Zaltrap bụ ọgwụ antitumor eji mee ihe na ọgwụgwọ nke ọrịa cancer colorectal metastatic, mgbe kemoterapi anaghị enye ọria ọgwụgwọ n'ihi nnukwu nguzo nke tum tum ma ọ bụ nloghachi ya.
International Nonproprietary Aha
ZALTRAP.
Zaltrap bụ ọgwụ ejiri ọgwụ mgbochi a na-eji na ọgwụgwọ nke metastatic colorectal cancer n’ime ndị okenye.
ATX
L01XX - ọgwụ antitumor ọzọ.
Weputara udi ya na ihe mebere ya
Itinye uche site na nke akwadoro maka infusion. Vials nwere olu nke 4 ml na 8 ml. Onu ogugu nke isi ihe bu milili 25 n’ime 1 ml. Nhọrọ nke abuo bu ihe ejikere nke oma nke akwadoro maka ochichi intraven. Agba nke ihe ngwọta dị n ’ọpụpụ ma ọ bụ jiri obere odo na-acha odo odo.
Akụkụ bụ isi bụ protein prolibercept. Ndị pụrụ iche: sodium phosphate, citric acid, hydrochloric acid, sucrose, sodium chloride, sodium hydroxide, mmiri.
Omume ọgwụ
Aflibercept na-egbochi ọrụ nke ndị na-anabata ya, nke bụ ọrụ maka ịkpụpụta arịa ọbara ọhụrụ ndị na-eri tumo ahụ ma na-atụnye ụtụ ya. N'ịnọ ebe a na-enyeghị ọbara, neoplasm na-amalite ibelata nha. Usoro nke ito eto na nkewa sel ya na - adịghị emerụ ahụ na - akwụsị.
Ileghara anya na-egbochi ọrụ ndị nnabata, nke nwere ọrụ ihiwe arịa ọbara ọhụrụ.
Mlọ ọgwụ
Enweghị data na metabolism nke protein aflibercept. O yikarịrị ka, dị ka protein ọ bụla ọzọ, isi ihe dị na ọgwụ ahụ na-ekewa n'ime amino acid na peptides. Ọkara iwepu ọkara bụ ụbọchị isii. A na-etepụ protein n’ozu akụrụ ya na mmamịrị.
Ihe ngosi maka ojiji
A na-eji ya agwakọta ya na ọgwụ folinic acid, Irinotecan na Fluorouracil maka ọrịa kansa nke metastatic cancer colorectal na oke iguzogide ọgwụ mgbochi ọgwụ ndị ọzọ. Edere ya maka ọgwụgwọ ịlaghachi azụ.
Ihe ngbanwe
Amachibidoro iji ya maka ọgwụgwọ n'ọnọdụ ndị a:
- ọbara ọgbụgba dị ukwuu;
- ọbara mgbali elu nke ụdị akwara, mgbe ọgwụgwọ ọgwụ dara;
- Agba 3 na 4 nke nkụda obi na-adịghị ala ala;
- onye ọrịa ahụ nwere ọgwụ mgbochi n'otu akụkụ nke ọgwụ ahụ;
- nnukwu nsogbu gbasara akwara.
Mgbochi afọ - ndị ọrịa na-erubeghị afọ 18.
Jiri nlezianya
Nyochaa onodu ahụike mgbe niile gbasara ndị ọrịa nwere akwara akwara, ọbara ọgbụgba, ọrịa obi, yana usoro mmalite nke nkụda obi. N'iji nlezianya, a na-enye ọgwụ ahụ maka ndị ọrịa agadi na-arịa ọrịa na ahụike ọ bụla, ma ọ bụrụ na ọkwa ọkwa adịghị elu karịa isi abụọ.
Uzo esi ewere Zaltrap
Nlekọta intravenous - infusion maka 1 awa. Usoro onunu ogwu di 4 mg kwa kilogram nke aru. Aka ịbanye na usoro ọgwụgwọ chemotherapeutic:
- ụbọchị mbụ nke ọgwụgwọ: infusion intravenous with a Y-cat catheter eji Irinotecan 180 mg / m² maka nkeji 90, Calcium folinate maka nkeji 120 na ọnụọgụ nke 400 mg / m² na 400 mg / m² Fluorouracil;
- infusion na-esote na-aga n’ihu na-ewe awa 46 na usoro onunu ogwu nke Fluorouracil 2400 mg / m².
Nlekọta intravenous - infusion maka 1 awa.
A na-emegharị okirikiri kwa ụbọchị iri na anọ.
Na-arịa ọrịa shuga
Dose ukpụhọde adịghị.
Nsonaazụ nke Zaltrap
A chọpụtawo ikpe ugboro ugboro nke afọ ọsịsa, proteinuria, stomatitis, dysphonia, na ọrịa urinary. N’ọtụtụ ndị ọrịa, agụụ na-ebelata, ọbara ọgbụgba, imenyụ ibu na-adị. Ike na-agwụ ike, asthenia.
Ihe mgbaàmà dị iche iche sitere na sistem iku ume: dyspnea nke ogo ịdị iche iche, rhinorrhea, na ọbara ọgbụgba na-enwekarị.
Site na anụ ahụ na akwara
Patientsfọdụ ndị ọrịa na-ebute akwa osteonecrosis.
Ọkpụkpụ afọ
Ọrịa afọ ọsịsa, ọnya afọ nke ịdị iche iche, mmepe nke hemorrhoids, nguzobe fistulas na ike, eriri afọ, obere eriri afọ. O nwere ike mgbu mgbu, ọgbụgbọ, ọnya ọgbụgba, ikpu. Fistulas dị na usoro mgbari nri na imebi mgbidi ya anaghị adịkarị, nke nwere ike ibute ọnwụ onye ọrịa.
Ihe mgbaàmà nke sitere na sistem iku ume: dyspnea na - apụtakarị.
Ahụhụ Hematopoietic
Ọtụtụ mgbe enwere leukopenia na neutropenia nke ogo dịgasị iche.
Sistemụ akwara Central
Ihe fọrọ nke nta ka ọ bụrụ oge niile enwere isi ọwụwa dị iche iche, obi nkoropụ ugboro ugboro.
Site na usoro urinary
Ọtụtụ mgbe - proteinuria, adịkarịghị - mmepe nke nephrotic syndrome.
Na anụahụ
Itching, redness na friza, urticaria.
Site na usoro mkpụrụ ndụ ihe nketa
Ọrịa, na - egbochi nwoke na nwanyị.
N'ime ọtụtụ ndị ọrịa, ị Zụ Zaltrap nwere ike ibute thromboembolism.
Site na usoro akwara obi
Jumps na ọbara mgbali, ọbara ọgbụgba n'ime. N'ime ọtụtụ ndị ọrịa: thromboembolism, mwakpo ischemic, angina pectoris, nnukwu ihe ize ndụ nke infarction myocardial. N’oge na-adịghị anya: oghere nke ọbara ọgbụgba craniocerebral, ịkwafu ọbara, na-eme ka ọbara na-agba n’afọ, bụ ihe na-akpata ọnwụ.
N'akuku nke imeju na akụkụ biliary
Mmepe nke imeju ọdịda.
Site n'akụkụ nke metabolism
N'ọtụtụ oge, enweghị agụụ, oge ụfọdụ - mmiri na-egbu (site na obere ruo na nnukwu).
Ahụhụ
Mmeghachi ike hyperensitivity siri ike: bronchospasm, mkpụmkpụ ume ọkụkụ, ujo anacticlactic.
Mmetụta ikike ịchịkwa usoro
Enweghị data na ọmụmụ banyere nsonaazụ ọgwụ ahụ ga-ekwe omume na itinye uche. A na-atụ aro ka ọ kwụsị ịkwọ ụgbọala ma rụọ ọrụ na usoro mgbagwoju anya ma ọ bụrụ na onye ọrịa ahụ nwere nsonaazụ ya site na sistemụ akwara etiti, nsogbu psychomotor.
Tupu usoro ọgwụgwọ ọhụụ (ụbọchị 14 ọ bụla), ekwesịrị ime nyocha ọbara.
Ntụziaka pụrụ iche
Tupu usoro ọgwụgwọ ọhụụ (ụbọchị 14 ọ bụla), ekwesịrị ime nyocha ọbara. A na-enye ọgwụ ahụ naanị na ọnọdụ ụlọ ọgwụ maka nzaghachi oge nke ihe mgbaàmà nke mmiri akpịrị, na -akpọ mgbidi nke eriri afọ.
Ndị ọrịa nwere ntụpọ ahụike n'ogo nke isi 2 ma ọ bụ karịa nwere ihe ize ndụ nke nsonaazụ ọjọọ. Ha na-achọ nlekọta ahụike mgbe niile maka nchọpụta oge nke arịa ọrịa.
Formationmepụta fistulas n'agbanyeghị ọnọdụ ha bụ ihe ngosipụta maka ịkwụsị ọgwụgwọ ozugbo. Amachibidoro iji ọgwụ mee ihe na ọgwụgwọ nke ndị ọrịa emeela ọtụtụ usoro ịwa ahụ (ruo mgbe ọnya ahụ gwọrọ kpamkpam).
Andmụ nwoke na ụmụ nwanyị toro ịmụ nwa kwesịrị iji ụzọ dị iche iche nke igbochi egbochi n’ime ọnwa isii (n’adịghị ala) mgbe usoro ọgwụgwọ ikpeazụ nke Zaltrap gasịrị. Ekwesịrị ịtụrụ ime nwata.
Ihe ngwọta Zaltrap bụ hyperosmotic. Ihe mejuputara ya wezuga iji ogwu eme ihe maka intraocular oghere. Amachibidoro ịmebata ihe ahụ n'ime ahụ anụre.
Jiri na agadi
E nwere nnukwu nsogbu nke ibute ọrịa afọ ọsịsa, akpịrị ọgbụgba, ịbelata ngwa ngwa na akpịrị ịkpọ nkụ n'ime ndị ọrịa nọ n'agbata afọ 65 na karịa. Ekwesịrị ime ọgwụgwọ saltrap naanị n'okpuru nlekọta nke ndị ọrụ ahụike. Na akara izizi nke afọ ọsịsa ma ọ bụ akpịrị ịkpọ nkụ, a na-achọ ọgwụgwọ ngwa ngwa.
Ekwesịrị ime ọgwụgwọ saltrap naanị n'okpuru nlekọta nke ndị ọrụ ahụike.
Inye umuaka
Emebeghi nchekwa nke Zaltrap na ụmụaka.
Jiri n'oge ime na lactation
Ihe omuma banyere ojiji nke Zaltrap di ime na ndi na-enye ara. N’inye ihe egwu dị iche iche enwere ike ibute nwata, ọgaghị enye ọgwụ mgbochi maka ụdị ndị ọrịa a. Onweghi ihe omuma banyere ma mmanu a gha aru oru n’ime ogwu ara. Ọ bụrụ na ọ dị mkpa, jiri ọgwụ na-agwọ ọrịa kansa na nwanyị na-enye nwa ara, a ga-akagbu ume ọmụmụ.
Ngwa maka ọrụ ezughi oke ọrụ
Anabatachara iji Zaltrap mee ndị ọrịa nwere nnukwu ahazi aha anaghị adịkarị. Enweghị ihe omuma banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nwere nnukwu akụrụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Enweghị data banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nwere nnukwu ịba ọcha n'anya. Usoro ọgwụgwọ nke ndị ọrịa nwere oke imeju, ma jiri oke nlezianya na nlezianya n'okpuru nlekọta dọkịta, ka ekwe.
Anabatara ọgwụgwọ nke ndị ọrịa nwere oke imeju.
Do Overụbiga Zaltrap ókè
Onweghi ihe omuma banyere otu uzo ogwu si ju ihe 7 mg / n'arọ ibu otu ugboro n’ime ubochi 14 obula ma obu 9 mg / kg otu ubochi iri abuo na abuo metoro ahu.
Enwere ike igosipụta ịdoụbiga ihe ókè site na mmụba ike nke mgbaàmà akụkụ. Ọgwụgwọ - ọgwụgwọ mmezi, ịchekwa ọbara ọgbụgba oge niile. Ọ nweghị ọgwụ mgbochi.
Mmekọrịta na ọgwụ ndị ọzọ
Ductme ihe omumu nke pharmacokinetic na nyocha ihe omimi egosighi mmekorita nke pharmacokinetic nke Zaltrap ya na ogwu ndi ozo.
Mmanya ndakọrịta
A machibidoro ị Dụ mmanya na-egbu egbu n'oge ọgwụgwọ.
Analogs
Nkwadebe nke nwere ụdị ihe ngosi nka: Agrelide, Bortezovista, Vizirin, Irinotecan, Namibor, Ertikan.
Irinotecan bụ ọgwụ nwere ụdị ọrụ a.
Ahịa ọgwụ na-ahapụ okwu
Naanị site n'inye dọkịta ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ?
A na-ahapụ ahịa ahịa OTC.
Ọnụahịa
Site na 8500 rub. kwa karama.
Ọnọdụ nchekwa maka ọgwụ
Mgbe ọnọdụ okpomọkụ dị site na +2 ruo + 8 Celsius.
Bọchị mmebi
Afọ 3 Enwekwu ọgwụ ọzọ.
Emeputa
Sanofi-Aventis Deutschland GmbH, Germany.
Nyocha
Ksenia, dị afọ 55, Moscow: “Edebere nna m ụzọ Zaltrap maka ọgwụgwọ kansa. Ọgwụ ahụ dị mma, dị irè, ma bụrụkwa nnukwu ihe. Enwere mmetụta mgbe niile Ọ dị mma na a na-elekọta ya naanị otu izu abụọ, n'ihi na mgbe ọgwụgwọ ọgwụ agwọ ọrịa nna nwere mgbe ọ bụla ruo nwa oge. akawanye njọ, mana nyocha gosipụtara omume dị mma iji belata neoplasm. "
Eugene, 38 dị afọ iri atọ na asatọ, Astana: “Ahụrụ m ọtụtụ mmetụta site na Zaltrap. Enwere m ọnọdụ jọgburu onwe ya: ọgbụgbọ, ọgbụgbọ, isi ọwụwa oge niile, adịghị ike. Ma ọgwụ a na-amalite na ngwọta ahụ ngwa ngwa mmetụta ya na-eji n'ịgwọ ọrịa cancer kwesịrị ya. ndibọhọ ufen ndutụhọ emi. ”
Alina, onye gbara afọ 49, Kemerovo: “Nke a bụ ọgwụ dị oke ọnụ, ọ naghị adị m ka mụ na ya biri mgbe ọ gwọchara ya. Ma na ọ na-arụ ọrụ. Na n’ ụzọ 1, tum tum akpịrị m apụọ. Dọkịta kwuru na enwere ohere ịlaghachị, mana obere. Mịnịsta ọgwụ. Tupu Zaltrap, a na-eji ọgwụ ndị ọzọ eme ihe, mana ihe ọ rụpụtara bụ mkpụmkpụ oge, mgbe nke ahụ gasị, ebi m na-enweghị ọrịa afọ 3. "
