A na-eji Atomax agwọ ndị ọrịa ọrịa hypercholesterolemia, ọrịa hyperlipidemia, dysbetalipoproteinemia. Onye na-ahụ maka ọnya hypoglycemic na-enye gị ohere imezi ọkwa nke lipids, ndị na-egosi kọlestrọl ọnụ, triglycerides na arụmọrụ nke usoro nri na ịba ụba nke mmega ahụ. Ogologo oge ị ofụ ọgwụ ahụ na-ebelata ohere nke atherosclerotic mgbanwe na vaskụla endothelium na cholesterol plaques.
International Nonproprietary Aha
Atorvastatin.
ATX
C10AA05.
Ha weputara udi ya na ihe mebere ya
Emere ọgwụ a n'ụdị mbadamba maka nchịkwa ọnụ. Ngalaba ọgwụ ọ bụla nwere 10 mg ma ọ bụ 20 mg atorvastatin calcium trihydrate dị ka ihe na-arụ ọrụ. Isi ahụ nwekwara ihe ndị ọzọ dị mkpa iji meziwanye bioavailability na nnabata nke ihe na-arụ ọrụ n'ime eriri afọ:
- silicon dioxide akpọnwụwo;
- mmiri ara ehi shuga;
- stachi;
- triacetin;
- steeti magnesium;
- povidone;
- sodium croscarmellose.
A na-eme ọgwụ a n'ụdị mbadamba maka iji ọnụ mee ihe, akụkụ nke ọ bụla nke ọgwụ ahụ nwere 10 ma ọ bụ 20 mg nke calcium triorrate atorvastatin.
Mpempe akwụkwọ ọcha gbara gburugburu nwere ihe nkiri mejupụtara mejupụtara titanium dioxide, talc, crospovidone, hypromellose.
Omume ọgwụ
Usoro ihe eji eme ka ọgwụ dị ala na-ebute na atorvastatin, nke bụ ihe mgbochi nke HMG-CoA reductase. Enzyme a dị mkpa maka ịkpụ mevalonic acid, ihe na-ebute cholesterol. Site na mgbochi nke ọrụ arụmọrụ nke HMG-CoA reductase, atorvastatin nwere ike ịkwụsị nguzobe cholesterol, lipoproteins dị ala (LDL) na triglycerides na imeju.
Ọgwụ na-abawanye ọnụ ọgụgụ ndị na-anabata LDL na mkpụrụ ndụ akwara, nke na -ewelite uptake na metabolism nke lipoproteins. Na-emegide ngbanwe nke mkpokọta LDL, a na-achọpụta mmụba nke ọnụ ọgụgụ lipoproteins dị elu (HDL).
Mlọ ọgwụ
Mgbe ọ batara n’ahụ, akụrụngwa nọ n'ọrụ na-amalite itinyesi ike n’akụkụ mgbidi obere eriri afọ. Bioavailability bụ 100%. Mgbe ọ batara n’ọbara, atorvastatin na-eme beta-oxidation n’ime sel imeju na ịmepụta nguzo nke metabolic nke nwere mmetụta na-ebelata. A na-enyocha ọgwụ ọgwụ ahụ na ọnụnọ nke P450 isoenzyme. A na-enweta ọgwụgwọ ọgwụgwọ 70% n'ihi metabolites nọ n'ọrụ.
A na-eji Atomax agwọ ndị ọrịa ọrịa hypercholesterolemia, ọrịa hyperlipidemia, dysbetalipoproteinemia.
Atorvastatin dị 95% na protein plasma. Akụrụngwa nọ n'ọrụ na ngwaahịa metabolic na-ahapụ ahụ tumadi site na traktị biliary mgbe metabolism metabolism gasịrị. Ihe dị ka pacenti abụọ dị n ’ọgwụ dị na ọgwụ mbụ ya ka ọ dị na mmamịrị. Nkeji ọkara bụ awa iri na anọ.
Ihe ngosi maka ojiji
A na-eji ọgwụ ahụ belata cholesterol dị elu, triglycerides na LDL. Ọgwụ dị irè maka ndị ọrịa nwere:
- hereditary ma ọ bụ isi hypercholesterolemia;
- dysbetalipoproteinemia na ọdịda nri;
- jikọtara hyperlipidemia;
- elu ọbara triglycerides.
Inweta mmetụta hypoliplera zuru oke ga-ekwe omume naanị yana ijikọtara ya na usoro nri pụrụ iche iji belata cholesterol dị elu.
Ihe ngbanwe
A machibidoro ọgwụ a ọgwụ n'ọnọdụ ndị a:
- ịba ụba ka ọgwụ ndị mejupụtara ọgwụ ahụ;
- mmụba nke ịba ọcha n'anya transminases na ọbara na oke iwu site opekempe ugboro atọ maka ebumnuche amaghi;
- ọrịa imeju siri ike;
- womenmụ nwanyị dị ime na ndị na-actụ nwa;
- na nwata na etolite rue afo iri na asatọ.
Ekwesịrị ịkpachara anya mgbe ị na-ewere mbadamba maka ndị nwere nsogbu endocrine.
Ekwesịrị ịkpachara anya mgbe ị na-ewere mbadamba maka ndị nwere:
- pathologies nke imeju dị nfe ma ọ bụ agafeghị oke:
- wepu ọrịa mmanya;
- mmebi siri ike nke metabolism mmiri-nnu;
- usoro endocrine;
- Akwụkwụ na-adọ adọ.
Otu esi ewere Atomax
Tupu ịmalite Atomax, a na-enye onye ọrịa ọgwụ nri na-ebelata.
Usoro ọgwụgwọ maka ndị okenye na mmalite ọgwụgwọ bụ 10 mg maka otu oge. Iji mee ka mmetụta ọgwụgwọ dịkwuo elu, a na-enwe ike ịbawanye mkpụrụedemede lipid, yana ịnabata ezigbo ndidi, gaa na 80 mg. Otutu maka ntinye - oge 1 kwa ụbọchị.
Kwa ụbọchị 14-28, ọ dị mkpa ka ị mee ule maka plasma ịta nke lipids. Dabere na data enwetara, a na-agbazi usoro onunu ogwu nke onye dibia bekee.
Na hyperlipidemia na hypercholesterolemia jikọtara ọnụ, usoro ọkọlọtọ bụ 10 mg kwa ụbọchị. A na-ahụta ọgwụgwọ ahụ n'ime ụbọchị iri na anọ, ogo kachasị na-egosipụta mmerụ ahụ na-apụta ìhè ka izu anọ gachara amalite ọgwụgwọ. Site n'iji Atomax mee ogologo oge, ọgwụgwọ ahụ na-adịgide.
Na-arịa ọrịa shuga
Ọgwụ enweghị ike imetụta mkpokọta glucose na ahụ ma ọ nweghị mmerụ ahụ na mkpụrụ ndụ beta nke pancreas. N'oge ọgwụgwọ ọ dị mkpa iji nyochaa ọkwa glucose oge niile. N'ọnọdụ mgbanwe dị mkpa, gakwuru ndị endocrinologist banyere mgbazi nke usoro onunu ogwu nke ọgwụ hypoglycemic.
Nsonaazụ Atomax
Mmetụta na-adịghị mma na-etolite n'ọtụtụ oge site n'iji ihe nnọchi anya na-adịghị mma.
Na akụkụ ahụ nke ọhụụ
Akọrọ nkụ, ọbara ọgbụgba na nku anya, mmụba na nrụgide intraocular.
Site na anụ ahụ na akwara
Site na imebi usoro akwara, mmepe nke ọrịa ogbu na nkwonkwo, ihe na-egbu mgbu, mgbu na nkwonkwo na akwara. N'ọnọdụ ndị pụrụ iche, ọrịa rhabdomyolysis, myopathy na-amalite.
Ọkpụkpụ afọ
Udiri nri ndi mmadu na - eweputa dika o kwere omume na:
- ọgbụgbọ
- obi mgbawa;
- afọ ọsịsa
- mẹ iphemiphe, ẹphe meru;
- stomatitis, glossitis;
- ọnya afọ nke afọ na duodenum;
- mbufụt nke pancreas;
- ụba hepatic aminotransferases;
- melena;
- ọbara ọgbụgba nke akụkụ anọ.
Ahụhụ Hematopoietic
Na imebi ụmị ọkpụkpụ, ọnụ ọgụgụ akwara ọbara na-agbadata.
Sistemụ akwara Central
Ihe ọghọm nke sistemụ ụjọ na-esonyere ya na mmepe nke afọ ọsịsọ na isi ọwụwa, nsogbu ihi ụra, neuropathy akụkụ, mwepu nke mmetụta uche, na ọdịdị nke ọnọdụ ịda mba.
Site na usoro urinary
O nwere ihe ize ndụ nke ịrịa akụkụ, ọrịa nke urinary system, dysuria, mbufụt nke akụrụ, hematuria, ọbara ọgbụgba na urolithiasis.
Site na sistem iku ume
Ikekwe mmepe nke usoro mkpali na bronchi, paranasal sinuses, ọdịda okuku ume.
Na anụahụ
N'ime ụmụ nwoke, ntutu nwere ike ịpụ. Enwere mmụba na ọsụsọ, ọdịdị nke dandruff, eczema.
Site na usoro mkpụrụ ndụ ihe nketa
Site na imebi usoro ịmụ nwa, libido na-ebelata, nrụrụ na ejupụta na-apụta.
Site na usoro akwara obi
Enwere mgbu obi, arrhythmia, vasodilation, phlebitis na hypotension art art.
Site n'akụkụ nke metabolism
Site na nsogbu nke metabolism nke izugbe, mmụba n'ọbara nke phoineho phosphokinase ga-ekwe omume. Ọnwụ nke njikwa glycemic, mmepe nke albuminuria na ụba ọrụ nke ALT, Apụ apụtaghị. N'ụfọdụ, oke ibu, ihe na-aka njọ nke akara nke gout, ọbara mgbali elu na-ahụ.
Ahụhụ
Mmeghachi omume nfụkasị ahụ na-eme n’etiti ndị ọrịa nwere nnabata onwe onye n’ihe mejupụtara Atomax. Ejiri ihe nfụkasị ahụ bụ mmepe nke rashes, itching na contact dermatitis. N’ebe ndị a na-adịghị ahụkebe, angioedema, hypersensitivity to light, anaphylactic shock, Stevens-Johnson na ọrịa Lyell nwere ike ime.
Mmetụta ikike ịchịkwa usoro
Ọgwụ a anaghị emetụta ọrụ nke akwara ma ọ bụ etiti akwara na-enweghị ọgwụgwọ, yabụ n'oge ọgwụgwọ Atomax, a na-ahapụ ya ka ọ chịkwaa usoro ndị dị mgbagwoju anya ma na-anya ụgbọ.
Ntụziaka pụrụ iche
Ndị na-egbochi HMG-CoA reductase na-ebute mgbanwe na ọrụ biochemical nke hepatocytes. Ya mere, tupu ịmalite usoro ọgwụgwọ, na izu isii na izu iri na abụọ mgbe atọpụtara Atomax, ọ dị mkpa iji nyochaa ọrụ imeju. Site na ntachi obi dị mma na enzymes imeju nkịtị, a na-eme nnwale ọrụ imeju na mmụba na usoro kwa ụbọchị yana ọnwa isii ọ bụla.
Ndị ọrịa Obese kwesịrị ịgbalị ịkwalite cholesterol ha tupu ịmalite ọgwụgwọ.
Ọ dị mkpa icheta na ị atụ atorvastatin nwere ike ibute myopathy. Ọ dị mkpa ịgwa dọkịta banyere ọdịdị mgbu na adịghị ike na akwara, karịsịa na mmepe nke ahụ ọkụ na oke ịrịa. Ọ bụrụ na myalgia emee, a na-atụ aro ka ị kwụsị ị Atụ Atomax. Ọ bụrụ na nsonaazụ nke nyocha ọbara gosipụtara mmụba na ọrụ nke creatine phosphokinase, nke karịrị iwu 10 ma ọ bụ karịa, a na-akwụsị ịgwọ atorvastatin.
N'ime oge ọgwụgwọ ọgwụ, enwere ihe ize ndụ nke myoglobinuria. Na-emegide usoro nke pathological, rhabdomyolysis na dalfunction na akụrụ nwere ike ime. Ọ bụrụ na mgbaàmà nke myopathy ma ọ bụ akụrụ na-eme, kwụsịrị ọgwụgwọ Atomax.
Ndị ọrịa nwere oke mmanụ tupu ịmalite ọgwụgwọ kwesịrị ịgbalị ijikwa ọkwa cholesterol ha site na iji usoro ọgwụgwọ nri, ịba ụba mmega ahụ na usoro ndị ọzọ iji belata oke ahụ.
Jiri na agadi
Mgbe ọ dị afọ karịa iri afọ isii na ise, a na-atụ aro ịgbaso usoro usoro onunu ogwu ma soro ndụmọdụ nke ọkachamara ahụike.
Inye umuaka
A machibidoro ị theụ ọgwụ ahụ maka ụmụaka na-erubeghị afọ 18. Onweghi data banyere atorvastatin na etolite anụ ahụ nke na - eto eto.
Jiri n'oge ime na lactation
A machibidoro ọgwụ a na ụmụ nwanyị n'oge afọ ime n'ihi enweghị data na phytotoxicity nke Atomax. A maghị Atorvastatin ka ọ banye n’ime mmiri ara: ya mere, a na-atụ aro ka ị nyefee nwa ahụ ka ọ na-eri nri na ngwakọta aka n'oge ọgwụgwọ.
Ngwa maka ọrụ ezughi oke ọrụ
Ọrịa akụrụ anaghị emetụta oke ọpụrụiche nke atorvastatin yana ihe dị n'ime ọbara, yabụ akwadoro ị were usoro onunu ogwu maka ọrịa akụrụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Ndị ọrịa nwere ọrịa imeju kwesịrị ị theụ ọgwụ n'okpuru nlekọta nke dọkịta. Ewezuga ya bụ ndị nwere ọrụ ọria ịba ọchasịransferases, na-agbasokarị iwu ugboro atọ ma ọ bụ karịa. N’ihe atụ a, amachibidoro inye mmanụ ọrụ iji rụọ ọrụ.
Omaụbiga mmanya ókè nke Atomax
Na usoro ịre ahịa na-azụ ahịa, enwebeghị ikpe ọ bụla nke ịdoụbiga mmanya ókè. Ọ bụrụ na ikike iwu ga-ekwe ka 80 mg karịrị akarị, ọ ga-ekwe omume ịbawanye ma ọ bụ nwekwuo ohere nke nsonaazụ. N'ihi ụkọ data, emebeghị ọgwụ mgbochi akọwapụtara. A na-eji usoro ọgwụgwọ Symptomatic kpochapụ mmeghachi omume na-adịghị mma. Ogwu n’iru iji kpochapu ogwu n’agha adighi ike.
Mmekọrịta na ọgwụ ndị ọzọ
Enwere ihe ize ndụ nke ịmalite ọrịa myopathy na nhazi nke Atomax antifungal ndị otu sitere na azoles, ọgwụ cyclosporin, Niacin, usoro nke fibroic acid, Erythromycin.
Site na iji oge akpọrọ ihe nke nwere sọlfọ alumini na magnesium, plasma ịta nke atorvastatin na-ebelata 35%, ebe ọkwa LDL-cholesterol complex anaghị agbanwe. Akụkụ dị ike nke Atomax anaghị emetụta ọgwụ pharmokokinetics nke Antipyrine, Azithromycin. Mgbe ị na-eji 80 mg nke Digoxin, ọ ga-ekwe omume iwelie ọkwa ọbara ya site na 20%. Ndị ọrịa nwere mgbanwe a na mkpokọ Digoxin nọ n'okpuru nlekọta ahụike.
Atorvastatin na-abawanye ikike nke AUC nke ọmụmụ ọmụmụ etylene estradiol site na 20%.
Colestipol nwere ike ibute mbelata nke plasma plasma na 25%. N'okwu a, enwere mmụba nke mmelata lible.
Mmanya ndakọrịta
N'oge ọgwụgwọ, a naghị atụ aro ị drinkụ ihe ọholicụholicụ na-egbu egbu na ọgwụ nwere ethanol. Mmanya Ethyl na-akpata egbu egbu, platelet na mkpokọta ọbara ọbara, nke na-emetụta steeti sistem na obi ọgbụgba. A na-achọpụta mmetụta na-adịghị ike nke ọgwụgwọ yana ọfụma na pathologies nke sistem ọbara.
Analogs
Ọ bụrụ na enweghị mmetụta adịghị ike, enwere ike dochie mbadamba Atomax na otu n'ime ọgwụ ndị a:
- Liprimar;
- Atoris;
- Liptonorm;
- Tulip;
- Vazotor;
- Atorvastatin-SZ.
Ahịa ọgwụ na-ahapụ okwu
N'aka ogwu ka eji ere ogwu ahu.
Enwere m ike ịzụta na ndenye ọgwụ
Ogwu a na-egbute egbugbere ọnụ na-akwụghị ụgwọ n'ihi oke ihe ọghọm dị na ya ma ọ bụrụ na ejighị ya nke ọma.
Ọnụahịa
Onu ogugu Atomax di 400-500 rubles.
Ọnọdụ nchekwa maka ọgwụ
Debe mbadamba iche na ìhè anyanwụ n'ebe ebe iru mmiri dị. A na-atụ aro ka ị were ọgwụ ahụ na okpomọkụ nke + 8 ... + 25 Celsius.
Bọchị mmebi
Afọ 2
Emeputa
CJSC MAKIZ-PHARMA, Russia.
Na enweghị mmetụta nke lipid, enwere ike dochie mbadamba Atomax na Liprimar.
Nyocha
Eduard Petukhov, 38 afọ, Rostov-on-Don
Echere m na ọgwụ bụ ụzọ dị mma iji lụ ọgụ cholesterol. Ọnwa isii gara aga, enyere ha iwu ị drinkụ mbadamba nkume cholesterol nke 7.5 mmol. Nnwale ọbara gara aga izu abụọ gara aga gosipụtara mbelata na 6 mmol. Agam n’ihu ọgwụgwọ. Enweghị mmeghachi ahụ nfụkasị maka oge ọgwụgwọ niile.
Vasily Zafiraki, onye dibia bekee, St. Petersburg
N'ime usoro ọmụmụ gbasara ọgwụgwọ nke Atomax na Lipirimar, ọkwa triglyceride na ọrụ ọrụ vaskụla endothelium ka ejiri ọgwụ 2 mee ogologo oge. Nchoputa egosiputala uru nke Atomax. Ndị ọzọ na-emepụta atorvastatin anaghị eme nnwale ndị yiri nke ahụ ma depụta ọnụahịa dị ala maka ọgwụ, nke a na-eme ka anyị chee banyere ịdị irè nke ọgwụ ha. Ọ masịrị m na Atomax nwere ọtụtụ usoro onunu ogwu.
