu nke 40 mg na ngwongwo 240 nke Diltiazem na-eduga na mmụba na mkpokọta plasma nke atorvastatin n'ime ọbara. Mgbe ị na-ewere 200 mg nke Itraconazole na 20-40 mg nke Liprimar, a hụrụ mmụba na AUC nke atorvastatin.
- Rifampicin na-ebelata ọkwa plasma nke atorvastatin.
- Colestipol na-ebute mbelata nke ọgwụ na-agbada Plasma cholesterol.
- Na nkwonkwo ngwakọta na digoxin, itinye uche nke ikpeazụ na-abawanye site na 20%.
Ihe ọ juiceụpeụ mkpụrụ osisi grepu na-egbochi ihe cytochrome isoenzyme CYP3A4, nke kpatara ya mgbe ị na-a moreụ ihe karịrị 1.2 lita ihe ọ citụrusụ citrus kwa ụbọchị, ịba ụba nke plasma nke atorvastatin na-abawanye. A na-ahụ mmetụta yiri nke ahụ mgbe ị na-ewere ndị na - egbochi CYP3A4 (Ritonavir, Ketoconazole).
A machibidoro Liprimar iji ụmụ nwanyị dị ime 10.
Jiri n'oge ime na lactation
Amachibidoro iji ọgwụ a maka ụmụ nwanyị dị ime, dịka enwere nsogbu nke imebi ezi anụ ahụ na akwara n'oge uto nke afọ. Enweghị data banyere ike nke Liprimar ịbanye na mgbochi hematoplacental.
N'oge ọgwụgwọ ọgwụ, a ga-akwụsị ịfeụ ara.
Analogs
Ihe ọgwụ ọgwụ nwere mmetụta yiri ya na-agụnye:
- Atoris;
- Tulip;
- Vazator;
- Atorakord;
- Atorvastatin-SZ.
A na-eme mgbanwe mgbe emechara nyocha ahụike.
Ahịa ọgwụ na-ahapụ okwu
Erere ọgwụ a kpam kpam site na ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ?
Ee e.
Ọnụ ego maka Liprimar 10
Ọnụ ego nke mbadamba 10 mg bụ 750-1000 rubles.
Ọnọdụ nchekwa maka ọgwụ
Ọ dị mkpa idobe ọgwụ a ebe ọnụọgụ mmiri dị ala na-erughị ala 15 + + 25 Celsius.
Bọchị mmebi
Afọ 3
Emeputa
Gedecke GmbH, Germany.
Liprimar analog - a na-ere ọgwụ Atoris n'ụlọ ahịa ọgwụ nke ọma dabere na ndenye ọgwụ.
Nyocha na Liprimar 10
Elvira Ignatieva, onye gbara afọ 76, Lipetsk
Ọnwa isii gara aga, mgbe ị na-agafe nyocha ọbara izugbe, ekpughere ọkwa cholesterol dị elu nke 7.5 mmol. Enwere m ọrịa akwara obi, ya mere, iji gbochie nsogbu akwara, a ga-ebelata cholesterol ozugbo n’ime obere oge. Dọkịta nyere Liprimar 40 mg kwa ụbọchị. Ọnụahịa ahụ dị elu, mana ziri ezi site na arụmọrụ. Nchoputa ohuru gosiputara mbelata cholesterol rue 6 mmol.
Kristina Molchanova, 24 afọ, Yaroslavl
Nne nne nwere atherosclerosis nke arịa nke ala akụkụ ya na cholesterol ya na LDL na-abawanye. Onye mbu họpụtara Rosuvastatin, nke adabaghị. Enweghị ezigbo mgbanwe. Mgbe Rosuvastatin gasịrị, edepụtara Liprimar.Site na ọgwụ ahụ, profaịlụ nke ikpeazụ ahụ gosipụtara mmezi: cholesterol na ịdị arọ nke anụ ahụ belatara, mkpo nke lipoproteins dị elu mụbara.
